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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Alligator mississippiensis (American alligator)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiAlligator mississippiensis (American alligator)
Taxonomic identifieri8496 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525422 – 142Hemoglobin subunit alphaAdd BLAST141

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP01999
SMRiP01999
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709
KOiK13822
OrthoDBiEOG091G0S0X
PhylomeDBiP01999

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01999-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSMEDKSN VKAIWGKASG HLEEYGAEAL ERMFCAYPQT KIYFPHFDMS
60 70 80 90 100
HNSAQIRAHG KKVFSALHEA VNHIDDLPGA LCRLSELHAH SLRVDPVNFK
110 120 130 140
FLAHCVLVVF AIHHPSALSP EIHASLDKFL CAVSAVLTSK YR
Length:142
Mass (Da):15,865
Last modified:January 23, 2007 - v2
Checksum:iD5995EF90A6B45E9
GO

Sequence databases

PIRiA02320 HAAQ
RefSeqiXP_006261904.1, XM_006261842.3

Genome annotation databases

GeneIDi102559387
KEGGiamj:102559387

Similar proteinsi

Entry informationi

Entry nameiHBA_ALLMI
AccessioniPrimary (citable) accession number: P01999
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health