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Protein

Hemoglobin subunit alpha

Gene

HBA

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi58Iron (heme distal ligand)1
Metal bindingi87Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin
Hemoglobin alpha chain
Gene namesi
Name:HBA
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000526421 – 141Hemoglobin subunit alphaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3PhosphoserineBy similarity1
Modified residuei7N6-succinyllysineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei11N6-succinyllysineBy similarity1
Modified residuei16N6-acetyllysine; alternateBy similarity1
Modified residuei16N6-succinyllysine; alternateBy similarity1
Modified residuei24PhosphotyrosineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei40N6-succinyllysineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei102PhosphoserineBy similarity1
Modified residuei108PhosphothreonineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Modified residuei131PhosphoserineBy similarity1
Modified residuei134PhosphothreonineBy similarity1
Modified residuei137PhosphothreonineBy similarity1
Modified residuei138PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP01923

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000027456

Structurei

3D structure databases

ProteinModelPortaliP01923
SMRiP01923
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709
InParanoidiP01923

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P01923-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VLSPADKTNV KAAWGKVGAH AGDYGAEALE RMFLSFPTTK TYFPHFDLSH
60 70 80 90 100
GSAQVKGHGK KVADALTNAV AHVDDMPNAL SALSDLHAHK LRVDPVNFKL
110 120 130 140
LSHCLLVTLA AHLPAEFTPA VHASLDKFLA SVSTVLTSKY R
Length:141
Mass (Da):15,112
Last modified:July 21, 1986 - v1
Checksum:i25D13618E72A3306
GO

Sequence databases

PIRiE93303 HAGO

Similar proteinsi

Entry informationi

Entry nameiHBA_GORGO
AccessioniPrimary (citable) accession number: P01923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health