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P01920 (DQB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class II histocompatibility antigen, DQ beta 1 chain
Alternative name(s):
MHC class II antigen DQB1
Gene names
Name:HLA-DQB1
Synonyms:HLA-DQB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Subunit structure

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Ref.89 Ref.90 Ref.91 Ref.92

Subcellular location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Polymorphism

The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.

DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).

DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence AAC64403.2 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAJ57391.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processImmunity
   Cellular componentCell membrane
Endoplasmic reticulum
Endosome
Golgi apparatus
Lysosome
Membrane
MHC II
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processT cell costimulation

Traceable author statement. Source: Reactome

T cell receptor signaling pathway

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class II

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

humoral immune response mediated by circulating immunoglobulin

Inferred from direct assay PubMed 17050030. Source: UniProtKB

immune response

Non-traceable author statement Ref.5. Source: UniProtKB

immunoglobulin production involved in immunoglobulin mediated immune response

Inferred from direct assay PubMed 17050030. Source: UniProtKB

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

clathrin-coated endocytic vesicle membrane

Traceable author statement. Source: Reactome

endocytic vesicle membrane

Traceable author statement. Source: Reactome

endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

lysosomal membrane

Traceable author statement. Source: Reactome

membrane

Non-traceable author statement Ref.5. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

trans-Golgi network membrane

Traceable author statement. Source: Reactome

transport vesicle membrane

Traceable author statement. Source: Reactome

   Molecular_functionMHC class II receptor activity

Non-traceable author statement Ref.5. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3232 Ref.25
Chain33 – 261229HLA class II histocompatibility antigen, DQ beta 1 chain
PRO_0000018989

Regions

Topological domain33 – 230198Extracellular Potential
Transmembrane231 – 25121Helical; Potential
Topological domain252 – 26110Cytoplasmic Potential
Domain129 – 21789Ig-like C1-type
Region33 – 12694Beta-1
Region127 – 22094Beta-2
Region221 – 23010Connecting peptide

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 111 Ref.89 Ref.90 Ref.92
Disulfide bond149 ↔ 205 Ref.89 Ref.90 Ref.92

Natural variations

Natural variant61A → S in allele DQB1*05:01 and allele DQB1*05:02.
Corresponds to variant rs1049056 [ dbSNP | Ensembl ].
VAR_056570
Natural variant121G → D in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049057 [ dbSNP | Ensembl ].
VAR_062679
Natural variant151A → V in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Ref.8
Corresponds to variant rs3189152 [ dbSNP | Ensembl ].
VAR_062680
Natural variant231A → S in allele DQB1*02:01 and allele DQB1*02:02.
Corresponds to variant rs3891176 [ dbSNP | Ensembl ].
VAR_062681
Natural variant241M → I in allele DQB1*05:01 and allele DQB1*05:02.
Corresponds to variant rs1049059 [ dbSNP | Ensembl ].
VAR_062682
Natural variant271T → A in allele DQB1*04:01.
VAR_062683
Natural variant271T → S in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049060 [ dbSNP | Ensembl ].
VAR_062684
Natural variant281P → L in allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049062 [ dbSNP | Ensembl ].
VAR_062685
Natural variant281P → S in allele DQB1*05:01 and allele DQB1*05:02. Ref.8
VAR_062686
Natural variant291V → L in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1130366 [ dbSNP | Ensembl ].
VAR_062687
Natural variant351S → P in allele DQB1*06:01.
VAR_062688
Natural variant411Y → F in allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37.
Corresponds to variant rs9274407 [ dbSNP | Ensembl ].
VAR_062689
Natural variant411Y → L in allele DQB1*06:01 and allele DQB1*06:35; requires 2 nucleotide substitutions.
VAR_062690
Natural variant431F → L in allele DQB1*06:33.
Corresponds to variant rs56173496 [ dbSNP | Ensembl ].
VAR_062691
Natural variant451A → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Ref.8
Corresponds to variant rs1130375 [ dbSNP | Ensembl ].
VAR_061472
Natural variant461M → L in allele DQB1*03:11, allele DQB1*03:26, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, allele DQB1*06:20 and allele DQB1*06:31.
Corresponds to variant rs1130368 [ dbSNP | Ensembl ].
VAR_061473
Natural variant551R → L in allele DQB1*04:01.
Corresponds to variant rs41540813 [ dbSNP | Ensembl ].
VAR_062692
Natural variant581Y → G in allele DQB1*03:05, allele DQB1*03:17, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:23; requires 2 nucleotide substitutions.
VAR_062693
Natural variant581Y → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. Ref.8
VAR_062694
Natural variant591V → L in allele DQB1*03:18.
Corresponds to variant rs41563539 [ dbSNP | Ensembl ].
VAR_062695
Natural variant601T → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274405 [ dbSNP | Ensembl ].
VAR_062696
Natural variant621Y → H in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062697
Natural variant621Y → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062698
Natural variant691Y → D in allele DQB1*06:01 and allele DQB1*06:35.
Corresponds to variant rs1130370 [ dbSNP | Ensembl ].
VAR_062699
Natural variant691Y → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; requires 2 nucleotide substitutions.
VAR_062700
Natural variant701A → T in allele DQB1*03:20.
Corresponds to variant rs45519640 [ dbSNP | Ensembl ].
VAR_062701
Natural variant701A → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and allele DQB1*06:35.
Corresponds to variant rs1063318 [ dbSNP | Ensembl ].
VAR_062702
Natural variant771E → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Ref.8
Corresponds to variant rs1049083 [ dbSNP | Ensembl ].
VAR_062703
Natural variant781V → E in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274398 [ dbSNP | Ensembl ].
VAR_062704
Natural variant791Y → F in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274397 [ dbSNP | Ensembl ].
VAR_062705
Natural variant811A → V in allele DQB1*03:07.
Corresponds to variant rs41558214 [ dbSNP | Ensembl ].
VAR_062706
Natural variant841P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274395 [ dbSNP | Ensembl ].
VAR_062707
Natural variant851L → Q in allele DQB1*03:23, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140313 [ dbSNP | Ensembl ].
VAR_062708
Natural variant871P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062709
Natural variant871P → Q in allele DQB1*03:16.
VAR_062710
Natural variant871P → R in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1130380 [ dbSNP | Ensembl ].
VAR_062711
Natural variant881P → L in allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02 and allele DQB1*04:03.
Corresponds to variant rs1130381 [ dbSNP | Ensembl ].
VAR_062712
Natural variant891D → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, allele DQB1*03:18 and allele DQB1*06:29.
Corresponds to variant rs1071637 [ dbSNP | Ensembl ].
VAR_062713
Natural variant891D → S in allele DQB1*05:02, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; requires 2 nucleotide substitutions.
VAR_062714
Natural variant891D → V in allele DQB1*05:01, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062715
Natural variant921Y → N in allele DQB1*06:16.
VAR_062716
Natural variant941N → K in allele DQB1*06:37.
VAR_062717
Natural variant951S → R in allele DQB1*03:15.
VAR_062718
Natural variant981E → D in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
Corresponds to variant rs9274390 [ dbSNP | Ensembl ].
VAR_062719
Natural variant991V → D in allele DQB1*03:13.
VAR_062720
Natural variant991V → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
VAR_062721
Natural variant1021R → E in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
VAR_062722
Natural variant1021R → G in allele DQB1*03:08, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31 and allele DQB1*06:33. Ref.8
Corresponds to variant rs1130386 [ dbSNP | Ensembl ].
VAR_062723
Natural variant1031T → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, allele DQB1*06:24 and allele DQB1*06:30.
VAR_062724
Natural variant1031T → D in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
VAR_062725
Natural variant1031T → K in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062726
Natural variant1061E → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and allele DQB1*06:06.
Corresponds to variant rs1130387 [ dbSNP | Ensembl ].
VAR_062727
Natural variant1061E → S in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04 and allele DQB1*05:05; requires 2 nucleotide substitutions.
VAR_062728
Natural variant1071L → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
Corresponds to variant rs9274384 [ dbSNP | Ensembl ].
VAR_062729
Natural variant1091T → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
Corresponds to variant rs1130392 [ dbSNP | Ensembl ].
VAR_062730
Natural variant1161Q → E in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39.
Corresponds to variant rs1140316 [ dbSNP | Ensembl ].
VAR_062731
Natural variant1171L → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140317 [ dbSNP | Ensembl ].
VAR_062732
Natural variant1181E → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
VAR_062733
Natural variant1181E → G in allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062734
Natural variant1191L → F in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
Corresponds to variant rs9274379 [ dbSNP | Ensembl ].
VAR_062735
Natural variant1191L → Y in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
VAR_062736
Natural variant1211T → G in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
VAR_062737
Natural variant1221T → I in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140320 [ dbSNP | Ensembl ].
VAR_062738
Natural variant1481V → I in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
Corresponds to variant rs1049100 [ dbSNP | Ensembl ].
VAR_056571
Natural variant1571A → G in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062739
Natural variant1571A → S in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
VAR_062740
Natural variant1581Q → H in allele DQB1*05:02.
VAR_062741
Natural variant1621R → Q in allele DQB1*03:22, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36 and allele DQB1*06:38.
VAR_062742
Natural variant1651R → Q in allele DQB1*06:38.
VAR_062744
Natural variant1651R → W in allele DQB1*03:21.
VAR_062743
Natural variant1671D → G in allele DQB1*02:02.
VAR_062745
Natural variant1681Q → E in allele DQB1*02:04.
VAR_062746
Natural variant1721T → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Ref.93
Corresponds to variant rs1063323 [ dbSNP | Ensembl ].
VAR_062747
Natural variant1941E → D.
Corresponds to variant rs9273952 [ dbSNP | Ensembl ].
VAR_056572
Natural variant1971P → L.
Corresponds to variant rs9273948 [ dbSNP | Ensembl ].
VAR_059522
Natural variant1991H → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Ref.8
VAR_062748
Natural variant200 – 2012GD → A in allele DQB1*03:09.
VAR_062749
Natural variant2021V → I in allele DQB1*03:24.
VAR_062750
Natural variant2141N → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062751
Natural variant2171T → I in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, allele DQB1*04:01 and allele DQB1*04:02.
VAR_062752
Natural variant2181V → A in allele DQB1*06:36.
VAR_062753
Natural variant2291S → N in allele DQB1*06:01.
VAR_062754
Natural variant2351I → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
VAR_062755
Natural variant2521H → R in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
Corresponds to variant rs1140342 [ dbSNP | Ensembl ].
VAR_062756
Natural variant2531H → Q in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
VAR_062757
Natural variant2561Q → R in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
Corresponds to variant rs1130432 [ dbSNP | Ensembl ].
VAR_061474

Experimental info

Sequence conflict1111C → S in AAD39697. Ref.71
Sequence conflict1131H → Q in AAF28315. Ref.22
Sequence conflict1731G → A in X76553. Ref.24
Sequence conflict1731G → A in X76554. Ref.24
Sequence conflict2141N → T in AAA59770. Ref.8

Secondary structure

...................................... 261
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01920 [UniParc].

Last modified March 2, 2010. Version 2.
Checksum: 79B1E571A628CF96

FASTA26129,991
        10         20         30         40         50         60 
MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT 

        70         80         90        100        110        120 
RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR 

       130        140        150        160        170        180 
TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI 

       190        200        210        220        230        240 
RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL 

       250        260 
GLIFLGLGLI IHHRSQKGLL H 

« Hide

References

« Hide 'large scale' references
[1]"Molecular analysis of human class II transplantation antigens and their genes."
Larhammar D., Andersson G., Andersson M., Bill P., Boehme J., Claesson L., Denaro M., Emmoth E., Gustafsson K., Hammarling U., Heldin E., Hyldig-Nielsen J.-J., Lind P., Schenning L., Servenius B., Widmark E., Rask L., Peterson P.A.
Hum. Immunol. 8:95-103(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01).
[2]"Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens."
Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L., Rask L., Peterson P.A.
Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01).
[3]"Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene."
Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G., Rask L., Peterson P.A.
Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
[4]"Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta."
Boss J.M., Strominger J.L.
Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
[5]"DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression."
Tonnelle C., Demars R., Long E.O.
EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
[6]"Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers."
Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.
Immunogenetics 26:282-290(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
[7]"Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
[8]"Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line."
Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S., Tieber V.L., Kittlesen D.J., Schwartz B.D.
J. Immunol. 139:228-233(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-15; SER-28; GLY-45; LEU-58; GLY-77; GLY-102 AND ARG-199.
[9]"MHC class II sequences of an HLA-DR2 narcoleptic."
Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J.
Immunogenetics 27:449-455(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02).
[10]"Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins that differ only at amino acid 57."
Giorda R., Turco E., Trucco M.
Immunogenetics 33:404-408(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03).
[11]"Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-PCR."
Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.
Tissue Antigens 48:589-592(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12).
[12]"HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy."
Ellis M.C., Hetisimer A.H., Ruddy D.A., Hansen S.L., Kronmal G.S., McClelland E., Quintana L., Drayna D.T., Aldrich M.S., Mignot E.
Immunogenetics 46:410-417(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
[13]"Ancient haplotypes of the HLA Class II region."
Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.
Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03).
[14]Kim E., Lee E., Kwack K.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND DQB1*05:02).
[15]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02; DQB1*03:01 AND DQB1*03:03).
[16]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02).
Tissue: B-cell.
[17]"Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes."
Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.
Immunogenetics 29:186-190(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02).
[18]"Nucleotide Deletions in a DQB1*0301 variant."
White J.M., Baxter-Lowe L.A.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09).
[19]"No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2."
Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J., Ando A., Tsuji K., Inoko H.
Hum. Immunol. 24:175-181(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02).
[20]"Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity."
Jonsson A.-K., Andersson L., Rask L.
Immunogenetics 30:232-234(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02).
[21]"Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01; DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01).
[22]"Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310."
Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L.
Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10).
[23]Yasunaga S.
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09).
[24]"HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping."
Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D., Cao A., De Virgiliis S., Congia M.
Hum. Immunol. 40:143-149(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND DQB1*03:05).
[25]"Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."
Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E., Koelbel S., Egert G., Wernet P., Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02).
[26]"Two divergent routes of evolution gave rise to the DRw13 haplotypes."
Lee K.W., Johnson A.H., Hurley C.K.
J. Immunol. 145:3119-3125(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05).
[27]"Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype."
Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J., Alber C., Silver J.
J. Immunol. 137:2886-2890(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01).
[28]"Identification of a novel allele HLA-DQB1*0622."
Chang Y., Fan T.X., Santana Z., Day N.K.
Tissue Antigens 70:442-444(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22).
[29]"Structural and functional variability among DQ beta alleles of DR2 subtypes."
Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.
Immunogenetics 26:85-91(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02).
[30]"A novel allele, DQB1*0307, in a West African family."
Thye T., Muntau B., Stelma F.F., Horstmann R.D.
Tissue Antigens 49:517-518(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07).
[31]"Identification of a novel HLA-DQB1*06 allele, DQB1*0618."
Casamitjana N., Gil J., Campos E., Santos M., Nogues N., Ribera A., Palou E.
Tissue Antigens 58:269-271(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18).
[32]"A new DQB1*0602 variant found in Australian Caucasian."
Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19).
[33]"Identification of a new DQB1*0613 allele in a family."
Hsu S.H., Robbins F.M., Modelo R.B., Brunner J., Flomenberg N.
Tissue Antigens 50:685-687(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13).
[34]"New HLA-DQB1*06 allele found in a voluntary blood stem cell donor."
Skrablin P.S., Richter R., Seidl C., Seifried E.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36).
Tissue: Peripheral blood.
[35]"HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102."
Witter K., Mautner J., Albert T., Zahn R., Kauke T.
Tissue Antigens 70:73-75(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19).
[36]"HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation."
Witter K., Albert T., Zahn R., Kauke T.
Tissue Antigens 71:486-488(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34).
[37]"Novel alleles at the HLA-DRB1 and -DQB1 loci."
Lazaro A.M., Xiao Y., Masaberg C., Lebeck L., Ng J., Hurley C.K., Posch P.E.
Tissue Antigens 72:72-74(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND DQB1*03:20).
[38]"Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322."
Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.
Tissue Antigens 73:283-285(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22).
Tissue: Peripheral blood.
[39]"DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele."
Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.
Tissue Antigens 73:624-625(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23).
Tissue: Peripheral blood.
[40]"Identification of a novel HLA-DQB1*02 allele."
Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04).
[41]"Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel allele, exons 2 and 3."
Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.
Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25).
[42]"A new HLA-DQB allele, identified by routine sequencing."
Michaud C., Giannoli C., Favre Victoire I., Dubois V.
Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24).
[43]"New alleles found during routine SBT HLA typing."
Anholts J.D.H.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND DQB1*06:39).
Tissue: Blood.
[44]"Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57-codon."
Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G., Rossau R.
Tissue Antigens 48:217-220(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10).
[45]"A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences."
Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M., Oguchi H., Ishii E., Fukushima H.
Tissue Antigens 48:580-585(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06).
Tissue: Blood.
[46]"Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620."
Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M., Dunckley H.
Tissue Antigens 64:515-517(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20).
[47]"A novel DQB1*03 allele revealed by rSSOP and identified by SBT."
Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.
Hum. Immunol. 66:30-30(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16).
[48]"Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population."
Gu H., Kimm K., Lee J.K., Oh B.
Tissue Antigens 65:503-504(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14).
[49]"A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302."
Witter K., Albert T., Zahn R., Kauke T.
Tissue Antigens 69:102-103(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28).
[50]"Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632."
Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.
Tissue Antigens 71:94-95(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32).
Tissue: Blood.
[51]"Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505."
Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.
Tissue Antigens 73:622-623(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05).
[52]"A novel DQB1*02 allele."
Olerup O.H.
Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03).
[53]"Detection of a new DQB1 allele."
Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K., Van Reybroeck G., Mersch G.
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
[54]"Two novel DQB1*06 alleles, identified by reverse line blot assay."
Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15).
[55]"A new variant form of the HLA DQB1*0305 allele."
Moine A.
Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
Tissue: Peripheral blood.
[56]"Homo sapiens HLA-DQB1*0312 allele, exon 2."
Schwarz K., Zenz C.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12).
[57]"Novel human HLA-DQB1 allele identified in potential bone marrow donors."
Wu J., Bassinger S., Williams T.M.
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13).
[58]"Identification of a new HLA-DQB1*06 allele by INNO-LiPA."
De Canck I.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21).
[59]"Novel DQB1*06 alleles."
Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17).
[60]"Characterization of a new HLA-DQB1 allele by direct sequencing."
Hirv K., Krauss A., Mytilineos J.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23).
[61]"Novel HLA-DQB1*03 allele."
Velickovic Z.M.
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15).
Tissue: Peripheral blood.
[62]"A new HLA-DQB1 allele."
Schranz P., Seelig R., Seelig H.P.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24).
[63]"Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele: HLA-DQB1*060401V."
Watabe K., Hashimoto M.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25).
[64]"A novel DQB1 allele found in Taiwan."
Chu C.-C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17).
[65]"High resolution genotyping of HLA-DQB1 exon 2 and 3."
Hendrix M.M., Cordovado S.K., Mueller P.W.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18).
[66]"A novel HLA-DRQ1*06 allele."
Horn P.A., Blasczyk R.
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29).
[67]"Identification of several new class I and II alleles in routine HLA-testing."
Nieberle I., Hirschmann D., Woelpl A.
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31).
[68]"A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP donor."
Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E., Jennings L.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33).
[69]"Characterization of a new HLA-Cw*07 allele."
Vigh A., Hirv K., Mytilineos J.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03).
[70]"A new variant of HLA-DQB1*06."
Fuerst D., Mytilineos J.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37).
[71]"Novel DQB1*03 found in CAP test sample."
Yang K., Chen M.
Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26).
[72]"Identification of a novel DQB1 allele DBQ1*0616."
Luo M., Blanchard J., Maclean I., Brunham R.
Tissue Antigens 53:381-382(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16).
[73]"Novel HLA-DQB1 allele."
Rizzo M., Hurley C.K.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30).
[74]"A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."
Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.
Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14).
Tissue: Blood.
[75]"Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing."
Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D., Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.
Tissue Antigens 48:143-147(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11).
[76]"HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin."
Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E., Martin H., Seidl C.
Tissue Antigens 67:160-162(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27).
[77]Dinauer D.M., Hessner M.J.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND DQB1*06:08).
[78]"Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-DQw1."
Fenske T.S., Baxter-Lowe L.A.
Tissue Antigens 40:49-52(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04).
[79]"Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex."
Gyllensten U.B., Lashkari D., Erlich H.A.
Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01).
[80]"Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA."
Bugawan T.L., Erlich H.A.
Immunogenetics 33:163-170(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND DQB1*06:02).
[81]"Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C antigen subunits and immunoglobulin chains."
Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K., Peterson P.A., Rask L.
Scand. J. Immunol. 14:617-622(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01).
[82]"CSF hypocretin-1 assessment in sleep and neurological disorders."
Bourgin P., Zeitzer J.M., Mignot E.
Lancet Neurol. 7:649-662(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[83]"Invariant chain structure and MHC class II function."
Cresswell P.
Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[84]"Presentation of antigens by MHC class II molecules: getting the most out of them."
Villadangos J.A.
Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[85]"MHC class II molecules on the move for successful antigen presentation."
Rocha N., Neefjes J.
EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[86]"Autophagy in MHC class II presentation: sampling from within."
Menendez-Benito V., Neefjes J.
Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[87]"MHC class II transport at a glance."
Berger A.C., Roche P.A.
J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[88]"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
Beswick E.J., Reyes V.E.
World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[89]"Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes."
Lee K.H., Wucherpfennig K.W., Wiley D.C.
Nat. Immunol. 2:501-507(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, DISULFIDE BONDS.
[90]"Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."
Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A., Bell J.I., Strominger J.L., Jones E.Y., Fugger L.
Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
[91]"Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease."
Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.
Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1 HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, SUBUNIT, POLYMORPHISM.
[92]"A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease."
Henderson K.N., Tye-Din J.A., Reid H.H., Chen Z., Borg N.A., Beissbarth T., Tatham A., Mannering S.I., Purcell A.W., Dudek N.L., van Heel D.A., McCluskey J., Rossjohn J., Anderson R.P.
Immunity 27:23-34(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
[93]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

SHMPD

The Singapore human mutation and polymorphism database

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01499 Genomic DNA. Translation: AAA98746.1.
K02405 Genomic DNA. Translation: AAA75521.1.
X03068 mRNA. Translation: CAA26872.1.
M17564 mRNA. Translation: AAA59765.1.
M29613 Genomic DNA. No translation available.
M29616 Genomic DNA. No translation available.
M16996 mRNA. Translation: AAA59770.1.
M20432 mRNA. Translation: AAA59769.1.
M60028 mRNA. Translation: AAA59755.1.
X96420 mRNA. Translation: CAA65280.1.
U92032 Genomic DNA. Translation: AAB91991.1.
AY663393 Genomic DNA. Translation: AAU87973.1.
AY663394 Genomic DNA. Translation: AAU87977.1.
AY663397 Genomic DNA. Translation: AAU87986.1.
AY663409 Genomic DNA. Translation: AAU88017.1.
AY663404 Genomic DNA. Translation: AAU88002.1.
AY663410 Genomic DNA. Translation: AAU88020.1.
AY663412 Genomic DNA. Translation: AAU88027.1.
AY656681 mRNA. Translation: AAV71028.1.
AY656682 mRNA. Translation: AAV71029.1.
AY656683 mRNA. Translation: AAV71030.1.
BX927168 Genomic DNA. Translation: CAQ08747.1.
CR753846 Genomic DNA. Translation: CAQ09755.1.
CR933859 Genomic DNA. Translation: CAQ09239.1.
BC012106 mRNA. Translation: AAH12106.1.
M25327 mRNA. Translation: AAA59677.1.
U66400 mRNA. Translation: AAB51698.1.
U83582 mRNA. Translation: AAB41231.1.
AH002887 Genomic DNA. Translation: AAA59762.1.
M26042 mRNA. Translation: AAA36270.1.
M33907 mRNA. Translation: AAA52672.1.
L34096 mRNA. Translation: AAC41964.1.
L34098 mRNA. Translation: AAC41966.1.
L34101 mRNA. Translation: AAC41969.1.
L34103 mRNA. Translation: AAC41971.1.
L34104 mRNA. Translation: AAC41972.1.
L34105 mRNA. Translation: AAC41973.1.
L34106 mRNA. Translation: AAC41974.1.
L34107 mRNA. Translation: AAC41975.1.
AF195245 mRNA. Translation: AAF28315.1.
L42626 mRNA. Translation: AAA85335.1.
X76553 mRNA. No translation available.
X76554 mRNA. No translation available.
M59800 mRNA. Translation: AAA64235.1.
M14189 mRNA. Translation: AAA36268.1.
AY672649 Genomic DNA. Translation: AAT77952.1.
M17207 mRNA. Translation: AAA59697.1.
Z49215 Genomic DNA. No translation available.
AY026349 Genomic DNA. Translation: AAK01944.1.
AF091305 Genomic DNA. Translation: AAC64403.2. Sequence problems.
U77344 Genomic DNA. Translation: AAB19215.1.
FN256435 Genomic DNA. Translation: CAX62164.1.
FN256435 Genomic DNA. Translation: CAX62165.1.
AM400970 Genomic DNA. Translation: CAL47037.1.
AM421131 Genomic DNA. Translation: CAM07104.1.
EF484936 Genomic DNA. Translation: ABO87661.1.
EF484939 Genomic DNA. Translation: ABO87664.1.
EU275158 Genomic DNA. Translation: ABY26531.1.
AM944346 Genomic DNA. Translation: CAQ16179.1.
FM200854 Genomic DNA. Translation: CAR31119.1.
AH013029 Genomic DNA. Translation: AAP93137.1.
EU770203 Genomic DNA. Translation: ACF16333.1.
FM955320 Genomic DNA. Translation: CAW24712.1.
FN552709 Genomic DNA. Translation: CBF35736.1.
FN552710 Genomic DNA. Translation: CBF35739.1.
X86327 Genomic DNA. No translation available.
D78569 Genomic DNA. Translation: BAA11413.1.
AF439338 Genomic DNA. Translation: AAL35222.1.
AF384556 Genomic DNA. Translation: AAM53072.1.
DQ026226 Genomic DNA. Translation: AAY89656.1.
AY762968 Genomic DNA. Translation: AAV97949.1.
AM181332 Genomic DNA. Translation: CAJ57391.1. Sequence problems.
AM691798 Genomic DNA. Translation: CAM88661.1.
AM259942 Genomic DNA. Translation: CAJ90956.1.
U39090 Genomic DNA. Translation: AAB02681.1.
AJ003005 Genomic DNA. No translation available.
AJ012156 Genomic DNA. Translation: CAA09929.1.
AJ290396 Genomic DNA. Translation: CAC27418.1.
AF469118 Genomic DNA. Translation: AAL77085.1.
AF479569 Genomic DNA. Translation: AAM09472.1.
AJ535315 Genomic DNA. Translation: CAD59445.2.
AF181983 Genomic DNA. Translation: AAD54423.2.
AY733062 Genomic DNA. Translation: AAU33811.1.
AJ854065 Genomic DNA. Translation: CAH69441.1.
AJ964903 Genomic DNA. Translation: CAI79639.1.
AB211231 Genomic DNA. Translation: BAD95610.1.
DQ114427 Genomic DNA. Translation: AAZ20753.1.
DQ227421 Genomic DNA. Translation: ABB05231.1.
AM403489 Genomic DNA. Translation: CAL48285.1.
AM490069 Genomic DNA. Translation: CAM32717.1.
EF622510 Genomic DNA. Translation: ABR24117.1.
EU410617 Genomic DNA. Translation: ABZ89500.1.
GQ422610 Genomic DNA. Translation: ACV66342.1.
FN550110 Genomic DNA. Translation: CBE66554.1.
AF087939 Genomic DNA. Translation: AAD39697.1.
AY094140 Genomic DNA. Translation: AAM14401.1.
AJ001257 Genomic DNA. Translation: CAA04631.1.
U39086 Genomic DNA. Translation: AAA93181.1.
AJ965439 Genomic DNA. Translation: CAI84643.1.
AF112463 Genomic DNA. Translation: AAD23990.1.
AF112464 Genomic DNA. Translation: AAD23991.1.
M94773 Genomic DNA. No translation available.
M65042 Genomic DNA. Translation: AAA36241.1.
M25025 mRNA. Translation: AAA59793.1.
PIRHLHU1C. A02234.
A35055.
HLHUDB. A94003.
B32527.
B37044.
HLHU2C. C24669.
F30575.
I54480.
I68732.
I72482.
S46648.
RefSeqNP_001230891.1. NM_001243962.1.
NP_002114.3. NM_002123.4.
UniGeneHs.409934.
Hs.534322.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40B35-224[»]
1NBNmodel-B35-224[»]
1S9VX-ray2.22B/E33-230[»]
1UVQX-ray1.80B35-231[»]
2NNAX-ray2.10B33-224[»]
4GG6X-ray3.20B/D33-227[»]
ProteinModelPortalP01920.
SMRP01920. Positions 35-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109364. 1 interaction.
IntActP01920. 1 interaction.
MINTMINT-199658.
STRING9606.ENSP00000382034.

Chemistry

DrugBankDB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

PTM databases

PhosphoSiteP01920.

Polymorphism databases

DMDM290457643.

Proteomic databases

PaxDbP01920.
PRIDEP01920.

Protocols and materials databases

DNASU3119.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000399088; ENSP00000382038; ENSG00000231286.
ENST00000413089; ENSP00000396539; ENSG00000231286.
ENST00000416192; ENSP00000410107; ENSG00000233209.
ENST00000419914; ENSP00000402865; ENSG00000225824.
ENST00000422950; ENSP00000414079; ENSG00000233209.
ENST00000424806; ENSP00000410330; ENSG00000225824.
GeneID3119.
KEGGhsa:3119.
UCSCuc011hzw.2. human.

Organism-specific databases

CTD3119.
GeneCardsGC06M032629.
GC06Mk32602.
GC06Ml32782.
GC06Mm32658.
HGNCHGNC:4944. HLA-DQB1.
HPAHPA013667.
MIM604305. gene.
neXtProtNX_P01920.
Orphanet703. Bullous pemphigoid.
555. Celiac disease.
243377. Diabetes mellitus type 1.
802. Multiple sclerosis.
83465. Narcolepsy without cataplexy.
2073. Narcolepsy-cataplexy.
PharmGKBPA35068.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68200.
HOVERGENHBG012730.
InParanoidP01920.
KOK06752.
PhylomeDBP01920.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-DQB1.
GenevestigatorP01920.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DQB1. human.
EvolutionaryTraceP01920.
GeneWikiHLA-DQB1.
GenomeRNAi3119.
NextBio20783717.
PROP01920.
SOURCESearch...

Entry information

Entry nameDQB1_HUMAN
AccessionPrimary (citable) accession number: P01920
Secondary accession number(s): A1KR27 expand/collapse secondary AC list , A2RPH3, A4Q9R4, A4USG2, A4USG5, A6N8I7, A9YQA0, B0S7Y7, B1A0K6, B1GXI3, B3VLT3, B5BLN7, B7VU69, C0MQ34, C0MQ35, C8ZL52, C8ZLJ8, C8ZLJ9, C9DRQ3, O19708, O19713, O19724, O62861, O78046, O78221, O78223, O98034, O98201, P01917, P01918, P01919, P03992, P05537, P79482, P79526, P79544, P79551, Q08GC8, Q09035, Q0E4V9, Q1M312, Q29731, Q29877, Q29884, Q29915, Q29966, Q2P9N3, Q2QK85, Q30061, Q30075, Q30076, Q30080, Q30081, Q30082, Q30083, Q30084, Q30089, Q30095, Q31633, Q38I47, Q45UE3, Q4QZB5, Q53I44, Q564J6, Q5G841, Q5ISH1, Q5ISH3, Q5W1E1, Q5Y7G8, Q643R4, Q6B9X1, Q70VH8, Q7YP69, Q8HWH0, Q8MH58, Q8SNB4, Q8SND1, Q8SP70, Q8WMA3, Q9BD17, Q9MYH2, Q9TPA9, Q9XRY6, Q9XRY7, Q9XRZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: April 16, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM