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P01990

- HBA_ANSIN

UniProt

P01990 - HBA_ANSIN

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Protein

Hemoglobin subunit alpha-A

Gene
HBAA
Organism
Anser indicus (Bar-headed goose) (Anas indica)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiAnser indicus (Bar-headed goose) (Anas indica)
Taxonomic identifieri8846 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 142141Hemoglobin subunit alpha-APRO_0000052552Add
BLAST

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-1515082.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1814
Helixi22 – 3615
Helixi38 – 436
Helixi54 – 7118
Turni72 – 754
Helixi77 – 804
Helixi82 – 898
Helixi97 – 11317
Turni115 – 1173
Helixi120 – 13617
Helixi139 – 1413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4FX-ray2.00A2-142[»]
1C40X-ray2.30A2-142[»]
1HV4X-ray2.80A/C/E/G2-142[»]
ProteinModelPortaliP01990.
SMRiP01990. Positions 2-142.

Miscellaneous databases

EvolutionaryTraceiP01990.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01990-1 [UniParc]FASTAAdd to Basket

« Hide

MVLSAADKTN VKGVFSKISG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ    50
HGSAQIKAHG KKVVAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK 100
FLGHCFLVVV AIHHPSALTA EVHASLDKFL CAVGTVLTAK YR 142
Length:142
Mass (Da):15,468
Last modified:January 23, 2007 - v2
Checksum:i3E1691F128B173F0
GO

Sequence databases

PIRiA02311. HAGSI.

Cross-referencesi

Sequence databases

PIRi A02311. HAGSI.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A4F X-ray 2.00 A 2-142 [» ]
1C40 X-ray 2.30 A 2-142 [» ]
1HV4 X-ray 2.80 A/C/E/G 2-142 [» ]
ProteinModelPortali P01990.
SMRi P01990. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1515082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009709.

Miscellaneous databases

EvolutionaryTracei P01990.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus): primary structure and physiology of respiration, systematic and evolution."
    Oberthur W., Braunitzer G., Wurdinger I.
    Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
  2. "The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)."
    Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X.
    J. Mol. Biol. 255:484-493(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiHBA_ANSIN
AccessioniPrimary (citable) accession number: P01990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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