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P01958

- HBA_HORSE

UniProt

P01958 - HBA_HORSE

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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052652Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-succinyllysineBy similarity
Modified residuei12 – 121N6-succinyllysineBy similarity
Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
Modified residuei17 – 171N6-succinyllysine; alternateBy similarity
Modified residuei41 – 411N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-242180.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1713
Turni18 – 203
Helixi22 – 3615
Helixi38 – 436
Helixi46 – 505
Helixi54 – 7118
Helixi72 – 765
Helixi77 – 804
Helixi82 – 909
Helixi96 – 11318
Turni115 – 1173
Helixi120 – 13718
Turni138 – 1403

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90A2-142[»]
1IBEX-ray1.80A2-142[»]
1IWHX-ray1.55A2-142[»]
1NS6X-ray2.05A2-142[»]
1NS9X-ray1.60A2-142[»]
1Y8HX-ray3.10A/C2-142[»]
1Y8IX-ray2.60A/C2-142[»]
1Y8KX-ray2.30A/C2-142[»]
2D5XX-ray1.45A2-142[»]
2DHBX-ray2.80A2-142[»]
2MHBX-ray2.00A2-142[»]
2ZLTX-ray1.90A2-142[»]
2ZLUX-ray2.00A2-142[»]
2ZLVX-ray2.00A2-142[»]
2ZLWX-ray2.90A/C2-142[»]
2ZLXX-ray2.80A/C2-142[»]
ProteinModelPortaliP01958.
SMRiP01958. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01958.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP01958.
KOiK13822.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01958-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKAAWSKVGG HAGEYGAEAL ERMFLGFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKAHG KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLSTL AVHLPNDFTP AVHASLDKFL SSVSTVLTSK YR
Length:142
Mass (Da):15,245
Last modified:January 23, 2007 - v2
Checksum:i33BB917E15C9CD15
GO

Polymorphismi

Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251Y → F Exist in both chains.
Natural varianti61 – 611K → Q in fast chain.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01086 Genomic DNA. Translation: CAA25564.1.
M17902 Genomic DNA. Translation: AAD15306.1.
M17903 Genomic DNA. Translation: AAA30948.1.
X07053 Genomic DNA. Translation: CAA30097.1.
PIRiI46302. HAHO.
RefSeqiNP_001078901.1. NM_001085432.1.
UniGeneiEca.11653.

Genome annotation databases

GeneIDi100036557.
KEGGiecb:100036557.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01086 Genomic DNA. Translation: CAA25564.1 .
M17902 Genomic DNA. Translation: AAD15306.1 .
M17903 Genomic DNA. Translation: AAA30948.1 .
X07053 Genomic DNA. Translation: CAA30097.1 .
PIRi I46302. HAHO.
RefSeqi NP_001078901.1. NM_001085432.1.
UniGenei Eca.11653.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1G0B X-ray 1.90 A 2-142 [» ]
1IBE X-ray 1.80 A 2-142 [» ]
1IWH X-ray 1.55 A 2-142 [» ]
1NS6 X-ray 2.05 A 2-142 [» ]
1NS9 X-ray 1.60 A 2-142 [» ]
1Y8H X-ray 3.10 A/C 2-142 [» ]
1Y8I X-ray 2.60 A/C 2-142 [» ]
1Y8K X-ray 2.30 A/C 2-142 [» ]
2D5X X-ray 1.45 A 2-142 [» ]
2DHB X-ray 2.80 A 2-142 [» ]
2MHB X-ray 2.00 A 2-142 [» ]
2ZLT X-ray 1.90 A 2-142 [» ]
2ZLU X-ray 2.00 A 2-142 [» ]
2ZLV X-ray 2.00 A 2-142 [» ]
2ZLW X-ray 2.90 A/C 2-142 [» ]
2ZLX X-ray 2.80 A/C 2-142 [» ]
ProteinModelPortali P01958.
SMRi P01958. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-242180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100036557.
KEGGi ecb:100036557.

Organism-specific databases

CTDi 15121.

Phylogenomic databases

HOVERGENi HBG009709.
InParanoidi P01958.
KOi K13822.

Miscellaneous databases

EvolutionaryTracei P01958.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene."
    Clegg J.B., Goodbourn S.E.Y., Braend M.
    Nucleic Acids Res. 12:7847-7858(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Gene conversions in the horse alpha-globin gene complex."
    Clegg J.B.
    Mol. Biol. Evol. 4:492-503(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse."
    Matsuda G., Maita T., Braunitzer G., Schrank B.
    Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
  4. "A correction to the sequence of the alpha chains of horse haemoglobin."
    Ladner R.C., Air G.M., Fogg J.H.
    J. Mol. Biol. 103:675-677(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  5. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis."
    Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.
    Nature 219:29-32(1968) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  6. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model."
    Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.
    Nature 219:131-139(1968) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
  7. "The structure of horse methaemoglobin at 2.0-A resolution."
    Ladner R.C., Heidner E.J., Perutz M.F.
    J. Mol. Biol. 114:385-414(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Entry informationi

Entry nameiHBA_HORSE
AccessioniPrimary (citable) accession number: P01958
Secondary accession number(s): Q28384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3