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P01958

- HBA_HORSE

UniProt

P01958 - HBA_HORSE

Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from the lung to the various peripheral tissues.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme distal ligand)
    Metal bindingi88 – 881Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit alpha
    Alternative name(s):
    Alpha-globin
    Hemoglobin alpha chain
    Gene namesi
    Name:HBA
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052652Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81N6-succinyllysineBy similarity
    Modified residuei12 – 121N6-succinyllysineBy similarity
    Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
    Modified residuei17 – 171N6-succinyllysine; alternateBy similarity
    Modified residuei41 – 411N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.

    Protein-protein interaction databases

    MINTiMINT-242180.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1713
    Turni18 – 203
    Helixi22 – 3615
    Helixi38 – 436
    Helixi46 – 505
    Helixi54 – 7118
    Helixi72 – 765
    Helixi77 – 804
    Helixi82 – 909
    Helixi96 – 11318
    Turni115 – 1173
    Helixi120 – 13718
    Turni138 – 1403

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G0BX-ray1.90A2-142[»]
    1IBEX-ray1.80A2-142[»]
    1IWHX-ray1.55A2-142[»]
    1NS6X-ray2.05A2-142[»]
    1NS9X-ray1.60A2-142[»]
    1Y8HX-ray3.10A/C2-142[»]
    1Y8IX-ray2.60A/C2-142[»]
    1Y8KX-ray2.30A/C2-142[»]
    2D5XX-ray1.45A2-142[»]
    2DHBX-ray2.80A2-142[»]
    2MHBX-ray2.00A2-142[»]
    2ZLTX-ray1.90A2-142[»]
    2ZLUX-ray2.00A2-142[»]
    2ZLVX-ray2.00A2-142[»]
    2ZLWX-ray2.90A/C2-142[»]
    2ZLXX-ray2.80A/C2-142[»]
    ProteinModelPortaliP01958.
    SMRiP01958. Positions 2-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01958.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.
    KOiK13822.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01958-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSAADKTN VKAAWSKVGG HAGEYGAEAL ERMFLGFPTT KTYFPHFDLS    50
    HGSAQVKAHG KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK 100
    LLSHCLLSTL AVHLPNDFTP AVHASLDKFL SSVSTVLTSK YR 142
    Length:142
    Mass (Da):15,245
    Last modified:January 23, 2007 - v2
    Checksum:i33BB917E15C9CD15
    GO

    Polymorphismi

    Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251Y → F Exist in both chains.
    Natural varianti61 – 611K → Q in fast chain.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01086 Genomic DNA. Translation: CAA25564.1.
    M17902 Genomic DNA. Translation: AAD15306.1.
    M17903 Genomic DNA. Translation: AAA30948.1.
    X07053 Genomic DNA. Translation: CAA30097.1.
    PIRiI46302. HAHO.
    RefSeqiNP_001078901.1. NM_001085432.1.
    UniGeneiEca.11653.

    Genome annotation databases

    GeneIDi100036557.
    KEGGiecb:100036557.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The man behind the molecular lung - Issue 21 of April 2002

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01086 Genomic DNA. Translation: CAA25564.1 .
    M17902 Genomic DNA. Translation: AAD15306.1 .
    M17903 Genomic DNA. Translation: AAA30948.1 .
    X07053 Genomic DNA. Translation: CAA30097.1 .
    PIRi I46302. HAHO.
    RefSeqi NP_001078901.1. NM_001085432.1.
    UniGenei Eca.11653.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G0B X-ray 1.90 A 2-142 [» ]
    1IBE X-ray 1.80 A 2-142 [» ]
    1IWH X-ray 1.55 A 2-142 [» ]
    1NS6 X-ray 2.05 A 2-142 [» ]
    1NS9 X-ray 1.60 A 2-142 [» ]
    1Y8H X-ray 3.10 A/C 2-142 [» ]
    1Y8I X-ray 2.60 A/C 2-142 [» ]
    1Y8K X-ray 2.30 A/C 2-142 [» ]
    2D5X X-ray 1.45 A 2-142 [» ]
    2DHB X-ray 2.80 A 2-142 [» ]
    2MHB X-ray 2.00 A 2-142 [» ]
    2ZLT X-ray 1.90 A 2-142 [» ]
    2ZLU X-ray 2.00 A 2-142 [» ]
    2ZLV X-ray 2.00 A 2-142 [» ]
    2ZLW X-ray 2.90 A/C 2-142 [» ]
    2ZLX X-ray 2.80 A/C 2-142 [» ]
    ProteinModelPortali P01958.
    SMRi P01958. Positions 2-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-242180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100036557.
    KEGGi ecb:100036557.

    Organism-specific databases

    CTDi 15121.

    Phylogenomic databases

    HOVERGENi HBG009709.
    KOi K13822.

    Miscellaneous databases

    EvolutionaryTracei P01958.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene."
      Clegg J.B., Goodbourn S.E.Y., Braend M.
      Nucleic Acids Res. 12:7847-7858(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Gene conversions in the horse alpha-globin gene complex."
      Clegg J.B.
      Mol. Biol. Evol. 4:492-503(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse."
      Matsuda G., Maita T., Braunitzer G., Schrank B.
      Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-142.
    4. "A correction to the sequence of the alpha chains of horse haemoglobin."
      Ladner R.C., Air G.M., Fogg J.H.
      J. Mol. Biol. 103:675-677(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    5. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis."
      Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.
      Nature 219:29-32(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    6. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model."
      Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.
      Nature 219:131-139(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    7. "The structure of horse methaemoglobin at 2.0-A resolution."
      Ladner R.C., Heidner E.J., Perutz M.F.
      J. Mol. Biol. 114:385-414(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiHBA_HORSE
    AccessioniPrimary (citable) accession number: P01958
    Secondary accession number(s): Q28384
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3