Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit zeta

Gene

HBZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit zeta
Alternative name(s):
HBAZ
Hemoglobin zeta chain
Zeta-globin
Gene namesi
Name:HBZ
Synonyms:HBZ2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:4835. HBZ.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • hemoglobin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3050.
MalaCardsiHBZ.
OpenTargetsiENSG00000130656.
PharmGKBiPA29212.

Polymorphism and mutation databases

DMDMi122335.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved4 Publications
ChainiPRO_00000528512 – 142Hemoglobin subunit zetaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine2 Publications1
Modified residuei29PhosphothreonineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP02008.
PaxDbiP02008.
PeptideAtlasiP02008.
PRIDEiP02008.

PTM databases

iPTMnetiP02008.
PhosphoSitePlusiP02008.

Expressioni

Tissue specificityi

Detected in fetal erythrocytes (at protein level).2 Publications

Developmental stagei

Detected in the yolk sac of the early embryo and in erythrocytes from fetal umbilical cord blood. Detected at low levels after 10 weeks of gestation. Hemoglobin Portland levels are increased in fetuses with homozygous alpha-thalassemia, but it constitutes only a minor proportion of total hemoglobin and its levels decrease steadily after 10 weeks of gestation. Hemoglobin Portland-2 is detected in blood from still-born neoneates with homozygous alpha-thalassemia (at protein level).5 Publications

Gene expression databases

BgeeiENSG00000130656.
CleanExiHS_HBZ.
GenevisibleiP02008. HS.

Interactioni

Subunit structurei

Heterotetramer of two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1; two zeta chains and two gamma chains in fetal hemoglobin Portland-1. Heterotetramer of two zeta chains and two beta chains in hemoglobin Portland-2, detected in fetuses and neonates with homozygous alpha-thalassemia.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DOCK8Q8NF50-23EBI-719843,EBI-10174653
HBBP688712EBI-719843,EBI-715554
HBDP020425EBI-719843,EBI-6152722
HBE1P021003EBI-719843,EBI-6190240
KHDRBS2Q5VWX13EBI-719843,EBI-742808
KRT40Q6A1623EBI-719843,EBI-10171697
KRTAP10-7P604093EBI-719843,EBI-10172290
KRTAP10-9P604113EBI-719843,EBI-10172052
NOTCH2NLQ7Z3S95EBI-719843,EBI-945833

Protein-protein interaction databases

BioGridi109300. 23 interactors.
IntActiP02008. 21 interactors.
MINTiMINT-1416153.
STRINGi9606.ENSP00000252951.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 19Combined sources15
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi54 – 72Combined sources19
Helixi74 – 76Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Turni90 – 92Combined sources3
Helixi97 – 113Combined sources17
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Helixi139 – 141Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JEBX-ray2.10A/C2-142[»]
3W4UX-ray1.95A/C/E1-142[»]
ProteinModelPortaliP02008.
SMRiP02008.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02008.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02008.
KOiK13826.
OMAiETHAAWD.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02008.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTKTERTI IVSMWAKIST QADTIGTETL ERLFLSHPQT KTYFPHFDLH
60 70 80 90 100
PGSAQLRAHG SKVVAAVGDA VKSIDDIGGA LSKLSELHAY ILRVDPVNFK
110 120 130 140
LLSHCLLVTL AARFPADFTA EAHAAWDKFL SVVSSVLTEK YR
Length:142
Mass (Da):15,637
Last modified:January 23, 2007 - v2
Checksum:iB62A9B825743A155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00182 Genomic DNA. Translation: AAB59406.1.
M24173 mRNA. Translation: AAA61306.1.
Z84721 Genomic DNA. Translation: CAB06552.1.
CR456848 mRNA. Translation: CAG33129.1.
AE006462 Genomic DNA. Translation: AAK61214.1.
CH471112 Genomic DNA. Translation: EAW85864.1.
BC027892 mRNA. Translation: AAH27892.1.
CCDSiCCDS10397.1.
PIRiA90832. HZHU.
RefSeqiNP_005323.1. NM_005332.2.
XP_005255345.1. XM_005255288.3.
UniGeneiHs.585357.

Genome annotation databases

EnsembliENST00000252951; ENSP00000252951; ENSG00000130656.
GeneIDi3050.
KEGGihsa:3050.
UCSCiuc002cft.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00182 Genomic DNA. Translation: AAB59406.1.
M24173 mRNA. Translation: AAA61306.1.
Z84721 Genomic DNA. Translation: CAB06552.1.
CR456848 mRNA. Translation: CAG33129.1.
AE006462 Genomic DNA. Translation: AAK61214.1.
CH471112 Genomic DNA. Translation: EAW85864.1.
BC027892 mRNA. Translation: AAH27892.1.
CCDSiCCDS10397.1.
PIRiA90832. HZHU.
RefSeqiNP_005323.1. NM_005332.2.
XP_005255345.1. XM_005255288.3.
UniGeneiHs.585357.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JEBX-ray2.10A/C2-142[»]
3W4UX-ray1.95A/C/E1-142[»]
ProteinModelPortaliP02008.
SMRiP02008.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109300. 23 interactors.
IntActiP02008. 21 interactors.
MINTiMINT-1416153.
STRINGi9606.ENSP00000252951.

PTM databases

iPTMnetiP02008.
PhosphoSitePlusiP02008.

Polymorphism and mutation databases

DMDMi122335.

Proteomic databases

MaxQBiP02008.
PaxDbiP02008.
PeptideAtlasiP02008.
PRIDEiP02008.

Protocols and materials databases

DNASUi3050.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252951; ENSP00000252951; ENSG00000130656.
GeneIDi3050.
KEGGihsa:3050.
UCSCiuc002cft.2. human.

Organism-specific databases

CTDi3050.
DisGeNETi3050.
GeneCardsiHBZ.
GeneReviewsiHBZ.
H-InvDBHIX0059565.
HGNCiHGNC:4835. HBZ.
MalaCardsiHBZ.
MIMi142310. gene.
neXtProtiNX_P02008.
OpenTargetsiENSG00000130656.
PharmGKBiPA29212.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02008.
KOiK13826.
OMAiETHAAWD.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02008.
TreeFamiTF332328.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000130656-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP02008.
GeneWikiiHBZ.
GenomeRNAii3050.
PROiP02008.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130656.
CleanExiHS_HBZ.
GenevisibleiP02008. HS.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002340. Haemoglobin_zeta.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00816. ZETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAZ_HUMAN
AccessioniPrimary (citable) accession number: P02008
Secondary accession number(s): Q6IBF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.