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Protein

Hemoglobin subunit alpha

Gene

Hba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

  • cellular oxidant detoxification Source: GOC
  • erythrocyte development Source: MGI
  • in utero embryonic development Source: MGI
  • response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:Hba
Synonyms:Hba-a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96015. Hba-a1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000526942 – 142Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei8N6-succinyllysineCombined sources1
Modified residuei12N6-succinyllysineCombined sources1
Modified residuei17N6-acetyllysine; alternateBy similarity1
Modified residuei17N6-succinyllysine; alternateCombined sources1
Modified residuei25PhosphotyrosineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41N6-succinyllysineCombined sources1
Modified residuei50PhosphoserineBy similarity1
Modified residuei103PhosphoserineCombined sources1
Modified residuei109PhosphothreonineCombined sources1
Modified residuei112PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei135PhosphothreonineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei139PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP01942.
MaxQBiP01942.
PaxDbiP01942.
PeptideAtlasiP01942.
PRIDEiP01942.

2D gel databases

REPRODUCTION-2DPAGEIPI00469114.
P01942.
SWISS-2DPAGEP01942.

PTM databases

iPTMnetiP01942.
PhosphoSitePlusiP01942.
SwissPalmiP01942.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

CleanExiMM_HBA-A1.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

DIPiDIP-34118N.
IntActiP01942. 9 interactors.
MINTiMINT-1869504.
STRINGi10090.ENSMUSP00000090897.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi39 – 43Combined sources5
Beta strandi45 – 47Combined sources3
Helixi54 – 70Combined sources17
Turni78 – 80Combined sources3
Helixi84 – 89Combined sources6
Helixi97 – 113Combined sources17
Turni115 – 117Combined sources3
Helixi120 – 137Combined sources18
Helixi138 – 141Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HRWX-ray2.80A/C2-142[»]
ProteinModelPortaliP01942.
SMRiP01942.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01942.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP01942.
PhylomeDBiP01942.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALASA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,085
Last modified:January 23, 2007 - v2
Checksum:i2F70043BFF66E24A
GO

Polymorphismi

In inbred mouse strains there are at least 6 alleles that can occur at the HBA locus: A, B, C, D, F, or G. Strains carrying the A and F alleles produce a single kind of alpha chain, whereas those carrying B, C, D, or G each produce 2 kinds of chains. The sequence shown is that of the B1 and D1 allele chains.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti26G → V in allele chain C(1) and in strain NB. 3 Publications1
Natural varianti63V → I in allele chain C(1) and in strain NB. 3 Publications1
Natural varianti69S → N in allele chains A, C(2), D(2), F, G(1) and G(2) and in strain C57BL. Combined sources3 Publications1
Natural varianti69S → T in allele chain B(2) and in 1 BALB/C strain sequence. 3 Publications1
Natural varianti79G → A in allele chains F and G(2). 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00714 Genomic DNA. Translation: CAA24095.1.
M10703 Genomic DNA. Translation: AAA37782.2.
M10840 mRNA. Translation: AAA37784.1.
CCDSiCCDS24523.1.
PIRiA90791. HAMS.
UniGeneiMm.196110.
Mm.459653.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00714 Genomic DNA. Translation: CAA24095.1.
M10703 Genomic DNA. Translation: AAA37782.2.
M10840 mRNA. Translation: AAA37784.1.
CCDSiCCDS24523.1.
PIRiA90791. HAMS.
UniGeneiMm.196110.
Mm.459653.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HRWX-ray2.80A/C2-142[»]
ProteinModelPortaliP01942.
SMRiP01942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-34118N.
IntActiP01942. 9 interactors.
MINTiMINT-1869504.
STRINGi10090.ENSMUSP00000090897.

PTM databases

iPTMnetiP01942.
PhosphoSitePlusiP01942.
SwissPalmiP01942.

2D gel databases

REPRODUCTION-2DPAGEIPI00469114.
P01942.
SWISS-2DPAGEP01942.

Proteomic databases

EPDiP01942.
MaxQBiP01942.
PaxDbiP01942.
PeptideAtlasiP01942.
PRIDEiP01942.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96015. Hba-a1.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiP01942.
PhylomeDBiP01942.

Miscellaneous databases

EvolutionaryTraceiP01942.
PROiP01942.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBA-A1.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_MOUSE
AccessioniPrimary (citable) accession number: P01942
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.