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P01920

- DQB1_HUMAN

UniProt

P01920 - DQB1_HUMAN

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Protein
HLA class II histocompatibility antigen, DQ beta 1 chain
Gene
HLA-DQB1, HLA-DQB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  1. MHC class II receptor activity Source: UniProtKB
  2. peptide antigen binding Source: UniProt

GO - Biological processi

  1. T cell costimulation Source: Reactome
  2. T cell receptor signaling pathway Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  4. cytokine-mediated signaling pathway Source: Reactome
  5. humoral immune response mediated by circulating immunoglobulin Source: UniProtKB
  6. immune response Source: UniProtKB
  7. immunoglobulin production involved in immunoglobulin mediated immune response Source: UniProtKB
  8. interferon-gamma-mediated signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ beta 1 chain
Alternative name(s):
MHC class II antigen DQB1
Gene namesi
Synonyms:HLA-DQB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4944. HLA-DQB1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 230198Extracellular Reviewed prediction
Add
BLAST
Transmembranei231 – 25121Helical; Reviewed prediction
Add
BLAST
Topological domaini252 – 26110Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. ER to Golgi transport vesicle membrane Source: Reactome
  2. Golgi membrane Source: Reactome
  3. MHC class II protein complex Source: UniProt
  4. clathrin-coated endocytic vesicle membrane Source: Reactome
  5. endocytic vesicle membrane Source: Reactome
  6. endosome membrane Source: UniProtKB-SubCell
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. lysosomal membrane Source: Reactome
  9. membrane Source: UniProtKB
  10. plasma membrane Source: Reactome
  11. trans-Golgi network membrane Source: Reactome
  12. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

Orphaneti703. Bullous pemphigoid.
555. Celiac disease.
243377. Diabetes mellitus type 1.
802. Multiple sclerosis.
83465. Narcolepsy without cataplexy.
2073. Narcolepsy-cataplexy.
PharmGKBiPA35068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 32321 Publication
Add
BLAST
Chaini33 – 261229HLA class II histocompatibility antigen, DQ beta 1 chain
PRO_0000018989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 1113 Publications
Glycosylationi51 – 511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 2053 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01920.
PaxDbiP01920.
PRIDEiP01920.

PTM databases

PhosphoSiteiP01920.

Expressioni

Gene expression databases

CleanExiHS_HLA-DQB1.
GenevestigatoriP01920.

Organism-specific databases

HPAiHPA013667.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

Protein-protein interaction databases

BioGridi109364. 1 interaction.
IntActiP01920. 1 interaction.
MINTiMINT-199658.
STRINGi9606.ENSP00000382034.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 5011
Turni51 – 544
Beta strandi55 – 6410
Beta strandi67 – 737
Turni74 – 763
Beta strandi78 – 836
Helixi84 – 863
Helixi87 – 948
Helixi97 – 10913
Helixi111 – 1177
Helixi119 – 1224
Beta strandi130 – 1356
Beta strandi141 – 1444
Beta strandi146 – 15712
Beta strandi160 – 1656
Beta strandi168 – 1703
Beta strandi174 – 1763
Beta strandi183 – 1853
Beta strandi187 – 1948
Beta strandi203 – 2086
Beta strandi216 – 2205

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40B35-224[»]
1NBNmodel-B35-224[»]
1S9VX-ray2.22B/E33-230[»]
1UVQX-ray1.80B35-230[»]
2NNAX-ray2.10B33-224[»]
4GG6X-ray3.20B/D33-224[»]
4OZFX-ray2.70B33-224[»]
4OZGX-ray3.00B/D33-224[»]
4OZHX-ray2.80B/D33-224[»]
4OZIX-ray3.20B/D33-224[»]
ProteinModelPortaliP01920.
SMRiP01920. Positions 35-224.

Miscellaneous databases

EvolutionaryTraceiP01920.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini129 – 21789Ig-like C1-type
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 12694Beta-1
Add
BLAST
Regioni127 – 22094Beta-2
Add
BLAST
Regioni221 – 23010Connecting peptide

Sequence similaritiesi

Belongs to the MHC class II family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68200.
HOVERGENiHBG012730.
InParanoidiP01920.
KOiK06752.
PhylomeDBiP01920.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01920-1 [UniParc]FASTAAdd to Basket

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MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT    50
NGTERVRYVT RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL 100
ERTRAELDTV CRHNYQLELR TTLQRRVEPT VTISPSRTEA LNHHNLLVCS 150
VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI RNGDWTFQIL VMLEMTPQHG 200
DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL GLIFLGLGLI 250
IHHRSQKGLL H 261
Length:261
Mass (Da):29,991
Last modified:March 2, 2010 - v2
Checksum:i79B1E571A628CF96
GO

Sequence cautioni

The sequence AAC64403.2 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAJ57391.1 differs from that shown. Reason: Erroneous gene model prediction.

Polymorphismi

The following alleles of HLA-DQB1 are known: DQB1*02:01, DQB1*02:02, DQB1*02:03, DQB1*02:04, DQB1*02:05, DQB1*03:01, DQB1*03:02, DQB1*03:03, DQB1*03:04, DQB1*03:05, DQB1*03:06, DQB1*03:07, DQB1*03:08, DQB1*03:09, DQB1*03:10, DQB1*03:11, DQB1*03:12, DQB1*03:13, DQB1*03:14, DQB1*03:15, DQB1*03:16, DQB1*03:17, DQB1*03:18, DQB1*03:19, DQB1*03:20, DQB1*03:21, DQB1*03:22, DQB1*03:23, DQB1*03:24, DQB1*03:25, DQB1*03:26, DQB1*04:01, DQB1*04:02, DQB1*04:03, DQB1*05:01, DQB1*05:02, DQB1*05:03, DQB1*05:04, DQB1*05:05, DQB1*06:01, DQB1*06:02, DQB1*06:03, DQB1*06:04, DQB1*06:05, DQB1*06:06, DQB1*06:07, DQB1*06:08, DQB1*06:09, DQB1*06:10, DQB1*06:11, DQB1*06:12, DQB1*06:13, DQB1*06:14, DQB1*06:15, DQB1*06:16, DQB1*06:17, DQB1*06:18, DQB1*06:19, DQB1*06:20, DQB1*06:21, DQB1*06:22, DQB1*06:23, DQB1*06:24, DQB1*06:25, DQB1*06:27, DQB1*06:28, DQB1*06:29, DQB1*06:30, DQB1*06:31, DQB1*06:32, DQB1*06:33, DQB1*06:34, DQB1*06:35, DQB1*06:36, DQB1*06:37, DQB1*06:38, and DQB1*06:39. The sequence shown is that of DQB1*03:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02).
DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy. DQB1*06:02 has been found to be present in most of the narcolepsy patients. As well 98% of the patients with an HCRT deficiency are positive for DQB1*06:02.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61A → S in allele DQB1*05:01 and allele DQB1*05:02.
Corresponds to variant rs1049056 [ dbSNP | Ensembl ].
VAR_056570
Natural varianti12 – 121G → D in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049057 [ dbSNP | Ensembl ].
VAR_062679
Natural varianti15 – 151A → V in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*04:01, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12. 1 Publication
Corresponds to variant rs3189152 [ dbSNP | Ensembl ].
VAR_062680
Natural varianti23 – 231A → S in allele DQB1*02:01 and allele DQB1*02:02.
Corresponds to variant rs3891176 [ dbSNP | Ensembl ].
VAR_062681
Natural varianti24 – 241M → I in allele DQB1*05:01 and allele DQB1*05:02.
Corresponds to variant rs1049059 [ dbSNP | Ensembl ].
VAR_062682
Natural varianti27 – 271T → A in allele DQB1*04:01.
VAR_062683
Natural varianti27 – 271T → S in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049060 [ dbSNP | Ensembl ].
VAR_062684
Natural varianti28 – 281P → L in allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1049062 [ dbSNP | Ensembl ].
VAR_062685
Natural varianti28 – 281P → S in allele DQB1*05:01 and allele DQB1*05:02. 1 Publication
VAR_062686
Natural varianti29 – 291V → L in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*06:02 and allele DQB1*06:12.
Corresponds to variant rs1130366 [ dbSNP | Ensembl ].
VAR_062687
Natural varianti35 – 351S → P in allele DQB1*06:01.
VAR_062688
Natural varianti41 – 411Y → F in allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:10, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:29, allele DQB1*06:33 and allele DQB1*06:37.
Corresponds to variant rs9274407 [ dbSNP | Ensembl ].
VAR_062689
Natural varianti41 – 411Y → L in allele DQB1*06:01 and allele DQB1*06:35; requires 2 nucleotide substitutions.
VAR_062690
Natural varianti43 – 431F → L in allele DQB1*06:33.
Corresponds to variant rs56173496 [ dbSNP | Ensembl ].
VAR_062691
Natural varianti45 – 451A → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
Corresponds to variant rs1130375 [ dbSNP | Ensembl ].
VAR_061472
Natural varianti46 – 461M → L in allele DQB1*03:11, allele DQB1*03:26, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:05, allele DQB1*06:20 and allele DQB1*06:31.
Corresponds to variant rs1130368 [ dbSNP | Ensembl ].
VAR_061473
Natural varianti55 – 551R → L in allele DQB1*04:01.
Corresponds to variant rs41540813 [ dbSNP | Ensembl ].
VAR_062692
Natural varianti58 – 581Y → G in allele DQB1*03:05, allele DQB1*03:17, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:23; requires 2 nucleotide substitutions.
VAR_062693
Natural varianti58 – 581Y → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:15, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions. 1 Publication
VAR_062694
Natural varianti59 – 591V → L in allele DQB1*03:18.
Corresponds to variant rs41563539 [ dbSNP | Ensembl ].
VAR_062695
Natural varianti60 – 601T → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274405 [ dbSNP | Ensembl ].
VAR_062696
Natural varianti62 – 621Y → H in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:14, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062697
Natural varianti62 – 621Y → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062698
Natural varianti69 – 691Y → D in allele DQB1*06:01 and allele DQB1*06:35.
Corresponds to variant rs1130370 [ dbSNP | Ensembl ].
VAR_062699
Natural varianti69 – 691Y → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05; requires 2 nucleotide substitutions.
VAR_062700
Natural varianti70 – 701A → T in allele DQB1*03:20.
Corresponds to variant rs45519640 [ dbSNP | Ensembl ].
VAR_062701
Natural varianti70 – 701A → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*06:01, allele DQB1*06:28 and allele DQB1*06:35.
Corresponds to variant rs1063318 [ dbSNP | Ensembl ].
VAR_062702
Natural varianti77 – 771E → G in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:06, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:10, allele DQB1*03:11, allele DQB1*03:12, allele DQB1*03:14, allele DQB1*03:15, allele DQB1*03:17, allele DQB1*03:18, allele DQB1*03:20, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*03:26, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
Corresponds to variant rs1049083 [ dbSNP | Ensembl ].
VAR_062703
Natural varianti78 – 781V → E in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274398 [ dbSNP | Ensembl ].
VAR_062704
Natural varianti79 – 791Y → F in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274397 [ dbSNP | Ensembl ].
VAR_062705
Natural varianti81 – 811A → V in allele DQB1*03:07.
Corresponds to variant rs41558214 [ dbSNP | Ensembl ].
VAR_062706
Natural varianti84 – 841P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
Corresponds to variant rs9274395 [ dbSNP | Ensembl ].
VAR_062707
Natural varianti85 – 851L → Q in allele DQB1*03:23, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:20, allele DQB1*06:22, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140313 [ dbSNP | Ensembl ].
VAR_062708
Natural varianti87 – 871P → L in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062709
Natural varianti87 – 871P → Q in allele DQB1*03:16.
VAR_062710
Natural varianti87 – 871P → R in allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1130380 [ dbSNP | Ensembl ].
VAR_062711
Natural varianti88 – 881P → L in allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02 and allele DQB1*04:03.
Corresponds to variant rs1130381 [ dbSNP | Ensembl ].
VAR_062712
Natural varianti89 – 891D → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:02, allele DQB1*03:04, allele DQB1*03:05, allele DQB1*03:07, allele DQB1*03:08, allele DQB1*03:11, allele DQB1*03:14, allele DQB1*03:18 and allele DQB1*06:29.
Corresponds to variant rs1071637 [ dbSNP | Ensembl ].
VAR_062713
Natural varianti89 – 891D → S in allele DQB1*05:02, allele DQB1*05:04, allele DQB1*05:05, allele DQB1*06:10 and allele DQB1*06:25; requires 2 nucleotide substitutions.
VAR_062714
Natural varianti89 – 891D → V in allele DQB1*05:01, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:06, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:27, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062715
Natural varianti92 – 921Y → N in allele DQB1*06:16.
VAR_062716
Natural varianti94 – 941N → K in allele DQB1*06:37.
VAR_062717
Natural varianti95 – 951S → R in allele DQB1*03:15.
VAR_062718
Natural varianti98 – 981E → D in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
Corresponds to variant rs9274390 [ dbSNP | Ensembl ].
VAR_062719
Natural varianti99 – 991V → D in allele DQB1*03:13.
VAR_062720
Natural varianti99 – 991V → I in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:04, allele DQB1*06:01 and allele DQB1*06:35.
VAR_062721
Natural varianti102 – 1021R → E in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
VAR_062722
Natural varianti102 – 1021R → G in allele DQB1*03:08, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31 and allele DQB1*06:33. 1 Publication
Corresponds to variant rs1130386 [ dbSNP | Ensembl ].
VAR_062723
Natural varianti103 – 1031T → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:17, allele DQB1*06:24 and allele DQB1*06:30.
VAR_062724
Natural varianti103 – 1031T → D in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03 and allele DQB1*05:04; requires 2 nucleotide substitutions.
VAR_062725
Natural varianti103 – 1031T → K in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04 and allele DQB1*02:05.
VAR_062726
Natural varianti106 – 1061E → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05 and allele DQB1*06:06.
Corresponds to variant rs1130387 [ dbSNP | Ensembl ].
VAR_062727
Natural varianti106 – 1061E → S in allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04 and allele DQB1*05:05; requires 2 nucleotide substitutions.
VAR_062728
Natural varianti107 – 1071L → V in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*02:05, allele DQB1*03:06, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*04:03, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
Corresponds to variant rs9274384 [ dbSNP | Ensembl ].
VAR_062729
Natural varianti109 – 1091T → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:03, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:04, allele DQB1*05:05 and allele DQB1*06:06.
Corresponds to variant rs1130392 [ dbSNP | Ensembl ].
VAR_062730
Natural varianti116 – 1161Q → E in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38, allele DQB1*06:39.
Corresponds to variant rs1140316 [ dbSNP | Ensembl ].
VAR_062731
Natural varianti117 – 1171L → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140317 [ dbSNP | Ensembl ].
VAR_062732
Natural varianti118 – 1181E → A in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
VAR_062733
Natural varianti118 – 1181E → G in allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062734
Natural varianti119 – 1191L → F in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:08, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:16, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:20, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:35 and allele DQB1*06:37.
Corresponds to variant rs9274379 [ dbSNP | Ensembl ].
VAR_062735
Natural varianti119 – 1191L → Y in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:15, allele DQB1*06:17, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:25, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
VAR_062736
Natural varianti121 – 1211T → G in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:13, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39; requires 2 nucleotide substitutions.
VAR_062737
Natural varianti122 – 1221T → I in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*05:05, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:05, allele DQB1*06:07, allele DQB1*06:08, allele DQB1*06:09, allele DQB1*06:10, allele DQB1*06:11, allele DQB1*06:12, allele DQB1*06:14, allele DQB1*06:15, allele DQB1*06:16, allele DQB1*06:17, allele DQB1*06:18, allele DQB1*06:19, allele DQB1*06:21, allele DQB1*06:22, allele DQB1*06:23, allele DQB1*06:24, allele DQB1*06:25, allele DQB1*06:27, allele DQB1*06:28, allele DQB1*06:29, allele DQB1*06:30, allele DQB1*06:31, allele DQB1*06:32, allele DQB1*06:33, allele DQB1*06:34, allele DQB1*06:35, allele DQB1*06:36, allele DQB1*06:37, allele DQB1*06:38 and allele DQB1*06:39.
Corresponds to variant rs1140320 [ dbSNP | Ensembl ].
VAR_062738
Natural varianti148 – 1481V → I in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
Corresponds to variant rs1049100 [ dbSNP | Ensembl ].
VAR_056571
Natural varianti157 – 1571A → G in allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062739
Natural varianti157 – 1571A → S in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
VAR_062740
Natural varianti158 – 1581Q → H in allele DQB1*05:02.
VAR_062741
Natural varianti162 – 1621R → Q in allele DQB1*03:22, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36 and allele DQB1*06:38.
VAR_062742
Natural varianti165 – 1651R → Q in allele DQB1*06:38.
VAR_062744
Natural varianti165 – 1651R → W in allele DQB1*03:21.
VAR_062743
Natural varianti167 – 1671D → G in allele DQB1*02:02.
VAR_062745
Natural varianti168 – 1681Q → E in allele DQB1*02:04.
VAR_062746
Natural varianti172 – 1721T → A in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
Corresponds to variant rs1063323 [ dbSNP | Ensembl ].
VAR_062747
Natural varianti194 – 1941E → D.
Corresponds to variant rs9273952 [ dbSNP | Ensembl ].
VAR_056572
Natural varianti197 – 1971P → L.
Corresponds to variant rs9273948 [ dbSNP | Ensembl ].
VAR_059522
Natural varianti199 – 1991H → R in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:23, allele DQB1*03:25, allele DQB1*04:01, allele DQB1*04:02, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39. 1 Publication
VAR_062748
Natural varianti200 – 2012GD → A in allele DQB1*03:09.
VAR_062749
Natural varianti202 – 2021V → I in allele DQB1*03:24.
VAR_062750
Natural varianti214 – 2141N → S in allele DQB1*02:01, allele DQB1*02:02, allele DQB1*02:04, allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12, allele DQB1*06:34, allele DQB1*06:36, allele DQB1*06:38 and allele DQB1*06:39.
VAR_062751
Natural varianti217 – 2171T → I in allele DQB1*03:02, allele DQB1*03:03, allele DQB1*03:05, allele DQB1*03:19, allele DQB1*03:25, allele DQB1*04:01 and allele DQB1*04:02.
VAR_062752
Natural varianti218 – 2181V → A in allele DQB1*06:36.
VAR_062753
Natural varianti229 – 2291S → N in allele DQB1*06:01.
VAR_062754
Natural varianti235 – 2351I → V in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
VAR_062755
Natural varianti252 – 2521H → R in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
Corresponds to variant rs1140342 [ dbSNP | Ensembl ].
VAR_062756
Natural varianti253 – 2531H → Q in allele DQB1*05:01, allele DQB1*05:02, allele DQB1*05:03, allele DQB1*06:01, allele DQB1*06:02, allele DQB1*06:03, allele DQB1*06:04, allele DQB1*06:09, allele DQB1*06:12 and allele DQB1*06:36.
VAR_062757
Natural varianti256 – 2561Q → R in allele DQB1*05:01, allele DQB1*05:02 and allele DQB1*05:03.
Corresponds to variant rs1130432 [ dbSNP | Ensembl ].
VAR_061474

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111C → S in AAD39697. 1 Publication
Sequence conflicti113 – 1131H → Q in AAF28315. 1 Publication
Sequence conflicti173 – 1731G → A in X76553. 1 Publication
Sequence conflicti173 – 1731G → A in X76554. 1 Publication
Sequence conflicti214 – 2141N → T in AAA59770. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01499 Genomic DNA. Translation: AAA98746.1.
K02405 Genomic DNA. Translation: AAA75521.1.
X03068 mRNA. Translation: CAA26872.1.
M17564 mRNA. Translation: AAA59765.1.
M29613 Genomic DNA. No translation available.
M29616 Genomic DNA. No translation available.
M16996 mRNA. Translation: AAA59770.1.
M20432 mRNA. Translation: AAA59769.1.
M60028 mRNA. Translation: AAA59755.1.
X96420 mRNA. Translation: CAA65280.1.
U92032 Genomic DNA. Translation: AAB91991.1.
AY663393 Genomic DNA. Translation: AAU87973.1.
AY663394 Genomic DNA. Translation: AAU87977.1.
AY663397 Genomic DNA. Translation: AAU87986.1.
AY663409 Genomic DNA. Translation: AAU88017.1.
AY663404 Genomic DNA. Translation: AAU88002.1.
AY663410 Genomic DNA. Translation: AAU88020.1.
AY663412 Genomic DNA. Translation: AAU88027.1.
AY656681 mRNA. Translation: AAV71028.1.
AY656682 mRNA. Translation: AAV71029.1.
AY656683 mRNA. Translation: AAV71030.1.
BX927168 Genomic DNA. Translation: CAQ08747.1.
CR753846 Genomic DNA. Translation: CAQ09755.1.
CR933859 Genomic DNA. Translation: CAQ09239.1.
BC012106 mRNA. Translation: AAH12106.1.
M25327 mRNA. Translation: AAA59677.1.
U66400 mRNA. Translation: AAB51698.1.
U83582 mRNA. Translation: AAB41231.1.
AH002887 Genomic DNA. Translation: AAA59762.1.
M26042 mRNA. Translation: AAA36270.1.
M33907 mRNA. Translation: AAA52672.1.
L34096 mRNA. Translation: AAC41964.1.
L34098 mRNA. Translation: AAC41966.1.
L34101 mRNA. Translation: AAC41969.1.
L34103 mRNA. Translation: AAC41971.1.
L34104 mRNA. Translation: AAC41972.1.
L34105 mRNA. Translation: AAC41973.1.
L34106 mRNA. Translation: AAC41974.1.
L34107 mRNA. Translation: AAC41975.1.
AF195245 mRNA. Translation: AAF28315.1.
L42626 mRNA. Translation: AAA85335.1.
X76553 mRNA. No translation available.
X76554 mRNA. No translation available.
M59800 mRNA. Translation: AAA64235.1.
M14189 mRNA. Translation: AAA36268.1.
AY672649 Genomic DNA. Translation: AAT77952.1.
M17207 mRNA. Translation: AAA59697.1.
Z49215 Genomic DNA. No translation available.
AY026349 Genomic DNA. Translation: AAK01944.1.
AF091305 Genomic DNA. Translation: AAC64403.2. Sequence problems.
U77344 Genomic DNA. Translation: AAB19215.1.
FN256435 Genomic DNA. Translation: CAX62164.1.
FN256435 Genomic DNA. Translation: CAX62165.1.
AM400970 Genomic DNA. Translation: CAL47037.1.
AM421131 Genomic DNA. Translation: CAM07104.1.
EF484936 Genomic DNA. Translation: ABO87661.1.
EF484939 Genomic DNA. Translation: ABO87664.1.
EU275158 Genomic DNA. Translation: ABY26531.1.
AM944346 Genomic DNA. Translation: CAQ16179.1.
FM200854 Genomic DNA. Translation: CAR31119.1.
AH013029 Genomic DNA. Translation: AAP93137.1.
EU770203 Genomic DNA. Translation: ACF16333.1.
FM955320 Genomic DNA. Translation: CAW24712.1.
FN552709 Genomic DNA. Translation: CBF35736.1.
FN552710 Genomic DNA. Translation: CBF35739.1.
X86327 Genomic DNA. No translation available.
D78569 Genomic DNA. Translation: BAA11413.1.
AF439338 Genomic DNA. Translation: AAL35222.1.
AF384556 Genomic DNA. Translation: AAM53072.1.
DQ026226 Genomic DNA. Translation: AAY89656.1.
AY762968 Genomic DNA. Translation: AAV97949.1.
AM181332 Genomic DNA. Translation: CAJ57391.1. Sequence problems.
AM691798 Genomic DNA. Translation: CAM88661.1.
AM259942 Genomic DNA. Translation: CAJ90956.1.
U39090 Genomic DNA. Translation: AAB02681.1.
AJ003005 Genomic DNA. No translation available.
AJ012156 Genomic DNA. Translation: CAA09929.1.
AJ290396 Genomic DNA. Translation: CAC27418.1.
AF469118 Genomic DNA. Translation: AAL77085.1.
AF479569 Genomic DNA. Translation: AAM09472.1.
AJ535315 Genomic DNA. Translation: CAD59445.2.
AF181983 Genomic DNA. Translation: AAD54423.2.
AY733062 Genomic DNA. Translation: AAU33811.1.
AJ854065 Genomic DNA. Translation: CAH69441.1.
AJ964903 Genomic DNA. Translation: CAI79639.1.
AB211231 Genomic DNA. Translation: BAD95610.1.
DQ114427 Genomic DNA. Translation: AAZ20753.1.
DQ227421 Genomic DNA. Translation: ABB05231.1.
AM403489 Genomic DNA. Translation: CAL48285.1.
AM490069 Genomic DNA. Translation: CAM32717.1.
EF622510 Genomic DNA. Translation: ABR24117.1.
EU410617 Genomic DNA. Translation: ABZ89500.1.
GQ422610 Genomic DNA. Translation: ACV66342.1.
FN550110 Genomic DNA. Translation: CBE66554.1.
AF087939 Genomic DNA. Translation: AAD39697.1.
AY094140 Genomic DNA. Translation: AAM14401.1.
AJ001257 Genomic DNA. Translation: CAA04631.1.
U39086 Genomic DNA. Translation: AAA93181.1.
AJ965439 Genomic DNA. Translation: CAI84643.1.
AF112463 Genomic DNA. Translation: AAD23990.1.
AF112464 Genomic DNA. Translation: AAD23991.1.
M94773 Genomic DNA. No translation available.
M65042 Genomic DNA. Translation: AAA36241.1.
M25025 mRNA. Translation: AAA59793.1.
PIRiA02234. HLHU1C.
A35055.
A94003. HLHUDB.
B32527.
B37044.
C24669. HLHU2C.
F30575.
I54480.
I68732.
I72482.
S46648.
RefSeqiNP_001230891.1. NM_001243962.1.
NP_002114.3. NM_002123.4.
UniGeneiHs.409934.
Hs.534322.

Genome annotation databases

EnsembliENST00000399088; ENSP00000382038; ENSG00000231286.
ENST00000413089; ENSP00000396539; ENSG00000231286.
ENST00000416192; ENSP00000410107; ENSG00000233209.
ENST00000419914; ENSP00000402865; ENSG00000225824.
ENST00000422950; ENSP00000414079; ENSG00000233209.
ENST00000424806; ENSP00000410330; ENSG00000225824.
GeneIDi3119.
KEGGihsa:3119.
UCSCiuc011hzw.2. human.

Polymorphism databases

DMDMi290457643.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01499 Genomic DNA. Translation: AAA98746.1 .
K02405 Genomic DNA. Translation: AAA75521.1 .
X03068 mRNA. Translation: CAA26872.1 .
M17564 mRNA. Translation: AAA59765.1 .
M29613 Genomic DNA. No translation available.
M29616 Genomic DNA. No translation available.
M16996 mRNA. Translation: AAA59770.1 .
M20432 mRNA. Translation: AAA59769.1 .
M60028 mRNA. Translation: AAA59755.1 .
X96420 mRNA. Translation: CAA65280.1 .
U92032 Genomic DNA. Translation: AAB91991.1 .
AY663393 Genomic DNA. Translation: AAU87973.1 .
AY663394 Genomic DNA. Translation: AAU87977.1 .
AY663397 Genomic DNA. Translation: AAU87986.1 .
AY663409 Genomic DNA. Translation: AAU88017.1 .
AY663404 Genomic DNA. Translation: AAU88002.1 .
AY663410 Genomic DNA. Translation: AAU88020.1 .
AY663412 Genomic DNA. Translation: AAU88027.1 .
AY656681 mRNA. Translation: AAV71028.1 .
AY656682 mRNA. Translation: AAV71029.1 .
AY656683 mRNA. Translation: AAV71030.1 .
BX927168 Genomic DNA. Translation: CAQ08747.1 .
CR753846 Genomic DNA. Translation: CAQ09755.1 .
CR933859 Genomic DNA. Translation: CAQ09239.1 .
BC012106 mRNA. Translation: AAH12106.1 .
M25327 mRNA. Translation: AAA59677.1 .
U66400 mRNA. Translation: AAB51698.1 .
U83582 mRNA. Translation: AAB41231.1 .
AH002887 Genomic DNA. Translation: AAA59762.1 .
M26042 mRNA. Translation: AAA36270.1 .
M33907 mRNA. Translation: AAA52672.1 .
L34096 mRNA. Translation: AAC41964.1 .
L34098 mRNA. Translation: AAC41966.1 .
L34101 mRNA. Translation: AAC41969.1 .
L34103 mRNA. Translation: AAC41971.1 .
L34104 mRNA. Translation: AAC41972.1 .
L34105 mRNA. Translation: AAC41973.1 .
L34106 mRNA. Translation: AAC41974.1 .
L34107 mRNA. Translation: AAC41975.1 .
AF195245 mRNA. Translation: AAF28315.1 .
L42626 mRNA. Translation: AAA85335.1 .
X76553 mRNA. No translation available.
X76554 mRNA. No translation available.
M59800 mRNA. Translation: AAA64235.1 .
M14189 mRNA. Translation: AAA36268.1 .
AY672649 Genomic DNA. Translation: AAT77952.1 .
M17207 mRNA. Translation: AAA59697.1 .
Z49215 Genomic DNA. No translation available.
AY026349 Genomic DNA. Translation: AAK01944.1 .
AF091305 Genomic DNA. Translation: AAC64403.2 . Sequence problems.
U77344 Genomic DNA. Translation: AAB19215.1 .
FN256435 Genomic DNA. Translation: CAX62164.1 .
FN256435 Genomic DNA. Translation: CAX62165.1 .
AM400970 Genomic DNA. Translation: CAL47037.1 .
AM421131 Genomic DNA. Translation: CAM07104.1 .
EF484936 Genomic DNA. Translation: ABO87661.1 .
EF484939 Genomic DNA. Translation: ABO87664.1 .
EU275158 Genomic DNA. Translation: ABY26531.1 .
AM944346 Genomic DNA. Translation: CAQ16179.1 .
FM200854 Genomic DNA. Translation: CAR31119.1 .
AH013029 Genomic DNA. Translation: AAP93137.1 .
EU770203 Genomic DNA. Translation: ACF16333.1 .
FM955320 Genomic DNA. Translation: CAW24712.1 .
FN552709 Genomic DNA. Translation: CBF35736.1 .
FN552710 Genomic DNA. Translation: CBF35739.1 .
X86327 Genomic DNA. No translation available.
D78569 Genomic DNA. Translation: BAA11413.1 .
AF439338 Genomic DNA. Translation: AAL35222.1 .
AF384556 Genomic DNA. Translation: AAM53072.1 .
DQ026226 Genomic DNA. Translation: AAY89656.1 .
AY762968 Genomic DNA. Translation: AAV97949.1 .
AM181332 Genomic DNA. Translation: CAJ57391.1 . Sequence problems.
AM691798 Genomic DNA. Translation: CAM88661.1 .
AM259942 Genomic DNA. Translation: CAJ90956.1 .
U39090 Genomic DNA. Translation: AAB02681.1 .
AJ003005 Genomic DNA. No translation available.
AJ012156 Genomic DNA. Translation: CAA09929.1 .
AJ290396 Genomic DNA. Translation: CAC27418.1 .
AF469118 Genomic DNA. Translation: AAL77085.1 .
AF479569 Genomic DNA. Translation: AAM09472.1 .
AJ535315 Genomic DNA. Translation: CAD59445.2 .
AF181983 Genomic DNA. Translation: AAD54423.2 .
AY733062 Genomic DNA. Translation: AAU33811.1 .
AJ854065 Genomic DNA. Translation: CAH69441.1 .
AJ964903 Genomic DNA. Translation: CAI79639.1 .
AB211231 Genomic DNA. Translation: BAD95610.1 .
DQ114427 Genomic DNA. Translation: AAZ20753.1 .
DQ227421 Genomic DNA. Translation: ABB05231.1 .
AM403489 Genomic DNA. Translation: CAL48285.1 .
AM490069 Genomic DNA. Translation: CAM32717.1 .
EF622510 Genomic DNA. Translation: ABR24117.1 .
EU410617 Genomic DNA. Translation: ABZ89500.1 .
GQ422610 Genomic DNA. Translation: ACV66342.1 .
FN550110 Genomic DNA. Translation: CBE66554.1 .
AF087939 Genomic DNA. Translation: AAD39697.1 .
AY094140 Genomic DNA. Translation: AAM14401.1 .
AJ001257 Genomic DNA. Translation: CAA04631.1 .
U39086 Genomic DNA. Translation: AAA93181.1 .
AJ965439 Genomic DNA. Translation: CAI84643.1 .
AF112463 Genomic DNA. Translation: AAD23990.1 .
AF112464 Genomic DNA. Translation: AAD23991.1 .
M94773 Genomic DNA. No translation available.
M65042 Genomic DNA. Translation: AAA36241.1 .
M25025 mRNA. Translation: AAA59793.1 .
PIRi A02234. HLHU1C.
A35055.
A94003. HLHUDB.
B32527.
B37044.
C24669. HLHU2C.
F30575.
I54480.
I68732.
I72482.
S46648.
RefSeqi NP_001230891.1. NM_001243962.1.
NP_002114.3. NM_002123.4.
UniGenei Hs.409934.
Hs.534322.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JK8 X-ray 2.40 B 35-224 [» ]
1NBN model - B 35-224 [» ]
1S9V X-ray 2.22 B/E 33-230 [» ]
1UVQ X-ray 1.80 B 35-230 [» ]
2NNA X-ray 2.10 B 33-224 [» ]
4GG6 X-ray 3.20 B/D 33-224 [» ]
4OZF X-ray 2.70 B 33-224 [» ]
4OZG X-ray 3.00 B/D 33-224 [» ]
4OZH X-ray 2.80 B/D 33-224 [» ]
4OZI X-ray 3.20 B/D 33-224 [» ]
ProteinModelPortali P01920.
SMRi P01920. Positions 35-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109364. 1 interaction.
IntActi P01920. 1 interaction.
MINTi MINT-199658.
STRINGi 9606.ENSP00000382034.

Chemistry

DrugBanki DB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

PTM databases

PhosphoSitei P01920.

Polymorphism databases

DMDMi 290457643.

Proteomic databases

MaxQBi P01920.
PaxDbi P01920.
PRIDEi P01920.

Protocols and materials databases

DNASUi 3119.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000399088 ; ENSP00000382038 ; ENSG00000231286 .
ENST00000413089 ; ENSP00000396539 ; ENSG00000231286 .
ENST00000416192 ; ENSP00000410107 ; ENSG00000233209 .
ENST00000419914 ; ENSP00000402865 ; ENSG00000225824 .
ENST00000422950 ; ENSP00000414079 ; ENSG00000233209 .
ENST00000424806 ; ENSP00000410330 ; ENSG00000225824 .
GeneIDi 3119.
KEGGi hsa:3119.
UCSCi uc011hzw.2. human.

Organism-specific databases

CTDi 3119.
GeneCardsi GC06M032629.
GC06Mk32602.
GC06Ml32782.
GC06Mm32658.
GeneReviewsi HLA-DQB1.
HGNCi HGNC:4944. HLA-DQB1.
HPAi HPA013667.
MIMi 604305. gene.
neXtProti NX_P01920.
Orphaneti 703. Bullous pemphigoid.
555. Celiac disease.
243377. Diabetes mellitus type 1.
802. Multiple sclerosis.
83465. Narcolepsy without cataplexy.
2073. Narcolepsy-cataplexy.
PharmGKBi PA35068.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68200.
HOVERGENi HBG012730.
InParanoidi P01920.
KOi K06752.
PhylomeDBi P01920.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi HLA-DQB1. human.
EvolutionaryTracei P01920.
GeneWikii HLA-DQB1.
GenomeRNAii 3119.
NextBioi 20783717.
PROi P01920.
SOURCEi Search...

Gene expression databases

CleanExi HS_HLA-DQB1.
Genevestigatori P01920.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (CLONE PII-BETA-2) (ALLELE DQB1*05:01).
  2. "Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens."
    Larhammar D., Schenning L., Gustafsson K., Wiman K., Claesson L., Rask L., Peterson P.A.
    Proc. Natl. Acad. Sci. U.S.A. 79:3687-3691(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*02:01).
  3. "Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene."
    Larhammar D., Hyldig-Nielsen J.-J., Servenius B., Andersson G., Rask L., Peterson P.A.
    Proc. Natl. Acad. Sci. U.S.A. 80:7313-7317(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
  4. "Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta."
    Boss J.M., Strominger J.L.
    Proc. Natl. Acad. Sci. U.S.A. 81:5199-5203(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
  5. "DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression."
    Tonnelle C., Demars R., Long E.O.
    EMBO J. 4:2839-2847(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
  6. "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers."
    Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.
    Immunogenetics 26:282-290(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*05:01).
  7. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
    Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
    J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*03:02).
  8. "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line."
    Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S., Tieber V.L., Kittlesen D.J., Schwartz B.D.
    J. Immunol. 139:228-233(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-15; SER-28; GLY-45; LEU-58; GLY-77; GLY-102 AND ARG-199.
  9. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:02).
  10. "Full length beta chain cDNAs of DQw9 and DQw8 molecules encode proteins that differ only at amino acid 57."
    Giorda R., Turco E., Trucco M.
    Immunogenetics 33:404-408(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*03:03).
  11. "Complete coding region of the new HLA-DQB1*0612 allele, obtained by RT-PCR."
    Vilches C., Garcia-Pacheco J.M., de Pablo R., Puente S., Kreisler M.
    Tissue Antigens 48:589-592(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQB1*06:12).
  12. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQB1*02:01).
  13. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQB1*03:01 AND DQB1*03:03).
  14. Kim E., Lee E., Kwack K.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQB1*03:01; DQB1*04:01 AND DQB1*05:02).
  15. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQB1*02:02; DQB1*03:01 AND DQB1*03:03).
  16. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQB1*03:02).
    Tissue: B-cell.
  17. "Sequence analysis of HLA class II domains: characterization of the DQw3 family of DQB genes."
    Hiraiwa A., Seyfried C.E., Nepom G.T., Milner E.C.
    Immunogenetics 29:186-190(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-126 (ALLELE DQB1*06:02).
  18. "Nucleotide Deletions in a DQB1*0301 variant."
    White J.M., Baxter-Lowe L.A.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-261 (ALLELE DQB1*03:01), NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:09).
  19. "No difference in the nucleotide sequence of the DQ beta beta 1 domain between narcoleptic and healthy individuals with DR2,Dw2."
    Uryu N., Maeda M., Nagata Y., Matsuki K., Juji T., Honda Y., Kawai J., Ando A., Tsuji K., Inoko H.
    Hum. Immunol. 24:175-181(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 10-126 (ALLELE DQB1*06:02).
  20. "Complete sequences of DQA1 and DQB1 cDNA clones corresponding to the DQw4 specificity."
    Jonsson A.-K., Andersson L., Rask L.
    Immunogenetics 30:232-234(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*04:02).
  21. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
    Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
    Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELES DQB1*03:03; DQB1*05:01; DQB1*05:03; DQB1*06:01; DQB1*06:02; DQB1*06:03 AND DQB1*06:04), NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*03:01).
  22. "Identification by sequencing based typing and complete coding region analysis of three new HLA class II alleles: DRB3*0210, DRB3*0211 and DQB1*0310."
    Balas A., Santos S., Aviles M.J., Garcia-Sanchez F., Lillo R., Vicario J.L.
    Tissue Antigens 56:380-384(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*03:10).
  23. Yasunaga S.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-261 (ALLELE DQB1*06:09).
  24. "HLA-DQB1*0305 and -DQB1*0304 alleles among Sardinians. Evolutionary and practical implications for oligotyping."
    Cucca F., Frau F., Lampis R., Floris M., Argiolas L., Macis D., Cao A., De Virgiliis S., Congia M.
    Hum. Immunol. 40:143-149(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-231 (ALLELES DQB1*03:04 AND DQB1*03:05).
  25. "Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."
    Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E., Koelbel S., Egert G., Wernet P., Hilschmann N.
    Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 33-181 AND 200-230 (ALLELE DQB1*06:02).
  26. "Two divergent routes of evolution gave rise to the DRw13 haplotypes."
    Lee K.W., Johnson A.H., Hurley C.K.
    J. Immunol. 145:3119-3125(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-140 (ALLELE DQB1*06:05).
  27. "Analysis of DR-beta and DQ-beta chain cDNA clones from a DR7 haplotype."
    Karr R.W., Gregersen P.K., Obata F., Goldberg D., Maccari J., Alber C., Silver J.
    J. Immunol. 137:2886-2890(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-126 (ALLELE DQB1*02:01).
  28. "Identification of a novel allele HLA-DQB1*0622."
    Chang Y., Fan T.X., Santana Z., Day N.K.
    Tissue Antigens 70:442-444(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-126 (ALLELE DQB1*06:22).
  29. "Structural and functional variability among DQ beta alleles of DR2 subtypes."
    Lee B.S., Bell J.I., Rust N.A., McDevitt H.O.
    Immunogenetics 26:85-91(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-122 (ALLELE DQB1*06:02).
  30. "A novel allele, DQB1*0307, in a West African family."
    Thye T., Muntau B., Stelma F.F., Horstmann R.D.
    Tissue Antigens 49:517-518(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 33-107 (ALLELE DQB1*03:07).
  31. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:18).
  32. "A new DQB1*0602 variant found in Australian Caucasian."
    Bowman S., Diviney M., Dunckley H., Holdsworth R., Varney M.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-126 (ALLELE DQB1*06:19).
  33. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-121 (ALLELE DQB1*06:13).
  34. "New HLA-DQB1*06 allele found in a voluntary blood stem cell donor."
    Skrablin P.S., Richter R., Seidl C., Seifried E.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-257 (ALLELE DQB1*06:36).
    Tissue: Peripheral blood.
  35. "HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102."
    Witter K., Mautner J., Albert T., Zahn R., Kauke T.
    Tissue Antigens 70:73-75(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:19).
  36. "HLA-DQB1*0634, a novel DQB1 allele found by high-resolution HLA typing of a sibling pair for potential bone marrow transplantation."
    Witter K., Albert T., Zahn R., Kauke T.
    Tissue Antigens 71:486-488(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*06:34).
  37. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:21), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELES DQB1*02:05 AND DQB1*03:20).
  38. "Sequence-based HLA high-resolution retyping of a bone marrow donor/recipient pair reveals the novel HLA allele DQB1*0322."
    Witter K., Lochmann E., Vecchiato C., Albert T., Zahn R., Kauke T.
    Tissue Antigens 73:283-285(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:22).
    Tissue: Peripheral blood.
  39. "DQB1*0323 is the result of a gene conversion event between a DQB1*06 and a DQB1*030303 allele."
    Wienzek S., Verboom M., Blasczyk R., Bein G., Horn P.A.
    Tissue Antigens 73:624-625(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:23).
    Tissue: Peripheral blood.
  40. "Identification of a novel HLA-DQB1*02 allele."
    Gragg H., Cordovado S.K., Hendrix M.M., Mueller P.W.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*02:04).
  41. "Homo sapiens novel MHC class II HLA-DQB1 gene HLA-DQB1*03 novel allele, exons 2 and 3."
    Thompson E.M., Mehdizadeh Kashi Z., Martin R.K.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:25).
  42. "A new HLA-DQB allele, identified by routine sequencing."
    Michaud C., Giannoli C., Favre Victoire I., Dubois V.
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELE DQB1*03:24).
  43. "New alleles found during routine SBT HLA typing."
    Anholts J.D.H.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-220 (ALLELES DQB1*06:38 AND DQB1*06:39).
    Tissue: Blood.
  44. "Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57-codon."
    Mersch G., Semana G., De Canck I., Jannes G., Rombout A., Sterker G., Rossau R.
    Tissue Antigens 48:217-220(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:10).
  45. "A new HLA-DQB1*0306 allele sharing motifs from DQB1*03032 and DQB1*04 sequences."
    Saito S., Ota S., Hashizume K., Yamada E., Kaneshige T., Hashimoto M., Oguchi H., Ishii E., Fukushima H.
    Tissue Antigens 48:580-585(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:06).
    Tissue: Blood.
  46. "Identification of two novel HLA class II alleles, DQB1*0311 and DQB1*0620."
    Hogbin J.P., Greville W., Chapman G., Kennedy A., Velickovic Z.M., Dunckley H.
    Tissue Antigens 64:515-517(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:11), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-120 (ALLELE DQB1*06:20).
  47. "A novel DQB1*03 allele revealed by rSSOP and identified by SBT."
    Chen D.-F., DeOliveira A., Peplinski S., Herczyk W., Reinsmoen N.L.
    Hum. Immunol. 66:30-30(2005)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:16).
  48. "Identification of a novel HLA-DQB1 allele, DQB1*0314, by sequence-based typing in the Korean population."
    Gu H., Kimm K., Lee J.K., Oh B.
    Tissue Antigens 65:503-504(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:14).
  49. "A novel HLA-DQB1*06 allele, DQB1*0628, found through routine sequence-based HLA typing and confirmation of DQB1*060302."
    Witter K., Albert T., Zahn R., Kauke T.
    Tissue Antigens 69:102-103(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:28).
  50. "Identification of a novel HLA-DQB1 allele, HLA-DQB1*0632."
    Emmerich F., Schonemann C., Diederich G., Horn P.A., Salama A.
    Tissue Antigens 71:94-95(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:32).
    Tissue: Blood.
  51. "Two new HLA-DQB alleles routinely identified by sequence-based typing: DQB1*030103 and DQB1*0505."
    Giannoli C., Paturel L., Favre-Victoire I., Bera O., Dubois V.
    Tissue Antigens 73:622-623(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*05:05).
  52. "A novel DQB1*02 allele."
    Olerup O.H.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*02:03).
  53. "Detection of a new DQB1 allele."
    Rugg J., Blanton M., Whitacre L., Balakrishnan K., Lebeer K., Van Reybroeck G., Mersch G.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
  54. "Two novel DQB1*06 alleles, identified by reverse line blot assay."
    Shah A., Ross J., Chenery P., Holman R., Madrigal A., Little A.M.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:15).
  55. "A new variant form of the HLA DQB1*0305 allele."
    Moine A.
    Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:05).
    Tissue: Peripheral blood.
  56. "Homo sapiens HLA-DQB1*0312 allele, exon 2."
    Schwarz K., Zenz C.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:12).
  57. "Novel human HLA-DQB1 allele identified in potential bone marrow donors."
    Wu J., Bassinger S., Williams T.M.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:13).
  58. "Identification of a new HLA-DQB1*06 allele by INNO-LiPA."
    De Canck I.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:21).
  59. "Novel DQB1*06 alleles."
    Bassinger S., Wu J., Zhang Q., Brinkema C., Smith A.G., Williams T.M.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:17).
  60. "Characterization of a new HLA-DQB1 allele by direct sequencing."
    Hirv K., Krauss A., Mytilineos J.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:23).
  61. "Novel HLA-DQB1*03 allele."
    Velickovic Z.M.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:15).
    Tissue: Peripheral blood.
  62. "A new HLA-DQB1 allele."
    Schranz P., Seelig R., Seelig H.P.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:24).
  63. "Homo sapiens HLA-DQ gene for MHC class2 antigen, partial cds, allele: HLA-DQB1*060401V."
    Watabe K., Hashimoto M.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:25).
  64. "A novel DQB1 allele found in Taiwan."
    Chu C.-C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:17).
  65. "High resolution genotyping of HLA-DQB1 exon 2 and 3."
    Hendrix M.M., Cordovado S.K., Mueller P.W.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:18).
  66. "A novel HLA-DRQ1*06 allele."
    Horn P.A., Blasczyk R.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:29).
  67. "Identification of several new class I and II alleles in routine HLA-testing."
    Nieberle I., Hirschmann D., Woelpl A.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:31).
  68. "A novel HLA-DQB1*06 allele identified by PCR-SBT in a caucasian NMDP donor."
    Yu M., Hall J.E., Hartman K.J., Caparelli E., Czech J., Smyth E., Jennings L.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:33).
  69. "Characterization of a new HLA-Cw*07 allele."
    Vigh A., Hirv K., Mytilineos J.
    Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*04:03).
  70. "A new variant of HLA-DQB1*06."
    Fuerst D., Mytilineos J.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*06:37).
  71. "Novel DQB1*03 found in CAP test sample."
    Yang K., Chen M.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-126 (ALLELE DQB1*03:26).
  72. "Identification of a novel DQB1 allele DBQ1*0616."
    Luo M., Blanchard J., Maclean I., Brunham R.
    Tissue Antigens 53:381-382(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-122 (ALLELE DQB1*06:16).
  73. "Novel HLA-DQB1 allele."
    Rizzo M., Hurley C.K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-115 (ALLELE DQB1*06:30).
  74. "A novel DRB3 allele (DRB3*0208), a new allelic variant of DRB1*1502 (DRB1*15023) and two new DQB1 (DQB1*03012 and DQB1*0614) alleles."
    Hashemi-tavoularis S., Ouellet S., Sengar D.P.S., Buyse I.M.
    Tissue Antigens 52:294-299(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-126 (ALLELE DQB1*06:14).
    Tissue: Blood.
  75. "Strategy for distinguishing a new DQB1 allele (DQB1*0611) from the closely related DQB1*0602 allele via sequence specific PCR or direct DNA sequencing."
    Williams T.M., Bassinger S., Moehlenkamp C., Wu J., Montoya G.D., Griffith B.B., McAuley J.D., Goldman S., Maurer D.H., Troup G.M.
    Tissue Antigens 48:143-147(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:11).
  76. "HLA-DRB1*0826 and HLA-DQB1*0627, two novel class II alleles identified in blood stem cell donors of Caucasian origin."
    Brixner V., Mosebach M., Schmidt M., Hermann S., Seifried E., Martin H., Seidl C.
    Tissue Antigens 67:160-162(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-125 (ALLELE DQB1*06:27).
  77. Dinauer D.M., Hessner M.J.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-122 (ALLELES DQB1*06:07 AND DQB1*06:08).
  78. "Two novel HLA-DQB1*06 alleles reveal additional heterogeneity of HLA-DQw1."
    Fenske T.S., Baxter-Lowe L.A.
    Tissue Antigens 40:49-52(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-114 (ALLELE DQB1*05:04).
  79. "Allelic diversification at the class II DQB locus of the mammalian major histocompatibility complex."
    Gyllensten U.B., Lashkari D., Erlich H.A.
    Proc. Natl. Acad. Sci. U.S.A. 87:1835-1839(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELE DQB1*02:01).
  80. "Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA."
    Bugawan T.L., Erlich H.A.
    Immunogenetics 33:163-170(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-109 (ALLELES DQB1*02:01 AND DQB1*06:02).
  81. "Evolutionary relationship between HLA-DR antigen beta-chains, HLA-A, B, C antigen subunits and immunoglobulin chains."
    Larhammar D., Wiman K., Schenning L., Claesson L., Gustafsson K., Peterson P.A., Rask L.
    Scand. J. Immunol. 14:617-622(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 135-217 (ALLELE DQB1*02:01).
  82. "CSF hypocretin-1 assessment in sleep and neurological disorders."
    Bourgin P., Zeitzer J.M., Mignot E.
    Lancet Neurol. 7:649-662(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  83. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  84. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  85. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  86. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  87. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  88. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  89. "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes."
    Lee K.H., Wucherpfennig K.W., Wiley D.C.
    Nat. Immunol. 2:501-507(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 35-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, DISULFIDE BONDS.
  90. "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."
    Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A., Bell J.I., Strominger J.L., Jones E.Y., Fugger L.
    Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 35-231 OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
  91. "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease."
    Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.
    Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 33-230 OF HLA-DQA1/HLA-DQB1 HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, SUBUNIT, POLYMORPHISM.
  92. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 33-224 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BONDS.
  93. Cited for: VARIANT [LARGE SCALE ANALYSIS] ALA-172, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDQB1_HUMAN
AccessioniPrimary (citable) accession number: P01920
Secondary accession number(s): A1KR27
, A2RPH3, A4Q9R4, A4USG2, A4USG5, A6N8I7, A9YQA0, B0S7Y7, B1A0K6, B1GXI3, B3VLT3, B5BLN7, B7VU69, C0MQ34, C0MQ35, C8ZL52, C8ZLJ8, C8ZLJ9, C9DRQ3, O19708, O19713, O19724, O62861, O78046, O78221, O78223, O98034, O98201, P01917, P01918, P01919, P03992, P05537, P79482, P79526, P79544, P79551, Q08GC8, Q09035, Q0E4V9, Q1M312, Q29731, Q29877, Q29884, Q29915, Q29966, Q2P9N3, Q2QK85, Q30061, Q30075, Q30076, Q30080, Q30081, Q30082, Q30083, Q30084, Q30089, Q30095, Q31633, Q38I47, Q45UE3, Q4QZB5, Q53I44, Q564J6, Q5G841, Q5ISH1, Q5ISH3, Q5W1E1, Q5Y7G8, Q643R4, Q6B9X1, Q70VH8, Q7YP69, Q8HWH0, Q8MH58, Q8SNB4, Q8SND1, Q8SP70, Q8WMA3, Q9BD17, Q9MYH2, Q9TPA9, Q9XRY6, Q9XRY7, Q9XRZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 2, 2010
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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