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Protein

H-2 class II histocompatibility antigen, A-D beta chain

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • peptide antigen binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, A-D beta chain
Gene namesi
Name:H2-Ab1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 226199ExtracellularSequence analysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence analysisAdd
BLAST
Topological domaini248 – 26518CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • early endosome Source: MGI
  • external side of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • integral component of membrane Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • MHC class II protein complex Source: MGI
  • multivesicular body Source: MGI
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Add
BLAST
Chaini28 – 265238H-2 class II histocompatibility antigen, A-D beta chainPRO_0000018994Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 106PROSITE-ProRule annotation
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Disulfide bondi145 ↔ 201PROSITE-ProRule annotation

Post-translational modificationi

Ubiquitinated in immature dendritic cells leading to down-regulation of MHC class II.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP01921.
PeptideAtlasiP01921.
PRIDEiP01921.

Expressioni

Gene expression databases

CleanExiMM_H2-AB1.

Interactioni

Protein-protein interaction databases

IntActiP01921. 1 interaction.
MINTiMINT-1533608.

Structurei

Secondary structure

1
265
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 4511Combined sources
Turni46 – 494Combined sources
Beta strandi50 – 5910Combined sources
Beta strandi62 – 687Combined sources
Turni69 – 713Combined sources
Beta strandi73 – 786Combined sources
Helixi79 – 813Combined sources
Helixi82 – 909Combined sources
Helixi92 – 10413Combined sources
Helixi106 – 1116Combined sources
Helixi113 – 1164Combined sources
Helixi118 – 1203Combined sources
Beta strandi126 – 1316Combined sources
Beta strandi133 – 1397Combined sources
Beta strandi143 – 15311Combined sources
Beta strandi156 – 1616Combined sources
Beta strandi164 – 1663Combined sources
Beta strandi170 – 1723Combined sources
Beta strandi179 – 1813Combined sources
Beta strandi183 – 1897Combined sources
Beta strandi199 – 2046Combined sources
Beta strandi212 – 2165Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IAOX-ray2.60B28-216[»]
2IADX-ray2.40B28-216[»]
ProteinModelPortaliP01921.
SMRiP01921. Positions 25-218.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01921.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 21389Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 12295Beta-1Add
BLAST
Regioni123 – 21694Beta-2Add
BLAST
Regioni217 – 22610Connecting peptide

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP01921.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01921-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALQIPSLLL SAAVVVLMVL SSPRTEGGNS ERHFVVQFKG ECYYTNGTQR
60 70 80 90 100
IRLVTRYIYN REEYVRYDSD VGEYRAVTEL GRPDAEYWNS QPEILERTRA
110 120 130 140 150
EVDTACRHNY EGPETSTSLR RLEQPNVAIS LSRTEALNHH NTLVCSVTDF
160 170 180 190 200
YPAKIKVRWF RNGQEETVGV SSTQLIRNGD WTFQVLVMLE MTPHQGEVYT
210 220 230 240 250
CHVEHPSLKS PITVEWRAQS ESARSKMLSG IGGCVLGVIF LGLGLFIRHR
260
SQKGPRGPPP AGLLQ
Length:265
Mass (Da):29,954
Last modified:July 21, 1986 - v1
Checksum:i3A6274DD8920F564
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00008, K00007 Genomic DNA. Translation: AAA39548.1.
M29248 Genomic DNA. Translation: AAA39543.1.
K00113
, K00109, K00110, K00112, K00111 Genomic DNA. Translation: AAA39544.1.
K01143 mRNA. Translation: AAA39545.1.
PIRiA02236. HLMSAB.
UniGeneiMm.254067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00008, K00007 Genomic DNA. Translation: AAA39548.1.
M29248 Genomic DNA. Translation: AAA39543.1.
K00113
, K00109, K00110, K00112, K00111 Genomic DNA. Translation: AAA39544.1.
K01143 mRNA. Translation: AAA39545.1.
PIRiA02236. HLMSAB.
UniGeneiMm.254067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IAOX-ray2.60B28-216[»]
2IADX-ray2.40B28-216[»]
ProteinModelPortaliP01921.
SMRiP01921. Positions 25-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01921. 1 interaction.
MINTiMINT-1533608.

Proteomic databases

EPDiP01921.
PeptideAtlasiP01921.
PRIDEiP01921.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:103070. H2-Ab1.

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP01921.

Miscellaneous databases

EvolutionaryTraceiP01921.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-AB1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d."
    Malissen M., Hunkapiller T., Hood L.E.
    Science 221:750-754(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/cJ.
  2. "Murine i-a-beta chain polymorphism: nucleotide sequences of three allelic i-a-beta genes."
    Choi E.C., McIntyre K., Germain R.N., Seidman J.G.
    Science 221:283-286(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-265.
  3. "An intronic 10-base-pair deletion in a class II A beta gene affects RNA processing."
    Ghogawala Z., Choi E., Daly K.R., Blanco L.R., Griffith I.J., Glimcher L.H.
    Mol. Cell. Biol. 9:4402-4408(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 124-261.
  4. "Extensive polymorphism surrounding the murine Ia A-beta chain gene."
    Robinson R.R., Germain R.N., McKean D.J., Mescher M., Seidman J.G.
    J. Immunol. 131:2025-2031(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-265.
  5. "Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination."
    van Niel G., Wubbolts R., Ten Broeke T., Buschow S.I., Ossendorp F.A., Melief C.J., Raposo G., van Balkom B.W., Stoorvogel W.
    Immunity 25:885-894(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  6. "Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination."
    Shin J.S., Ebersold M., Pypaert M., Delamarre L., Hartley A., Mellman I.
    Nature 444:115-118(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiHB2D_MOUSE
AccessioniPrimary (citable) accession number: P01921
Secondary accession number(s): O19456
, O19457, O19458, Q31133, Q31138, Q31139
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.