Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P01942

- HBA_MOUSE

UniProt

P01942 - HBA_MOUSE

Protein

Hemoglobin subunit alpha

Gene

Hba

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from the lung to the various peripheral tissues.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi59 – 591Iron (heme distal ligand)
    Metal bindingi88 – 881Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. response to stilbenoid Source: UniProtKB

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit alpha
    Alternative name(s):
    Alpha-globin
    Hemoglobin alpha chain
    Gene namesi
    Name:Hba
    Synonyms:Hba-a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96015. Hba-a1.

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 142141Hemoglobin subunit alphaPRO_0000052694Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81N6-succinyllysine1 Publication
    Modified residuei12 – 121N6-succinyllysine1 Publication
    Modified residuei17 – 171N6-acetyllysine; alternateBy similarity
    Modified residuei17 – 171N6-succinyllysine; alternate1 Publication
    Modified residuei41 – 411N6-succinyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP01942.
    PaxDbiP01942.
    PRIDEiP01942.

    2D gel databases

    REPRODUCTION-2DPAGEIPI00469114.
    P01942.
    SWISS-2DPAGEP01942.

    PTM databases

    PhosphoSiteiP01942.

    Expressioni

    Tissue specificityi

    Red blood cells.

    Gene expression databases

    CleanExiMM_HBA-A1.
    GenevestigatoriP01942.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.

    Protein-protein interaction databases

    DIPiDIP-34118N.
    IntActiP01942. 8 interactions.
    MINTiMINT-1869504.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1712
    Helixi19 – 213
    Helixi22 – 3615
    Helixi39 – 435
    Beta strandi45 – 473
    Helixi54 – 7017
    Turni78 – 803
    Helixi84 – 896
    Helixi97 – 11317
    Turni115 – 1173
    Helixi120 – 13718
    Helixi138 – 1414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HRWX-ray2.80A/C2-142[»]
    ProteinModelPortaliP01942.
    SMRiP01942. Positions 2-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01942.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG283543.
    HOGENOMiHOG000036867.
    HOVERGENiHBG009709.
    InParanoidiP01942.
    PhylomeDBiP01942.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01942-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS    50
    HGSAQVKGHG KKVADALASA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK 100
    LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR 142
    Length:142
    Mass (Da):15,085
    Last modified:January 23, 2007 - v2
    Checksum:i2F70043BFF66E24A
    GO

    Polymorphismi

    In inbred mouse strains there are at least 6 alleles that can occur at the HBA locus: A, B, C, D, F, or G. Strains carrying the A and F alleles produce a single kind of alpha chain, whereas those carrying B, C, D, or G each produce 2 kinds of chains. The sequence shown is that of the B1 and D1 allele chains.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti26 – 261G → V in allele chain C(1) and in strain NB. 3 Publications
    Natural varianti63 – 631V → I in allele chain C(1) and in strain NB. 3 Publications
    Natural varianti69 – 691S → N in allele chains A, C(2), D(2), F, G(1) and G(2) and in strain C57BL. 3 Publications
    Natural varianti69 – 691S → T in allele chain B(2) and in 1 BALB/C strain sequence. 3 Publications
    Natural varianti79 – 791G → A in allele chains F and G(2). 3 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00714 Genomic DNA. Translation: CAA24095.1.
    M10703 Genomic DNA. Translation: AAA37782.2.
    M10840 mRNA. Translation: AAA37784.1.
    CCDSiCCDS24523.1.
    PIRiA90791. HAMS.
    UniGeneiMm.196110.
    Mm.459653.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00714 Genomic DNA. Translation: CAA24095.1 .
    M10703 Genomic DNA. Translation: AAA37782.2 .
    M10840 mRNA. Translation: AAA37784.1 .
    CCDSi CCDS24523.1.
    PIRi A90791. HAMS.
    UniGenei Mm.196110.
    Mm.459653.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HRW X-ray 2.80 A/C 2-142 [» ]
    ProteinModelPortali P01942.
    SMRi P01942. Positions 2-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-34118N.
    IntActi P01942. 8 interactions.
    MINTi MINT-1869504.

    PTM databases

    PhosphoSitei P01942.

    2D gel databases

    REPRODUCTION-2DPAGE IPI00469114.
    P01942.
    SWISS-2DPAGE P01942.

    Proteomic databases

    MaxQBi P01942.
    PaxDbi P01942.
    PRIDEi P01942.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96015. Hba-a1.

    Phylogenomic databases

    eggNOGi NOG283543.
    HOGENOMi HOG000036867.
    HOVERGENi HBG009709.
    InParanoidi P01942.
    PhylomeDBi P01942.

    Miscellaneous databases

    EvolutionaryTracei P01942.
    PROi P01942.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HBA-A1.
    Genevestigatori P01942.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002338. Haemoglobin_a.
    IPR002339. Haemoglobin_pi.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00612. ALPHAHAEM.
    PR00815. PIHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete sequence of a chromosomal mouse alpha-globin gene reveals elements conserved throughout vertebrate evolution."
      Nishioka Y., Leder P.
      Cell 18:875-882(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
    2. "Hemoglobins of mice: sequence and possible ambiguity at one position of the alpha chain."
      Popp R.A.
      J. Mol. Biol. 27:9-16(1967) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-142.
      Strain: BALB/c, C57BL/6 and NB.
    3. Lubec G., Klug S., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 18-57; 94-100 AND 129-140, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain and Hippocampus.
    4. "Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology."
      Leder A., Miller H.I., Hamer D.H., Seidman J.G., Norman B., Sullivan M., Leder P.
      Proc. Natl. Acad. Sci. U.S.A. 75:6187-6191(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-99.
    5. "Characterization and kinetics of synthesis of 15S beta-globin RNA, a putative precursor of beta-globin mRNA."
      Curtis P.J., Mantei N., Weissmann C.
      Cold Spring Harb. Symp. Quant. Biol. 42:971-984(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 84-109.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-8; LYS-12; LYS-17 AND LYS-41, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    7. "Studies on the mouse hemoglobin loci. 8. A fourth alpha-chain phenotype."
      Popp R.A.
      J. Hered. 60:126-133(1969) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.
    8. Popp R.A.
      (In) Altman P.A., Katz D.D. (eds.); Inbred and genetically defined strains of laboratory animals, pp.105-105, Federation of American Societies for Experimental Biology, Bethesda (1979)
      Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.
    9. "The primary structure of genetic variants of mouse hemoglobin."
      Popp R.A., Bailiff E.G., Skow L.C., Whitney J.B. III
      Biochem. Genet. 20:199-208(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS VAL-26; ILE-63; ASN-69; THR-69 AND ALA-79.

    Entry informationi

    Entry nameiHBA_MOUSE
    AccessioniPrimary (citable) accession number: P01942
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3