##gff-version 3 P01909 UniProtKB Signal peptide 1 23 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:6576979;Dbxref=PMID:6576979 P01909 UniProtKB Chain 24 254 . . . ID=PRO_0000018970;Note=HLA class II histocompatibility antigen%2C DQ alpha 1 chain P01909 UniProtKB Topological domain 24 216 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01909 UniProtKB Transmembrane 217 239 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01909 UniProtKB Topological domain 240 254 . . . Note=Cytoplasmic P01909 UniProtKB Domain 112 204 . . . Note=Ig-like C1-type P01909 UniProtKB Region 24 119 . . . Note=Alpha-1 P01909 UniProtKB Region 120 203 . . . Note=Alpha-2 P01909 UniProtKB Region 204 216 . . . Note=Connecting peptide P01909 UniProtKB Glycosylation 103 103 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01909 UniProtKB Glycosylation 143 143 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P01909 UniProtKB Disulfide bond 132 188 . . . Ontology_term=ECO:0000255,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:11376336,ECO:0000269|PubMed:14769912,ECO:0000269|PubMed:17629515;Dbxref=PMID:11376336,PMID:14769912,PMID:17629515 P01909 UniProtKB Natural variant 8 8 . . . ID=VAR_033399;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*04:01 and allele DQA1*06:01. M->L;Dbxref=dbSNP:rs1047989 P01909 UniProtKB Natural variant 11 11 . . . ID=VAR_033400;Note=In allele DQA1*05:05%2C allele DQA1*05:08 and allele DQA1*05:09. A->T;Dbxref=dbSNP:rs1047992 P01909 UniProtKB Natural variant 17 17 . . . ID=VAR_050380;Note=In allele DQA1*01:04 and allele DQA1*01:05. V->M;Dbxref=dbSNP:rs12722039 P01909 UniProtKB Natural variant 18 18 . . . ID=VAR_050381;Note=In allele DQA1*03:03. M->T;Dbxref=dbSNP:rs11545686 P01909 UniProtKB Natural variant 24 24 . . . ID=VAR_060493;Note=In allele DQA1*05:09. E->K;Dbxref=dbSNP:rs41545012 P01909 UniProtKB Natural variant 25 25 . . . ID=VAR_050382;Note=In allele DQA1*01:04 and allele DQA1*01:05. D->G;Dbxref=dbSNP:rs12722042 P01909 UniProtKB Natural variant 34 34 . . . ID=VAR_060494;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. Y->C;Dbxref=dbSNP:rs1129740 P01909 UniProtKB Natural variant 41 41 . . . ID=VAR_033401;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. S->F;Dbxref=dbSNP:rs1071630 P01909 UniProtKB Natural variant 44 44 . . . ID=VAR_060495;Note=In allele DQA1*05:04. P->L;Dbxref=dbSNP:rs41549715 P01909 UniProtKB Natural variant 48 48 . . . ID=VAR_033402;Note=In allele DQA1*02:01%2C allele DQA1*01:03%2C allele DQA1*06:01 and allele DQA1*06:02. Y->F;Dbxref=dbSNP:rs12722051 P01909 UniProtKB Natural variant 49 49 . . . ID=VAR_033403;Note=In allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. T->S;Dbxref=dbSNP:rs1048023 P01909 UniProtKB Natural variant 57 57 . . . ID=VAR_014604;Note=In allele DQA1*01:01%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. Q->E;Dbxref=dbSNP:rs10093 P01909 UniProtKB Natural variant 63 63 . . . ID=VAR_060496;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. G->E;Dbxref=dbSNP:rs1142323 P01909 UniProtKB Natural variant 64 64 . . . ID=VAR_050383;Note=In allele DQA1*01:03. R->K;Dbxref=dbSNP:rs36219699 P01909 UniProtKB Natural variant 67 67 . . . ID=VAR_060497;Note=In allele DQA1*01:06. T->A;Dbxref=dbSNP:rs41543221 P01909 UniProtKB Natural variant 68 68 . . . ID=VAR_060498;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. V->A;Dbxref=dbSNP:rs1142324 P01909 UniProtKB Natural variant 70 70 . . . ID=VAR_060499;Note=In allele DQA1*02:01%3B requires 2 nucleotide substitutions. C->K P01909 UniProtKB Natural variant 70 70 . . . ID=VAR_060500;Note=In allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03%3B requires 2 nucleotide substitutions. C->Q P01909 UniProtKB Natural variant 70 70 . . . ID=VAR_060501;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. C->R;Dbxref=dbSNP:rs1142326 P01909 UniProtKB Natural variant 70 70 . . . ID=VAR_033404;Note=C->Y;Dbxref=dbSNP:rs3207983 P01909 UniProtKB Natural variant 71 71 . . . ID=VAR_060502;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2Callele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. L->W;Dbxref=dbSNP:rs1142328 P01909 UniProtKB Natural variant 73 73 . . . ID=VAR_033406;Note=V->D;Dbxref=dbSNP:rs760671632 P01909 UniProtKB Natural variant 73 73 . . . ID=VAR_060503;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. V->E;Dbxref=dbSNP:rs3208105 P01909 UniProtKB Natural variant 73 73 . . . ID=VAR_033405;Note=In allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. V->L;Dbxref=dbSNP:rs12722061 P01909 UniProtKB Natural variant 74 74 . . . ID=VAR_060504;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. L->F;Dbxref=dbSNP:rs9272698 P01909 UniProtKB Natural variant 75 75 . . . ID=VAR_060505;Note=In allele DQA1*02:01. R->H;Dbxref=dbSNP:rs28383449 P01909 UniProtKB Natural variant 75 75 . . . ID=VAR_060506;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. R->S;Dbxref=dbSNP:rs9272699 P01909 UniProtKB Natural variant 76 76 . . . ID=VAR_060507;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. Q->K;Dbxref=dbSNP:rs1048052 P01909 UniProtKB Natural variant 76 76 . . . ID=VAR_060508;Note=In allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. Q->R;Dbxref=dbSNP:rs12722069 P01909 UniProtKB Natural variant 77 77 . . . ID=VAR_060509;Note=In allele DQA1*02:01. F->L;Dbxref=dbSNP:rs3188043 P01909 UniProtKB Natural variant 78 78 . . . ID=VAR_060510;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2Callele DQA1*01:06 and allele DQA1*01:07. R->GG;Dbxref=dbSNP:rs4193 P01909 UniProtKB Natural variant 78 78 . . . ID=VAR_060511;Note=In allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. R->RR P01909 UniProtKB Natural variant 81 81 . . . ID=VAR_060512;Note=In allele DQA1*05:02. P->R;Dbxref=dbSNP:rs41541412 P01909 UniProtKB Natural variant 83 83 . . . ID=VAR_060513;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07%3B requires 2 nucleotide substitutions. F->G P01909 UniProtKB Natural variant 86 86 . . . ID=VAR_033408;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. T->R;Dbxref=dbSNP:rs1142333 P01909 UniProtKB Natural variant 88 88 . . . ID=VAR_033409;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. I->M;Dbxref=dbSNP:rs1142334 P01909 UniProtKB Natural variant 91 91 . . . ID=VAR_060514;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07%3B requires 2 nucleotide substitutions. L->A P01909 UniProtKB Natural variant 91 91 . . . ID=VAR_060515;Note=In allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02%3B requires 2 nucleotide substitutions. L->T P01909 UniProtKB Natural variant 97 97 . . . ID=VAR_060516;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. S->I;Dbxref=dbSNP:rs9279910 P01909 UniProtKB Natural variant 98 98 . . . ID=VAR_060517;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. L->M;Dbxref=dbSNP:rs1064944 P01909 UniProtKB Natural variant 98 98 . . . ID=VAR_060518;Note=In allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. L->V;Dbxref=dbSNP:rs1064944 P01909 UniProtKB Natural variant 101 101 . . . ID=VAR_060519;Note=In allele DQA1*01:07. R->C;Dbxref=dbSNP:rs41542116 P01909 UniProtKB Natural variant 102 102 . . . ID=VAR_050384;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:06 and allele DQA1*01:07. S->Y;Dbxref=dbSNP:rs1129808 P01909 UniProtKB Natural variant 124 124 . . . ID=VAR_060520;Note=In allele DQA1*05:06. L->V;Dbxref=dbSNP:rs41555012 P01909 UniProtKB Natural variant 129 129 . . . ID=VAR_050385;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. I->T;Dbxref=dbSNP:rs707952 P01909 UniProtKB Natural variant 151 151 . . . ID=VAR_050386;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:04%2C allele DQA1*01:05 and allele DQA1*01:07. H->Q;Dbxref=dbSNP:rs707950 P01909 UniProtKB Natural variant 152 152 . . . ID=VAR_060521;Note=In allele DQA1*01:03. S->A;Dbxref=dbSNP:rs41547417 P01909 UniProtKB Natural variant 160 160 . . . ID=VAR_060522;Note=In allele DQA1*04:02. T->I;Dbxref=dbSNP:rs41545514 P01909 UniProtKB Natural variant 161 161 . . . ID=VAR_060524;Note=In allele DQA1*05:08. S->I;Dbxref=dbSNP:rs41544114 P01909 UniProtKB Natural variant 161 161 . . . ID=VAR_060523;Note=In allele DQA1*06:02. S->R;Dbxref=dbSNP:rs41552014 P01909 UniProtKB Natural variant 175 175 . . . ID=VAR_060525;Note=In allele DQA1*04:04. Y->H;Dbxref=dbSNP:rs41550317 P01909 UniProtKB Natural variant 178 178 . . . ID=VAR_060526;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. L->F;Dbxref=dbSNP:rs707949 P01909 UniProtKB Natural variant 182 182 . . . ID=VAR_060527;Note=In allele DQA1*03:02 and allele DQA1*03:03. A->D;Dbxref=dbSNP:rs7990 P01909 UniProtKB Natural variant 182 182 . . . ID=VAR_060528;Note=In allele DQA1*05:03%2C allele DQA1*05:06 and allele DQA1*05:07. A->S;Dbxref=dbSNP:rs41561312 P01909 UniProtKB Natural variant 183 183 . . . ID=VAR_060529;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. E->D;Dbxref=dbSNP:rs707963 P01909 UniProtKB Natural variant 185 185 . . . ID=VAR_060530;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05%2C allele DQA1*01:07%2C allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. S->I;Dbxref=dbSNP:rs707962 P01909 UniProtKB Natural variant 197 197 . . . ID=VAR_060531;Note=In allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02%2C allele DQA1*03:03%2C allele DQA1*04:01%2C allele DQA1*04:02%2C allele DQA1*04:04%2C allele DQA1*06:01 and allele DQA1*06:02. K->E;Dbxref=dbSNP:rs2308891 P01909 UniProtKB Natural variant 197 197 . . . ID=VAR_060532;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04%2C allele DQA1*01:05 and allele DQA1*01:07. K->Q;Dbxref=dbSNP:rs2308891 P01909 UniProtKB Natural variant 209 209 . . . ID=VAR_050387;Note=In allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. A->T;Dbxref=dbSNP:rs9272785 P01909 UniProtKB Natural variant 221 221 . . . ID=VAR_050388;Note=In allele DQA1*01:04. A->T;Dbxref=dbSNP:rs35087390 P01909 UniProtKB Natural variant 229 229 . . . ID=VAR_033411;Note=In allele DQA1*01:02. V->M;Dbxref=dbSNP:rs9260 P01909 UniProtKB Natural variant 230 230 . . . ID=VAR_060533;Note=In allele DQA1*05:07. G->C;Dbxref=dbSNP:rs41545416 P01909 UniProtKB Natural variant 237 237 . . . ID=VAR_033412;Note=In allele DQA1*02:01%2C allele DQA1*03:01%2C allele DQA1*03:02 and allele DQA1*03:03. F->L;Dbxref=dbSNP:rs1048430 P01909 UniProtKB Natural variant 240 240 . . . ID=VAR_033413;Note=In allele DQA1*01:01%2C allele DQA1*01:02%2C allele DQA1*01:03%2C allele DQA1*01:04 and allele DQA1*01:05. R->Q;Dbxref=dbSNP:rs1048439 P01909 UniProtKB Sequence conflict 11 11 . . . Note=A->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Sequence conflict 23 27 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Sequence conflict 91 91 . . . Note=L->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Sequence conflict 107 107 . . . Note=A->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Sequence conflict 156 156 . . . Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Sequence conflict 213 213 . . . Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P01909 UniProtKB Beta strand 29 40 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Turn 41 44 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 45 52 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 55 61 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Turn 62 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 66 71 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Helix 72 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Helix 81 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Turn 102 104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1JK8 P01909 UniProtKB Beta strand 113 120 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 124 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OZF P01909 UniProtKB Beta strand 128 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 143 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 151 153 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 157 159 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 170 178 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 186 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 195 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M P01909 UniProtKB Beta strand 199 203 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3M