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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-BTA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-BTA-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Protein family/group databases

Allergomei8242 Bos d HG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000525682 – 142Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP01966
PeptideAtlasiP01966
PRIDEiP01966

Miscellaneous databases

PMAP-CutDBiP01966

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSBTAG00000026417

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi169070, 1 interactor
STRINGi9913.ENSBTAP00000037374

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Beta strandi45 – 47Combined sources3
Helixi54 – 72Combined sources19
Helixi73 – 76Combined sources4
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi97 – 113Combined sources17
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Turni138 – 140Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSXX-ray2.10A/C2-142[»]
1G08X-ray1.90A/C2-142[»]
1G09X-ray2.04A/C2-142[»]
1G0AX-ray2.04A/C2-142[»]
1HDAX-ray2.20A/C2-142[»]
2QSPX-ray1.85A/C2-142[»]
2QSSX-ray1.75A/C2-142[»]
3CIUX-ray3.50A/C2-142[»]
3PI8X-ray2.20A/C2-142[»]
3PI9X-ray2.90A/C2-142[»]
3PIAX-ray2.10A/C2-142[»]
ProteinModelPortaliP01966
SMRiP01966
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01966

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP01966
KOiK13822
OMAiDKFLCAV
OrthoDBiEOG091G0S0X
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01966-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKGN VKAAWGKVGG HAAEYGAEAL ERMFLSFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKGHG AKVAAALTKA VEHLDDLPGA LSELSDLHAH KLRVDPVNFK
110 120 130 140
LLSHSLLVTL ASHLPSDFTP AVHASLDKFL ANVSTVLTSK YR
Length:142
Mass (Da):15,184
Last modified:January 23, 2007 - v2
Checksum:i6D20CADDA05C0DC5
GO

Polymorphismi

There are 3 alleles in Podolian cattle; N, S and Y.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti90H → Y in allele Y. 1 Publication1
Natural varianti132N → S in allele S. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242797 Genomic DNA Translation: CAB56827.1
AJ242798 Genomic DNA Translation: CAB56828.1
AJ242799 Genomic DNA Translation: CAB56829.1
BC102940 mRNA Translation: AAI02941.1
BC133477 mRNA Translation: AAI33478.1
PIRiA02289 HABO
RefSeqiNP_001070890.2, NM_001077422.3
XP_001788728.1, XM_001788676.4
XP_003585623.1, XM_003585575.2
UniGeneiBt.10591

Genome annotation databases

EnsembliENSBTAT00000022034; ENSBTAP00000022034; ENSBTAG00000026417
ENSBTAT00000037545; ENSBTAP00000037374; ENSBTAG00000026418
GeneIDi100140149
512439
KEGGibta:100140149
bta:512439

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBA_BOVIN
AccessioniPrimary (citable) accession number: P01966
Secondary accession number(s): A3KN13
, Q3SZE0, Q9TTR9, Q9TTS0, Q9TTS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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