Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01958 (HBA_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene names
Name:HBA
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Polymorphism

Horse has two non-allelic alpha chains, slow and fast. The slow chain sequence is shown.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 142141Hemoglobin subunit alpha
PRO_0000052652

Sites

Metal binding591Iron (heme distal ligand)
Metal binding881Iron (heme proximal ligand)

Amino acid modifications

Modified residue81N6-succinyllysine By similarity
Modified residue121N6-succinyllysine By similarity
Modified residue171N6-acetyllysine; alternate By similarity
Modified residue171N6-succinyllysine; alternate By similarity
Modified residue411N6-succinyllysine By similarity

Natural variations

Natural variant251Y → F Exist in both chains.
Natural variant611K → Q in fast chain.

Secondary structure

....................... 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01958 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 33BB917E15C9CD15

FASTA14215,245
        10         20         30         40         50         60 
MVLSAADKTN VKAAWSKVGG HAGEYGAEAL ERMFLGFPTT KTYFPHFDLS HGSAQVKAHG 

        70         80         90        100        110        120 
KKVGDALTLA VGHLDDLPGA LSNLSDLHAH KLRVDPVNFK LLSHCLLSTL AVHLPNDFTP 

       130        140 
AVHASLDKFL SSVSTVLTSK YR 

« Hide

References

[1]"Genetic organization of the polymorphic equine alpha globin locus and sequence of the BII alpha 1 gene."
Clegg J.B., Goodbourn S.E.Y., Braend M.
Nucleic Acids Res. 12:7847-7858(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Gene conversions in the horse alpha-globin gene complex."
Clegg J.B.
Mol. Biol. Evol. 4:492-503(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse."
Matsuda G., Maita T., Braunitzer G., Schrank B.
Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-142.
[4]"A correction to the sequence of the alpha chains of horse haemoglobin."
Ladner R.C., Air G.M., Fogg J.H.
J. Mol. Biol. 103:675-677(1976) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[5]"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis."
Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.
Nature 219:29-32(1968) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[6]"Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model."
Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.
Nature 219:131-139(1968) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[7]"The structure of horse methaemoglobin at 2.0-A resolution."
Ladner R.C., Heidner E.J., Perutz M.F.
J. Mol. Biol. 114:385-414(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+Additional computationally mapped references.

Web resources

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X01086 Genomic DNA. Translation: CAA25564.1.
M17902 Genomic DNA. Translation: AAD15306.1.
M17903 Genomic DNA. Translation: AAA30948.1.
X07053 Genomic DNA. Translation: CAA30097.1.
PIRHAHO. I46302.
RefSeqNP_001078901.1. NM_001085432.1.
UniGeneEca.11653.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90A2-142[»]
1IBEX-ray1.80A2-142[»]
1IWHX-ray1.55A2-142[»]
1NS6X-ray2.05A2-142[»]
1NS9X-ray1.60A2-142[»]
1Y8HX-ray3.10A/C2-142[»]
1Y8IX-ray2.60A/C2-142[»]
1Y8KX-ray2.30A/C2-142[»]
2D5XX-ray1.45A2-142[»]
2DHBX-ray2.80A2-142[»]
2MHBX-ray2.00A2-142[»]
2ZLTX-ray1.90A2-142[»]
2ZLUX-ray2.00A2-142[»]
2ZLVX-ray2.00A2-142[»]
2ZLWX-ray2.90A/C2-142[»]
2ZLXX-ray2.80A/C2-142[»]
ProteinModelPortalP01958.
SMRP01958. Positions 2-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-242180.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100036557.
KEGGecb:100036557.

Organism-specific databases

CTD15121.

Phylogenomic databases

HOVERGENHBG009709.
KOK13822.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01958.

Entry information

Entry nameHBA_HORSE
AccessionPrimary (citable) accession number: P01958
Secondary accession number(s): Q28384
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references