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Protein

Hemoglobin subunit alpha-1/2

Gene

Hba1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

In rats there are two non-allelic alpha chains and two non-allelic beta chains. The alpha-1 chain sequence is shown.

Caution

PubMed:8334153 incorrectly assigned their sequence fragment as a fatty acid-binding protein.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

  • amyloid-beta binding Source: RGD
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen carrier activity Source: UniProtKB-KW

GO - Biological processi

  • negative regulation of blood pressure Source: RGD
  • regulation of sensory perception of pain Source: RGD

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-RNO-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-RNO-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-1/2
Alternative name(s):
Alpha-1/2-globin
Hemoglobin alpha-1/2 chain
Gene namesi
Name:Hba1
Synonyms:Hba-a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2782 Hba1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000527512 – 142Hemoglobin subunit alpha-1/2Add BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineBy similarity1
Modified residuei9PhosphothreonineBy similarity1
Modified residuei12N6-succinyllysineBy similarity1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateBy similarity1
Modified residuei25PhosphotyrosineBy similarity1
Modified residuei41N6-succinyllysineBy similarity1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineBy similarity1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei132PhosphoserineBy similarity1
Modified residuei135PhosphothreonineBy similarity1
Modified residuei138PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP01946
PRIDEiP01946

PTM databases

CarbonylDBiP01946
iPTMnetiP01946
PhosphoSitePlusiP01946

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSRNOG00000029886
ExpressionAtlasiP01946 baseline and differential
GenevisibleiP01946 RN

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi247661, 1 interactor
261987, 1 interactor
IntActiP01946, 1 interactor
STRINGi10116.ENSRNOP00000044233

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 44Combined sources7
Beta strandi50 – 52Combined sources3
Helixi54 – 72Combined sources19
Helixi74 – 76Combined sources3
Helixi77 – 80Combined sources4
Helixi82 – 89Combined sources8
Helixi96 – 113Combined sources18
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DHTX-ray2.98A2-142[»]
3HF4X-ray2.70A/E2-142[»]
ProteinModelPortaliP01946
SMRiP01946
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01946

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP01946
KOiK13822
OMAiSKHILAH
OrthoDBiEOG091G0S0X
PhylomeDBiP01946
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSADDKTN IKNCWGKIGG HGGEYGEEAL QRMFAAFPTT KTYFSHIDVS
60 70 80 90 100
PGSAQVKAHG KKVADALAKA ADHVEDLPGA LSTLSDLHAH KLRVDPVNFK
110 120 130 140
FLSHCLLVTL ACHHPGDFTP AMHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,329
Last modified:January 23, 2007 - v3
Checksum:iDEF6857594C42A99
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21H → S AA sequence (PubMed:8334153).Curated1
Sequence conflicti71 – 79ADHVEDLPG → GAHLBBVPZ AA sequence (PubMed:1191258).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti6D → A in alpha-2. 3 Publications1
Natural varianti45S → N. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17083 mRNA Translation: AAA41308.1
X56325 Genomic DNA Translation: CAA39764.1
X65495 Genomic DNA Translation: CAA46476.1
U29528 Genomic DNA Translation: AAA99054.1
BC059150 mRNA Translation: AAH59150.1
BC091567 mRNA Translation: AAH91567.1
S66657 Genomic DNA Translation: AAP13984.1
M32510 mRNA Translation: AAA41315.1
PIRiI54239 HART1
RefSeqiNP_001007723.1, NM_001007722.1
NP_037228.1, NM_013096.1
UniGeneiRn.107334
Rn.203003

Genome annotation databases

EnsembliENSRNOT00000051483; ENSRNOP00000044233; ENSRNOG00000029886
GeneIDi25632
360504
KEGGirno:25632
rno:360504
UCSCiRGD:2782 rat

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBA_RAT
AccessioniPrimary (citable) accession number: P01946
Secondary accession number(s): P33583
, Q63243, Q80XV2, Q91V15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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