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Protein

Hemoglobin subunit alpha-2

Gene
N/A
Organism
Tachyglossus aculeatus aculeatus (Southeast Australian short-beaked echidna)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

This alpha chain is the A variant from the minor hemoglobin II. Its sequence differs from those of the alpha-1 chain variants A and B at nine positions each.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-2
Alternative name(s):
Alpha-2-globin
Hemoglobin alpha-2 chain
OrganismiTachyglossus aculeatus aculeatus (Southeast Australian short-beaked echidna)
Taxonomic identifieri49271 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataTachyglossidaeTachyglossus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000527741 – 141Hemoglobin subunit alpha-2Add BLAST141

Proteomic databases

PRIDEiP01978.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP01978.
SMRiP01978.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P01978-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLTDAERKEV TSLWGKASGH AEDYGAEALE RLFLSFPTTK TYFSHMDLSK
60 70 80 90 100
GSAHVRAHGK KVADALTTAV GHFNDMDGAL SDLSDLHAHK LRVDPVNFKL
110 120 130 140
LAHCFLVVLA RHHPEEFTPS AHAAMDKFLS RVATVLTSKY R
Length:141
Mass (Da):15,585
Last modified:July 21, 1986 - v1
Checksum:iB8923A938F67F867
GO

Sequence databases

PIRiA02301. HATG2.

Similar proteinsi

Entry informationi

Entry nameiHBA2_TACAC
AccessioniPrimary (citable) accession number: P01978
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families