Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HLA class II histocompatibility antigen, DQ beta 1 chain

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  • MHC class II receptor activity Source: UniProtKB
  • peptide antigen binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ beta 1 chain
Alternative name(s):
MHC class II antigen DQB1
Gene namesi
Name:HLA-DQB1
Synonyms:HLA-DQB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4944. HLA-DQB1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 230ExtracellularSequence analysisAdd BLAST198
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 261CytoplasmicSequence analysis10

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

DisGeNETi3119.
MalaCardsiHLA-DQB1.
OpenTargetsiENSG00000231286.
Orphaneti703. Bullous pemphigoid.
555. Celiac disease.
243377. Diabetes mellitus type 1.
930. Idiopathic achalasia.
802. Multiple sclerosis.
83465. Narcolepsy without cataplexy.
2073. Narcolepsy-cataplexy.
PharmGKBiPA35068.

Polymorphism and mutation databases

BioMutaiHLA-DQB1.
DMDMi290457643.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 321 PublicationAdd BLAST32
ChainiPRO_000001898933 – 261HLA class II histocompatibility antigen, DQ beta 1 chainAdd BLAST229

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 111
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 205

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01920.
PRIDEiP01920.

PTM databases

iPTMnetiP01920.
PhosphoSitePlusiP01920.

Expressioni

Gene expression databases

BgeeiENSG00000225824.
CleanExiHS_HLA-DQB1.

Organism-specific databases

HPAiHPA013667.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

Protein-protein interaction databases

IntActiP01920. 1 interactor.
MINTiMINT-199658.

Structurei

Secondary structure

1261
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi40 – 50Combined sources11
Turni51 – 54Combined sources4
Beta strandi55 – 64Combined sources10
Beta strandi67 – 73Combined sources7
Turni74 – 76Combined sources3
Beta strandi78 – 83Combined sources6
Helixi84 – 86Combined sources3
Helixi87 – 94Combined sources8
Helixi97 – 109Combined sources13
Helixi111 – 117Combined sources7
Helixi119 – 122Combined sources4
Beta strandi130 – 135Combined sources6
Beta strandi141 – 144Combined sources4
Beta strandi146 – 157Combined sources12
Beta strandi160 – 165Combined sources6
Beta strandi168 – 170Combined sources3
Beta strandi174 – 176Combined sources3
Beta strandi183 – 185Combined sources3
Beta strandi187 – 194Combined sources8
Beta strandi203 – 208Combined sources6
Beta strandi216 – 220Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40B35-224[»]
1NBNmodel-B35-224[»]
1S9VX-ray2.22B/E33-230[»]
1UVQX-ray1.80B35-230[»]
2NNAX-ray2.10B33-224[»]
4GG6X-ray3.20B/D33-224[»]
4OZFX-ray2.70B33-224[»]
4OZGX-ray3.00B/D33-224[»]
4OZHX-ray2.80B/D33-224[»]
4OZIX-ray3.20B/D33-224[»]
ProteinModelPortaliP01920.
SMRiP01920.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 217Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 126Beta-1Add BLAST94
Regioni127 – 220Beta-2Add BLAST94
Regioni221 – 230Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP01920.
KOiK06752.
PhylomeDBiP01920.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT
60 70 80 90 100
NGTERVRYVT RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL
110 120 130 140 150
ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQHG
210 220 230 240 250
DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI
260
IHHRSQKGLL H
Length:261
Mass (Da):29,991
Last modified:March 2, 2010 - v2
Checksum:i79B1E571A628CF96
GO

Sequence cautioni

The sequence AAC64403 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAJ57391 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111C → S in AAD39697 (Ref. 71) Curated1
Sequence conflicti113H → Q in AAF28315 (PubMed:11098940).Curated1
Sequence conflicti173G → A in X76553 (PubMed:7928445).Curated1
Sequence conflicti173G → A in X76554 (PubMed:7928445).Curated1
Sequence conflicti214N → T in AAA59770 (PubMed:3584986).Curated1

Polymorphismi

The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).
DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0565706A → S in allele DQB1*05:01 and allele DQB1*05:02. Corresponds to variant rs1049056dbSNPEnsembl.1
Natural variantiVAR_06267912G → D in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant rs1049057dbSNPEnsembl.1
Natural variantiVAR_06268015A → V in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. 1 PublicationCorresponds to variant rs3189152dbSNPEnsembl.1
Natural variantiVAR_06268123A → S in allele DQB1*02:01 and allele DQB1*02:02. Corresponds to variant rs3891176dbSNPEnsembl.1
Natural variantiVAR_06268224M → I in allele DQB1*05:01 and allele DQB1*05:02. Corresponds to variant rs1049059dbSNPEnsembl.1
Natural variantiVAR_06268327T → A in allele DQB1*04:01. Corresponds to variant rs1049060dbSNPEnsembl.1
Natural variantiVAR_06268427T → S in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant rs1049060dbSNPEnsembl.1
Natural variantiVAR_06268528P → L in allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant rs1049062dbSNPEnsembl.1
Natural variantiVAR_06268628P → S in allele DQB1*05:01 and allele DQB1*05:02. 1 PublicationCorresponds to variant rs1049061dbSNPEnsembl.1
Natural variantiVAR_06268729V → L in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. Corresponds to variant rs1130366dbSNPEnsembl.1
Natural variantiVAR_06268835S → P in allele DQB1*06:01. Corresponds to variant rs12722106dbSNPEnsembl.1
Natural variantiVAR_06268941Y → F in allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37. Corresponds to variant rs9274407dbSNPEnsembl.1
Natural variantiVAR_06269041Y → L in allele DQB1*06:01 and allele DQB1*06:35; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06269143F → L in allele DQB1*06:33. Corresponds to variant rs56173496dbSNPEnsembl.1
Natural variantiVAR_06147245A → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant rs1130375dbSNPEnsembl.1
Natural variantiVAR_06147346M → L in allele DQB1*03:11, allele DQB1*03:26, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, allele DQB1*06:20 and allele DQB1*06:31. Corresponds to variant rs1130368dbSNPEnsembl.1
Natural variantiVAR_06269255R → L in allele DQB1*04:01. Corresponds to variant rs41540813dbSNPEnsembl.1
Natural variantiVAR_06269358Y → G in allele DQB1*03:05, allele DQB1*03:17, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:23; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06269458Y → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant rs766817072dbSNPEnsembl.1
Natural variantiVAR_06269559V → L in allele DQB1*03:18. Corresponds to variant rs41563539dbSNPEnsembl.1
Natural variantiVAR_06269660T → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant rs9274405dbSNPEnsembl.1
Natural variantiVAR_06269762Y → H in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs281862065dbSNPEnsembl.1
Natural variantiVAR_06269862Y → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. 1
Natural variantiVAR_06269969Y → D in allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant rs1130370dbSNPEnsembl.1
Natural variantiVAR_06270069Y → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06270170A → T in allele DQB1*03:20. Corresponds to variant rs45519640dbSNPEnsembl.1
Natural variantiVAR_06270270A → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and allele DQB1*06:35. Corresponds to variant rs1063318dbSNPEnsembl.1
Natural variantiVAR_06270377E → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant rs1049083dbSNPEnsembl.1
Natural variantiVAR_06270478V → E in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant rs9274398dbSNPEnsembl.1
Natural variantiVAR_06270579Y → F in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant rs9274397dbSNPEnsembl.1
Natural variantiVAR_06270681A → V in allele DQB1*03:07. Corresponds to variant rs41558214dbSNPEnsembl.1
Natural variantiVAR_06270784P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant rs9274395dbSNPEnsembl.1
Natural variantiVAR_06270885L → Q in allele DQB1*03:23, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1140313dbSNPEnsembl.1
Natural variantiVAR_06270987P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. Corresponds to variant rs1130380dbSNPEnsembl.1
Natural variantiVAR_06271087P → Q in allele DQB1*03:16. Corresponds to variant rs1130380dbSNPEnsembl.1
Natural variantiVAR_06271187P → R in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1130380dbSNPEnsembl.1
Natural variantiVAR_06271288P → L in allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02 and allele DQB1*04:03. Corresponds to variant rs1130381dbSNPEnsembl.1
Natural variantiVAR_06271389D → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, allele DQB1*03:18 and allele DQB1*06:29. Corresponds to variant rs1071637dbSNPEnsembl.1
Natural variantiVAR_06271489D → S in allele DQB1*05:02, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06271589D → V in allele DQB1*05:01, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1071637dbSNPEnsembl.1
Natural variantiVAR_06271692Y → N in allele DQB1*06:16. Corresponds to variant rs41562414dbSNPEnsembl.1
Natural variantiVAR_06271794N → K in allele DQB1*06:37. Corresponds to variant rs1130382dbSNPEnsembl.1
Natural variantiVAR_06271895S → R in allele DQB1*03:15. Corresponds to variant rs41556215dbSNPEnsembl.1
Natural variantiVAR_06271998E → D in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant rs9274390dbSNPEnsembl.1
Natural variantiVAR_06272099V → D in allele DQB1*03:13. Corresponds to variant rs41563814dbSNPEnsembl.1
Natural variantiVAR_06272199V → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35. Corresponds to variant rs9274390dbSNPEnsembl.1
Natural variantiVAR_062722102R → E in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062723102R → G in allele DQB1*03:08, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31 and allele DQB1*06:33. 1 PublicationCorresponds to variant rs1130386dbSNPEnsembl.1
Natural variantiVAR_062724103T → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, allele DQB1*06:24 and allele DQB1*06:30. Corresponds to variant rs1130390dbSNPEnsembl.1
Natural variantiVAR_062725103T → D in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062726103T → K in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05. 1
Natural variantiVAR_062727106E → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and allele DQB1*06:06. Corresponds to variant rs1130387dbSNPEnsembl.1
Natural variantiVAR_062728106E → S in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04 and allele DQB1*05:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062729107L → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06. Corresponds to variant rs9274384dbSNPEnsembl.1
Natural variantiVAR_062730109T → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06. Corresponds to variant rs1130392dbSNPEnsembl.1
Natural variantiVAR_062731116Q → E in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39. Corresponds to variant rs1140316dbSNPEnsembl.1
Natural variantiVAR_062732117L → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1140317dbSNPEnsembl.1
Natural variantiVAR_062733118E → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37. Corresponds to variant rs9274380dbSNPEnsembl.1
Natural variantiVAR_062734118E → G in allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs9274380dbSNPEnsembl.1
Natural variantiVAR_062735119L → F in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37. Corresponds to variant rs9274379dbSNPEnsembl.1
Natural variantiVAR_062736119L → Y in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062737121T → G in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1
Natural variantiVAR_062738122T → I in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1140320dbSNPEnsembl.1
Natural variantiVAR_056571148V → I in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. Corresponds to variant rs1049100dbSNPEnsembl.1
Natural variantiVAR_062739157A → G in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1063322dbSNPEnsembl.1
Natural variantiVAR_062740157A → S in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. 1
Natural variantiVAR_062741158Q → H in allele DQB1*05:02. Corresponds to variant rs41542812dbSNPEnsembl.1
Natural variantiVAR_062742162R → Q in allele DQB1*03:22, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36 and allele DQB1*06:38. Corresponds to variant rs41544112dbSNPEnsembl.1
Natural variantiVAR_062744165R → Q in allele DQB1*06:38. Corresponds to variant rs9273989dbSNPEnsembl.1
Natural variantiVAR_062743165R → W in allele DQB1*03:21. Corresponds to variant rs63626961dbSNPEnsembl.1
Natural variantiVAR_062745167D → G in allele DQB1*02:02. Corresponds to variant rs2647032dbSNPEnsembl.1
Natural variantiVAR_062746168Q → E in allele DQB1*02:04. Corresponds to variant rs9273981dbSNPEnsembl.1
Natural variantiVAR_062747172T → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Combined sourcesCorresponds to variant rs1063323dbSNPEnsembl.1
Natural variantiVAR_056572194E → D.Corresponds to variant rs9273952dbSNPEnsembl.1
Natural variantiVAR_059522197P → L.Corresponds to variant rs9273948dbSNPEnsembl.1
Natural variantiVAR_062748199H → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 PublicationCorresponds to variant rs701564dbSNPEnsembl.1
Natural variantiVAR_062749200 – 201GD → A in allele DQB1*03:09. 2
Natural variantiVAR_062750202V → I in allele DQB1*03:24. Corresponds to variant rs80255621dbSNPEnsembl.1
Natural variantiVAR_062751214N → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. Corresponds to variant rs1130398dbSNPEnsembl.1
Natural variantiVAR_062752217T → I in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, allele DQB1*04:01 and allele DQB1*04:02. Corresponds to variant rs1130399dbSNPEnsembl.1
Natural variantiVAR_062753218V → A in allele DQB1*06:36. Corresponds to variant rs281864132dbSNPEnsembl.1
Natural variantiVAR_062754229S → N in allele DQB1*06:01. Corresponds to variant rs1130429dbSNPEnsembl.1
Natural variantiVAR_062755235I → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant rs1049163dbSNPEnsembl.1
Natural variantiVAR_062756252H → R in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant rs1140342dbSNPEnsembl.1
Natural variantiVAR_062757253H → Q in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36. Corresponds to variant rs1140343dbSNPEnsembl.1
Natural variantiVAR_061474256Q → R in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03. Corresponds to variant rs1130432dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01499 Genomic DNA. Translation: AAA98746.1.
K02405 Genomic DNA. Translation: AAA75521.1.
X03068 mRNA. Translation: CAA26872.1.
M17564 mRNA. Translation: AAA59765.1.
M29613 Genomic DNA. No translation available.
M29616 Genomic DNA. No translation available.
M16996 mRNA. Translation: AAA59770.1.
M20432 mRNA. Translation: AAA59769.1.
M60028 mRNA. Translation: AAA59755.1.
X96420 mRNA. Translation: CAA65280.1.
U92032 Genomic DNA. Translation: AAB91991.1.
AY663393 Genomic DNA. Translation: AAU87973.1.
AY663394 Genomic DNA. Translation: AAU87977.1.
AY663397 Genomic DNA. Translation: AAU87986.1.
AY663409 Genomic DNA. Translation: AAU88017.1.
AY663404 Genomic DNA. Translation: AAU88002.1.
AY663410 Genomic DNA. Translation: AAU88020.1.
AY663412 Genomic DNA. Translation: AAU88027.1.
AY656681 mRNA. Translation: AAV71028.1.
AY656682 mRNA. Translation: AAV71029.1.
AY656683 mRNA. Translation: AAV71030.1.
BX927168 Genomic DNA. Translation: CAQ08747.1.
CR753846 Genomic DNA. Translation: CAQ09755.1.
CR933859 Genomic DNA. Translation: CAQ09239.1.
BC012106 mRNA. Translation: AAH12106.1.
M25327 mRNA. Translation: AAA59677.1.
U66400 mRNA. Translation: AAB51698.1.
U83582 mRNA. Translation: AAB41231.1.
AH002887 Genomic DNA. Translation: AAA59762.1.
M26042 mRNA. Translation: AAA36270.1.
M33907 mRNA. Translation: AAA52672.1.
L34096 mRNA. Translation: AAC41964.1.
L34098 mRNA. Translation: AAC41966.1.
L34101 mRNA. Translation: AAC41969.1.
L34103 mRNA. Translation: AAC41971.1.
L34104 mRNA. Translation: AAC41972.1.
L34105 mRNA. Translation: AAC41973.1.
L34106 mRNA. Translation: AAC41974.1.
L34107 mRNA. Translation: AAC41975.1.
AF195245 mRNA. Translation: AAF28315.1.
L42626 mRNA. Translation: AAA85335.1.
X76553 mRNA. No translation available.
X76554 mRNA. No translation available.
M59800 mRNA. Translation: AAA64235.1.
M14189 mRNA. Translation: AAA36268.1.
AY672649 Genomic DNA. Translation: AAT77952.1.
M17207 mRNA. Translation: AAA59697.1.
Z49215 Genomic DNA. No translation available.
AY026349 Genomic DNA. Translation: AAK01944.1.
AF091305 Genomic DNA. Translation: AAC64403.2. Sequence problems.
U77344 Genomic DNA. Translation: AAB19215.1.
FN256435 Genomic DNA. Translation: CAX62164.1.
FN256435 Genomic DNA. Translation: CAX62165.1.
AM400970 Genomic DNA. Translation: CAL47037.1.
AM421131 Genomic DNA. Translation: CAM07104.1.
EF484936 Genomic DNA. Translation: ABO87661.1.
EF484939 Genomic DNA. Translation: ABO87664.1.
EU275158 Genomic DNA. Translation: ABY26531.1.
AM944346 Genomic DNA. Translation: CAQ16179.1.
FM200854 Genomic DNA. Translation: CAR31119.1.
AH013029 Genomic DNA. Translation: AAP93137.1.
EU770203 Genomic DNA. Translation: ACF16333.1.
FM955320 Genomic DNA. Translation: CAW24712.1.
FN552709 Genomic DNA. Translation: CBF35736.1.
FN552710 Genomic DNA. Translation: CBF35739.1.
X86327 Genomic DNA. No translation available.
D78569 Genomic DNA. Translation: BAA11413.1.
AF439338 Genomic DNA. Translation: AAL35222.1.
AF384556 Genomic DNA. Translation: AAM53072.1.
DQ026226 Genomic DNA. Translation: AAY89656.1.
AY762968 Genomic DNA. Translation: AAV97949.1.
AM181332 Genomic DNA. Translation: CAJ57391.1. Sequence problems.
AM691798 Genomic DNA. Translation: CAM88661.1.
AM259942 Genomic DNA. Translation: CAJ90956.1.
U39090 Genomic DNA. Translation: AAB02681.1.
AJ003005 Genomic DNA. No translation available.
AJ012156 Genomic DNA. Translation: CAA09929.1.
AJ290396 Genomic DNA. Translation: CAC27418.1.
AF469118 Genomic DNA. Translation: AAL77085.1.
AF479569 Genomic DNA. Translation: AAM09472.1.
AJ535315 Genomic DNA. Translation: CAD59445.2.
AF181983 Genomic DNA. Translation: AAD54423.2.
AY733062 Genomic DNA. Translation: AAU33811.1.
AJ854065 Genomic DNA. Translation: CAH69441.1.
AJ964903 Genomic DNA. Translation: CAI79639.1.
AB211231 Genomic DNA. Translation: BAD95610.1.
DQ114427 Genomic DNA. Translation: AAZ20753.1.
DQ227421 Genomic DNA. Translation: ABB05231.1.
AM403489 Genomic DNA. Translation: CAL48285.1.
AM490069 Genomic DNA. Translation: CAM32717.1.
EF622510 Genomic DNA. Translation: ABR24117.1.
EU410617 Genomic DNA. Translation: ABZ89500.1.
GQ422610 Genomic DNA. Translation: ACV66342.1.
FN550110 Genomic DNA. Translation: CBE66554.1.
AF087939 Genomic DNA. Translation: AAD39697.1.
AY094140 Genomic DNA. Translation: AAM14401.1.
AJ001257 Genomic DNA. Translation: CAA04631.1.
U39086 Genomic DNA. Translation: AAA93181.1.
AJ965439 Genomic DNA. Translation: CAI84643.1.
AF112463 Genomic DNA. Translation: AAD23990.1.
AF112464 Genomic DNA. Translation: AAD23991.1.
M94773 Genomic DNA. No translation available.
M65042 Genomic DNA. Translation: AAA36241.1.
M25025 mRNA. Translation: AAA59793.1.
PIRiA02234. HLHU1C.
A35055.
A94003. HLHUDB.
B32527.
B37044.
C24669. HLHU2C.
F30575.
I54480.
I68732.
I72482.
S46648.
RefSeqiNP_001230891.1. NM_001243962.1.
NP_002114.3. NM_002123.4.
UniGeneiHs.409934.
Hs.534322.

Genome annotation databases

EnsembliENST00000399088; ENSP00000382038; ENSG00000231286.
ENST00000413089; ENSP00000396539; ENSG00000231286.
ENST00000416192; ENSP00000410107; ENSG00000233209.
ENST00000419914; ENSP00000402865; ENSG00000225824.
ENST00000422950; ENSP00000414079; ENSG00000233209.
ENST00000424806; ENSP00000410330; ENSG00000225824.
GeneIDi3119.
KEGGihsa:3119.
UCSCiuc011hep.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01499 Genomic DNA. Translation: AAA98746.1.
K02405 Genomic DNA. Translation: AAA75521.1.
X03068 mRNA. Translation: CAA26872.1.
M17564 mRNA. Translation: AAA59765.1.
M29613 Genomic DNA. No translation available.
M29616 Genomic DNA. No translation available.
M16996 mRNA. Translation: AAA59770.1.
M20432 mRNA. Translation: AAA59769.1.
M60028 mRNA. Translation: AAA59755.1.
X96420 mRNA. Translation: CAA65280.1.
U92032 Genomic DNA. Translation: AAB91991.1.
AY663393 Genomic DNA. Translation: AAU87973.1.
AY663394 Genomic DNA. Translation: AAU87977.1.
AY663397 Genomic DNA. Translation: AAU87986.1.
AY663409 Genomic DNA. Translation: AAU88017.1.
AY663404 Genomic DNA. Translation: AAU88002.1.
AY663410 Genomic DNA. Translation: AAU88020.1.
AY663412 Genomic DNA. Translation: AAU88027.1.
AY656681 mRNA. Translation: AAV71028.1.
AY656682 mRNA. Translation: AAV71029.1.
AY656683 mRNA. Translation: AAV71030.1.
BX927168 Genomic DNA. Translation: CAQ08747.1.
CR753846 Genomic DNA. Translation: CAQ09755.1.
CR933859 Genomic DNA. Translation: CAQ09239.1.
BC012106 mRNA. Translation: AAH12106.1.
M25327 mRNA. Translation: AAA59677.1.
U66400 mRNA. Translation: AAB51698.1.
U83582 mRNA. Translation: AAB41231.1.
AH002887 Genomic DNA. Translation: AAA59762.1.
M26042 mRNA. Translation: AAA36270.1.
M33907 mRNA. Translation: AAA52672.1.
L34096 mRNA. Translation: AAC41964.1.
L34098 mRNA. Translation: AAC41966.1.
L34101 mRNA. Translation: AAC41969.1.
L34103 mRNA. Translation: AAC41971.1.
L34104 mRNA. Translation: AAC41972.1.
L34105 mRNA. Translation: AAC41973.1.
L34106 mRNA. Translation: AAC41974.1.
L34107 mRNA. Translation: AAC41975.1.
AF195245 mRNA. Translation: AAF28315.1.
L42626 mRNA. Translation: AAA85335.1.
X76553 mRNA. No translation available.
X76554 mRNA. No translation available.
M59800 mRNA. Translation: AAA64235.1.
M14189 mRNA. Translation: AAA36268.1.
AY672649 Genomic DNA. Translation: AAT77952.1.
M17207 mRNA. Translation: AAA59697.1.
Z49215 Genomic DNA. No translation available.
AY026349 Genomic DNA. Translation: AAK01944.1.
AF091305 Genomic DNA. Translation: AAC64403.2. Sequence problems.
U77344 Genomic DNA. Translation: AAB19215.1.
FN256435 Genomic DNA. Translation: CAX62164.1.
FN256435 Genomic DNA. Translation: CAX62165.1.
AM400970 Genomic DNA. Translation: CAL47037.1.
AM421131 Genomic DNA. Translation: CAM07104.1.
EF484936 Genomic DNA. Translation: ABO87661.1.
EF484939 Genomic DNA. Translation: ABO87664.1.
EU275158 Genomic DNA. Translation: ABY26531.1.
AM944346 Genomic DNA. Translation: CAQ16179.1.
FM200854 Genomic DNA. Translation: CAR31119.1.
AH013029 Genomic DNA. Translation: AAP93137.1.
EU770203 Genomic DNA. Translation: ACF16333.1.
FM955320 Genomic DNA. Translation: CAW24712.1.
FN552709 Genomic DNA. Translation: CBF35736.1.
FN552710 Genomic DNA. Translation: CBF35739.1.
X86327 Genomic DNA. No translation available.
D78569 Genomic DNA. Translation: BAA11413.1.
AF439338 Genomic DNA. Translation: AAL35222.1.
AF384556 Genomic DNA. Translation: AAM53072.1.
DQ026226 Genomic DNA. Translation: AAY89656.1.
AY762968 Genomic DNA. Translation: AAV97949.1.
AM181332 Genomic DNA. Translation: CAJ57391.1. Sequence problems.
AM691798 Genomic DNA. Translation: CAM88661.1.
AM259942 Genomic DNA. Translation: CAJ90956.1.
U39090 Genomic DNA. Translation: AAB02681.1.
AJ003005 Genomic DNA. No translation available.
AJ012156 Genomic DNA. Translation: CAA09929.1.
AJ290396 Genomic DNA. Translation: CAC27418.1.
AF469118 Genomic DNA. Translation: AAL77085.1.
AF479569 Genomic DNA. Translation: AAM09472.1.
AJ535315 Genomic DNA. Translation: CAD59445.2.
AF181983 Genomic DNA. Translation: AAD54423.2.
AY733062 Genomic DNA. Translation: AAU33811.1.
AJ854065 Genomic DNA. Translation: CAH69441.1.
AJ964903 Genomic DNA. Translation: CAI79639.1.
AB211231 Genomic DNA. Translation: BAD95610.1.
DQ114427 Genomic DNA. Translation: AAZ20753.1.
DQ227421 Genomic DNA. Translation: ABB05231.1.
AM403489 Genomic DNA. Translation: CAL48285.1.
AM490069 Genomic DNA. Translation: CAM32717.1.
EF622510 Genomic DNA. Translation: ABR24117.1.
EU410617 Genomic DNA. Translation: ABZ89500.1.
GQ422610 Genomic DNA. Translation: ACV66342.1.
FN550110 Genomic DNA. Translation: CBE66554.1.
AF087939 Genomic DNA. Translation: AAD39697.1.
AY094140 Genomic DNA. Translation: AAM14401.1.
AJ001257 Genomic DNA. Translation: CAA04631.1.
U39086 Genomic DNA. Translation: AAA93181.1.
AJ965439 Genomic DNA. Translation: CAI84643.1.
AF112463 Genomic DNA. Translation: AAD23990.1.
AF112464 Genomic DNA. Translation: AAD23991.1.
M94773 Genomic DNA. No translation available.
M65042 Genomic DNA. Translation: AAA36241.1.
M25025 mRNA. Translation: AAA59793.1.
PIRiA02234. HLHU1C.
A35055.
A94003. HLHUDB.
B32527.
B37044.
C24669. HLHU2C.
F30575.
I54480.
I68732.
I72482.
S46648.
RefSeqiNP_001230891.1. NM_001243962.1.
NP_002114.3. NM_002123.4.
UniGeneiHs.409934.
Hs.534322.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40B35-224[»]
1NBNmodel-B35-224[»]
1S9VX-ray2.22B/E33-230[»]
1UVQX-ray1.80B35-230[»]
2NNAX-ray2.10B33-224[»]
4GG6X-ray3.20B/D33-224[»]
4OZFX-ray2.70B33-224[»]
4OZGX-ray3.00B/D33-224[»]
4OZHX-ray2.80B/D33-224[»]
4OZIX-ray3.20B/D33-224[»]
ProteinModelPortaliP01920.
SMRiP01920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01920. 1 interactor.
MINTiMINT-199658.

PTM databases

iPTMnetiP01920.
PhosphoSitePlusiP01920.

Polymorphism and mutation databases

BioMutaiHLA-DQB1.
DMDMi290457643.

Proteomic databases

PeptideAtlasiP01920.
PRIDEiP01920.

Protocols and materials databases

DNASUi3119.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000399088; ENSP00000382038; ENSG00000231286.
ENST00000413089; ENSP00000396539; ENSG00000231286.
ENST00000416192; ENSP00000410107; ENSG00000233209.
ENST00000419914; ENSP00000402865; ENSG00000225824.
ENST00000422950; ENSP00000414079; ENSG00000233209.
ENST00000424806; ENSP00000410330; ENSG00000225824.
GeneIDi3119.
KEGGihsa:3119.
UCSCiuc011hep.3. human.

Organism-specific databases

CTDi3119.
DisGeNETi3119.
GeneCardsiHLA-DQB1.
GeneReviewsiHLA-DQB1.
HGNCiHGNC:4944. HLA-DQB1.
HPAiHPA013667.
MalaCardsiHLA-DQB1.
MIMi604305. gene.
neXtProtiNX_P01920.
OpenTargetsiENSG00000231286.
Orphaneti703. Bullous pemphigoid.
555. Celiac disease.
243377. Diabetes mellitus type 1.
930. Idiopathic achalasia.
802. Multiple sclerosis.
83465. Narcolepsy without cataplexy.
2073. Narcolepsy-cataplexy.
PharmGKBiPA35068.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG012730.
InParanoidiP01920.
KOiK06752.
PhylomeDBiP01920.

Enzyme and pathway databases

ReactomeiR-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-2132295. MHC class II antigen presentation.
R-HSA-389948. PD-1 signaling.
R-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiHLA-DQB1. human.
EvolutionaryTraceiP01920.
GeneWikiiHLA-DQB1.
GenomeRNAii3119.
PROiP01920.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000225824.
CleanExiHS_HLA-DQB1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDQB1_HUMAN
AccessioniPrimary (citable) accession number: P01920
Secondary accession number(s): A1KR27
, A2RPH3, A4Q9R4, A4USG2, A4USG5, A6N8I7, A9YQA0, B0S7Y7, B1A0K6, B1GXI3, B3VLT3, B5BLN7, B7VU69, C0MQ34, C0MQ35, C8ZL52, C8ZLJ8, C8ZLJ9, C9DRQ3, O19708, O19713, O19724, O62861, O78046, O78221, O78223, O98034, O98201, P01917, P01918, P01919, P03992, P05537, P79482, P79526, P79544, P79551, Q08GC8, Q09035, Q0E4V9, Q1M312, Q29731, Q29877, Q29884, Q29915, Q29966, Q2P9N3, Q2QK85, Q30061, Q30075, Q30076, Q30080, Q30081, Q30082, Q30083, Q30084, Q30089, Q30095, Q31633, Q38I47, Q45UE3, Q4QZB5, Q53I44, Q564J6, Q5G841, Q5ISH1, Q5ISH3, Q5W1E1, Q5Y7G8, Q643R4, Q6B9X1, Q70VH8, Q7YP69, Q8HWH0, Q8MH58, Q8SNB4, Q8SND1, Q8SP70, Q8WMA3, Q9BD17, Q9MYH2, Q9TPA9, Q9XRY6, Q9XRY7, Q9XRZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: November 2, 2016
This is version 159 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.