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P01990

- HBA_ANSIN

UniProt

P01990 - HBA_ANSIN

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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Anser indicus (Bar-headed goose) (Anas indica)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiAnser indicus (Bar-headed goose) (Anas indica)
Taxonomic identifieri8846 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeAnseriformesAnatidaeAnser

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 142141Hemoglobin subunit alpha-APRO_0000052552Add
BLAST

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-1515082.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1814
Helixi22 – 3615
Helixi38 – 436
Helixi54 – 7118
Turni72 – 754
Helixi77 – 804
Helixi82 – 898
Helixi97 – 11317
Turni115 – 1173
Helixi120 – 13617
Helixi139 – 1413

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A4FX-ray2.00A2-142[»]
1C40X-ray2.30A2-142[»]
1HV4X-ray2.80A/C/E/G2-142[»]
ProteinModelPortaliP01990.
SMRiP01990. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01990.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01990-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKGVFSKISG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ
60 70 80 90 100
HGSAQIKAHG KKVVAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK
110 120 130 140
FLGHCFLVVV AIHHPSALTA EVHASLDKFL CAVGTVLTAK YR
Length:142
Mass (Da):15,468
Last modified:January 23, 2007 - v2
Checksum:i3E1691F128B173F0
GO

Sequence databases

PIRiA02311. HAGSI.

Cross-referencesi

Sequence databases

PIRi A02311. HAGSI.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A4F X-ray 2.00 A 2-142 [» ]
1C40 X-ray 2.30 A 2-142 [» ]
1HV4 X-ray 2.80 A/C/E/G 2-142 [» ]
ProteinModelPortali P01990.
SMRi P01990. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1515082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009709.

Miscellaneous databases

EvolutionaryTracei P01990.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus): primary structure and physiology of respiration, systematic and evolution."
    Oberthur W., Braunitzer G., Wurdinger I.
    Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
  2. "The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)."
    Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X.
    J. Mol. Biol. 255:484-493(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiHBA_ANSIN
AccessioniPrimary (citable) accession number: P01990
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3