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Protein

Hemoglobin subunit alpha-3

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

Two kinds of alpha-3 chains were found in one gorilla. An Asx replaces one Ser (at position 131, 133, or 138) in the tryptic peptide comprising residues 128-139.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha-3
Alternative name(s):
Alpha-3-globin
Hemoglobin alpha-2 chain
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000526431 – 141Hemoglobin subunit alpha-3Add BLAST141

Proteomic databases

PRIDEiP01934.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P01934-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSPADKTNV KAAWGKVGAH AGDYGAEALE RMFLSFPTTK TYFPHFDLSH
60 70 80 90 100
GSAZVKGHGK KVAKALTBAV ZHLDDMPNAL SALSBLHAHK LRVBPVBFKL
110 120 130 140
LNHCLLVTLA ABFPSZFTPA VHASVDKFLA SVSTVLTSKY R
Length:141
Mass (Da):15,238
Last modified:July 21, 1986 - v1
Checksum:i26DB4610C73E32E9
GO

Sequence databases

PIRiA02258. HAGO3.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHBA3_GORGO
AccessioniPrimary (citable) accession number: P01934
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 10, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families