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P01959

- HBA_EQUAS

UniProt

P01959 - HBA_EQUAS

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Protein

Hemoglobin subunit alpha

Gene

HBA1

more
Organism
Equus asinus (Donkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA1
AND
Name:HBA2
OrganismiEquus asinus (Donkey)
Taxonomic identifieri9793 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-succinyllysineBy similarity
Modified residuei12 – 121N6-succinyllysineBy similarity
Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
Modified residuei17 – 171N6-succinyllysine; alternateBy similarity
Modified residuei41 – 411N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1814
Helixi19 – 213
Helixi22 – 3615
Helixi38 – 436
Helixi54 – 7219
Helixi74 – 763
Helixi77 – 804
Helixi82 – 887
Turni89 – 924
Helixi97 – 11317
Turni115 – 1173
Helixi120 – 13617
Turni137 – 1415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1S0HX-ray3.00A2-142[»]
ProteinModelPortaliP01959.
SMRiP01959. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01959.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01959-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKAAWSKVGG NAGEFGAEAL ERMFLGFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKAHG KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLSTL AVHLPNDFTP AVHASLDKFL STVSTVLTSK YR
Length:142
Mass (Da):15,220
Last modified:January 23, 2007 - v3
Checksum:i93B837BC15C1D175
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321T → S AA sequence (PubMed:6030605)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69894 Genomic DNA. Translation: AAD13640.1.
U69895 Genomic DNA. Translation: AAD13641.1.
PIRiA02282. HAHOD.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U69894 Genomic DNA. Translation: AAD13640.1 .
U69895 Genomic DNA. Translation: AAD13641.1 .
PIRi A02282. HAHOD.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1S0H X-ray 3.00 A 2-142 [» ]
ProteinModelPortali P01959.
SMRi P01959. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009709.

Miscellaneous databases

EvolutionaryTracei P01959.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogenetic relationships within the genus Equus and the evolution of alpha and theta globin genes."
    Oakenfull E.A., Clegg J.B.
    J. Mol. Evol. 47:772-783(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HBA1 AND HBA2).
  2. "Amino-acid replacements in horse haemoglobin."
    Kilmartin J.V., Clegg J.B.
    Nature 213:269-271(1967) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
  3. "Crystal structure of haemoglobin from donkey (Equus asinus) at 3A resolution."
    Balasundaresan D., Saraboji K., Ponnuswamy M.N.
    Biochimie 88:719-723(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).

Entry informationi

Entry nameiHBA_EQUAS
AccessioniPrimary (citable) accession number: P01959
Secondary accession number(s): P82988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3