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P01959 (HBA_EQUAS) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene names
Name:HBA1
AND
Name:HBA2
OrganismEquus asinus (Donkey)
Taxonomic identifier9793 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 142141Hemoglobin subunit alpha
PRO_0000052624

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Amino acid modifications

Modified residue81N6-succinyllysine By similarity
Modified residue121N6-succinyllysine By similarity
Modified residue171N6-acetyllysine; alternate By similarity
Modified residue171N6-succinyllysine; alternate By similarity
Modified residue411N6-succinyllysine By similarity

Experimental info

Sequence conflict1321T → S AA sequence Ref.2

Secondary structure

...................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01959 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 93B837BC15C1D175

FASTA14215,220
        10         20         30         40         50         60 
MVLSAADKTN VKAAWSKVGG NAGEFGAEAL ERMFLGFPTT KTYFPHFDLS HGSAQVKAHG 

        70         80         90        100        110        120 
KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK LLSHCLLSTL AVHLPNDFTP 

       130        140 
AVHASLDKFL STVSTVLTSK YR 

« Hide

References

[1]"Phylogenetic relationships within the genus Equus and the evolution of alpha and theta globin genes."
Oakenfull E.A., Clegg J.B.
J. Mol. Evol. 47:772-783(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HBA1 AND HBA2).
[2]"Amino-acid replacements in horse haemoglobin."
Kilmartin J.V., Clegg J.B.
Nature 213:269-271(1967) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-142.
[3]"Crystal structure of haemoglobin from donkey (Equus asinus) at 3A resolution."
Balasundaresan D., Saraboji K., Ponnuswamy M.N.
Biochimie 88:719-723(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U69894 Genomic DNA. Translation: AAD13640.1.
U69895 Genomic DNA. Translation: AAD13641.1.
PIRHAHOD. A02282.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1S0HX-ray3.00A2-142[»]
ProteinModelPortalP01959.
SMRP01959. Positions 2-142.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01959.

Entry information

Entry nameHBA_EQUAS
AccessionPrimary (citable) accession number: P01959
Secondary accession number(s): P82988
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 90 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references