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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525912 – 142Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP01947.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.1 Publication

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000000235.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 44Combined sources7
Helixi54 – 71Combined sources18
Turni72 – 75Combined sources4
Helixi77 – 80Combined sources4
Helixi82 – 88Combined sources7
Turni89 – 91Combined sources3
Helixi96 – 114Combined sources19
Helixi115 – 117Combined sources3
Helixi120 – 137Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A0GX-ray2.50A2-142[»]
3HYUX-ray1.67A2-142[»]
ProteinModelPortaliP01947.
SMRiP01947.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01947.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP01947.
OMAiDKFLCAV.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01947-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSAADKNN VKTTWDKIGG HAAEYVAEGL TRMFTSFPTT KTYFHHIDVS
60 70 80 90 100
PGSGDIKAHG KKVADALTTA VGHLDDLPTA LSTLSDVHAH KLRVDPVNFK
110 120 130 140
FLNHCLLVTL AAHLGADFTP SIHASLDKFF ASVSTVLTSK YR
Length:142
Mass (Da):15,361
Last modified:January 23, 2007 - v2
Checksum:i7F095AF1C5C5910D
GO

Sequence databases

PIRiA02269. HAGP.
RefSeqiXP_003478455.1. XM_003478407.3.

Genome annotation databases

EnsembliENSCPOT00000000270; ENSCPOP00000000235; ENSCPOG00000000267.
GeneIDi100712878.

Cross-referencesi

Sequence databases

PIRiA02269. HAGP.
RefSeqiXP_003478455.1. XM_003478407.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3A0GX-ray2.50A2-142[»]
3HYUX-ray1.67A2-142[»]
ProteinModelPortaliP01947.
SMRiP01947.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000000235.

Proteomic databases

PRIDEiP01947.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCPOT00000000270; ENSCPOP00000000235; ENSCPOG00000000267.
GeneIDi100712878.

Organism-specific databases

CTDi3040.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP01947.
OMAiDKFLCAV.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Miscellaneous databases

EvolutionaryTraceiP01947.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_CAVPO
AccessioniPrimary (citable) accession number: P01947
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.