P01990 (HBA_ANSIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit alpha-A

Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain

Gene names

Name:

HBAA

Organism

Anser indicus (Bar-headed goose) (Anas indica)

Taxonomic identifier

8846 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anser

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed By similarity

Chain

2 – 142

141

Hemoglobin subunit alpha-A

PRO_0000052552

Sites

Metal binding

59

1

Iron (heme distal ligand)

Metal binding

88

1

Iron (heme proximal ligand)

Secondary structure

1

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142

Helix Strand Turn

Details...

Helix

5 – 18

14

Helix

22 – 36

15

Helix

38 – 43

6

Helix

54 – 71

18

Turn

72 – 75

4

Helix

77 – 80

4

Helix

82 – 89

8

Helix

97 – 113

17

Turn

115 – 117

3

Helix

120 – 136

17

Helix

139 – 141

3

Sequences

	Sequence		Length	Mass (Da)
	P01990 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 3E1691F128B173F0	FASTA	142	15,468
	10 20 30 40 50 60 MVLSAADKTN VKGVFSKISG HAEEYGAETL ERMFTAYPQT KTYFPHFDLQ HGSAQIKAHG 70 80 90 100 110 120 KKVVAALVEA VNHIDDIAGA LSKLSDLHAQ KLRVDPVNFK FLGHCFLVVV AIHHPSALTA 130 140 EVHASLDKFL CAVGTVLTAK YR

References

[1]	"Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus): primary structure and physiology of respiration, systematic and evolution." Oberthur W., Braunitzer G., Wurdinger I. Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-142.
[2]	"The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)." Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X. J. Mol. Biol. 255:484-493(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

PIR

HAGSI. A02311.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A4F	X-ray	2.00	A	2-142	[»]
1C40	X-ray	2.30	A	2-141	[»]
1HV4	X-ray	2.80	A/C/E/G	2-141	[»]

ProteinModelPortal

P01990.

SMR

P01990. Positions 2-142.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

Gene3D

1.10.490.10. 1 hit.

InterPro

IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR018331. Haemoglobin_alpha_chain.
IPR002339. Haemoglobin_pi.
[Graphical view]

PANTHER

PTHR11442:SF14. PTHR11442:SF14. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00612. ALPHAHAEM.
PR00815. PIHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01990.

Entry information

Entry name

HBA_ANSIN

Accession

Primary (citable) accession number: P01990

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program