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Protein

Hemoglobin subunit alpha-1/2

Gene
N/A
Organism
Odocoileus virginianus virginianus (Virginia white-tailed deer)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)
Metal bindingi87 – 871Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-1/2
Alternative name(s):
Alpha-1/2-globin
Hemoglobin alpha-1/2 chain
OrganismiOdocoileus virginianus virginianus (Virginia white-tailed deer)
Taxonomic identifieri9875 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraCervidaeOdocoileinaeOdocoileus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin subunit alpha-1/2PRO_0000052708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei7 – 71N6-succinyllysineBy similarity
Modified residuei11 – 111N6-succinyllysineBy similarity
Modified residuei16 – 161N6-acetyllysine; alternateBy similarity
Modified residuei16 – 161N6-succinyllysine; alternateBy similarity
Modified residuei24 – 241PhosphotyrosineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei40 – 401N6-succinyllysineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei108 – 1081PhosphothreonineBy similarity
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei134 – 1341PhosphothreonineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1411Combined sources
Turni15 – 173Combined sources
Helixi22 – 287Combined sources
Turni33 – 353Combined sources
Helixi40 – 423Combined sources
Helixi54 – 6916Combined sources
Helixi76 – 794Combined sources
Turni81 – 833Combined sources
Helixi84 – 885Combined sources
Turni89 – 913Combined sources
Helixi95 – 973Combined sources
Helixi98 – 11215Combined sources
Turni114 – 1163Combined sources
Helixi119 – 13517Combined sources
Turni136 – 1394Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HDSX-ray1.98A/C1-141[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01972.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSAABKSBV KAAWGKVGGN AAPYGAZALZ RMFLSFPTTK TYFPHFBLSH
60 70 80 90 100
GSAZVKAHGZ KVABALTKAV GHLBBLPGTL SBLSBLHAHK LRVBPVBFKL
110 120 130 140
LSHSLLVTLA THLPBBFTPA VHASLBKFLA BVSTVLTSKY R
Length:141
Mass (Da):15,127
Last modified:July 21, 1986 - v1
Checksum:i5B2EBB566F902D4F
GO

Polymorphismi

There are three alleles of the alpha-1 chain (alpha-1*1, alpha-1*2 and alpha-1*3). The sequence shown is alpha-1*1. The alpha-2 chain is non-allelic.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51A → T in alpha-1*2 chain.
Natural varianti20 – 201N → K in alpha-2 chain.
Natural varianti24 – 241Y → F in alpha-2 chain and alpha-1*3 chain.

Sequence databases

PIRiA02296. HADE1V.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

PIRiA02296. HADE1V.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HDSX-ray1.98A/C1-141[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.

Miscellaneous databases

EvolutionaryTraceiP01972.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_ODOVI
AccessioniPrimary (citable) accession number: P01972
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.