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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi58 – 581Iron (heme distal ligand)
Metal bindingi87 – 871Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Hemoglobin subunit alphaPRO_0000052642Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei7 – 71N6-succinyllysineBy similarity
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei11 – 111N6-succinyllysineBy similarity
Modified residuei16 – 161N6-acetyllysine; alternateBy similarity
Modified residuei16 – 161N6-succinyllysine; alternateBy similarity
Modified residuei24 – 241PhosphotyrosineBy similarity
Modified residuei35 – 351PhosphoserineBy similarity
Modified residuei40 – 401N6-succinyllysineBy similarity
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei102 – 1021PhosphoserineBy similarity
Modified residuei108 – 1081PhosphothreonineBy similarity
Modified residuei124 – 1241PhosphoserineBy similarity
Modified residuei131 – 1311PhosphoserineBy similarity
Modified residuei134 – 1341PhosphothreonineBy similarity
Modified residuei137 – 1371PhosphothreonineBy similarity
Modified residuei138 – 1381PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP01923.
SMRiP01923. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP01923.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSPADKTNV KAAWGKVGAH AGDYGAEALE RMFLSFPTTK TYFPHFDLSH
60 70 80 90 100
GSAQVKGHGK KVADALTNAV AHVDDMPNAL SALSDLHAHK LRVDPVNFKL
110 120 130 140
LSHCLLVTLA AHLPAEFTPA VHASLDKFLA SVSTVLTSKY R
Length:141
Mass (Da):15,112
Last modified:July 21, 1986 - v1
Checksum:i25D13618E72A3306
GO

Sequence databases

PIRiE93303. HAGO.

Cross-referencesi

Sequence databases

PIRiE93303. HAGO.

3D structure databases

ProteinModelPortaliP01923.
SMRiP01923. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP01923.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amino-acid composition of the polypeptide chains of gorilla haemoglobin."
    Zuckerkandl E., Schroeder W.A.
    Nature 192:984-985(1961)
    Cited for: PROTEIN SEQUENCE.
  2. "Hemoglobin alpha-3 chains in apes. Primary structures and the presumptive nature of back mutation in a normally silent gene."
    Boyer S.H., Noyes A.N., Boyer M.L., Marr K.
    J. Biol. Chem. 248:992-1003(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-31.

Entry informationi

Entry nameiHBA_GORGO
AccessioniPrimary (citable) accession number: P01923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 14, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.