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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)
Metal bindingi87 – 871Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei8240. Gal d HG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin subunit alpha-DPRO_0000052822Add
BLAST

Proteomic databases

PaxDbiP02001.
PRIDEiP02001.

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Gene expression databases

BgeeiENSGALG00000007463.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains. The component D forms dimers of tetramers upon deoxygenation.

Protein-protein interaction databases

IntActiP02001. 1 interaction.
STRINGi9031.ENSGALP00000012054.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 426Combined sources
Helixi53 – 7119Combined sources
Turni72 – 743Combined sources
Helixi76 – 794Combined sources
Helixi81 – 888Combined sources
Turni89 – 913Combined sources
Helixi96 – 11318Combined sources
Helixi114 – 1163Combined sources
Helixi119 – 13618Combined sources
Turni137 – 1393Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HBRX-ray2.30A/C1-141[»]
ProteinModelPortaliP02001.
SMRiP02001. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02001.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02001.
OMAiFAHAIIV.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02001.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAEDKKLI QQAWEKAASH QEEFGAEALT RMFTTYPQTK TYFPHFDLSP
60 70 80 90 100
GSDQVRGHGK KVLGALGNAV KNVDNLSQAM AELSNLHAYN LRVDPVNFKL
110 120 130 140
LSQCIQVVLA VHMGKDYTPE VHAAFDKFLS AVSAVLAEKY R
Length:141
Mass (Da):15,695
Last modified:July 21, 1986 - v1
Checksum:i1FE426969B7B5384
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161K → R (PubMed:1656392).Curated
Sequence conflicti16 – 161K → R (Ref. 6) Curated
Sequence conflicti33 – 331F → L in AAA48584 (PubMed:6273837).Curated
Sequence conflicti107 – 1071V → C (PubMed:6273837).Curated
Sequence conflicti107 – 1071V → C (PubMed:7054172).Curated
Sequence conflicti109 – 1102LA → RL (PubMed:6273837).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15378 Genomic DNA. Translation: AAA48584.1.
V00411 Genomic DNA. Translation: CAA23702.1.
X59989 Genomic DNA. Translation: CAA42605.1.
AY016020 Genomic DNA. Translation: AAL35403.1.
AF098919 Genomic DNA. Translation: AAM09072.1.
PIRiB92421. HACH1.
RefSeqiNP_001004375.1. NM_001004375.1.
UniGeneiGga.2902.
Gga.46940.

Genome annotation databases

EnsembliENSGALT00000039703; ENSGALP00000038912; ENSGALG00000007463.
GeneIDi416651.
KEGGigga:416651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15378 Genomic DNA. Translation: AAA48584.1.
V00411 Genomic DNA. Translation: CAA23702.1.
X59989 Genomic DNA. Translation: CAA42605.1.
AY016020 Genomic DNA. Translation: AAL35403.1.
AF098919 Genomic DNA. Translation: AAM09072.1.
PIRiB92421. HACH1.
RefSeqiNP_001004375.1. NM_001004375.1.
UniGeneiGga.2902.
Gga.46940.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HBRX-ray2.30A/C1-141[»]
ProteinModelPortaliP02001.
SMRiP02001. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02001. 1 interaction.
STRINGi9031.ENSGALP00000012054.

Protein family/group databases

Allergomei8240. Gal d HG.

Proteomic databases

PaxDbiP02001.
PRIDEiP02001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000039703; ENSGALP00000038912; ENSGALG00000007463.
GeneIDi416651.
KEGGigga:416651.

Organism-specific databases

CTDi100301693.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02001.
OMAiFAHAIIV.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02001.

Miscellaneous databases

EvolutionaryTraceiP02001.
PROiP02001.

Gene expression databases

BgeeiENSGALG00000007463.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBAD_CHICK
AccessioniPrimary (citable) accession number: P02001
Secondary accession number(s): Q549K7, Q78AJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Ref. 6 chain was isolated from Hbm, the least abundant of the four early chick hemoglobins.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.