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Protein

Hemoglobin subunit alpha-D

Gene

HBAD

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

Ref. 6 chain was isolated from Hbm, the least abundant of the four early chick hemoglobins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-D
Alternative name(s):
Alpha-D-globin
Hemoglobin alpha-D chain
Gene namesi
Name:HBAD
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Protein family/group databases

Allergomei8240. Gal d HG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528221 – 141Hemoglobin subunit alpha-DAdd BLAST141

Proteomic databases

PaxDbiP02001.
PRIDEiP02001.

Expressioni

Tissue specificityi

Red blood cells.

Developmental stagei

In birds, the alpha-D chain occurs in a minor hemoglobin component, called hemoglobin d, which is expressed in late embryonic and adult life.

Gene expression databases

BgeeiENSGALG00000007463.

Interactioni

Subunit structurei

Heterotetramer of two alpha-D chains and two beta chains. The component D forms dimers of tetramers upon deoxygenation.

Protein-protein interaction databases

IntActiP02001. 1 interactor.
STRINGi9031.ENSGALP00000012054.

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi53 – 71Combined sources19
Turni72 – 74Combined sources3
Helixi76 – 79Combined sources4
Helixi81 – 88Combined sources8
Turni89 – 91Combined sources3
Helixi96 – 113Combined sources18
Helixi114 – 116Combined sources3
Helixi119 – 136Combined sources18
Turni137 – 139Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HBRX-ray2.30A/C1-141[»]
ProteinModelPortaliP02001.
SMRiP02001.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02001.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP02001.
OMAiAGHEAPF.
OrthoDBiEOG091G0S0X.
PhylomeDBiP02001.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P02001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAEDKKLI QQAWEKAASH QEEFGAEALT RMFTTYPQTK TYFPHFDLSP
60 70 80 90 100
GSDQVRGHGK KVLGALGNAV KNVDNLSQAM AELSNLHAYN LRVDPVNFKL
110 120 130 140
LSQCIQVVLA VHMGKDYTPE VHAAFDKFLS AVSAVLAEKY R
Length:141
Mass (Da):15,695
Last modified:July 21, 1986 - v1
Checksum:i1FE426969B7B5384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16K → R (PubMed:1656392).Curated1
Sequence conflicti16K → R (Ref. 6) Curated1
Sequence conflicti33F → L in AAA48584 (PubMed:6273837).Curated1
Sequence conflicti107V → C (PubMed:6273837).Curated1
Sequence conflicti107V → C (PubMed:7054172).Curated1
Sequence conflicti109 – 110LA → RL (PubMed:6273837).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15378 Genomic DNA. Translation: AAA48584.1.
V00411 Genomic DNA. Translation: CAA23702.1.
X59989 Genomic DNA. Translation: CAA42605.1.
AY016020 Genomic DNA. Translation: AAL35403.1.
AF098919 Genomic DNA. Translation: AAM09072.1.
PIRiB92421. HACH1.
RefSeqiNP_001004375.1. NM_001004375.2.
UniGeneiGga.2902.

Genome annotation databases

EnsembliENSGALT00000060227; ENSGALP00000053010; ENSGALG00000031597.
GeneIDi416651.
KEGGigga:416651.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHBAD_CHICK
AccessioniPrimary (citable) accession number: P02001
Secondary accession number(s): Q549K7, Q78AJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 7, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families