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Reviewed, UniProtKB/Swiss-Prot P01958 (HBA_HORSE)

Last modified June 16, 2009. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Hemoglobin subunit alpha
Alternative name(s):
    Hemoglobin alpha chain
    Alpha-globin
Gene names
Name: HBA
OrganismEquus caballus (Horse)
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Polymorphism

Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.

Sequence similarities

Belongs to the globin family.

Ontologies

Keywords
   Biological processOxygen transport
Transport
   Coding sequence diversityPolymorphism
   LigandHeme
Iron
Metal-binding
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological processoxygen transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componenthemoglobin complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionheme binding

Inferred from electronic annotation. Source: InterPro

oxygen binding

Inferred from electronic annotation. Source: InterPro

oxygen transporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 142141Hemoglobin subunit alpha
PRO_0000052652

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Natural variations

Natural variant251Y → F Exist in both chains.
Natural variant611K → Q in fast chain.

Secondary structure

..................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01958-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 33BB917E15C9CD15

FASTA14215,245
        10         20         30         40         50         60 
MVLSAADKTN VKAAWSKVGG HAGEYGAEAL ERMFLGFPTT KTYFPHFDLS HGSAQVKAHG 

        70         80         90        100        110        120 
KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK LLSHCLLSTL AVHLPNDFTP 

       130        140 
AVHASLDKFL SSVSTVLTSK YR 

« Hide

References

[1]"Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene."
Clegg J.B., Goodbourn S.E.Y., Braend M.
Nucleic Acids Res. 12:7847-7858(1984) [PubMed: 6093055] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Gene conversions in the horse alpha-globin gene complex."
Clegg J.B.
Mol. Biol. Evol. 4:492-503(1987) [PubMed: 2835578] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse."
Matsuda G., Maita T., Braunitzer G., Schrank B.
Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980) [PubMed: 7409745] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-142.
[4]"A correction to the sequence of the alpha chains of horse haemoglobin."
Ladner R.C., Air G.M., Fogg J.H.
J. Mol. Biol. 103:675-677(1976) [PubMed: 940162] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis."
Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.
Nature 219:29-32(1968) [PubMed: 5659617] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model."
Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.
Nature 219:131-139(1968) [PubMed: 5659637] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[7]"The structure of horse methaemoglobin at 2.0-A resolution."
Ladner R.C., Heidner E.J., Perutz M.F.
J. Mol. Biol. 114:385-414(1977) [PubMed: 561852] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Web resources

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Cross-references

Sequence databases

X01086 Genomic DNA. Translation: CAA25564.1.
M17902 Genomic DNA. Translation: AAD15306.1.
M17903 Genomic DNA. Translation: AAA30948.1.
X07053 Genomic DNA. Translation: CAA30097.1.
PIRHAHO. I46302.
UniGeneEca.11653
Eca.15779

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90A2-141[»]
1IBEX-ray1.80A2-141[»]
1IWHX-ray1.55A2-141[»]
1NS6X-ray2.05A2-141[»]
1NS9X-ray1.60A2-141[»]
1Y8HX-ray3.10A/C2-141[»]
1Y8IX-ray2.60A/C2-141[»]
1Y8KX-ray2.30A/C2-141[»]
2D5XX-ray1.45A2-141[»]
2DHBX-ray2.80A2-141[»]
2MHBX-ray2.00A2-142[»]
2ZLTX-ray1.90A2-142[»]
2ZLUX-ray2.00A2-142[»]
2ZLVX-ray2.00A2-142[»]
2ZLWX-ray2.90A/C2-142[»]
2ZLXX-ray2.80A/C2-142[»]
ModBaseSearch...

Phylogenomic databases

HOVERGENP01958.

Family and domain databases

InterProIPR000971. Globin_subset.
IPR002338. Haemoglobin_a.
IPR018331. Haemoglobin_alpha_chain.
IPR002339. Haemoglobin_pi.
[Graphical view]
PANTHERPTHR11442:SF14. Pi_haem. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHBA_HORSE
AccessionPrimary (citable) accession number: P01958
Secondary accession number(s): Q28384
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents