P01911 (2B1F_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class II histocompatibility antigen, DRB1-15 beta chain

Alternative name(s):
DW2.2/DR2.2
MHC class II antigen DRB1*15

Gene names

Name:	HLA-DRB1
Synonyms:	HLA-DRB2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
Subunit structure	Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms an heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B cells, in order to release CLIP and facilitate the binding of antigenic peptides.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus › trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation. Ref.15
Post-translational modification	Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC class II Probable. Ref.15
Polymorphism	The following alleles of DRB1-15 are known: DRB1*15:01, DRB1*15:02, DRB1*15:03, DRB1*15:04, DRB1*15:05, DRB1*15:06, DRB1*15:07, DRB1*15:08, DRB1*15:09, DRB1*15:10, DRB1*15:11, DRB1*15:12, DRB1*15:13, DRB1*15:14, DRB1*15:15, DRB1*15:16, DRB1*15:18, DRB1*15:19, DRB1*15:20, DRB1*15:21, DRB1*15:22, DRB1*15:23, DRB1*15:24, DRB1*15:25, DRB1*15:26, DRB1*15:27, DRB1*15:28, DRB1*15:29, DRB1*15:30, DRB1*15:31 and DRB1*15:32. The sequence shown is that of DRB1*15:01.
Miscellaneous	The chain shown constituted about 70% of a pool of at least seven similar beta chains.
Sequence similarities	Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane Endoplasmic reticulum Endosome Golgi apparatus Lysosome MHC II Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Isopeptide bond Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW late endosome membrane Inferred from direct assay Ref.15. Source: UniProtKB lysosomal membrane Inferred from direct assay Ref.15. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

29

Ref.9 Ref.10

Chain

30 – 266

237

HLA class II histocompatibility antigen, DRB1-15 beta chain

PRO_0000080744

Regions

Topological domain

30 – 227

198

Extracellular Potential

Transmembrane

228 – 248

21

Helical; Potential

Topological domain

249 – 266

18

Cytoplasmic Potential

Domain

126 – 214

89

Ig-like C1-type

Region

30 – 124

95

Beta-1

Region

125 – 227

103

Beta-2

Amino acid modifications

Glycosylation

48

1

N-linked (GlcNAc...)

Disulfide bond

44 ↔ 108

Disulfide bond

146 ↔ 202

Cross-link

254

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Natural variations

Natural variant

5

1

K → R.
Corresponds to variant rs9270305 [ dbSNP | Ensembl ].

VAR_050364

Natural variant

55

1

F → Y.
Corresponds to variant rs16822516 [ dbSNP | Ensembl ].

VAR_050365

Natural variant

59

1

Y → H in allele DRB1*15:03.

VAR_038162

Natural variant

96

1

I → F in allele DRB1*15:04.

VAR_038163

Natural variant

106

1

T → N.
Corresponds to variant rs9269941 [ dbSNP | Ensembl ].

VAR_050366

Natural variant

115

1

V → G in allele DRB1*15:02.

VAR_038164

Natural variant

164

1

G → S.
Corresponds to variant rs1059633 [ dbSNP | Ensembl ].

VAR_050367

Natural variant

169

1

A → T.
Corresponds to variant rs2308768 [ dbSNP | Ensembl ].

VAR_050368

Natural variant

236

1

V → M.
Corresponds to variant rs2230816 [ dbSNP | Ensembl ].

VAR_050369

Natural variant

262

1

T → R.
Corresponds to variant rs9269744 [ dbSNP | Ensembl ].

VAR_050370

Experimental info

Sequence conflict

119

1

T → A in AAI08923. Ref.5

Sequence conflict

154

1

G → A in AAA59801. Ref.8

Sequence conflict

171

1

M → G AA sequence Ref.9

Sequence conflict

179 – 180

2

NG → D AA sequence Ref.9

Secondary structure

1

.

.

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266

Helix Strand Turn

Details...

Beta strand

36 – 38

3

Beta strand

41 – 47

7

Helix

49 – 51

3

Beta strand

52 – 54

3

Beta strand

56 – 61

6

Beta strand

64 – 70

7

Turn

71 – 74

4

Beta strand

77 – 80

4

Helix

81 – 83

3

Helix

84 – 92

9

Helix

95 – 106

12

Helix

108 – 115

8

Helix

116 – 118

3

Turn

119 – 121

3

Beta strand

127 – 132

6

Beta strand

144 – 154

11

Beta strand

157 – 162

6

Beta strand

165 – 167

3

Beta strand

169 – 172

4

Beta strand

180 – 182

3

Beta strand

184 – 190

7

Beta strand

200 – 205

6

Beta strand

209 – 211

3

Beta strand

213 – 217

5

Sequences

	Sequence		Length	Mass (Da)
	P01911 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 3B5912820A4654BE	FASTA	266	29,966
	10 20 30 40 50 60 MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF 70 80 90 100 110 120 YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV 130 140 150 160 170 180 QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PTGFLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"MHC class II sequences of an HLA-DR2 narcoleptic." Lock C.B., So A.K., Welsh K.I., Parkes J.D., Trowsdale J. Immunogenetics 27:449-455(1988) [PubMed: 3259543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*15:01). Tissue: B-cell.
[2]	"Ancient haplotypes of the HLA Class II region." Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V. Genome Res. 15:1250-1257(2005) [PubMed: 16140993] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*15:01; DRB1*15:02 AND DRB1*15:03).
[3]	"Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113." Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L. Hum. Immunol. 67:1008-1016(2006) [PubMed: 17174751] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DRB1*15:03 AND DRB1*15:04). Tissue: Blood.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DRB1*15:01).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DRB1*15:01 AND DRB1*15:02). Tissue: Leukocyte.
[6]	"cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope." Wu S.K., Yabe T., Madden M., Saunders T.L., Bach F.H. J. Immunol. 138:2953-2959(1987) [PubMed: 3571980] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-266 (ALLELE DRB1*15:02). Tissue: Lymphoblast.
[7]	"HLA-DR2 subtypes form an additional supertypic family of DR beta alleles." Lee B.S.M., Rust N.A., McMichael A.J., McDevitt H.O. Proc. Natl. Acad. Sci. U.S.A. 84:4591-4595(1987) [PubMed: 2885840] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*15:01). Tissue: Lymphoblast.
[8]	"Allelic variation in the DR subregion of the human major histocompatibility complex." Bell J.I., Denney D. Jr., Foster L., Belt T.K., Todd J.A., McDevitt H.O. Proc. Natl. Acad. Sci. U.S.A. 84:6234-6238(1987) [PubMed: 3476943] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*15:01). Tissue: Lymphoblast.
[9]	"Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen." Kratzin H., Yang C.-Y., Gotz H., Pauly E., Kolbel S., Egert G., Thinnes F.P., Wernet P., Altevogt P., Hilschmann N. Hoppe-Seyler's Z. Physiol. Chem. 362:1665-1669(1981) [PubMed: 6947956] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-228. Tissue: Lymphoblast.
[10]	"N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens." Walker L.E., Hewick R., Hunkapiller M.W., Hood L.E., Dreyer W.J., Reisfeld R.A. Biochemistry 22:185-188(1983) [PubMed: 6600932] [Abstract] Cited for: PROTEIN SEQUENCE OF 30-64. Tissue: B-cell.
[11]	"Invariant chain structure and MHC class II function." Cresswell P. Cell 84:505-507(1996) [PubMed: 8598037] [Abstract] Cited for: REVIEW.
[12]	"Presentation of antigens by MHC class II molecules: getting the most out of them." Villadangos J.A. Mol. Immunol. 38:329-346(2001) [PubMed: 11684289] [Abstract] Cited for: REVIEW.
[13]	"Autophagy in MHC class II presentation: sampling from within." Menendez-Benito V., Neefjes J. Immunity 26:1-3(2007) [PubMed: 17241953] [Abstract] Cited for: REVIEW.
[14]	"MHC class II molecules on the move for successful antigen presentation." Rocha N., Neefjes J. EMBO J. 27:1-5(2008) [PubMed: 18046453] [Abstract] Cited for: REVIEW.
[15]	"MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." De Gassart A., Camosseto V., Thibodeau J., Ceppi M., Catalan N., Pierre P., Gatti E. Proc. Natl. Acad. Sci. U.S.A. 105:3491-3496(2008) [PubMed: 18305173] [Abstract] Cited for: UBIQUITINATION BY MARCH1, SUBCELLULAR LOCATION.
[16]	"MHC class II transport at a glance." Berger A.C., Roche P.A. J. Cell Sci. 122:1-4(2009) [PubMed: 19092054] [Abstract] Cited for: REVIEW.
[17]	"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract." Beswick E.J., Reyes V.E. World J. Gastroenterol. 15:2855-2861(2009) [PubMed: 19533806] [Abstract] Cited for: REVIEW.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor." Hahn M., Nicholson M.J., Pyrdol J., Wucherpfennig K.W. Nat. Immunol. 6:490-496(2005) [PubMed: 15821740] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 30-227.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M20430 mRNA. Translation: AAA59831.1.
AY663395 Genomic DNA. Translation: AAU87979.1.
AY663406 Genomic DNA. Translation: AAU88008.1.
AY663411 Genomic DNA. Translation: AAU88023.1.
AY663414 Genomic DNA. Translation: AAU88033.1.
AY961072 mRNA. Translation: AAX63460.1.
AY961073 mRNA. Translation: AAX63461.1.
AL713966 Genomic DNA. Translation: CAI18081.1.
BC033827 mRNA. Translation: AAH33827.1.
BC108922 mRNA. Translation: AAI08923.1.
M28584 mRNA. Translation: AAA59681.1.
M16957 mRNA. Translation: AAA36279.1.
M17378 mRNA. Translation: AAA59801.1.

IPI

IPI00472169.

PIR

HLHUWB. I68734.

RefSeq

NP_002115.2. NM_002124.3.

UniGene

Hs.534322.
Hs.696211.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BX2	X-ray	2.60	B/E	32-222	[»]
1YMM	X-ray	3.50	B	30-227	[»]
2WBJ	X-ray	3.00	B/F	30-227	[»]

ProteinModelPortal

P01911.

SMR

P01911. Positions 32-222.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01911. 1 interaction.

STRING

P01911.

Proteomic databases

PRIDE

P01911.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000360004; ENSP00000353099; ENSG00000196126.

GeneID

3123.

KEGG

hsa:3123.

UCSC

uc003obp.2. human.

Organism-specific databases

CTD

3123.

GeneCards

GC06M032546.

H-InvDB

HIX0018378.

HGNC

HGNC:4948. HLA-DRB1.

HPA

CAB015400.
CAB034021.

MIM

142857. gene.

neXtProt

NX_P01911.

PharmGKB

PA35072.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG012730.

InParanoid

P01911.

OMA

DAENWNS.

PhylomeDB

P01911.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Bgee

P01911.

CleanEx

HS_HLA-DRB1.

Genevestigator

P01911.

GermOnline

ENSG00000196126. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
G3DSA:3.10.320.10. MHC_II_alpha_N. 1 hit.

KO

K06752.

Pfam

PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]

ProDom

PD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

12394.

SOURCE

Search...

Entry information

Entry name

2B1F_HUMAN

Accession

Primary (citable) accession number: P01911
Secondary accession number(s): Q29790 , Q29975, Q30142, Q30166, Q32MY7, Q56FN9, Q5Y7B0, Q5Y7B9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 15, 2008
Last modified:	November 16, 2011
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.