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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

This alpha chain is from the adult major tetrameric component, which has been called hemoglobin A or AII.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-GGA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-GGA-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000525992 – 142Hemoglobin subunit alpha-AAdd BLAST141

Proteomic databases

PaxDbiP01994
PRIDEiP01994

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSGALG00000007468

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038904

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 28Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BEVX-ray2.10C20-30[»]
5AD0X-ray2.84C20-30[»]
ProteinModelPortaliP01994
SMRiP01994
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01994

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP01994
KOiK13822
OMAiDKFLCAV
OrthoDBiEOG091G0S0X
PhylomeDBiP01994

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKNN VKGIFTKIAG HAEEYGAETL ERMFTTYPPT KTYFPHFDLS
60 70 80 90 100
HGSAQIKGHG KKVVAALIEA ANHIDDIAGT LSKLSDLHAH KLRVDPVNFK
110 120 130 140
LLGQCFLVVV AIHHPAALTP EVHASLDKFL CAVGTVLTAK YR
Length:142
Mass (Da):15,429
Last modified:January 23, 2007 - v2
Checksum:i56847D9227928E2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90H → D in AAD32581 (Ref. 10) Curated1
Sequence conflicti93 – 95RVD → TGG in CAA23678 (PubMed:6253930).Curated3
Sequence conflicti111A → T (PubMed:6894907).Curated1
Sequence conflicti121E → K in CAA23678 (PubMed:6253930).Curated1
Sequence conflicti122V → I (PubMed:6894907).Curated1
Sequence conflicti128K → N in CAA23678 (PubMed:6253930).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59989 Genomic DNA Translation: CAA42606.1
V00379 mRNA Translation: CAA23678.1
V00380 mRNA Translation: CAA23679.1
V00410 Genomic DNA Translation: CAA23701.1
M15379 Genomic DNA Translation: AAA48582.1 Sequence problems.
AY016020 Genomic DNA Translation: AAL35404.1
AF098919 Genomic DNA Translation: AAM09073.1
AF125311 Genomic DNA Translation: AAD32581.1
M35068 mRNA Translation: AAA48583.1
PIRiS18673 HACH2
RefSeqiNP_001004376.1, NM_001004376.3
UniGeneiGga.34361

Genome annotation databases

EnsembliENSGALT00000075828; ENSGALP00000050043; ENSGALG00000043234
GeneIDi416652
KEGGigga:416652

Similar proteinsi

Entry informationi

Entry nameiHBA_CHICK
AccessioniPrimary (citable) accession number: P01994
Secondary accession number(s): Q9PWP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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