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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei8240. Gal d HG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528221 – 141Hemoglobin subunit alpha-DAdd BLAST141

Proteomic databases

PaxDbiP02001.
PRIDEiP02001.

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Gene expression databases

BgeeiENSGALG00000007463.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains. The component D forms dimers of tetramers upon deoxygenation.

Protein-protein interaction databases

IntActiP02001. 1 interactor.
STRINGi9031.ENSGALP00000012054.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi53 – 71Combined sources19
Turni72 – 74Combined sources3
Helixi76 – 79Combined sources4
Helixi81 – 88Combined sources8
Turni89 – 91Combined sources3
Helixi96 – 113Combined sources18
Helixi114 – 116Combined sources3
Helixi119 – 136Combined sources18
Turni137 – 139Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBRX-ray2.30A/C1-141[»]
ProteinModelPortaliP02001.
SMRiP02001.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02001.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02001.
OMAiFAHAIIV.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02001.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAEDKKLI QQAWEKAASH QEEFGAEALT RMFTTYPQTK TYFPHFDLSP
60 70 80 90 100
GSDQVRGHGK KVLGALGNAV KNVDNLSQAM AELSNLHAYN LRVDPVNFKL
110 120 130 140
LSQCIQVVLA VHMGKDYTPE VHAAFDKFLS AVSAVLAEKY R
Length:141
Mass (Da):15,695
Last modified:July 21, 1986 - v1
Checksum:i1FE426969B7B5384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16K → R (PubMed:1656392).Curated1
Sequence conflicti16K → R (Ref. 6) Curated1
Sequence conflicti33F → L in AAA48584 (PubMed:6273837).Curated1
Sequence conflicti107V → C (PubMed:6273837).Curated1
Sequence conflicti107V → C (PubMed:7054172).Curated1
Sequence conflicti109 – 110LA → RL (PubMed:6273837).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15378 Genomic DNA. Translation: AAA48584.1.
V00411 Genomic DNA. Translation: CAA23702.1.
X59989 Genomic DNA. Translation: CAA42605.1.
AY016020 Genomic DNA. Translation: AAL35403.1.
AF098919 Genomic DNA. Translation: AAM09072.1.
PIRiB92421. HACH1.
RefSeqiNP_001004375.1. NM_001004375.2.
UniGeneiGga.2902.

Genome annotation databases

EnsembliENSGALT00000060227; ENSGALP00000053010; ENSGALG00000031597.
GeneIDi416651.
KEGGigga:416651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15378 Genomic DNA. Translation: AAA48584.1.
V00411 Genomic DNA. Translation: CAA23702.1.
X59989 Genomic DNA. Translation: CAA42605.1.
AY016020 Genomic DNA. Translation: AAL35403.1.
AF098919 Genomic DNA. Translation: AAM09072.1.
PIRiB92421. HACH1.
RefSeqiNP_001004375.1. NM_001004375.2.
UniGeneiGga.2902.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBRX-ray2.30A/C1-141[»]
ProteinModelPortaliP02001.
SMRiP02001.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02001. 1 interactor.
STRINGi9031.ENSGALP00000012054.

Protein family/group databases

Allergomei8240. Gal d HG.

Proteomic databases

PaxDbiP02001.
PRIDEiP02001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000060227; ENSGALP00000053010; ENSGALG00000031597.
GeneIDi416651.
KEGGigga:416651.

Organism-specific databases

CTDi100301693.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02001.
OMAiFAHAIIV.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02001.

Miscellaneous databases

EvolutionaryTraceiP02001.
PROiP02001.

Gene expression databases

BgeeiENSGALG00000007463.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAD_CHICK
AccessioniPrimary (citable) accession number: P02001
Secondary accession number(s): Q549K7, Q78AJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ref. 6 chain was isolated from Hbm, the least abundant of the four early chick hemoglobins.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.