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P01920

- DQB1_HUMAN

UniProt

P01920 - DQB1_HUMAN

Protein

HLA class II histocompatibility antigen, DQ beta 1 chain

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (02 Mar 2010)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

    GO - Molecular functioni

    1. MHC class II receptor activity Source: UniProtKB
    2. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. humoral immune response mediated by circulating immunoglobulin Source: UniProtKB
    4. immune response Source: UniProtKB
    5. immunoglobulin production involved in immunoglobulin mediated immune response Source: UniProtKB
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. T cell costimulation Source: Reactome
    8. T cell receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DQ beta 1 chain
    Alternative name(s):
    MHC class II antigen DQB1
    Gene namesi
    Name:HLA-DQB1
    Synonyms:HLA-DQB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:4944. HLA-DQB1.

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. endocytic vesicle membrane Source: Reactome
    3. endosome membrane Source: UniProtKB-SubCell
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi membrane Source: Reactome
    6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    7. lysosomal membrane Source: Reactome
    8. membrane Source: UniProtKB
    9. MHC class II protein complex Source: UniProt
    10. plasma membrane Source: Reactome
    11. trans-Golgi network membrane Source: Reactome
    12. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti703. Bullous pemphigoid.
    555. Celiac disease.
    243377. Diabetes mellitus type 1.
    802. Multiple sclerosis.
    83465. Narcolepsy without cataplexy.
    2073. Narcolepsy-cataplexy.
    PharmGKBiPA35068.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 32321 PublicationAdd
    BLAST
    Chaini33 – 261229HLA class II histocompatibility antigen, DQ beta 1 chainPRO_0000018989Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 111
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 205

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP01920.
    PaxDbiP01920.
    PRIDEiP01920.

    PTM databases

    PhosphoSiteiP01920.

    Expressioni

    Gene expression databases

    CleanExiHS_HLA-DQB1.
    GenevestigatoriP01920.

    Organism-specific databases

    HPAiHPA013667.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

    Protein-protein interaction databases

    BioGridi109364. 1 interaction.
    IntActiP01920. 1 interaction.
    MINTiMINT-199658.
    STRINGi9606.ENSP00000382034.

    Structurei

    Secondary structure

    1
    261
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi40 – 5011
    Turni51 – 544
    Beta strandi55 – 6410
    Beta strandi67 – 737
    Turni74 – 763
    Beta strandi78 – 836
    Helixi84 – 863
    Helixi87 – 948
    Helixi97 – 10913
    Helixi111 – 1177
    Helixi119 – 1224
    Beta strandi130 – 1356
    Beta strandi141 – 1444
    Beta strandi146 – 15712
    Beta strandi160 – 1656
    Beta strandi168 – 1703
    Beta strandi174 – 1763
    Beta strandi183 – 1853
    Beta strandi187 – 1948
    Beta strandi203 – 2086
    Beta strandi216 – 2205

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JK8X-ray2.40B35-224[»]
    1NBNmodel-B35-224[»]
    1S9VX-ray2.22B/E33-230[»]
    1UVQX-ray1.80B35-230[»]
    2NNAX-ray2.10B33-224[»]
    4GG6X-ray3.20B/D33-224[»]
    4OZFX-ray2.70B33-224[»]
    4OZGX-ray3.00B/D33-224[»]
    4OZHX-ray2.80B/D33-224[»]
    4OZIX-ray3.20B/D33-224[»]
    ProteinModelPortaliP01920.
    SMRiP01920. Positions 35-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01920.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 230198ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini252 – 26110CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini129 – 21789Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 12694Beta-1Add
    BLAST
    Regioni127 – 22094Beta-2Add
    BLAST
    Regioni221 – 23010Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68200.
    HOVERGENiHBG012730.
    InParanoidiP01920.
    KOiK06752.
    PhylomeDBiP01920.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01920-1 [UniParc]FASTAAdd to Basket

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    MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT    50
    NGTERVRYVT RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL 100
    ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS 150
    VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQHG 200
    DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI 250
    IHHRSQKGLL H 261
    Length:261
    Mass (Da):29,991
    Last modified:March 2, 2010 - v2
    Checksum:i79B1E571A628CF96
    GO

    Sequence cautioni

    The sequence AAC64403.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAJ57391.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti111 – 1111C → S in AAD39697. 1 PublicationCurated
    Sequence conflicti113 – 1131H → Q in AAF28315. (PubMed:11098940)Curated
    Sequence conflicti173 – 1731G → A in X76553. (PubMed:7928445)Curated
    Sequence conflicti173 – 1731G → A in X76554. (PubMed:7928445)Curated
    Sequence conflicti214 – 2141N → T in AAA59770. (PubMed:3584986)Curated

    Polymorphismi

    The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.
    DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).
    DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61A → S in allele DQB1*05:01 and allele DQB1*05:02.
    Corresponds to variant rs1049056 [ dbSNP | Ensembl ].
    VAR_056570
    Natural varianti12 – 121G → D in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
    Corresponds to variant rs1049057 [ dbSNP | Ensembl ].
    VAR_062679
    Natural varianti15 – 151A → V in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. 1 Publication
    Corresponds to variant rs3189152 [ dbSNP | Ensembl ].
    VAR_062680
    Natural varianti23 – 231A → S in allele DQB1*02:01 and allele DQB1*02:02.
    Corresponds to variant rs3891176 [ dbSNP | Ensembl ].
    VAR_062681
    Natural varianti24 – 241M → I in allele DQB1*05:01 and allele DQB1*05:02.
    Corresponds to variant rs1049059 [ dbSNP | Ensembl ].
    VAR_062682
    Natural varianti27 – 271T → A in allele DQB1*04:01.
    VAR_062683
    Natural varianti27 – 271T → S in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
    Corresponds to variant rs1049060 [ dbSNP | Ensembl ].
    VAR_062684
    Natural varianti28 – 281P → L in allele DQB1*06:02 and allele DQB1*06:12.
    Corresponds to variant rs1049062 [ dbSNP | Ensembl ].
    VAR_062685
    Natural varianti28 – 281P → S in allele DQB1*05:01 and allele DQB1*05:02. 1 Publication
    VAR_062686
    Natural varianti29 – 291V → L in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
    Corresponds to variant rs1130366 [ dbSNP | Ensembl ].
    VAR_062687
    Natural varianti35 – 351S → P in allele DQB1*06:01.
    VAR_062688
    Natural varianti41 – 411Y → F in allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37.
    Corresponds to variant rs9274407 [ dbSNP | Ensembl ].
    VAR_062689
    Natural varianti41 – 411Y → L in allele DQB1*06:01 and allele DQB1*06:35; requires 2 nucleotide substitutions.
    VAR_062690
    Natural varianti43 – 431F → L in allele DQB1*06:33.
    Corresponds to variant rs56173496 [ dbSNP | Ensembl ].
    VAR_062691
    Natural varianti45 – 451A → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
    Corresponds to variant rs1130375 [ dbSNP | Ensembl ].
    VAR_061472
    Natural varianti46 – 461M → L in allele DQB1*03:11, allele DQB1*03:26, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, allele DQB1*06:20 and allele DQB1*06:31.
    Corresponds to variant rs1130368 [ dbSNP | Ensembl ].
    VAR_061473
    Natural varianti55 – 551R → L in allele DQB1*04:01.
    Corresponds to variant rs41540813 [ dbSNP | Ensembl ].
    VAR_062692
    Natural varianti58 – 581Y → G in allele DQB1*03:05, allele DQB1*03:17, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:23; requires 2 nucleotide substitutions.
    VAR_062693
    Natural varianti58 – 581Y → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1 Publication
    VAR_062694
    Natural varianti59 – 591V → L in allele DQB1*03:18.
    Corresponds to variant rs41563539 [ dbSNP | Ensembl ].
    VAR_062695
    Natural varianti60 – 601T → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    Corresponds to variant rs9274405 [ dbSNP | Ensembl ].
    VAR_062696
    Natural varianti62 – 621Y → H in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
    VAR_062697
    Natural varianti62 – 621Y → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    VAR_062698
    Natural varianti69 – 691Y → D in allele DQB1*06:01 and allele DQB1*06:35.
    Corresponds to variant rs1130370 [ dbSNP | Ensembl ].
    VAR_062699
    Natural varianti69 – 691Y → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; requires 2 nucleotide substitutions.
    VAR_062700
    Natural varianti70 – 701A → T in allele DQB1*03:20.
    Corresponds to variant rs45519640 [ dbSNP | Ensembl ].
    VAR_062701
    Natural varianti70 – 701A → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and allele DQB1*06:35.
    Corresponds to variant rs1063318 [ dbSNP | Ensembl ].
    VAR_062702
    Natural varianti77 – 771E → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
    Corresponds to variant rs1049083 [ dbSNP | Ensembl ].
    VAR_062703
    Natural varianti78 – 781V → E in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    Corresponds to variant rs9274398 [ dbSNP | Ensembl ].
    VAR_062704
    Natural varianti79 – 791Y → F in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    Corresponds to variant rs9274397 [ dbSNP | Ensembl ].
    VAR_062705
    Natural varianti81 – 811A → V in allele DQB1*03:07.
    Corresponds to variant rs41558214 [ dbSNP | Ensembl ].
    VAR_062706
    Natural varianti84 – 841P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    Corresponds to variant rs9274395 [ dbSNP | Ensembl ].
    VAR_062707
    Natural varianti85 – 851L → Q in allele DQB1*03:23, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
    Corresponds to variant rs1140313 [ dbSNP | Ensembl ].
    VAR_062708
    Natural varianti87 – 871P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    VAR_062709
    Natural varianti87 – 871P → Q in allele DQB1*03:16.
    VAR_062710
    Natural varianti87 – 871P → R in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
    Corresponds to variant rs1130380 [ dbSNP | Ensembl ].
    VAR_062711
    Natural varianti88 – 881P → L in allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02 and allele DQB1*04:03.
    Corresponds to variant rs1130381 [ dbSNP | Ensembl ].
    VAR_062712
    Natural varianti89 – 891D → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, allele DQB1*03:18 and allele DQB1*06:29.
    Corresponds to variant rs1071637 [ dbSNP | Ensembl ].
    VAR_062713
    Natural varianti89 – 891D → S in allele DQB1*05:02, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; requires 2 nucleotide substitutions.
    VAR_062714
    Natural varianti89 – 891D → V in allele DQB1*05:01, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
    VAR_062715
    Natural varianti92 – 921Y → N in allele DQB1*06:16.
    VAR_062716
    Natural varianti94 – 941N → K in allele DQB1*06:37.
    VAR_062717
    Natural varianti95 – 951S → R in allele DQB1*03:15.
    VAR_062718
    Natural varianti98 – 981E → D in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
    Corresponds to variant rs9274390 [ dbSNP | Ensembl ].
    VAR_062719
    Natural varianti99 – 991V → D in allele DQB1*03:13.
    VAR_062720
    Natural varianti99 – 991V → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
    VAR_062721
    Natural varianti102 – 1021R → E in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
    VAR_062722
    Natural varianti102 – 1021R → G in allele DQB1*03:08, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31 and allele DQB1*06:33. 1 Publication
    Corresponds to variant rs1130386 [ dbSNP | Ensembl ].
    VAR_062723
    Natural varianti103 – 1031T → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, allele DQB1*06:24 and allele DQB1*06:30.
    VAR_062724
    Natural varianti103 – 1031T → D in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
    VAR_062725
    Natural varianti103 – 1031T → K in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
    VAR_062726
    Natural varianti106 – 1061E → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and allele DQB1*06:06.
    Corresponds to variant rs1130387 [ dbSNP | Ensembl ].
    VAR_062727
    Natural varianti106 – 1061E → S in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04 and allele DQB1*05:05; requires 2 nucleotide substitutions.
    VAR_062728
    Natural varianti107 – 1071L → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
    Corresponds to variant rs9274384 [ dbSNP | Ensembl ].
    VAR_062729
    Natural varianti109 – 1091T → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
    Corresponds to variant rs1130392 [ dbSNP | Ensembl ].
    VAR_062730
    Natural varianti116 – 1161Q → E in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39.
    Corresponds to variant rs1140316 [ dbSNP | Ensembl ].
    VAR_062731
    Natural varianti117 – 1171L → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
    Corresponds to variant rs1140317 [ dbSNP | Ensembl ].
    VAR_062732
    Natural varianti118 – 1181E → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
    VAR_062733
    Natural varianti118 – 1181E → G in allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
    VAR_062734
    Natural varianti119 – 1191L → F in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
    Corresponds to variant rs9274379 [ dbSNP | Ensembl ].
    VAR_062735
    Natural varianti119 – 1191L → Y in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
    VAR_062736
    Natural varianti121 – 1211T → G in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
    VAR_062737
    Natural varianti122 – 1221T → I in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
    Corresponds to variant rs1140320 [ dbSNP | Ensembl ].
    VAR_062738
    Natural varianti148 – 1481V → I in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
    Corresponds to variant rs1049100 [ dbSNP | Ensembl ].
    VAR_056571
    Natural varianti157 – 1571A → G in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
    VAR_062739
    Natural varianti157 – 1571A → S in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
    VAR_062740
    Natural varianti158 – 1581Q → H in allele DQB1*05:02.
    VAR_062741
    Natural varianti162 – 1621R → Q in allele DQB1*03:22, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36 and allele DQB1*06:38.
    VAR_062742
    Natural varianti165 – 1651R → Q in allele DQB1*06:38.
    VAR_062744
    Natural varianti165 – 1651R → W in allele DQB1*03:21.
    VAR_062743
    Natural varianti167 – 1671D → G in allele DQB1*02:02.
    VAR_062745
    Natural varianti168 – 1681Q → E in allele DQB1*02:04.
    VAR_062746
    Natural varianti172 – 1721T → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
    Corresponds to variant rs1063323 [ dbSNP | Ensembl ].
    VAR_062747
    Natural varianti194 – 1941E → D.
    Corresponds to variant rs9273952 [ dbSNP | Ensembl ].
    VAR_056572
    Natural varianti197 – 1971P → L.
    Corresponds to variant rs9273948 [ dbSNP | Ensembl ].
    VAR_059522
    Natural varianti199 – 1991H → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
    VAR_062748
    Natural varianti200 – 2012GD → A in allele DQB1*03:09.
    VAR_062749
    Natural varianti202 – 2021V → I in allele DQB1*03:24.
    VAR_062750
    Natural varianti214 – 2141N → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
    VAR_062751
    Natural varianti217 – 2171T → I in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, allele DQB1*04:01 and allele DQB1*04:02.
    VAR_062752
    Natural varianti218 – 2181V → A in allele DQB1*06:36.
    VAR_062753
    Natural varianti229 – 2291S → N in allele DQB1*06:01.
    VAR_062754
    Natural varianti235 – 2351I → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
    VAR_062755
    Natural varianti252 – 2521H → R in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
    Corresponds to variant rs1140342 [ dbSNP | Ensembl ].
    VAR_062756
    Natural varianti253 – 2531H → Q in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
    VAR_062757
    Natural varianti256 – 2561Q → R in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
    Corresponds to variant rs1130432 [ dbSNP | Ensembl ].
    VAR_061474

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01499 Genomic DNA. Translation: AAA98746.1.
    K02405 Genomic DNA. Translation: AAA75521.1.
    X03068 mRNA. Translation: CAA26872.1.
    M17564 mRNA. Translation: AAA59765.1.
    M29613 Genomic DNA. No translation available.
    M29616 Genomic DNA. No translation available.
    M16996 mRNA. Translation: AAA59770.1.
    M20432 mRNA. Translation: AAA59769.1.
    M60028 mRNA. Translation: AAA59755.1.
    X96420 mRNA. Translation: CAA65280.1.
    U92032 Genomic DNA. Translation: AAB91991.1.
    AY663393 Genomic DNA. Translation: AAU87973.1.
    AY663394 Genomic DNA. Translation: AAU87977.1.
    AY663397 Genomic DNA. Translation: AAU87986.1.
    AY663409 Genomic DNA. Translation: AAU88017.1.
    AY663404 Genomic DNA. Translation: AAU88002.1.
    AY663410 Genomic DNA. Translation: AAU88020.1.
    AY663412 Genomic DNA. Translation: AAU88027.1.
    AY656681 mRNA. Translation: AAV71028.1.
    AY656682 mRNA. Translation: AAV71029.1.
    AY656683 mRNA. Translation: AAV71030.1.
    BX927168 Genomic DNA. Translation: CAQ08747.1.
    CR753846 Genomic DNA. Translation: CAQ09755.1.
    CR933859 Genomic DNA. Translation: CAQ09239.1.
    BC012106 mRNA. Translation: AAH12106.1.
    M25327 mRNA. Translation: AAA59677.1.
    U66400 mRNA. Translation: AAB51698.1.
    U83582 mRNA. Translation: AAB41231.1.
    AH002887 Genomic DNA. Translation: AAA59762.1.
    M26042 mRNA. Translation: AAA36270.1.
    M33907 mRNA. Translation: AAA52672.1.
    L34096 mRNA. Translation: AAC41964.1.
    L34098 mRNA. Translation: AAC41966.1.
    L34101 mRNA. Translation: AAC41969.1.
    L34103 mRNA. Translation: AAC41971.1.
    L34104 mRNA. Translation: AAC41972.1.
    L34105 mRNA. Translation: AAC41973.1.
    L34106 mRNA. Translation: AAC41974.1.
    L34107 mRNA. Translation: AAC41975.1.
    AF195245 mRNA. Translation: AAF28315.1.
    L42626 mRNA. Translation: AAA85335.1.
    X76553 mRNA. No translation available.
    X76554 mRNA. No translation available.
    M59800 mRNA. Translation: AAA64235.1.
    M14189 mRNA. Translation: AAA36268.1.
    AY672649 Genomic DNA. Translation: AAT77952.1.
    M17207 mRNA. Translation: AAA59697.1.
    Z49215 Genomic DNA. No translation available.
    AY026349 Genomic DNA. Translation: AAK01944.1.
    AF091305 Genomic DNA. Translation: AAC64403.2. Sequence problems.
    U77344 Genomic DNA. Translation: AAB19215.1.
    FN256435 Genomic DNA. Translation: CAX62164.1.
    FN256435 Genomic DNA. Translation: CAX62165.1.
    AM400970 Genomic DNA. Translation: CAL47037.1.
    AM421131 Genomic DNA. Translation: CAM07104.1.
    EF484936 Genomic DNA. Translation: ABO87661.1.
    EF484939 Genomic DNA. Translation: ABO87664.1.
    EU275158 Genomic DNA. Translation: ABY26531.1.
    AM944346 Genomic DNA. Translation: CAQ16179.1.
    FM200854 Genomic DNA. Translation: CAR31119.1.
    AH013029 Genomic DNA. Translation: AAP93137.1.
    EU770203 Genomic DNA. Translation: ACF16333.1.
    FM955320 Genomic DNA. Translation: CAW24712.1.
    FN552709 Genomic DNA. Translation: CBF35736.1.
    FN552710 Genomic DNA. Translation: CBF35739.1.
    X86327 Genomic DNA. No translation available.
    D78569 Genomic DNA. Translation: BAA11413.1.
    AF439338 Genomic DNA. Translation: AAL35222.1.
    AF384556 Genomic DNA. Translation: AAM53072.1.
    DQ026226 Genomic DNA. Translation: AAY89656.1.
    AY762968 Genomic DNA. Translation: AAV97949.1.
    AM181332 Genomic DNA. Translation: CAJ57391.1. Sequence problems.
    AM691798 Genomic DNA. Translation: CAM88661.1.
    AM259942 Genomic DNA. Translation: CAJ90956.1.
    U39090 Genomic DNA. Translation: AAB02681.1.
    AJ003005 Genomic DNA. No translation available.
    AJ012156 Genomic DNA. Translation: CAA09929.1.
    AJ290396 Genomic DNA. Translation: CAC27418.1.
    AF469118 Genomic DNA. Translation: AAL77085.1.
    AF479569 Genomic DNA. Translation: AAM09472.1.
    AJ535315 Genomic DNA. Translation: CAD59445.2.
    AF181983 Genomic DNA. Translation: AAD54423.2.
    AY733062 Genomic DNA. Translation: AAU33811.1.
    AJ854065 Genomic DNA. Translation: CAH69441.1.
    AJ964903 Genomic DNA. Translation: CAI79639.1.
    AB211231 Genomic DNA. Translation: BAD95610.1.
    DQ114427 Genomic DNA. Translation: AAZ20753.1.
    DQ227421 Genomic DNA. Translation: ABB05231.1.
    AM403489 Genomic DNA. Translation: CAL48285.1.
    AM490069 Genomic DNA. Translation: CAM32717.1.
    EF622510 Genomic DNA. Translation: ABR24117.1.
    EU410617 Genomic DNA. Translation: ABZ89500.1.
    GQ422610 Genomic DNA. Translation: ACV66342.1.
    FN550110 Genomic DNA. Translation: CBE66554.1.
    AF087939 Genomic DNA. Translation: AAD39697.1.
    AY094140 Genomic DNA. Translation: AAM14401.1.
    AJ001257 Genomic DNA. Translation: CAA04631.1.
    U39086 Genomic DNA. Translation: AAA93181.1.
    AJ965439 Genomic DNA. Translation: CAI84643.1.
    AF112463 Genomic DNA. Translation: AAD23990.1.
    AF112464 Genomic DNA. Translation: AAD23991.1.
    M94773 Genomic DNA. No translation available.
    M65042 Genomic DNA. Translation: AAA36241.1.
    M25025 mRNA. Translation: AAA59793.1.
    PIRiA02234. HLHU1C.
    A35055.
    A94003. HLHUDB.
    B32527.
    B37044.
    C24669. HLHU2C.
    F30575.
    I54480.
    I68732.
    I72482.
    S46648.
    RefSeqiNP_001230891.1. NM_001243962.1.
    NP_002114.3. NM_002123.4.
    UniGeneiHs.409934.
    Hs.534322.

    Genome annotation databases

    EnsembliENST00000399088; ENSP00000382038; ENSG00000231286.
    ENST00000413089; ENSP00000396539; ENSG00000231286.
    ENST00000416192; ENSP00000410107; ENSG00000233209.
    ENST00000419914; ENSP00000402865; ENSG00000225824.
    ENST00000422950; ENSP00000414079; ENSG00000233209.
    ENST00000424806; ENSP00000410330; ENSG00000225824.
    GeneIDi3119.
    KEGGihsa:3119.
    UCSCiuc011hzw.2. human.

    Polymorphism databases

    DMDMi290457643.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01499 Genomic DNA. Translation: AAA98746.1 .
    K02405 Genomic DNA. Translation: AAA75521.1 .
    X03068 mRNA. Translation: CAA26872.1 .
    M17564 mRNA. Translation: AAA59765.1 .
    M29613 Genomic DNA. No translation available.
    M29616 Genomic DNA. No translation available.
    M16996 mRNA. Translation: AAA59770.1 .
    M20432 mRNA. Translation: AAA59769.1 .
    M60028 mRNA. Translation: AAA59755.1 .
    X96420 mRNA. Translation: CAA65280.1 .
    U92032 Genomic DNA. Translation: AAB91991.1 .
    AY663393 Genomic DNA. Translation: AAU87973.1 .
    AY663394 Genomic DNA. Translation: AAU87977.1 .
    AY663397 Genomic DNA. Translation: AAU87986.1 .
    AY663409 Genomic DNA. Translation: AAU88017.1 .
    AY663404 Genomic DNA. Translation: AAU88002.1 .
    AY663410 Genomic DNA. Translation: AAU88020.1 .
    AY663412 Genomic DNA. Translation: AAU88027.1 .
    AY656681 mRNA. Translation: AAV71028.1 .
    AY656682 mRNA. Translation: AAV71029.1 .
    AY656683 mRNA. Translation: AAV71030.1 .
    BX927168 Genomic DNA. Translation: CAQ08747.1 .
    CR753846 Genomic DNA. Translation: CAQ09755.1 .
    CR933859 Genomic DNA. Translation: CAQ09239.1 .
    BC012106 mRNA. Translation: AAH12106.1 .
    M25327 mRNA. Translation: AAA59677.1 .
    U66400 mRNA. Translation: AAB51698.1 .
    U83582 mRNA. Translation: AAB41231.1 .
    AH002887 Genomic DNA. Translation: AAA59762.1 .
    M26042 mRNA. Translation: AAA36270.1 .
    M33907 mRNA. Translation: AAA52672.1 .
    L34096 mRNA. Translation: AAC41964.1 .
    L34098 mRNA. Translation: AAC41966.1 .
    L34101 mRNA. Translation: AAC41969.1 .
    L34103 mRNA. Translation: AAC41971.1 .
    L34104 mRNA. Translation: AAC41972.1 .
    L34105 mRNA. Translation: AAC41973.1 .
    L34106 mRNA. Translation: AAC41974.1 .
    L34107 mRNA. Translation: AAC41975.1 .
    AF195245 mRNA. Translation: AAF28315.1 .
    L42626 mRNA. Translation: AAA85335.1 .
    X76553 mRNA. No translation available.
    X76554 mRNA. No translation available.
    M59800 mRNA. Translation: AAA64235.1 .
    M14189 mRNA. Translation: AAA36268.1 .
    AY672649 Genomic DNA. Translation: AAT77952.1 .
    M17207 mRNA. Translation: AAA59697.1 .
    Z49215 Genomic DNA. No translation available.
    AY026349 Genomic DNA. Translation: AAK01944.1 .
    AF091305 Genomic DNA. Translation: AAC64403.2 . Sequence problems.
    U77344 Genomic DNA. Translation: AAB19215.1 .
    FN256435 Genomic DNA. Translation: CAX62164.1 .
    FN256435 Genomic DNA. Translation: CAX62165.1 .
    AM400970 Genomic DNA. Translation: CAL47037.1 .
    AM421131 Genomic DNA. Translation: CAM07104.1 .
    EF484936 Genomic DNA. Translation: ABO87661.1 .
    EF484939 Genomic DNA. Translation: ABO87664.1 .
    EU275158 Genomic DNA. Translation: ABY26531.1 .
    AM944346 Genomic DNA. Translation: CAQ16179.1 .
    FM200854 Genomic DNA. Translation: CAR31119.1 .
    AH013029 Genomic DNA. Translation: AAP93137.1 .
    EU770203 Genomic DNA. Translation: ACF16333.1 .
    FM955320 Genomic DNA. Translation: CAW24712.1 .
    FN552709 Genomic DNA. Translation: CBF35736.1 .
    FN552710 Genomic DNA. Translation: CBF35739.1 .
    X86327 Genomic DNA. No translation available.
    D78569 Genomic DNA. Translation: BAA11413.1 .
    AF439338 Genomic DNA. Translation: AAL35222.1 .
    AF384556 Genomic DNA. Translation: AAM53072.1 .
    DQ026226 Genomic DNA. Translation: AAY89656.1 .
    AY762968 Genomic DNA. Translation: AAV97949.1 .
    AM181332 Genomic DNA. Translation: CAJ57391.1 . Sequence problems.
    AM691798 Genomic DNA. Translation: CAM88661.1 .
    AM259942 Genomic DNA. Translation: CAJ90956.1 .
    U39090 Genomic DNA. Translation: AAB02681.1 .
    AJ003005 Genomic DNA. No translation available.
    AJ012156 Genomic DNA. Translation: CAA09929.1 .
    AJ290396 Genomic DNA. Translation: CAC27418.1 .
    AF469118 Genomic DNA. Translation: AAL77085.1 .
    AF479569 Genomic DNA. Translation: AAM09472.1 .
    AJ535315 Genomic DNA. Translation: CAD59445.2 .
    AF181983 Genomic DNA. Translation: AAD54423.2 .
    AY733062 Genomic DNA. Translation: AAU33811.1 .
    AJ854065 Genomic DNA. Translation: CAH69441.1 .
    AJ964903 Genomic DNA. Translation: CAI79639.1 .
    AB211231 Genomic DNA. Translation: BAD95610.1 .
    DQ114427 Genomic DNA. Translation: AAZ20753.1 .
    DQ227421 Genomic DNA. Translation: ABB05231.1 .
    AM403489 Genomic DNA. Translation: CAL48285.1 .
    AM490069 Genomic DNA. Translation: CAM32717.1 .
    EF622510 Genomic DNA. Translation: ABR24117.1 .
    EU410617 Genomic DNA. Translation: ABZ89500.1 .
    GQ422610 Genomic DNA. Translation: ACV66342.1 .
    FN550110 Genomic DNA. Translation: CBE66554.1 .
    AF087939 Genomic DNA. Translation: AAD39697.1 .
    AY094140 Genomic DNA. Translation: AAM14401.1 .
    AJ001257 Genomic DNA. Translation: CAA04631.1 .
    U39086 Genomic DNA. Translation: AAA93181.1 .
    AJ965439 Genomic DNA. Translation: CAI84643.1 .
    AF112463 Genomic DNA. Translation: AAD23990.1 .
    AF112464 Genomic DNA. Translation: AAD23991.1 .
    M94773 Genomic DNA. No translation available.
    M65042 Genomic DNA. Translation: AAA36241.1 .
    M25025 mRNA. Translation: AAA59793.1 .
    PIRi A02234. HLHU1C.
    A35055.
    A94003. HLHUDB.
    B32527.
    B37044.
    C24669. HLHU2C.
    F30575.
    I54480.
    I68732.
    I72482.
    S46648.
    RefSeqi NP_001230891.1. NM_001243962.1.
    NP_002114.3. NM_002123.4.
    UniGenei Hs.409934.
    Hs.534322.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JK8 X-ray 2.40 B 35-224 [» ]
    1NBN model - B 35-224 [» ]
    1S9V X-ray 2.22 B/E 33-230 [» ]
    1UVQ X-ray 1.80 B 35-230 [» ]
    2NNA X-ray 2.10 B 33-224 [» ]
    4GG6 X-ray 3.20 B/D 33-224 [» ]
    4OZF X-ray 2.70 B 33-224 [» ]
    4OZG X-ray 3.00 B/D 33-224 [» ]
    4OZH X-ray 2.80 B/D 33-224 [» ]
    4OZI X-ray 3.20 B/D 33-224 [» ]
    ProteinModelPortali P01920.
    SMRi P01920. Positions 35-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109364. 1 interaction.
    IntActi P01920. 1 interaction.
    MINTi MINT-199658.
    STRINGi 9606.ENSP00000382034.

    Chemistry

    DrugBanki DB00047. Insulin Glargine recombinant.
    DB00046. Insulin Lyspro recombinant.
    DB00030. Insulin recombinant.
    DB00071. Insulin, porcine.

    PTM databases

    PhosphoSitei P01920.

    Polymorphism databases

    DMDMi 290457643.

    Proteomic databases

    MaxQBi P01920.
    PaxDbi P01920.
    PRIDEi P01920.

    Protocols and materials databases

    DNASUi 3119.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399088 ; ENSP00000382038 ; ENSG00000231286 .
    ENST00000413089 ; ENSP00000396539 ; ENSG00000231286 .
    ENST00000416192 ; ENSP00000410107 ; ENSG00000233209 .
    ENST00000419914 ; ENSP00000402865 ; ENSG00000225824 .
    ENST00000422950 ; ENSP00000414079 ; ENSG00000233209 .
    ENST00000424806 ; ENSP00000410330 ; ENSG00000225824 .
    GeneIDi 3119.
    KEGGi hsa:3119.
    UCSCi uc011hzw.2. human.

    Organism-specific databases

    CTDi 3119.
    GeneCardsi GC06M032629.
    GC06Mk32602.
    GC06Ml32782.
    GC06Mm32658.
    GeneReviewsi HLA-DQB1.
    HGNCi HGNC:4944. HLA-DQB1.
    HPAi HPA013667.
    MIMi 604305. gene.
    neXtProti NX_P01920.
    Orphaneti 703. Bullous pemphigoid.
    555. Celiac disease.
    243377. Diabetes mellitus type 1.
    802. Multiple sclerosis.
    83465. Narcolepsy without cataplexy.
    2073. Narcolepsy-cataplexy.
    PharmGKBi PA35068.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68200.
    HOVERGENi HBG012730.
    InParanoidi P01920.
    KOi K06752.
    PhylomeDBi P01920.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    ChiTaRSi HLA-DQB1. human.
    EvolutionaryTracei P01920.
    GeneWikii HLA-DQB1.
    GenomeRNAii 3119.
    NextBioi 20783717.
    PROi P01920.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_HLA-DQB1.
    Genevestigatori P01920.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01).
    2. "Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens."
      Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L., Rask L., Peterson P.A.
      Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01).
    3. "Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene."
      Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G., Rask L., Peterson P.A.
      Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
    4. "Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta."
      Boss J.M., Strominger J.L.
      Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
    5. "DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression."
      Tonnelle C., Demars R., Long E.O.
      EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
    6. "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers."
      Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.
      Immunogenetics 26:282-290(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
    7. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
      Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
      J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
    8. "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line."
      Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S., Tieber V.L., Kittlesen D.J., Schwartz B.D.
      J. Immunol. 139:228-233(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-15; SER-28; GLY-45; LEU-58; GLY-77; GLY-102 AND ARG-199.
    9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02).
    10. "Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins that differ only at amino acid 57."
      Giorda R., Turco E., Trucco M.
      Immunogenetics 33:404-408(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03).
    11. "Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-PCR."
      Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.
      Tissue Antigens 48:589-592(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12).
    12. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
    13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03).
    14. Kim E., Lee E., Kwack K.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND DQB1*05:02).
    15. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02; DQB1*03:01 AND DQB1*03:03).
    16. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02).
      Tissue: B-cell.
    17. "Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes."
      Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.
      Immunogenetics 29:186-190(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02).
    18. "Nucleotide Deletions in a DQB1*0301 variant."
      White J.M., Baxter-Lowe L.A.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09).
    19. "No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2."
      Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J., Ando A., Tsuji K., Inoko H.
      Hum. Immunol. 24:175-181(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02).
    20. "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity."
      Jonsson A.-K., Andersson L., Rask L.
      Immunogenetics 30:232-234(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02).
    21. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
      Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
      Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01; DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01).
    22. "Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310."
      Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L.
      Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10).
    23. Yasunaga S.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09).
    24. "HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping."
      Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D., Cao A., De Virgiliis S., Congia M.
      Hum. Immunol. 40:143-149(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND DQB1*03:05).
    25. "Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."
      Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E., Koelbel S., Egert G., Wernet P., Hilschmann N.
      Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02).
    26. "Two divergent routes of evolution gave rise to the DRw13 haplotypes."
      Lee K.W., Johnson A.H., Hurley C.K.
      J. Immunol. 145:3119-3125(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05).
    27. "Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype."
      Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J., Alber C., Silver J.
      J. Immunol. 137:2886-2890(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01).
    28. "Identification of a novel allele HLA-DQB1*0622."
      Chang Y., Fan T.X., Santana Z., Day N.K.
      Tissue Antigens 70:442-444(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22).
    29. "Structural and functional variability among DQ beta alleles of DR2 subtypes."
      Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.
      Immunogenetics 26:85-91(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02).
    30. "A novel allele, DQB1*0307, in a West African family."
      Thye T., Muntau B., Stelma F.F., Horstmann R.D.
      Tissue Antigens 49:517-518(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07).
    31. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18).
    32. "A new DQB1*0602 variant found in Australian Caucasian."
      Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19).
    33. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13).
    34. "New HLA-DQB1*06 allele found in a voluntary blood stem cell donor."
      Skrablin P.S., Richter R., Seidl C., Seifried E.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36).
      Tissue: Peripheral blood.
    35. "HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102."
      Witter K., Mautner J., Albert T., Zahn R., Kauke T.
      Tissue Antigens 70:73-75(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19).
    36. "HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation."
      Witter K., Albert T., Zahn R., Kauke T.
      Tissue Antigens 71:486-488(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34).
    37. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND DQB1*03:20).
    38. "Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322."
      Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.
      Tissue Antigens 73:283-285(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22).
      Tissue: Peripheral blood.
    39. "DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele."
      Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.
      Tissue Antigens 73:624-625(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23).
      Tissue: Peripheral blood.
    40. "Identification of a novel HLA-DQB1*02 allele."
      Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04).
    41. "Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel allele, exons 2 and 3."
      Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25).
    42. "A new HLA-DQB allele, identified by routine sequencing."
      Michaud C., Giannoli C., Favre Victoire I., Dubois V.
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24).
    43. "New alleles found during routine SBT HLA typing."
      Anholts J.D.H.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND DQB1*06:39).
      Tissue: Blood.
    44. "Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57-codon."
      Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G., Rossau R.
      Tissue Antigens 48:217-220(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10).
    45. "A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences."
      Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M., Oguchi H., Ishii E., Fukushima H.
      Tissue Antigens 48:580-585(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06).
      Tissue: Blood.
    46. "Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620."
      Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M., Dunckley H.
      Tissue Antigens 64:515-517(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20).
    47. "A novel DQB1*03 allele revealed by rSSOP and identified by SBT."
      Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.
      Hum. Immunol. 66:30-30(2005)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16).
    48. "Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population."
      Gu H., Kimm K., Lee J.K., Oh B.
      Tissue Antigens 65:503-504(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14).
    49. "A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302."
      Witter K., Albert T., Zahn R., Kauke T.
      Tissue Antigens 69:102-103(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28).
    50. "Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632."
      Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.
      Tissue Antigens 71:94-95(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32).
      Tissue: Blood.
    51. "Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505."
      Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.
      Tissue Antigens 73:622-623(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05).
    52. "A novel DQB1*02 allele."
      Olerup O.H.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03).
    53. "Detection of a new DQB1 allele."
      Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K., Van Reybroeck G., Mersch G.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
    54. "Two novel DQB1*06 alleles, identified by reverse line blot assay."
      Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15).
    55. "A new variant form of the HLA DQB1*0305 allele."
      Moine A.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
      Tissue: Peripheral blood.
    56. "Homo sapiens HLA-DQB1*0312 allele, exon 2."
      Schwarz K., Zenz C.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12).
    57. "Novel human HLA-DQB1 allele identified in potential bone marrow donors."
      Wu J., Bassinger S., Williams T.M.
      Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13).
    58. "Identification of a new HLA-DQB1*06 allele by INNO-LiPA."
      De Canck I.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21).
    59. "Novel DQB1*06 alleles."
      Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17).
    60. "Characterization of a new HLA-DQB1 allele by direct sequencing."
      Hirv K., Krauss A., Mytilineos J.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23).
    61. "Novel HLA-DQB1*03 allele."
      Velickovic Z.M.
      Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15).
      Tissue: Peripheral blood.
    62. "A new HLA-DQB1 allele."
      Schranz P., Seelig R., Seelig H.P.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24).
    63. "Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele: HLA-DQB1*060401V."
      Watabe K., Hashimoto M.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25).
    64. "A novel DQB1 allele found in Taiwan."
      Chu C.-C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17).
    65. "High resolution genotyping of HLA-DQB1 exon 2 and 3."
      Hendrix M.M., Cordovado S.K., Mueller P.W.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18).
    66. "A novel HLA-DRQ1*06 allele."
      Horn P.A., Blasczyk R.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29).
    67. "Identification of several new class I and II alleles in routine HLA-testing."
      Nieberle I., Hirschmann D., Woelpl A.
      Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31).
    68. "A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP donor."
      Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E., Jennings L.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33).
    69. "Characterization of a new HLA-Cw*07 allele."
      Vigh A., Hirv K., Mytilineos J.
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03).
    70. "A new variant of HLA-DQB1*06."
      Fuerst D., Mytilineos J.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37).
    71. "Novel DQB1*03 found in CAP test sample."
      Yang K., Chen M.
      Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26).
    72. "Identification of a novel DQB1 allele DBQ1*0616."
      Luo M., Blanchard J., Maclean I., Brunham R.
      Tissue Antigens 53:381-382(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16).
    73. "Novel HLA-DQB1 allele."
      Rizzo M., Hurley C.K.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30).
    74. "A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."
      Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.
      Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14).
      Tissue: Blood.
    75. "Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing."
      Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D., Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.
      Tissue Antigens 48:143-147(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11).
    76. "HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin."
      Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E., Martin H., Seidl C.
      Tissue Antigens 67:160-162(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27).
    77. Dinauer D.M., Hessner M.J.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND DQB1*06:08).
    78. "Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-DQw1."
      Fenske T.S., Baxter-Lowe L.A.
      Tissue Antigens 40:49-52(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04).
    79. "Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex."
      Gyllensten U.B., Lashkari D., Erlich H.A.
      Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01).
    80. "Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA."
      Bugawan T.L., Erlich H.A.
      Immunogenetics 33:163-170(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND DQB1*06:02).
    81. "Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C antigen subunits and immunoglobulin chains."
      Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K., Peterson P.A., Rask L.
      Scand. J. Immunol. 14:617-622(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01).
    82. "CSF hypocretin-1 assessment in sleep and neurological disorders."
      Bourgin P., Zeitzer J.M., Mignot E.
      Lancet Neurol. 7:649-662(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    83. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    84. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    85. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    86. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    87. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    88. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    89. "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes."
      Lee K.H., Wucherpfennig K.W., Wiley D.C.
      Nat. Immunol. 2:501-507(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, DISULFIDE BONDS.
    90. "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."
      Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A., Bell J.I., Strominger J.L., Jones E.Y., Fugger L.
      Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
    91. "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease."
      Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.
      Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1 HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, SUBUNIT, POLYMORPHISM.
    92. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
    93. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDQB1_HUMAN
    AccessioniPrimary (citable) accession number: P01920
    Secondary accession number(s): A1KR27
    , A2RPH3, A4Q9R4, A4USG2, A4USG5, A6N8I7, A9YQA0, B0S7Y7, B1A0K6, B1GXI3, B3VLT3, B5BLN7, B7VU69, C0MQ34, C0MQ35, C8ZL52, C8ZLJ8, C8ZLJ9, C9DRQ3, O19708, O19713, O19724, O62861, O78046, O78221, O78223, O98034, O98201, P01917, P01918, P01919, P03992, P05537, P79482, P79526, P79544, P79551, Q08GC8, Q09035, Q0E4V9, Q1M312, Q29731, Q29877, Q29884, Q29915, Q29966, Q2P9N3, Q2QK85, Q30061, Q30075, Q30076, Q30080, Q30081, Q30082, Q30083, Q30084, Q30089, Q30095, Q31633, Q38I47, Q45UE3, Q4QZB5, Q53I44, Q564J6, Q5G841, Q5ISH1, Q5ISH3, Q5W1E1, Q5Y7G8, Q643R4, Q6B9X1, Q70VH8, Q7YP69, Q8HWH0, Q8MH58, Q8SNB4, Q8SND1, Q8SP70, Q8WMA3, Q9BD17, Q9MYH2, Q9TPA9, Q9XRY6, Q9XRY7, Q9XRZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: March 2, 2010
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3