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P01942

- HBA_MOUSE

UniProt

P01942 - HBA_MOUSE

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Protein

Hemoglobin subunit alpha

Gene

Hba

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi59 – 591Iron (heme distal ligand)
Metal bindingi88 – 881Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  1. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:Hba
Synonyms:Hba-a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96015. Hba-a1.

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81N6-succinyllysine1 Publication
Modified residuei12 – 121N6-succinyllysine1 Publication
Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
Modified residuei17 – 171N6-succinyllysine; alternate1 Publication
Modified residuei41 – 411N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP01942.
PaxDbiP01942.
PRIDEiP01942.

2D gel databases

REPRODUCTION-2DPAGEIPI00469114.
P01942.
SWISS-2DPAGEP01942.

PTM databases

PhosphoSiteiP01942.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

CleanExiMM_HBA-A1.
GenevestigatoriP01942.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

DIPiDIP-34118N.
IntActiP01942. 8 interactions.
MINTiMINT-1869504.

Structurei

Secondary structure

1
142
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712Combined sources
Helixi19 – 213Combined sources
Helixi22 – 3615Combined sources
Helixi39 – 435Combined sources
Beta strandi45 – 473Combined sources
Helixi54 – 7017Combined sources
Turni78 – 803Combined sources
Helixi84 – 896Combined sources
Helixi97 – 11317Combined sources
Turni115 – 1173Combined sources
Helixi120 – 13718Combined sources
Helixi138 – 1414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HRWX-ray2.80A/C2-142[»]
ProteinModelPortaliP01942.
SMRiP01942. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01942.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG283543.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP01942.
PhylomeDBiP01942.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01942-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALASA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,085
Last modified:January 23, 2007 - v2
Checksum:i2F70043BFF66E24A
GO

Polymorphismi

In inbred mouse strains there are at least 6 alleles that can occur at the HBA locus: A, B, C, D, F, or G. Strains carrying the A and F alleles produce a single kind of alpha chain, whereas those carrying B, C, D, or G each produce 2 kinds of chains. The sequence shown is that of the B1 and D1 allele chains.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti26 – 261G → V in allele chain C(1) and in strain NB. 3 Publications
Natural varianti63 – 631V → I in allele chain C(1) and in strain NB. 3 Publications
Natural varianti69 – 691S → N in allele chains A, C(2), D(2), F, G(1) and G(2) and in strain C57BL. 3 Publications
Natural varianti69 – 691S → T in allele chain B(2) and in 1 BALB/C strain sequence. 3 Publications
Natural varianti79 – 791G → A in allele chains F and G(2). 3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00714 Genomic DNA. Translation: CAA24095.1.
M10703 Genomic DNA. Translation: AAA37782.2.
M10840 mRNA. Translation: AAA37784.1.
CCDSiCCDS24523.1.
PIRiA90791. HAMS.
UniGeneiMm.196110.
Mm.459653.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00714 Genomic DNA. Translation: CAA24095.1 .
M10703 Genomic DNA. Translation: AAA37782.2 .
M10840 mRNA. Translation: AAA37784.1 .
CCDSi CCDS24523.1.
PIRi A90791. HAMS.
UniGenei Mm.196110.
Mm.459653.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HRW X-ray 2.80 A/C 2-142 [» ]
ProteinModelPortali P01942.
SMRi P01942. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-34118N.
IntActi P01942. 8 interactions.
MINTi MINT-1869504.

PTM databases

PhosphoSitei P01942.

2D gel databases

REPRODUCTION-2DPAGE IPI00469114.
P01942.
SWISS-2DPAGE P01942.

Proteomic databases

MaxQBi P01942.
PaxDbi P01942.
PRIDEi P01942.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96015. Hba-a1.

Phylogenomic databases

eggNOGi NOG283543.
HOGENOMi HOG000036867.
HOVERGENi HBG009709.
InParanoidi P01942.
PhylomeDBi P01942.

Miscellaneous databases

EvolutionaryTracei P01942.
PROi P01942.
SOURCEi Search...

Gene expression databases

CleanExi MM_HBA-A1.
Genevestigatori P01942.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a chromosomal mouse alpha-globin gene reveals elements conserved throughout vertebrate evolution."
    Nishioka Y., Leder P.
    Cell 18:875-882(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  2. "Hemoglobins of mice: sequence and possible ambiguity at one position of the alpha chain."
    Popp R.A.
    J. Mol. Biol. 27:9-16(1967) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-142.
    Strain: BALB/c, C57BL/6 and NB.
  3. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 18-57; 94-100 AND 129-140, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain and Hippocampus.
  4. "Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology."
    Leder A., Miller H.I., Hamer D.H., Seidman J.G., Norman B., Sullivan M., Leder P.
    Proc. Natl. Acad. Sci. U.S.A. 75:6187-6191(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-99.
  5. "Characterization and kinetics of synthesis of 15S beta-globin RNA, a putative precursor of beta-globin mRNA."
    Curtis P.J., Mantei N., Weissmann C.
    Cold Spring Harb. Symp. Quant. Biol. 42:971-984(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 84-109.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-12; LYS-17 AND LYS-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Studies on the mouse hemoglobin loci. 8. A fourth alpha-chain phenotype."
    Popp R.A.
    J. Hered. 60:126-133(1969) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.
  8. Popp R.A.
    (In) Altman P.A., Katz D.D. (eds.); Inbred and genetically defined strains of laboratory animals, pp.105-105, Federation of American Societies for Experimental Biology, Bethesda (1979)
    Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.
  9. "The primary structure of genetic variants of mouse hemoglobin."
    Popp R.A., Bailiff E.G., Skow L.C., Whitney J.B. III
    Biochem. Genet. 20:199-208(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.

Entry informationi

Entry nameiHBA_MOUSE
AccessioniPrimary (citable) accession number: P01942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3