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Protein

Hemoglobin subunit alpha-A

Gene

HBAA

Organism
Anas platyrhynchos (Mallard) (Anas boschas)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-A
Alternative name(s):
Alpha-A-globin
Hemoglobin alpha-A chain
Gene namesi
Name:HBAA
OrganismiAnas platyrhynchos (Mallard) (Anas boschas)
Taxonomic identifieri8839 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeAnseriformesAnatidaeAnatinaeAnas
Proteomesi
  • UP000016666 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525472 – 142Hemoglobin subunit alpha-AAdd BLAST141

Proteomic databases

PRIDEiP01986

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi54 – 72Combined sources19
Turni73 – 75Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi97 – 113Combined sources17
Helixi115 – 117Combined sources3
Helixi120 – 137Combined sources18
Turni138 – 140Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EOKX-ray2.10A2-142[»]
ProteinModelPortaliP01986
SMRiP01986
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01986

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01986-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKGVFSKIGG HAEEYGAETL ERMFIAYPQT KTYFPHFDLS
60 70 80 90 100
HGSAQIKAHG KKVAAALVEA VNHVDDIAGA LSKLSDLHAQ KLRVDPVNFK
110 120 130 140
FLGHCFLVVV AIHHPAALTP EVHASLDKFM CAVGAVLTAK YR
Length:142
Mass (Da):15,365
Last modified:January 23, 2007 - v2
Checksum:iEA21F1750AE26503
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02008 mRNA Translation: CAA26039.1
PIRiA02309 HADK

Similar proteinsi

Entry informationi

Entry nameiHBA_ANAPL
AccessioniPrimary (citable) accession number: P01986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health