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P01990 (HBA_ANSIN) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene names
Name:HBAA
OrganismAnser indicus (Bar-headed goose) (Anas indica)
Taxonomic identifier8846 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 142141Hemoglobin subunit alpha-A
PRO_0000052552

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Secondary structure

...................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01990 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3E1691F128B173F0

FASTA14215,468
        10         20         30         40         50         60 
MVLSAADKTN VKGVFSKISG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ HGSAQIKAHG 

        70         80         90        100        110        120 
KKVVAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK FLGHCFLVVV AIHHPSALTA 

       130        140 
EVHASLDKFL CAVGTVLTAK YR 

« Hide

References

[1]"Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus): primary structure and physiology of respiration, systematic and evolution."
Oberthur W., Braunitzer G., Wurdinger I.
Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-142.
[2]"The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)."
Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X.
J. Mol. Biol. 255:484-493(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRHAGSI. A02311.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4FX-ray2.00A2-142[»]
1C40X-ray2.30A2-141[»]
1HV4X-ray2.80A/C/E/G2-141[»]
ProteinModelPortalP01990.
SMRP01990. Positions 2-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1515082.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR018331. Haemoglobin_alpha_chain.
IPR002339. Haemoglobin_pi.
[Graphical view]
PANTHERPTHR11442:SF14. PTHR11442:SF14. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01990.

Entry information

Entry nameHBA_ANSIN
AccessionPrimary (citable) accession number: P01990
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 16, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references