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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000526522 – 142Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiP01958.
PRIDEiP01958.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-242180.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 17Combined sources13
Turni18 – 20Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi46 – 50Combined sources5
Helixi54 – 71Combined sources18
Helixi72 – 76Combined sources5
Helixi77 – 80Combined sources4
Helixi82 – 90Combined sources9
Helixi96 – 113Combined sources18
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Turni138 – 140Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90A2-142[»]
1IBEX-ray1.80A2-142[»]
1IWHX-ray1.55A2-142[»]
1NS6X-ray2.05A2-142[»]
1NS9X-ray1.60A2-142[»]
1Y8HX-ray3.10A/C2-142[»]
1Y8IX-ray2.60A/C2-142[»]
1Y8KX-ray2.30A/C2-142[»]
2D5XX-ray1.45A2-142[»]
2DHBX-ray2.80A2-142[»]
2MHBX-ray2.00A2-142[»]
2ZLTX-ray1.90A2-142[»]
2ZLUX-ray2.00A2-142[»]
2ZLVX-ray2.00A2-142[»]
2ZLWX-ray2.90A/C2-142[»]
2ZLXX-ray2.80A/C2-142[»]
5C6EOther1.70A2-142[»]
ProteinModelPortaliP01958.
SMRiP01958.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01958.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP01958.
KOiK13822.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKTN VKAAWSKVGG HAGEYGAEAL ERMFLGFPTT KTYFPHFDLS
60 70 80 90 100
HGSAQVKAHG KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLSTL AVHLPNDFTP AVHASLDKFL SSVSTVLTSK YR
Length:142
Mass (Da):15,245
Last modified:January 23, 2007 - v2
Checksum:i33BB917E15C9CD15
GO

Polymorphismi

Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti25Y → F Exist in both chains. 1
Natural varianti61K → Q in fast chain. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01086 Genomic DNA. Translation: CAA25564.1.
M17902 Genomic DNA. Translation: AAD15306.1.
M17903 Genomic DNA. Translation: AAA30948.1.
X07053 Genomic DNA. Translation: CAA30097.1.
PIRiI46302. HAHO.
RefSeqiNP_001078901.1. NM_001085432.1.
UniGeneiEca.11653.

Genome annotation databases

GeneIDi100036557.
KEGGiecb:100036557.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01086 Genomic DNA. Translation: CAA25564.1.
M17902 Genomic DNA. Translation: AAD15306.1.
M17903 Genomic DNA. Translation: AAA30948.1.
X07053 Genomic DNA. Translation: CAA30097.1.
PIRiI46302. HAHO.
RefSeqiNP_001078901.1. NM_001085432.1.
UniGeneiEca.11653.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90A2-142[»]
1IBEX-ray1.80A2-142[»]
1IWHX-ray1.55A2-142[»]
1NS6X-ray2.05A2-142[»]
1NS9X-ray1.60A2-142[»]
1Y8HX-ray3.10A/C2-142[»]
1Y8IX-ray2.60A/C2-142[»]
1Y8KX-ray2.30A/C2-142[»]
2D5XX-ray1.45A2-142[»]
2DHBX-ray2.80A2-142[»]
2MHBX-ray2.00A2-142[»]
2ZLTX-ray1.90A2-142[»]
2ZLUX-ray2.00A2-142[»]
2ZLVX-ray2.00A2-142[»]
2ZLWX-ray2.90A/C2-142[»]
2ZLXX-ray2.80A/C2-142[»]
5C6EOther1.70A2-142[»]
ProteinModelPortaliP01958.
SMRiP01958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-242180.

Proteomic databases

PeptideAtlasiP01958.
PRIDEiP01958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100036557.
KEGGiecb:100036557.

Organism-specific databases

CTDi15121.

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP01958.
KOiK13822.

Miscellaneous databases

EvolutionaryTraceiP01958.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_HORSE
AccessioniPrimary (citable) accession number: P01958
Secondary accession number(s): Q28384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.