ID DQB1_HUMAN Reviewed; 261 AA. AC P01920; A1KR27; A2RPH3; A4Q9R4; A4USG2; A4USG5; A6N8I7; A9YQA0; B0S7Y7; AC B1A0K6; B1GXI3; B3VLT3; B5BLN7; B7VU69; C0MQ34; C0MQ35; C8ZL52; C8ZLJ8; AC C8ZLJ9; C9DRQ3; O19708; O19713; O19724; O62861; O78046; O78221; O78223; AC O98034; O98201; P01917; P01918; P01919; P03992; P05537; P79482; P79526; AC P79544; P79551; Q08GC8; Q09035; Q0E4V9; Q1M312; Q29731; Q29877; Q29884; AC Q29915; Q29966; Q2P9N3; Q2QK85; Q30061; Q30075; Q30076; Q30080; Q30081; AC Q30082; Q30083; Q30084; Q30089; Q30095; Q31633; Q38I47; Q45UE3; Q4QZB5; AC Q53I44; Q564J6; Q5G841; Q5ISH1; Q5ISH3; Q5W1E1; Q5Y7G8; Q643R4; Q6B9X1; AC Q70VH8; Q7YP69; Q8HWH0; Q8MH58; Q8SNB4; Q8SND1; Q8SP70; Q8WMA3; Q9BD17; AC Q9MYH2; Q9TPA9; Q9XRY6; Q9XRY7; Q9XRZ2; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 02-MAR-2010, sequence version 2. DT 24-JAN-2024, entry version 204. DE RecName: Full=HLA class II histocompatibility antigen, DQ beta 1 chain; DE AltName: Full=MHC class II antigen DQB1; DE Flags: Precursor; GN Name=HLA-DQB1; Synonyms=HLA-DQB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), AND NUCLEOTIDE SEQUENCE RP [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01). RX PubMed=6415003; DOI=10.1016/0198-8859(83)90087-3; RA Larhammar D., Andersson G., Andersson M., Bill P., Boehme J., Claesson L., RA Denaro M., Emmoth E., Gustafsson K., Hammarling U., Heldin E., RA Hyldig-Nielsen J.-J., Lind P., Schenning L., Servenius B., Widmark E., RA Rask L., Peterson P.A.; RT "Molecular analysis of human class II transplantation antigens and their RT genes."; RL Hum. Immunol. 8:95-103(1983). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01). RX PubMed=6954511; DOI=10.1073/pnas.79.12.3687; RA Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L., Rask L., RA Peterson P.A.; RT "Complete amino acid sequence of an HLA-DR antigen-like beta chain as RT predicted from the nucleotide sequence: similarities with immunoglobulins RT and HLA-A, -B, and -C antigens."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02). RX PubMed=6316358; DOI=10.1073/pnas.80.23.7313; RA Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G., Rask L., RA Peterson P.A.; RT "Exon-intron organization and complete nucleotide sequence of a human major RT histocompatibility antigen DC beta gene."; RL Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01). RX PubMed=6206493; DOI=10.1073/pnas.81.16.5199; RA Boss J.M., Strominger J.L.; RT "Cloning and sequence analysis of the human major histocompatibility RT complex gene DC-3 beta."; RL Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984). RN [5] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01). RX PubMed=2998758; DOI=10.1002/j.1460-2075.1985.tb04012.x; RA Tonnelle C., Demars R., Long E.O.; RT "DO beta: a new beta chain gene in HLA-D with a distinct regulation of RT expression."; RL EMBO J. 4:2839-2847(1985). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01). RX PubMed=2888727; DOI=10.1007/bf00346523; RA Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.; RT "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive RT heterodimers."; RL Immunogenetics 26:282-290(1987). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02). RX PubMed=3036828; DOI=10.1016/s0021-9258(18)47482-0; RA Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., RA Andersson G., Joergensen F., Peterson P.A., Rask L.; RT "Class II genes of the human major histocompatibility complex. Comparisons RT of the DQ and DX alpha and beta genes."; RL J. Biol. Chem. 262:8767-8777(1987). RN [8] RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-15; SER-28; GLY-45; LEU-58; RP GLY-77; GLY-102 AND ARG-199. RX PubMed=3584986; RA Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S., RA Tieber V.L., Kittlesen D.J., Schwartz B.D.; RT "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 RT cell line."; RL J. Immunol. 139:228-233(1987). RN [9] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02). RX PubMed=3259543; DOI=10.1007/bf00364432; RA Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J.; RT "MHC class II sequences of an HLA-DR2 narcoleptic."; RL Immunogenetics 27:449-455(1988). RN [10] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03). RX PubMed=2050393; DOI=10.1007/bf00216702; RA Giorda R., Turco E., Trucco M.; RT "Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins RT that differ only at amino acid 57."; RL Immunogenetics 33:404-408(1991). RN [11] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12). RX PubMed=8988543; DOI=10.1111/j.1399-0039.1996.tb02674.x; RA Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.; RT "Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT- RT PCR."; RL Tissue Antigens 48:589-592(1996). RN [12] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01). RX PubMed=9271631; DOI=10.1007/s002510050295; RA Ellis M.C., Hetisimer A.H., Ruddy D.A., Hansen S.L., Kronmal G.S., RA McClelland E., Quintana L., Drayna D.T., Aldrich M.S., Mignot E.; RT "HLA class II haplotype and sequence analysis support a role for DQ in RT narcolepsy."; RL Immunogenetics 46:410-417(1997). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03). RX PubMed=16140993; DOI=10.1101/gr.3554305; RA Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., RA Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.; RT "Ancient haplotypes of the HLA Class II region."; RL Genome Res. 15:1250-1257(2005). RN [14] RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND DQB1*05:02). RA Kim E., Lee E., Kwack K.; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [15] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02; RP DQB1*03:01 AND DQB1*03:03). RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [16] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02). RC TISSUE=B-cell; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [17] RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02). RX PubMed=2925231; DOI=10.1007/bf00373644; RA Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.; RT "Sequence analysis of HLA class II domains: characterization of the DQw3 RT family of DQB genes."; RL Immunogenetics 29:186-190(1989). RN [18] RP NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), AND NUCLEOTIDE RP SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09). RA White J.M., Baxter-Lowe L.A.; RT "Nucleotide Deletions in a DQB1*0301 variant."; RL Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases. RN [19] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02). RX PubMed=2494138; DOI=10.1016/0198-8859(89)90058-x; RA Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J., RA Ando A., Tsuji K., Inoko H.; RT "No difference in the nucleotide sequence of the DQ beta beta 1 domain RT between narcoleptic and healthy individuals with DR2,Dw2."; RL Hum. Immunol. 24:175-181(1989). RN [20] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02). RX PubMed=2777341; DOI=10.1007/bf02421214; RA Jonsson A.-K., Andersson L., Rask L.; RT "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 RT specificity."; RL Immunogenetics 30:232-234(1989). RN [21] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01; RP DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), AND RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01). RX PubMed=8929711; DOI=10.1111/j.1399-0039.1996.tb02512.x; RA Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.; RT "Different contribution of HLA-DR and -DQ genes in susceptibility and RT resistance to insulin-dependent diabetes mellitus (IDDM)."; RL Tissue Antigens 47:37-48(1996). RN [22] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10). RX PubMed=11098940; DOI=10.1034/j.1399-0039.2000.560412.x; RA Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., RA Vicario J.L.; RT "Identification by sequencing based typing and complete coding region RT analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and RT DQB1*0310."; RL Tissue Antigens 56:380-384(2000). RN [23] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09). RA Yasunaga S.; RL Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases. RN [24] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND RP DQB1*03:05). RX PubMed=7928445; DOI=10.1016/0198-8859(94)90060-4; RA Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D., Cao A., RA De Virgiliis S., Congia M.; RT "HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and RT practical implications for oligotyping."; RL Hum. Immunol. 40:143-149(1994). RN [25] RP PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02). RX PubMed=6576979; DOI=10.1515/bchm2.1983.364.1.749; RA Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E., RA Koelbel S., Egert G., Wernet P., Hilschmann N.; RT "Primary structure of human class II histocompatibility antigens 3rd RT communication. Amino acid sequence comparison between DR and DC subclass RT antigens derived from a lymphoblastoid B cell line homozygous at the HLA RT loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."; RL Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983). RN [26] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05). RX PubMed=2212675; RA Lee K.W., Johnson A.H., Hurley C.K.; RT "Two divergent routes of evolution gave rise to the DRw13 haplotypes."; RL J. Immunol. 145:3119-3125(1990). RN [27] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01). RX PubMed=3020127; RA Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J., Alber C., RA Silver J.; RT "Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype."; RL J. Immunol. 137:2886-2890(1986). RN [28] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22). RX PubMed=17868257; DOI=10.1111/j.1399-0039.2007.00927.x; RA Chang Y., Fan T.X., Santana Z., Day N.K.; RT "Identification of a novel allele HLA-DQB1*0622."; RL Tissue Antigens 70:442-444(2007). RN [29] RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02). RX PubMed=2886427; DOI=10.1007/bf00345459; RA Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.; RT "Structural and functional variability among DQ beta alleles of DR2 RT subtypes."; RL Immunogenetics 26:85-91(1987). RN [30] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07). RX PubMed=9174147; DOI=10.1111/j.1399-0039.1997.tb02789.x; RA Thye T., Muntau B., Stelma F.F., Horstmann R.D.; RT "A novel allele, DQB1*0307, in a West African family."; RL Tissue Antigens 49:517-518(1997). RN [31] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18). RX PubMed=11782280; DOI=10.1034/j.1399-0039.2001.580409.x; RA Casamitjana N., Gil J., Campos E., Santos M., Nogues N., Ribera A., RA Palou E.; RT "Identification of a novel HLA-DQB1*06 allele, DQB1*0618."; RL Tissue Antigens 58:269-271(2001). RN [32] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19). RA Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.; RT "A new DQB1*0602 variant found in Australian Caucasian."; RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases. RN [33] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13). RX PubMed=9458130; DOI=10.1111/j.1399-0039.1997.tb02935.x; RA Hsu S.H., Robbins F.M., Modelo R.B., Brunner J., Flomenberg N.; RT "Identification of a new DQB1*0613 allele in a family."; RL Tissue Antigens 50:685-687(1997). RN [34] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36). RC TISSUE=Peripheral blood; RA Skrablin P.S., Richter R., Seidl C., Seifried E.; RT "New HLA-DQB1*06 allele found in a voluntary blood stem cell donor."; RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases. RN [35] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19). RX PubMed=17559588; DOI=10.1111/j.1399-0039.2007.00848.x; RA Witter K., Mautner J., Albert T., Zahn R., Kauke T.; RT "HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association RT to HLA-DRB1*1102."; RL Tissue Antigens 70:73-75(2007). RN [36] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34). RX PubMed=18331527; DOI=10.1111/j.1399-0039.2008.01021.x; RA Witter K., Albert T., Zahn R., Kauke T.; RT "HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of RT a sibling pair for potential bone marrow transplantation."; RL Tissue Antigens 71:486-488(2008). RN [37] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), AND RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND RP DQB1*03:20). RX PubMed=18588576; DOI=10.1111/j.1399-0039.2008.01070.x; RA Lazaro A.M., Xiao Y., Masaberg C., Lebeck L., Ng J., Hurley C.K., RA Posch P.E.; RT "Novel alleles at the HLA-DRB1 and -DQB1 loci."; RL Tissue Antigens 72:72-74(2008). RN [38] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22). RC TISSUE=Peripheral blood; RX PubMed=19254265; DOI=10.1111/j.1399-0039.2008.01201.x; RA Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.; RT "Sequence-based HLA high-resolution retyping of a bone marrow RT donor/recipient pair reveals the novel HLA allele DQB1*0322."; RL Tissue Antigens 73:283-285(2009). RN [39] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23). RC TISSUE=Peripheral blood; RX PubMed=19493242; DOI=10.1111/j.1399-0039.2009.01231.x; RA Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.; RT "DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a RT DQB1*030303 allele."; RL Tissue Antigens 73:624-625(2009). RN [40] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04). RA Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.; RT "Identification of a novel HLA-DQB1*02 allele."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. RN [41] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25). RA Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.; RT "Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel allele, RT exons 2 and 3."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. RN [42] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24). RA Michaud C., Giannoli C., Favre Victoire I., Dubois V.; RT "A new HLA-DQB allele, identified by routine sequencing."; RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases. RN [43] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND RP DQB1*06:39). RC TISSUE=Blood; RA Anholts J.D.H.; RT "New alleles found during routine SBT HLA typing."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [44] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10). RX PubMed=8896183; DOI=10.1111/j.1399-0039.1996.tb02633.x; RA Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G., RA Rossau R.; RT "Characterization of a new DQB1 allele (DQB1*0610) which differs from RT DQB1*0602 at the highly polymorphic 57-codon."; RL Tissue Antigens 48:217-220(1996). RN [45] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06). RC TISSUE=Blood; RX PubMed=8988541; DOI=10.1111/j.1399-0039.1996.tb02672.x; RA Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M., RA Oguchi H., Ishii E., Fukushima H.; RT "A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 RT sequences."; RL Tissue Antigens 48:580-585(1996). RN [46] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), AND RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20). RX PubMed=15361133; DOI=10.1111/j.1399-0039.2004.00307.x; RA Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M., RA Dunckley H.; RT "Identification of two novel HLA class II alleles, DQB1*0311 and RT DQB1*0620."; RL Tissue Antigens 64:515-517(2004). RN [47] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16). RA Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.; RT "A novel DQB1*03 allele revealed by rSSOP and identified by SBT."; RL Hum. Immunol. 66:30-30(2005). RN [48] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14). RX PubMed=15853909; DOI=10.1111/j.1399-0039.2005.00397.x; RA Gu H., Kimm K., Lee J.K., Oh B.; RT "Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based RT typing in the Korean population."; RL Tissue Antigens 65:503-504(2005). RN [49] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28). RX PubMed=17212715; DOI=10.1111/j.1399-0039.2006.00733.x; RA Witter K., Albert T., Zahn R., Kauke T.; RT "A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence- RT based HLA typing and confirmation of DQB1*060302."; RL Tissue Antigens 69:102-103(2007). RN [50] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32). RC TISSUE=Blood; RX PubMed=17999653; DOI=10.1111/j.1399-0039.2007.00967.x; RA Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.; RT "Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632."; RL Tissue Antigens 71:94-95(2008). RN [51] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05). RX PubMed=19392794; DOI=10.1111/j.1399-0039.2009.01248.x; RA Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.; RT "Two new HLA-DQB alleles routinely identified by sequence-based typing: RT DQB1*030103 and DQB1*0505."; RL Tissue Antigens 73:622-623(2009). RN [52] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03). RA Olerup O.H.; RT "A novel DQB1*02 allele."; RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases. RN [53] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05). RA Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K., RA Van Reybroeck G., Mersch G.; RT "Detection of a new DQB1 allele."; RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases. RN [54] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15). RA Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.; RT "Two novel DQB1*06 alleles, identified by reverse line blot assay."; RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. RN [55] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05). RC TISSUE=Peripheral blood; RA Moine A.; RT "A new variant form of the HLA DQB1*0305 allele."; RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases. RN [56] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12). RA Schwarz K., Zenz C.; RT "Homo sapiens HLA-DQB1*0312 allele, exon 2."; RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases. RN [57] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13). RA Wu J., Bassinger S., Williams T.M.; RT "Novel human HLA-DQB1 allele identified in potential bone marrow donors."; RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases. RN [58] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21). RA De Canck I.; RT "Identification of a new HLA-DQB1*06 allele by INNO-LiPA."; RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases. RN [59] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17). RA Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.; RT "Novel DQB1*06 alleles."; RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. RN [60] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23). RA Hirv K., Krauss A., Mytilineos J.; RT "Characterization of a new HLA-DQB1 allele by direct sequencing."; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. RN [61] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15). RC TISSUE=Peripheral blood; RA Velickovic Z.M.; RT "Novel HLA-DQB1*03 allele."; RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases. RN [62] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24). RA Schranz P., Seelig R., Seelig H.P.; RT "A new HLA-DQB1 allele."; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [63] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25). RA Watabe K., Hashimoto M.; RT "Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele: HLA- RT DQB1*060401V."; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [64] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17). RA Chu C.-C.; RT "A novel DQB1 allele found in Taiwan."; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [65] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18). RA Hendrix M.M., Cordovado S.K., Mueller P.W.; RT "High resolution genotyping of HLA-DQB1 exon 2 and 3."; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [66] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29). RA Horn P.A., Blasczyk R.; RT "A novel HLA-DRQ1*06 allele."; RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases. RN [67] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31). RA Nieberle I., Hirschmann D., Woelpl A.; RT "Identification of several new class I and II alleles in routine HLA- RT testing."; RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases. RN [68] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33). RA Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E., RA Jennings L.; RT "A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP RT donor."; RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases. RN [69] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03). RA Vigh A., Hirv K., Mytilineos J.; RT "Characterization of a new HLA-Cw*07 allele."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [70] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37). RA Fuerst D., Mytilineos J.; RT "A new variant of HLA-DQB1*06."; RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases. RN [71] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26). RA Yang K., Chen M.; RT "Novel DQB1*03 found in CAP test sample."; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. RN [72] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16). RX PubMed=10323344; DOI=10.1034/j.1399-0039.1999.530410.x; RA Luo M., Blanchard J., Maclean I., Brunham R.; RT "Identification of a novel DQB1 allele DBQ1*0616."; RL Tissue Antigens 53:381-382(1999). RN [73] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30). RA Rizzo M., Hurley C.K.; RT "Novel HLA-DQB1 allele."; RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases. RN [74] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14). RC TISSUE=Blood; RX PubMed=9802612; DOI=10.1111/j.1399-0039.1998.tb03047.x; RA Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.; RT "A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 RT (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."; RL Tissue Antigens 52:294-299(1998). RN [75] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11). RX PubMed=8896171; DOI=10.1111/j.1399-0039.1996.tb02621.x; RA Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D., RA Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.; RT "Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely RT related DQB1*0602 allele via sequence specific PCR or direct DNA RT sequencing."; RL Tissue Antigens 48:143-147(1996). RN [76] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27). RX PubMed=16441489; DOI=10.1111/j.1399-0039.2006.00515.x; RA Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E., Martin H., RA Seidl C.; RT "HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in RT blood stem cell donors of Caucasian origin."; RL Tissue Antigens 67:160-162(2006). RN [77] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND RP DQB1*06:08). RA Dinauer D.M., Hessner M.J.; RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases. RN [78] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04). RX PubMed=1440562; DOI=10.1111/j.1399-0039.1992.tb01958.x; RA Fenske T.S., Baxter-Lowe L.A.; RT "Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA- RT DQw1."; RL Tissue Antigens 40:49-52(1992). RN [79] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01). RX PubMed=2308943; DOI=10.1073/pnas.87.5.1835; RA Gyllensten U.B., Lashkari D., Erlich H.A.; RT "Allelic diversification at the class II DQB locus of the mammalian major RT histocompatibility complex."; RL Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990). RN [80] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND RP DQB1*06:02). RX PubMed=2010218; DOI=10.1007/bf01719235; RA Bugawan T.L., Erlich H.A.; RT "Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive RT oligonucleotide probes and amplified DNA."; RL Immunogenetics 33:163-170(1991). RN [81] RP NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01). RX PubMed=6952552; DOI=10.1111/j.1365-3083.1981.tb00603.x; RA Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K., RA Peterson P.A., Rask L.; RT "Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C RT antigen subunits and immunoglobulin chains."; RL Scand. J. Immunol. 14:617-622(1981). RN [82] RP POLYMORPHISM. RX PubMed=18565458; DOI=10.1016/s1474-4422(08)70140-6; RA Bourgin P., Zeitzer J.M., Mignot E.; RT "CSF hypocretin-1 assessment in sleep and neurological disorders."; RL Lancet Neurol. 7:649-662(2008). RN [83] RP REVIEW. RX PubMed=8598037; DOI=10.1016/s0092-8674(00)81025-9; RA Cresswell P.; RT "Invariant chain structure and MHC class II function."; RL Cell 84:505-507(1996). RN [84] RP REVIEW. RX PubMed=11684289; DOI=10.1016/s0161-5890(01)00069-4; RA Villadangos J.A.; RT "Presentation of antigens by MHC class II molecules: getting the most out RT of them."; RL Mol. Immunol. 38:329-346(2001). RN [85] RP REVIEW. RX PubMed=18046453; DOI=10.1038/sj.emboj.7601945; RA Rocha N., Neefjes J.; RT "MHC class II molecules on the move for successful antigen presentation."; RL EMBO J. 27:1-5(2008). RN [86] RP REVIEW. RX PubMed=17241953; DOI=10.1016/j.immuni.2007.01.005; RA Menendez-Benito V., Neefjes J.; RT "Autophagy in MHC class II presentation: sampling from within."; RL Immunity 26:1-3(2007). RN [87] RP REVIEW. RX PubMed=19092054; DOI=10.1242/jcs.035089; RA Berger A.C., Roche P.A.; RT "MHC class II transport at a glance."; RL J. Cell Sci. 122:1-4(2009). RN [88] RP REVIEW. RX PubMed=19533806; DOI=10.3748/wjg.15.2855; RA Beswick E.J., Reyes V.E.; RT "CD74 in antigen presentation, inflammation, and cancers of the RT gastrointestinal tract."; RL World J. Gastroenterol. 15:2855-2861(2009). RN [89] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1 RP HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, AND DISULFIDE BONDS. RX PubMed=11376336; DOI=10.1038/88694; RA Lee K.H., Wucherpfennig K.W., Wiley D.C.; RT "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to RT type 1 diabetes."; RL Nat. Immunol. 2:501-507(2001). RN [90] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1 RP HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM, RP SUBUNIT, AND DISULFIDE BONDS. RX PubMed=14769912; DOI=10.1073/pnas.0308458100; RA Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A., RA Bell J.I., Strominger J.L., Jones E.Y., Fugger L.; RT "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and RT confers strong susceptibility to narcolepsy."; RL Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004). RN [91] RP X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1 RP HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN RP PEPTIDE, SUBUNIT, AND POLYMORPHISM. RX PubMed=15020763; DOI=10.1073/pnas.0306885101; RA Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.; RT "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in RT celiac disease."; RL Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004). RN [92] RP X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1 RP HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, RP POLYMORPHISM, SUBUNIT, AND DISULFIDE BONDS. RX PubMed=17629515; DOI=10.1016/j.immuni.2007.05.015; RA Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T., RA Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., van Heel D.A., RA McCluskey J., Rossjohn J., Anderson R.P.; RT "A structural and immunological basis for the role of human leukocyte RT antigen DQ8 in celiac disease."; RL Immunity 27:23-34(2007). RN [93] RP VARIANT [LARGE SCALE ANALYSIS] ALA-172, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Binds peptides derived from antigens that access the CC endocytic route of antigen presenting cells (APC) and presents them on CC the cell surface for recognition by the CD4 T-cells. The peptide CC binding cleft accommodates peptides of 10-30 residues. The peptides CC presented by MHC class II molecules are generated mostly by degradation CC of proteins that access the endocytic route, where they are processed CC by lysosomal proteases and other hydrolases. Exogenous antigens that CC have been endocytosed by the APC are thus readily available for CC presentation via MHC II molecules, and for this reason this antigen CC presentation pathway is usually referred to as exogenous. As membrane CC proteins on their way to degradation in lysosomes as part of their CC normal turn-over are also contained in the endosomal/lysosomal CC compartments, exogenous antigens must compete with those derived from CC endogenous components. Autophagy is also a source of endogenous CC peptides, autophagosomes constitutively fuse with MHC class II loading CC compartments. In addition to APCs, other cells of the gastrointestinal CC tract, such as epithelial cells, express MHC class II molecules and CC CD74 and act as APCs, which is an unusual trait of the GI tract. To CC produce a MHC class II molecule that presents an antigen, three MHC CC class II molecules (heterodimers of an alpha and a beta chain) CC associate with a CD74 trimer in the ER to form a heterononamer. Soon CC after the entry of this complex into the endosomal/lysosomal system CC where antigen processing occurs, CD74 undergoes a sequential CC degradation by various proteases, including CTSS and CTSL, leaving a CC small fragment termed CLIP (class-II-associated invariant chain CC peptide). The removal of CLIP is facilitated by HLA-DM via direct CC binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM CC stabilizes MHC class II molecules until primary high affinity antigenic CC peptides are bound. The MHC II molecule bound to a peptide is then CC transported to the cell membrane surface. In B-cells, the interaction CC between HLA-DM and MHC class II molecules is regulated by HLA-DO. CC Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal CC microenvironment has been implicated in the regulation of antigen CC loading into MHC II molecules, increased acidification produces CC increased proteolysis and efficient peptide loading. CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit; also referred as CC MHC class II molecule. In the endoplasmic reticulum (ER) it forms a CC heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also CC known as invariant chain or HLA class II histocompatibility antigen CC gamma chain). In the endosomal/lysosomal system; CD74 undergoes CC sequential degradation by various proteases; leaving a small fragment CC termed CLIP on each MHC class II molecule. MHC class II molecule CC interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP CC and facilitate the binding of antigenic peptides. CC {ECO:0000269|PubMed:11376336, ECO:0000269|PubMed:14769912, CC ECO:0000269|PubMed:15020763, ECO:0000269|PubMed:17629515}. CC -!- INTERACTION: CC P01920; P01909: HLA-DQA1; NbExp=8; IntAct=EBI-1038012, EBI-713389; CC -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane CC protein. Endoplasmic reticulum membrane; Single-pass type I membrane CC protein. Golgi apparatus, trans-Golgi network membrane; Single-pass CC type I membrane protein. Endosome membrane; Single-pass type I membrane CC protein. Lysosome membrane; Single-pass type I membrane protein. CC Note=The MHC class II complex transits through a number of CC intracellular compartments in the endocytic pathway until it reaches CC the cell membrane for antigen presentation. CC -!- POLYMORPHISM: The following alleles of HLA-DQB1 are known: DQB1*02:01, CC DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, CC DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, CC DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, CC DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, CC DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, CC DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, CC DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, CC DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, CC DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, CC DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, CC DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, CC DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, CC DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown CC is that of DQB1*03:01. CC -!- POLYMORPHISM: DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated CC with more than 90% of celiac disease patients. A minority displays DQ8 CC (heterodimer of DQA1*03/DQB1*03:02). CC -!- POLYMORPHISM: DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers CC dominant protection against type 1 diabetes (T1D) and strong CC susceptibility to narcolepsy. DQB1*06:02 has been found to be present CC in most of the narcolepsy patients. As well 98% of the patients with an CC HCRT deficiency are positive for DQB1*06:02. CC -!- SIMILARITY: Belongs to the MHC class II family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAC64403.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=CAJ57391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; K01499; AAA98746.1; -; Genomic_DNA. DR EMBL; K02405; AAA75521.1; -; Genomic_DNA. DR EMBL; X03068; CAA26872.1; -; mRNA. DR EMBL; M17564; AAA59765.1; -; mRNA. DR EMBL; M29613; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M29616; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M16996; AAA59770.1; -; mRNA. DR EMBL; M20432; AAA59769.1; -; mRNA. DR EMBL; M60028; AAA59755.1; -; mRNA. DR EMBL; X96420; CAA65280.1; -; mRNA. DR EMBL; U92032; AAB91991.1; -; Genomic_DNA. DR EMBL; AY663393; AAU87973.1; -; Genomic_DNA. DR EMBL; AY663394; AAU87977.1; -; Genomic_DNA. DR EMBL; AY663397; AAU87986.1; -; Genomic_DNA. DR EMBL; AY663409; AAU88017.1; -; Genomic_DNA. DR EMBL; AY663404; AAU88002.1; -; Genomic_DNA. DR EMBL; AY663410; AAU88020.1; -; Genomic_DNA. DR EMBL; AY663412; AAU88027.1; -; Genomic_DNA. DR EMBL; AY656681; AAV71028.1; -; mRNA. DR EMBL; AY656682; AAV71029.1; -; mRNA. DR EMBL; AY656683; AAV71030.1; -; mRNA. DR EMBL; BX927168; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR753846; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR933859; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC012106; AAH12106.1; -; mRNA. DR EMBL; M25327; AAA59677.1; -; mRNA. DR EMBL; U66400; AAB51698.1; -; mRNA. DR EMBL; U83582; AAB41231.1; -; mRNA. DR EMBL; AH002887; AAA59762.1; -; Genomic_DNA. DR EMBL; M26042; AAA36270.1; -; mRNA. DR EMBL; M33907; AAA52672.1; -; mRNA. DR EMBL; L34096; AAC41964.1; -; mRNA. DR EMBL; L34098; AAC41966.1; -; mRNA. DR EMBL; L34101; AAC41969.1; -; mRNA. DR EMBL; L34103; AAC41971.1; -; mRNA. DR EMBL; L34104; AAC41972.1; -; mRNA. DR EMBL; L34105; AAC41973.1; -; mRNA. DR EMBL; L34106; AAC41974.1; -; mRNA. DR EMBL; L34107; AAC41975.1; -; mRNA. DR EMBL; AF195245; AAF28315.1; -; mRNA. DR EMBL; L42626; AAA85335.1; -; mRNA. DR EMBL; X76553; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; X76554; -; NOT_ANNOTATED_CDS; mRNA. DR EMBL; M59800; AAA64235.1; -; mRNA. DR EMBL; M14189; AAA36268.1; -; mRNA. DR EMBL; AY672649; AAT77952.1; -; Genomic_DNA. DR EMBL; M17207; AAA59697.1; -; mRNA. DR EMBL; Z49215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY026349; AAK01944.1; -; Genomic_DNA. DR EMBL; AF091305; AAC64403.2; ALT_SEQ; Genomic_DNA. DR EMBL; U77344; AAB19215.1; -; Genomic_DNA. DR EMBL; FN256435; CAX62164.1; -; Genomic_DNA. DR EMBL; FN256435; CAX62165.1; -; Genomic_DNA. DR EMBL; AM400970; CAL47037.1; -; Genomic_DNA. DR EMBL; AM421131; CAM07104.1; -; Genomic_DNA. DR EMBL; EF484936; ABO87661.1; -; Genomic_DNA. DR EMBL; EF484939; ABO87664.1; -; Genomic_DNA. DR EMBL; EU275158; ABY26531.1; -; Genomic_DNA. DR EMBL; AM944346; CAQ16179.1; -; Genomic_DNA. DR EMBL; FM200854; CAR31119.1; -; Genomic_DNA. DR EMBL; AH013029; AAP93137.1; -; Genomic_DNA. DR EMBL; EU770203; ACF16333.1; -; Genomic_DNA. DR EMBL; FM955320; CAW24712.1; -; Genomic_DNA. DR EMBL; FN552709; CBF35736.1; -; Genomic_DNA. DR EMBL; FN552710; CBF35739.1; -; Genomic_DNA. DR EMBL; X86327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; D78569; BAA11413.1; -; Genomic_DNA. DR EMBL; AF439338; AAL35222.1; -; Genomic_DNA. DR EMBL; AF384556; AAM53072.1; -; Genomic_DNA. DR EMBL; DQ026226; AAY89656.1; -; Genomic_DNA. DR EMBL; AY762968; AAV97949.1; -; Genomic_DNA. DR EMBL; AM181332; CAJ57391.1; ALT_SEQ; Genomic_DNA. DR EMBL; AM691798; CAM88661.1; -; Genomic_DNA. DR EMBL; AM259942; CAJ90956.1; -; Genomic_DNA. DR EMBL; U39090; AAB02681.1; -; Genomic_DNA. DR EMBL; AJ003005; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJ012156; CAA09929.1; -; Genomic_DNA. DR EMBL; AJ290396; CAC27418.1; -; Genomic_DNA. DR EMBL; AF469118; AAL77085.1; -; Genomic_DNA. DR EMBL; AF479569; AAM09472.1; -; Genomic_DNA. DR EMBL; AJ535315; CAD59445.2; -; Genomic_DNA. DR EMBL; AF181983; AAD54423.2; -; Genomic_DNA. DR EMBL; AY733062; AAU33811.1; -; Genomic_DNA. DR EMBL; AJ854065; CAH69441.1; -; Genomic_DNA. DR EMBL; AJ964903; CAI79639.1; -; Genomic_DNA. DR EMBL; AB211231; BAD95610.1; -; Genomic_DNA. DR EMBL; DQ114427; AAZ20753.1; -; Genomic_DNA. DR EMBL; DQ227421; ABB05231.1; -; Genomic_DNA. DR EMBL; AM403489; CAL48285.1; -; Genomic_DNA. DR EMBL; AM490069; CAM32717.1; -; Genomic_DNA. DR EMBL; EF622510; ABR24117.1; -; Genomic_DNA. DR EMBL; EU410617; ABZ89500.1; -; Genomic_DNA. DR EMBL; GQ422610; ACV66342.1; -; Genomic_DNA. DR EMBL; FN550110; CBE66554.1; -; Genomic_DNA. DR EMBL; AF087939; AAD39697.1; -; Genomic_DNA. DR EMBL; AY094140; AAM14401.1; -; Genomic_DNA. DR EMBL; AJ001257; CAA04631.1; -; Genomic_DNA. DR EMBL; U39086; AAA93181.1; -; Genomic_DNA. DR EMBL; AJ965439; CAI84643.1; -; Genomic_DNA. DR EMBL; AF112463; AAD23990.1; -; Genomic_DNA. DR EMBL; AF112464; AAD23991.1; -; Genomic_DNA. DR EMBL; M94773; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; M65042; AAA36241.1; -; Genomic_DNA. DR EMBL; M25025; AAA59793.1; -; mRNA. DR PIR; A02234; HLHU1C. DR PIR; A35055; A35055. DR PIR; A94003; HLHUDB. DR PIR; B32527; B32527. DR PIR; B37044; B37044. DR PIR; C24669; HLHU2C. DR PIR; F30575; F30575. DR PIR; I54480; I54480. DR PIR; I68732; I68732. DR PIR; I72482; I72482. DR PIR; S46648; S46648. DR RefSeq; NP_001230891.1; NM_001243962.1. DR RefSeq; NP_002114.3; NM_002123.4. DR PDB; 1JK8; X-ray; 2.40 A; B=35-224. DR PDB; 1S9V; X-ray; 2.22 A; B/E=33-230. DR PDB; 1UVQ; X-ray; 1.80 A; B=35-230. DR PDB; 2NNA; X-ray; 2.10 A; B=33-224. DR PDB; 4GG6; X-ray; 3.20 A; B/D=33-224. DR PDB; 4OZF; X-ray; 2.70 A; B=33-224. DR PDB; 4OZG; X-ray; 3.00 A; B/D=33-224. DR PDB; 4OZH; X-ray; 2.80 A; B/D=33-224. DR PDB; 4OZI; X-ray; 3.20 A; B/D=33-224. DR PDBsum; 1JK8; -. DR PDBsum; 1S9V; -. DR PDBsum; 1UVQ; -. DR PDBsum; 2NNA; -. DR PDBsum; 4GG6; -. DR PDBsum; 4OZF; -. DR PDBsum; 4OZG; -. DR PDBsum; 4OZH; -. DR PDBsum; 4OZI; -. DR AlphaFoldDB; P01920; -. DR SMR; P01920; -. DR BioGRID; 109364; 118. DR IntAct; P01920; 1. DR MINT; P01920; -. DR STRING; 9606.ENSP00000364080; -. DR TCDB; 9.A.75.1.1; the mhc ii receptor (mhc2r) family. DR GlyCosmos; P01920; 1 site, No reported glycans. DR GlyGen; P01920; 2 sites. DR iPTMnet; P01920; -. DR PhosphoSitePlus; P01920; -. DR BioMuta; HLA-DQB1; -. DR DMDM; 290457643; -. DR jPOST; P01920; -. DR MassIVE; P01920; -. DR PaxDb; 9606-ENSP00000364080; -. DR PeptideAtlas; P01920; -. DR ProteomicsDB; 51513; -. DR ABCD; P01920; 26 sequenced antibodies. DR CPTC; P01920; 1 antibody. DR DNASU; 3119; -. DR Ensembl; ENST00000399088.8; ENSP00000382038.4; ENSG00000231286.7. DR Ensembl; ENST00000413089.1; ENSP00000396539.1; ENSG00000231286.7. DR Ensembl; ENST00000416192.6; ENSP00000410107.2; ENSG00000233209.6. DR Ensembl; ENST00000419914.6; ENSP00000402865.2; ENSG00000225824.8. DR Ensembl; ENST00000422950.1; ENSP00000414079.1; ENSG00000233209.6. DR Ensembl; ENST00000424806.1; ENSP00000410330.1; ENSG00000225824.8. DR GeneID; 3119; -. DR KEGG; hsa:3119; -. DR UCSC; uc011hep.3; human. DR AGR; HGNC:4944; -. DR CTD; 3119; -. DR DisGeNET; 3119; -. DR GeneCards; HLA-DQB1; -. DR GeneReviews; HLA-DQB1; -. DR HGNC; HGNC:4944; HLA-DQB1. DR MalaCards; HLA-DQB1; -. DR MIM; 604305; gene. DR neXtProt; NX_P01920; -. DR Orphanet; 703; Bullous pemphigoid. DR Orphanet; 930; Idiopathic achalasia. DR Orphanet; 2073; Narcolepsy type 1. DR Orphanet; 83465; Narcolepsy type 2. DR Orphanet; 555; NON RARE IN EUROPE: Celiac disease. DR Orphanet; 243377; NON RARE IN EUROPE: Diabetes mellitus type 1. DR Orphanet; 802; NON RARE IN EUROPE: Multiple sclerosis. DR Orphanet; 477738; Pediatric multiple sclerosis. DR PharmGKB; PA35068; -. DR eggNOG; ENOG502RYBQ; Eukaryota. DR InParanoid; P01920; -. DR PhylomeDB; P01920; -. DR PathwayCommons; P01920; -. DR Reactome; R-HSA-202424; Downstream TCR signaling. DR Reactome; R-HSA-202427; Phosphorylation of CD3 and TCR zeta chains. DR Reactome; R-HSA-202430; Translocation of ZAP-70 to Immunological synapse. DR Reactome; R-HSA-202433; Generation of second messenger molecules. DR Reactome; R-HSA-2132295; MHC class II antigen presentation. DR Reactome; R-HSA-389948; PD-1 signaling. DR Reactome; R-HSA-877300; Interferon gamma signaling. DR SignaLink; P01920; -. DR SIGNOR; P01920; -. DR BioGRID-ORCS; 3119; 11 hits in 1060 CRISPR screens. DR ChiTaRS; HLA-DQB1; human. DR EvolutionaryTrace; P01920; -. DR GeneWiki; HLA-DQB1; -. DR GenomeRNAi; 3119; -. DR Pharos; P01920; Tbio. DR PRO; PR:P01920; -. DR Proteomes; UP000005640; Unplaced. DR RNAct; P01920; Protein. DR Bgee; ENSG00000231286; Expressed in spleen and 10 other cell types or tissues. DR GO; GO:0030669; C:clathrin-coated endocytic vesicle membrane; TAS:Reactome. DR GO; GO:0030666; C:endocytic vesicle membrane; TAS:Reactome. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; TAS:Reactome. DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome. DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; TAS:Reactome. DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central. DR GO; GO:0016020; C:membrane; HDA:UniProtKB. DR GO; GO:0042613; C:MHC class II protein complex; ISS:CAFA. DR GO; GO:0005886; C:plasma membrane; TAS:Reactome. DR GO; GO:0032588; C:trans-Golgi network membrane; TAS:Reactome. DR GO; GO:0030658; C:transport vesicle membrane; TAS:Reactome. DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central. DR GO; GO:0032395; F:MHC class II receptor activity; NAS:UniProtKB. DR GO; GO:0042605; F:peptide antigen binding; ISS:CAFA. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:UniProtKB. DR GO; GO:0006959; P:humoral immune response; IMP:UniProtKB. DR GO; GO:0006955; P:immune response; NAS:UniProtKB. DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central. DR GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central. DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central. DR GO; GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB. DR CDD; cd21001; IgC1_MHC_II_beta_HLA-DQ_I-A; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF101; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW 3D-structure; Adaptive immunity; Cell membrane; Direct protein sequencing; KW Disulfide bond; Endoplasmic reticulum; Endosome; Glycoprotein; KW Golgi apparatus; Immunity; Lysosome; Membrane; MHC II; Reference proteome; KW Signal; Transmembrane; Transmembrane helix. FT SIGNAL 1..32 FT /evidence="ECO:0000269|PubMed:6576979" FT CHAIN 33..261 FT /note="HLA class II histocompatibility antigen, DQ beta 1 FT chain" FT /id="PRO_0000018989" FT TOPO_DOM 33..230 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 231..251 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 252..261 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT DOMAIN 129..217 FT /note="Ig-like C1-type" FT REGION 33..126 FT /note="Beta-1" FT REGION 127..220 FT /note="Beta-2" FT REGION 221..230 FT /note="Connecting peptide" FT CARBOHYD 51 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 47..111 FT DISULFID 149..205 FT VARIANT 6 FT /note="A -> S (in allele DQB1*05:01 and allele DQB1*05:02; FT dbSNP:rs1049056)" FT /id="VAR_056570" FT VARIANT 12 FT /note="G -> D (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1049057)" FT /id="VAR_062679" FT VARIANT 15 FT /note="A -> V (in allele DQB1*03:02, allele DQB1*03:03, FT allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs3189152)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062680" FT VARIANT 23 FT /note="A -> S (in allele DQB1*02:01 and allele DQB1*02:02; FT dbSNP:rs3891176)" FT /id="VAR_062681" FT VARIANT 24 FT /note="M -> I (in allele DQB1*05:01 and allele DQB1*05:02; FT dbSNP:rs1049059)" FT /id="VAR_062682" FT VARIANT 27 FT /note="T -> A (in allele DQB1*04:01; dbSNP:rs1049060)" FT /id="VAR_062683" FT VARIANT 27 FT /note="T -> S (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1049060)" FT /id="VAR_062684" FT VARIANT 28 FT /note="P -> L (in allele DQB1*06:02 and allele DQB1*06:12; FT dbSNP:rs1049062)" FT /id="VAR_062685" FT VARIANT 28 FT /note="P -> S (in allele DQB1*05:01 and allele DQB1*05:02; FT dbSNP:rs1049061)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062686" FT VARIANT 29 FT /note="V -> L (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*06:02 and allele DQB1*06:12; dbSNP:rs1130366)" FT /id="VAR_062687" FT VARIANT 35 FT /note="S -> P (in allele DQB1*06:01; dbSNP:rs12722106)" FT /id="VAR_062688" FT VARIANT 41 FT /note="Y -> F (in allele DQB1*04:01, allele DQB1*04:02, FT allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, FT allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, FT allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, FT allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37; FT dbSNP:rs9274407)" FT /id="VAR_062689" FT VARIANT 41 FT /note="Y -> L (in allele DQB1*06:01 and allele DQB1*06:35; FT requires 2 nucleotide substitutions)" FT /id="VAR_062690" FT VARIANT 43 FT /note="F -> L (in allele DQB1*06:33; dbSNP:rs56173496)" FT /id="VAR_062691" FT VARIANT 45 FT /note="A -> G (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, FT allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, FT allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, FT allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, FT allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, FT allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, FT allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, FT allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, FT allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, FT allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, FT allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, FT allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, FT allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, FT allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, FT allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, FT allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, FT allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; FT dbSNP:rs1130375)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_061472" FT VARIANT 46 FT /note="M -> L (in allele DQB1*03:11, allele DQB1*03:26, FT allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, FT allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, FT allele DQB1*06:20 and allele DQB1*06:31; dbSNP:rs1130368)" FT /id="VAR_061473" FT VARIANT 55 FT /note="R -> L (in allele DQB1*04:01; dbSNP:rs41540813)" FT /id="VAR_062692" FT VARIANT 58 FT /note="Y -> G (in allele DQB1*03:05, allele DQB1*03:17, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05 and allele DQB1*06:23; requires 2 FT nucleotide substitutions)" FT /id="VAR_062693" FT VARIANT 58 FT /note="Y -> L (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, FT allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, FT allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, FT allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, FT allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, FT allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, FT allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, FT allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, FT allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, FT allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and FT allele DQB1*06:39; requires 2 nucleotide substitutions; FT dbSNP:rs766817072)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062694" FT VARIANT 59 FT /note="V -> L (in allele DQB1*03:18; dbSNP:rs41563539)" FT /id="VAR_062695" FT VARIANT 60 FT /note="T -> S (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT dbSNP:rs9274405)" FT /id="VAR_062696" FT VARIANT 62 FT /note="Y -> H (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, FT allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, FT allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, FT allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, FT allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and FT allele DQB1*06:39; dbSNP:rs281862065)" FT /id="VAR_062697" FT VARIANT 62 FT /note="Y -> S (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele FT DQB1*02:05)" FT /id="VAR_062698" FT VARIANT 69 FT /note="Y -> D (in allele DQB1*06:01 and allele DQB1*06:35; FT dbSNP:rs281874782)" FT /id="VAR_062699" FT VARIANT 69 FT /note="Y -> I (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT requires 2 nucleotide substitutions)" FT /id="VAR_062700" FT VARIANT 70 FT /note="A -> T (in allele DQB1*03:20; dbSNP:rs45519640)" FT /id="VAR_062701" FT VARIANT 70 FT /note="A -> V (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, FT allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and FT allele DQB1*06:35; dbSNP:rs1063318)" FT /id="VAR_062702" FT VARIANT 77 FT /note="E -> G (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, FT allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, FT allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, FT allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, FT allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, FT allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, FT allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, FT allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, FT allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, FT allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, FT allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, FT allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, FT allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1049083)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062703" FT VARIANT 78 FT /note="V -> E (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT dbSNP:rs9274398)" FT /id="VAR_062704" FT VARIANT 79 FT /note="Y -> F (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT dbSNP:rs9274397)" FT /id="VAR_062705" FT VARIANT 81 FT /note="A -> V (in allele DQB1*03:07; dbSNP:rs41558214)" FT /id="VAR_062706" FT VARIANT 84 FT /note="P -> L (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT dbSNP:rs9274395)" FT /id="VAR_062707" FT VARIANT 85 FT /note="L -> Q (in allele DQB1*03:23, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, FT allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, FT allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, FT allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, FT allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, FT allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, FT allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and FT allele DQB1*06:39; dbSNP:rs1140313)" FT /id="VAR_062708" FT VARIANT 87 FT /note="P -> L (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; FT dbSNP:rs1130380)" FT /id="VAR_062709" FT VARIANT 87 FT /note="P -> Q (in allele DQB1*03:16; dbSNP:rs1130380)" FT /id="VAR_062710" FT VARIANT 87 FT /note="P -> R (in allele DQB1*03:23, allele DQB1*03:25, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, FT allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, FT allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, FT allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, FT allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, FT allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, FT allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, FT allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, FT allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, FT allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, FT allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, FT allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, FT allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; FT dbSNP:rs1130380)" FT /id="VAR_062711" FT VARIANT 88 FT /note="P -> L (in allele DQB1*03:25, allele DQB1*04:01, FT allele DQB1*04:02 and allele DQB1*04:03; dbSNP:rs1130381)" FT /id="VAR_062712" FT VARIANT 89 FT /note="D -> A (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, FT allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, FT allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, FT allele DQB1*03:18 and allele DQB1*06:29; dbSNP:rs1071637)" FT /id="VAR_062713" FT VARIANT 89 FT /note="D -> S (in allele DQB1*05:02, allele DQB1*05:04, FT allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; FT requires 2 nucleotide substitutions)" FT /id="VAR_062714" FT VARIANT 89 FT /note="D -> V (in allele DQB1*05:01, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, FT allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, FT allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, FT allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; FT dbSNP:rs1071637)" FT /id="VAR_062715" FT VARIANT 92 FT /note="Y -> N (in allele DQB1*06:16; dbSNP:rs41562414)" FT /id="VAR_062716" FT VARIANT 94 FT /note="N -> K (in allele DQB1*06:37; dbSNP:rs1130382)" FT /id="VAR_062717" FT VARIANT 95 FT /note="S -> R (in allele DQB1*03:15; dbSNP:rs41556215)" FT /id="VAR_062718" FT VARIANT 98 FT /note="E -> D (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, FT allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, FT allele DQB1*06:01 and allele DQB1*06:35; dbSNP:rs9274390)" FT /id="VAR_062719" FT VARIANT 99 FT /note="V -> D (in allele DQB1*03:13; dbSNP:rs41563814)" FT /id="VAR_062720" FT VARIANT 99 FT /note="V -> I (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, FT allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, FT allele DQB1*06:01 and allele DQB1*06:35; dbSNP:rs9274390)" FT /id="VAR_062721" FT VARIANT 102 FT /note="R -> E (in allele DQB1*03:06, allele DQB1*03:25, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and FT allele DQB1*05:04; requires 2 nucleotide substitutions)" FT /id="VAR_062722" FT VARIANT 102 FT /note="R -> G (in allele DQB1*03:08, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, FT allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, FT allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, FT allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, FT allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, FT allele DQB1*06:31 and allele DQB1*06:33; dbSNP:rs1130386)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062723" FT VARIANT 103 FT /note="T -> A (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, FT allele DQB1*06:24 and allele DQB1*06:30; dbSNP:rs1130390)" FT /id="VAR_062724" FT VARIANT 103 FT /note="T -> D (in allele DQB1*03:06, allele DQB1*03:25, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and FT allele DQB1*05:04; requires 2 nucleotide substitutions)" FT /id="VAR_062725" FT VARIANT 103 FT /note="T -> K (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04 and allele FT DQB1*02:05)" FT /id="VAR_062726" FT VARIANT 106 FT /note="E -> A (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and FT allele DQB1*06:06; dbSNP:rs1130387)" FT /id="VAR_062727" FT VARIANT 106 FT /note="E -> S (in allele DQB1*03:06, allele DQB1*03:25, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, FT allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, FT allele DQB1*05:04 and allele DQB1*05:05; requires 2 FT nucleotide substitutions)" FT /id="VAR_062728" FT VARIANT 107 FT /note="L -> V (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, FT allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, FT allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05 and allele DQB1*06:06; dbSNP:rs9274384)" FT /id="VAR_062729" FT VARIANT 109 FT /note="T -> R (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, FT allele DQB1*05:05 and allele DQB1*06:06; dbSNP:rs1130392)" FT /id="VAR_062730" FT VARIANT 116 FT /note="Q -> E (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, FT allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, FT allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, FT allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, FT allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, FT allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39; FT dbSNP:rs1140316)" FT /id="VAR_062731" FT VARIANT 117 FT /note="L -> V (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, FT allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, FT allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, FT allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, FT allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, FT allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, FT allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; FT dbSNP:rs1140317)" FT /id="VAR_062732" FT VARIANT 118 FT /note="E -> A (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, FT allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, FT allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, FT allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, FT allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, FT allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, FT allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and FT allele DQB1*06:37; dbSNP:rs9274380)" FT /id="VAR_062733" FT VARIANT 118 FT /note="E -> G (in allele DQB1*06:04, allele DQB1*06:05, FT allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, FT allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, FT allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, FT allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; FT dbSNP:rs9274380)" FT /id="VAR_062734" FT VARIANT 119 FT /note="L -> F (in allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, FT allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, FT allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, FT allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, FT allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, FT allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37; FT dbSNP:rs9274379)" FT /id="VAR_062735" FT VARIANT 119 FT /note="L -> Y (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, FT allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, FT allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, FT allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and FT allele DQB1*06:39; requires 2 nucleotide substitutions)" FT /id="VAR_062736" FT VARIANT 121 FT /note="T -> G (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, FT allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, FT allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, FT allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, FT allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, FT allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, FT allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, FT allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, FT allele DQB1*06:38 and allele DQB1*06:39; requires 2 FT nucleotide substitutions)" FT /id="VAR_062737" FT VARIANT 122 FT /note="T -> I (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, FT allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, FT allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, FT allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, FT allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, FT allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, FT allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, FT allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, FT allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, FT allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, FT allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, FT allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and FT allele DQB1*06:39; dbSNP:rs1140320)" FT /id="VAR_062738" FT VARIANT 148 FT /note="V -> I (in allele DQB1*05:01, allele DQB1*05:02 and FT allele DQB1*05:03; dbSNP:rs1049100)" FT /id="VAR_056571" FT VARIANT 157 FT /note="A -> G (in allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, FT allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1063322)" FT /id="VAR_062739" FT VARIANT 157 FT /note="A -> S (in allele DQB1*05:01, allele DQB1*05:02 and FT allele DQB1*05:03)" FT /id="VAR_062740" FT VARIANT 158 FT /note="Q -> H (in allele DQB1*05:02; dbSNP:rs41542812)" FT /id="VAR_062741" FT VARIANT 162 FT /note="R -> Q (in allele DQB1*03:22, allele DQB1*06:04, FT allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, FT allele DQB1*06:36 and allele DQB1*06:38; dbSNP:rs41544112)" FT /id="VAR_062742" FT VARIANT 165 FT /note="R -> Q (in allele DQB1*06:38; dbSNP:rs9273989)" FT /id="VAR_062744" FT VARIANT 165 FT /note="R -> W (in allele DQB1*03:21; dbSNP:rs63626961)" FT /id="VAR_062743" FT VARIANT 167 FT /note="D -> G (in allele DQB1*02:02; dbSNP:rs2647032)" FT /id="VAR_062745" FT VARIANT 168 FT /note="Q -> E (in allele DQB1*02:04; dbSNP:rs9273981)" FT /id="VAR_062746" FT VARIANT 172 FT /note="T -> A (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, FT allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1063323)" FT /evidence="ECO:0007744|PubMed:21269460" FT /id="VAR_062747" FT VARIANT 194 FT /note="E -> D (in dbSNP:rs9273952)" FT /id="VAR_056572" FT VARIANT 197 FT /note="P -> L (in dbSNP:rs9273948)" FT /id="VAR_059522" FT VARIANT 199 FT /note="H -> R (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, FT allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, FT allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, FT allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, FT allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs701564)" FT /evidence="ECO:0000269|PubMed:3584986" FT /id="VAR_062748" FT VARIANT 200..201 FT /note="GD -> A (in allele DQB1*03:09)" FT /id="VAR_062749" FT VARIANT 202 FT /note="V -> I (in allele DQB1*03:24; dbSNP:rs80255621)" FT /id="VAR_062750" FT VARIANT 214 FT /note="N -> S (in allele DQB1*02:01, allele DQB1*02:02, FT allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, FT allele DQB1*06:38 and allele DQB1*06:39; dbSNP:rs1130398)" FT /id="VAR_062751" FT VARIANT 217 FT /note="T -> I (in allele DQB1*03:02, allele DQB1*03:03, FT allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, FT allele DQB1*04:01 and allele DQB1*04:02; dbSNP:rs1130399)" FT /id="VAR_062752" FT VARIANT 218 FT /note="V -> A (in allele DQB1*06:36; dbSNP:rs281864132)" FT /id="VAR_062753" FT VARIANT 229 FT /note="S -> N (in allele DQB1*06:01; dbSNP:rs1130429)" FT /id="VAR_062754" FT VARIANT 235 FT /note="I -> V (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, FT allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and FT allele DQB1*06:36; dbSNP:rs1049163)" FT /id="VAR_062755" FT VARIANT 252 FT /note="H -> R (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12 and allele DQB1*06:36; dbSNP:rs1140342)" FT /id="VAR_062756" FT VARIANT 253 FT /note="H -> Q (in allele DQB1*05:01, allele DQB1*05:02, FT allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, FT allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, FT allele DQB1*06:12 and allele DQB1*06:36; dbSNP:rs1140343)" FT /id="VAR_062757" FT VARIANT 256 FT /note="Q -> R (in allele DQB1*05:01, allele DQB1*05:02 and FT allele DQB1*05:03; dbSNP:rs1130432)" FT /id="VAR_061474" FT CONFLICT 111 FT /note="C -> S (in Ref. 71; AAD39697)" FT /evidence="ECO:0000305" FT CONFLICT 113 FT /note="H -> Q (in Ref. 22; AAF28315)" FT /evidence="ECO:0000305" FT CONFLICT 173 FT /note="G -> A (in Ref. 24; X76553/X76554)" FT /evidence="ECO:0000305" FT CONFLICT 214 FT /note="N -> T (in Ref. 8; AAA59770)" FT /evidence="ECO:0000305" FT STRAND 40..50 FT /evidence="ECO:0007829|PDB:1UVQ" FT TURN 51..54 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 55..64 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 67..73 FT /evidence="ECO:0007829|PDB:1UVQ" FT TURN 74..76 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 78..83 FT /evidence="ECO:0007829|PDB:1UVQ" FT HELIX 84..86 FT /evidence="ECO:0007829|PDB:1UVQ" FT HELIX 87..94 FT /evidence="ECO:0007829|PDB:1UVQ" FT HELIX 97..109 FT /evidence="ECO:0007829|PDB:1UVQ" FT HELIX 111..117 FT /evidence="ECO:0007829|PDB:1UVQ" FT HELIX 119..122 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 130..135 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 141..144 FT /evidence="ECO:0007829|PDB:1JK8" FT STRAND 146..157 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 160..165 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 168..170 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 174..176 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 183..185 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 187..194 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 203..208 FT /evidence="ECO:0007829|PDB:1UVQ" FT STRAND 216..220 FT /evidence="ECO:0007829|PDB:1UVQ" SQ SEQUENCE 261 AA; 29991 MW; 79B1E571A628CF96 CRC64; MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI IHHRSQKGLL H //