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P01909

- DQA1_HUMAN

UniProt

P01909 - DQA1_HUMAN

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Protein

HLA class II histocompatibility antigen, DQ alpha 1 chain

Gene

HLA-DQA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

GO - Molecular functioni

  1. MHC class II receptor activity Source: UniProtKB
  2. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. immune response Source: UniProtKB
  4. interferon-gamma-mediated signaling pathway Source: Reactome
  5. T cell costimulation Source: Reactome
  6. T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ alpha 1 chain
Alternative name(s):
DC-1 alpha chain
DC-alpha
HLA-DCA
MHC class II DQA1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4942. HLA-DQA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 216193ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23923HelicalSequence AnalysisAdd
BLAST
Topological domaini240 – 25415CytoplasmicAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. endocytic vesicle membrane Source: Reactome
  3. endosome Source: UniProtKB-KW
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi membrane Source: Reactome
  6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  7. integral component of plasma membrane Source: UniProtKB
  8. lysosomal membrane Source: Reactome
  9. membrane Source: UniProtKB
  10. MHC class II protein complex Source: UniProt
  11. plasma membrane Source: Reactome
  12. trans-Golgi network membrane Source: Reactome
  13. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

Orphaneti555. Celiac disease.
243377. Diabetes mellitus type 1.
PharmGKBiPA35066.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 254231HLA class II histocompatibility antigen, DQ alpha 1 chainPRO_0000018970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi132 ↔ 1883 PublicationsPROSITE-ProRule annotation
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01909.
PRIDEiP01909.

Expressioni

Gene expression databases

BgeeiP01909.
CleanExiHS_HLA-DQA1.
ExpressionAtlasiP01909. baseline and differential.
GenevestigatoriP01909.

Organism-specific databases

HPAiHPA012315.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.4 Publications

Protein-protein interaction databases

BioGridi109362. 29 interactions.
IntActiP01909. 11 interactions.

Structurei

Secondary structure

1
254
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 4012Combined sources
Turni41 – 444Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Turni62 – 654Combined sources
Beta strandi66 – 683Combined sources
Helixi72 – 776Combined sources
Helixi81 – 10121Combined sources
Turni102 – 1043Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi124 – 1263Combined sources
Beta strandi128 – 13710Combined sources
Beta strandi143 – 1486Combined sources
Beta strandi151 – 1533Combined sources
Beta strandi157 – 1593Combined sources
Beta strandi170 – 1789Combined sources
Beta strandi186 – 1916Combined sources
Beta strandi195 – 1973Combined sources
Beta strandi199 – 2024Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JK8X-ray2.40A27-206[»]
1NBNmodel-A27-206[»]
1S9VX-ray2.22A/D24-216[»]
1UVQX-ray1.80A24-218[»]
2NNAX-ray2.10A24-206[»]
4GG6X-ray3.20A/C24-206[»]
4OZFX-ray2.70A24-206[»]
4OZGX-ray3.00A/C24-206[»]
4OZHX-ray2.80A/C24-206[»]
4OZIX-ray3.20A/C24-206[»]
ProteinModelPortaliP01909.
SMRiP01909. Positions 27-205.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01909.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 20493Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 11996Alpha-1Add
BLAST
Regioni120 – 20384Alpha-2Add
BLAST
Regioni204 – 21613Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26577.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG006862.
InParanoidiP01909.
KOiK06752.
OMAiHWEPEIS.
PhylomeDBiP01909.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01909-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILNKALMLG ALALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH
60 70 80 90 100
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK
110 120 130 140 150
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG
160 170 180 190 200
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL
210 220 230 240 250
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH

QGPL
Length:254
Mass (Da):27,805
Last modified:July 21, 1986 - v1
Checksum:i84E12B5A80E2A028
GO

Sequence cautioni

The sequence AAD56720.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111A → S in AAA59760. (PubMed:3584986)Curated
Sequence conflicti23 – 275Missing in AAA59754. (PubMed:3879967)Curated
Sequence conflicti91 – 911L → H in AAA59760. (PubMed:3584986)Curated
Sequence conflicti107 – 1071A → P in AAA59754. (PubMed:3879967)Curated
Sequence conflicti156 – 1561G → D in CAA25141. (PubMed:6584734)Curated
Sequence conflicti213 – 2131E → D in AAA59754. (PubMed:3879967)Curated

Polymorphismi

The following alleles of DQA1 are known: DQA1*01:01, DQA1*01:02, DQA1*01:03, DQA1*01:04, DQA1*01:05, DQA1*01:06, DQA1*01:07, DQA1*02:01, DQA1*03:01, DQA1*03:02, DQA1*03:03, DQA1*04:01, DQA1*04:02, DQA1*04:03, DQA1*04:04, DQA1*05:01, DQA1*05:02, DQA1*05:03, DQA1*05:04, DQA1*05:05, DQA1*05:06, DQA1*05:07, DQA1*05:08, DQA1*05:09, DQA1*06:01, DQA1*06:02. The sequence shown is that of DQA1*05:01.
DQ2 (heterodimer of DQA1*05:01/DQB1*02:01) is associated with more than 90% of celiac disease patients. A minority displays DQ8 (heterodimer of DQA1*03/DQB1*03:02). DQ0602 (heterodimer of DQA1*01:02/DQB1*06:02) confers dominant protection against type 1 diabetes (T1D) and strong susceptibility to narcolepsy.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81M → L in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*04:01 and allele DQA1*06:01.
Corresponds to variant rs1047989 [ dbSNP | Ensembl ].
VAR_033399
Natural varianti11 – 111A → T in allele DQA1*05:05, allele DQA1*05:08 and allele DQA1*05:09.
Corresponds to variant rs1047992 [ dbSNP | Ensembl ].
VAR_033400
Natural varianti17 – 171V → M in allele DQA1*01:04 and allele DQA1*01:05.
Corresponds to variant rs12722039 [ dbSNP | Ensembl ].
VAR_050380
Natural varianti18 – 181M → T in allele DQA1*03:03.
Corresponds to variant rs12722040 [ dbSNP | Ensembl ].
VAR_050381
Natural varianti24 – 241E → K in allele DQA1*05:09.
Corresponds to variant rs41545012 [ dbSNP | Ensembl ].
VAR_060493
Natural varianti25 – 251D → G in allele DQA1*01:04 and allele DQA1*01:05.
Corresponds to variant rs12722042 [ dbSNP | Ensembl ].
VAR_050382
Natural varianti34 – 341Y → C in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1129740 [ dbSNP | Ensembl ].
VAR_060494
Natural varianti41 – 411S → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1071630 [ dbSNP | Ensembl ].
VAR_033401
Natural varianti44 – 441P → L in allele DQA1*05:04.
Corresponds to variant rs41549715 [ dbSNP | Ensembl ].
VAR_060495
Natural varianti48 – 481Y → F in allele DQA1*02:01, allele DQA1*01:03, allele DQA1*06:01 and allele DQA1*06:02.
Corresponds to variant rs12722051 [ dbSNP | Ensembl ].
VAR_033402
Natural varianti49 – 491T → S in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs3188011 [ dbSNP | Ensembl ].
VAR_033403
Natural varianti57 – 571Q → E in allele DQA1*01:01, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs10093 [ dbSNP | Ensembl ].
VAR_014604
Natural varianti63 – 631G → E in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs1142323 [ dbSNP | Ensembl ].
VAR_060496
Natural varianti64 – 641R → K in allele DQA1*01:03.
Corresponds to variant rs36219699 [ dbSNP | Ensembl ].
VAR_050383
Natural varianti67 – 671T → A in allele DQA1*01:06.
Corresponds to variant rs41543221 [ dbSNP | Ensembl ].
VAR_060497
Natural varianti68 – 681V → A in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1142324 [ dbSNP | Ensembl ].
VAR_060498
Natural varianti70 – 701C → K in allele DQA1*02:01; requires 2 nucleotide substitutions.
VAR_060499
Natural varianti70 – 701C → Q in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03; requires 2 nucleotide substitutions.
VAR_060500
Natural varianti70 – 701C → R in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
VAR_060501
Natural varianti70 – 701C → Y.
Corresponds to variant rs3207983 [ dbSNP | Ensembl ].
VAR_033404
Natural varianti71 – 711L → W in allele DQA1*01:01, allele DQA1*01:02,allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1142328 [ dbSNP | Ensembl ].
VAR_060502
Natural varianti73 – 731V → D.
VAR_033406
Natural varianti73 – 731V → E in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs3208105 [ dbSNP | Ensembl ].
VAR_060503
Natural varianti73 – 731V → L in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
VAR_033405
Natural varianti74 – 741L → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs9272698 [ dbSNP | Ensembl ].
VAR_060504
Natural varianti75 – 751R → H in allele DQA1*02:01.
VAR_060505
Natural varianti75 – 751R → S in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs9272699 [ dbSNP | Ensembl ].
VAR_060506
Natural varianti76 – 761Q → K in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1048052 [ dbSNP | Ensembl ].
VAR_060507
Natural varianti76 – 761Q → R in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
VAR_060508
Natural varianti77 – 771F → L in allele DQA1*02:01.
Corresponds to variant rs3188043 [ dbSNP | Ensembl ].
VAR_060509
Natural varianti78 – 781R → GG in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05,allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs4193 [ dbSNP | Ensembl ].
VAR_060510
Natural varianti78 – 781R → RR in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
VAR_060511
Natural varianti78 – 781R → S.
Corresponds to variant rs36219345 [ dbSNP | Ensembl ].
VAR_033407
Natural varianti81 – 811P → R in allele DQA1*05:02.
Corresponds to variant rs41541412 [ dbSNP | Ensembl ].
VAR_060512
Natural varianti83 – 831F → G in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions.
VAR_060513
Natural varianti86 – 861T → R in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1048073 [ dbSNP | Ensembl ].
VAR_033408
Natural varianti88 – 881I → M in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1048080 [ dbSNP | Ensembl ].
VAR_033409
Natural varianti91 – 911L → A in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07; requires 2 nucleotide substitutions.
VAR_060514
Natural varianti91 – 911L → T in allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02; requires 2 nucleotide substitutions.
VAR_060515
Natural varianti91 – 911L → V.
Corresponds to variant rs1048085 [ dbSNP | Ensembl ].
VAR_033410
Natural varianti97 – 971S → I in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
VAR_060516
Natural varianti98 – 981L → M in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
VAR_060517
Natural varianti98 – 981L → V in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
VAR_060518
Natural varianti101 – 1011R → C in allele DQA1*01:07.
VAR_060519
Natural varianti102 – 1021S → Y in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:06 and allele DQA1*01:07.
Corresponds to variant rs1129808 [ dbSNP | Ensembl ].
VAR_050384
Natural varianti124 – 1241L → V in allele DQA1*05:06.
VAR_060520
Natural varianti129 – 1291I → T in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
Corresponds to variant rs707952 [ dbSNP | Ensembl ].
VAR_050385
Natural varianti151 – 1511H → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07.
Corresponds to variant rs707950 [ dbSNP | Ensembl ].
VAR_050386
Natural varianti152 – 1521S → A in allele DQA1*01:03.
VAR_060521
Natural varianti160 – 1601T → I in allele DQA1*04:02.
VAR_060522
Natural varianti161 – 1611S → I in allele DQA1*05:08.
VAR_060524
Natural varianti161 – 1611S → R in allele DQA1*06:02.
VAR_060523
Natural varianti175 – 1751Y → H in allele DQA1*04:04.
VAR_060525
Natural varianti178 – 1781L → F in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
Corresponds to variant rs707949 [ dbSNP | Ensembl ].
VAR_060526
Natural varianti182 – 1821A → D in allele DQA1*03:02 and allele DQA1*03:03.
VAR_060527
Natural varianti182 – 1821A → S in allele DQA1*05:03, allele DQA1*05:06 and allele DQA1*05:07.
VAR_060528
Natural varianti183 – 1831E → D in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
Corresponds to variant rs707963 [ dbSNP | Ensembl ].
VAR_060529
Natural varianti185 – 1851S → I in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05, allele DQA1*01:07, allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
VAR_060530
Natural varianti197 – 1971K → E in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02, allele DQA1*03:03, allele DQA1*04:01, allele DQA1*04:02, allele DQA1*04:04, allele DQA1*06:01 and allele DQA1*06:02.
VAR_060531
Natural varianti197 – 1971K → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04, allele DQA1*01:05 and allele DQA1*01:07.
VAR_060532
Natural varianti209 – 2091A → T in allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs9272785 [ dbSNP | Ensembl ].
VAR_050387
Natural varianti221 – 2211A → T in allele DQA1*01:04.
Corresponds to variant rs35087390 [ dbSNP | Ensembl ].
VAR_050388
Natural varianti229 – 2291V → M in allele DQA1*01:02.
Corresponds to variant rs9260 [ dbSNP | Ensembl ].
VAR_033411
Natural varianti230 – 2301G → C in allele DQA1*05:07.
VAR_060533
Natural varianti237 – 2371F → L in allele DQA1*02:01, allele DQA1*03:01, allele DQA1*03:02 and allele DQA1*03:03.
Corresponds to variant rs1048430 [ dbSNP | Ensembl ].
VAR_033412
Natural varianti240 – 2401R → Q in allele DQA1*01:01, allele DQA1*01:02, allele DQA1*01:03, allele DQA1*01:04 and allele DQA1*01:05.
Corresponds to variant rs9272793 [ dbSNP | Ensembl ].
VAR_033413

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00033 mRNA. Translation: CAA24917.1.
X00370 mRNA. No translation available.
X00452 mRNA. Translation: CAA25141.1.
M16995 mRNA. Translation: AAA59760.1.
U92032 Genomic DNA. Translation: AAB91990.1.
AY663395 Genomic DNA. Translation: AAU87978.1.
AY663398 Genomic DNA. Translation: AAU87987.1.
AY663400 Genomic DNA. Translation: AAU87992.1.
AY663406 Genomic DNA. Translation: AAU88007.1.
AY663411 Genomic DNA. Translation: AAU88022.1.
AY663413 Genomic DNA. Translation: AAU88028.1.
DQ178403
, DQ178400, DQ178401, DQ178402 Genomic DNA. Translation: ABA86855.1.
DQ178407
, DQ178404, DQ178405, DQ178406 Genomic DNA. Translation: ABA86856.1.
DQ178411
, DQ178408, DQ178409, DQ178410 Genomic DNA. Translation: ABA86857.1.
DQ178415
, DQ178412, DQ178413, DQ178414 Genomic DNA. Translation: ABA86858.1.
M29616, M29613 Genomic DNA. Translation: AAA59759.1.
AF322870
, AF322867, AF322868, AF322869 Genomic DNA. Translation: AAK11577.1.
AF395700
, AF395697, AF395698, AF395699 Genomic DNA. Translation: AAM69677.1.
CR450297 mRNA. Translation: CAG29293.1.
AM042559 Genomic DNA. Translation: CAJ14960.1.
AM042560 Genomic DNA. Translation: CAJ14961.1.
AK313975 mRNA. Translation: BAG36689.1.
BX248406 Genomic DNA. Translation: CAM26191.1.
AL662789 Genomic DNA. Translation: CAI18230.1.
Z84489 Genomic DNA. Translation: CAB06491.1.
BC008585 mRNA. Translation: AAH08585.1.
BC157865 mRNA. Translation: AAI57866.1.
L46875 mRNA. No translation available.
L46876 mRNA. No translation available.
L46877 mRNA. No translation available.
L46878 mRNA. No translation available.
L46880 mRNA. No translation available.
L46881 mRNA. No translation available.
M11124 mRNA. Translation: AAA59754.1.
M20431 mRNA. Translation: AAA59758.1.
L34082 mRNA. Translation: AAC41950.1.
L34085 mRNA. Translation: AAC41953.1.
L34086 mRNA. Translation: AAC41954.1.
L34089 mRNA. Translation: AAC41957.1.
L34090 mRNA. Translation: AAC41958.1.
L34092 mRNA. Translation: AAC41960.1.
L34093 mRNA. Translation: AAC41961.1.
L34094 mRNA. Translation: AAC41962.1.
L42625 mRNA. Translation: AAA85334.1.
AY197775 Genomic DNA. Translation: AAO45622.1.
AY547314 Genomic DNA. Translation: AAS49496.1.
AY206406 Genomic DNA. Translation: AAO47362.1.
AY585236 Genomic DNA. Translation: AAT09985.1.
M34997 Genomic DNA. Translation: AAA35772.1.
M34999 Genomic DNA. Translation: AAA74633.1.
U85035 Genomic DNA. Translation: AAB41891.1.
AF109734 Genomic DNA. Translation: AAD56720.1. Sequence problems.
U03675 Genomic DNA. Translation: AAB60341.1.
M20506 mRNA. Translation: AAA59774.1.
J00199 mRNA. No translation available.
M17846 mRNA. Translation: AAA59707.1.
PIRiA02211. HLHUD1.
A02213. HLHUDQ.
A02214. HLHUD7.
A02215. HLHU3C.
A93326. HLHUDC.
B27628.
D34512.
RefSeqiNP_002113.2. NM_002122.3.
XP_003120317.1. XM_003120269.3.
XP_005275010.1. XM_005274953.2.
XP_005275165.1. XM_005275108.2.
XP_005275599.1. XM_005275542.2.
XP_005276137.1. XM_005276080.2.
XP_006725547.1. XM_006725484.1.
XP_006726062.1. XM_006725999.1.
UniGeneiHs.387679.
Hs.591798.
Hs.706240.

Genome annotation databases

EnsembliENST00000343139; ENSP00000339398; ENSG00000196735.
ENST00000374949; ENSP00000364087; ENSG00000196735.
ENST00000383251; ENSP00000372738; ENSG00000206305.
ENST00000395363; ENSP00000378767; ENSG00000196735.
ENST00000399675; ENSP00000382583; ENSG00000206305.
ENST00000399678; ENSP00000382586; ENSG00000206305.
ENST00000418023; ENSP00000387892; ENSG00000232062.
ENST00000444296; ENSP00000413237; ENSG00000232062.
ENST00000548014; ENSP00000447970; ENSG00000206305.
GeneIDi100509457.
3117.
KEGGihsa:100509457.
hsa:3117.
UCSCiuc011fnq.1. human.

Polymorphism databases

DMDMi122188.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00033 mRNA. Translation: CAA24917.1 .
X00370 mRNA. No translation available.
X00452 mRNA. Translation: CAA25141.1 .
M16995 mRNA. Translation: AAA59760.1 .
U92032 Genomic DNA. Translation: AAB91990.1 .
AY663395 Genomic DNA. Translation: AAU87978.1 .
AY663398 Genomic DNA. Translation: AAU87987.1 .
AY663400 Genomic DNA. Translation: AAU87992.1 .
AY663406 Genomic DNA. Translation: AAU88007.1 .
AY663411 Genomic DNA. Translation: AAU88022.1 .
AY663413 Genomic DNA. Translation: AAU88028.1 .
DQ178403
, DQ178400 , DQ178401 , DQ178402 Genomic DNA. Translation: ABA86855.1 .
DQ178407
, DQ178404 , DQ178405 , DQ178406 Genomic DNA. Translation: ABA86856.1 .
DQ178411
, DQ178408 , DQ178409 , DQ178410 Genomic DNA. Translation: ABA86857.1 .
DQ178415
, DQ178412 , DQ178413 , DQ178414 Genomic DNA. Translation: ABA86858.1 .
M29616 , M29613 Genomic DNA. Translation: AAA59759.1 .
AF322870
, AF322867 , AF322868 , AF322869 Genomic DNA. Translation: AAK11577.1 .
AF395700
, AF395697 , AF395698 , AF395699 Genomic DNA. Translation: AAM69677.1 .
CR450297 mRNA. Translation: CAG29293.1 .
AM042559 Genomic DNA. Translation: CAJ14960.1 .
AM042560 Genomic DNA. Translation: CAJ14961.1 .
AK313975 mRNA. Translation: BAG36689.1 .
BX248406 Genomic DNA. Translation: CAM26191.1 .
AL662789 Genomic DNA. Translation: CAI18230.1 .
Z84489 Genomic DNA. Translation: CAB06491.1 .
BC008585 mRNA. Translation: AAH08585.1 .
BC157865 mRNA. Translation: AAI57866.1 .
L46875 mRNA. No translation available.
L46876 mRNA. No translation available.
L46877 mRNA. No translation available.
L46878 mRNA. No translation available.
L46880 mRNA. No translation available.
L46881 mRNA. No translation available.
M11124 mRNA. Translation: AAA59754.1 .
M20431 mRNA. Translation: AAA59758.1 .
L34082 mRNA. Translation: AAC41950.1 .
L34085 mRNA. Translation: AAC41953.1 .
L34086 mRNA. Translation: AAC41954.1 .
L34089 mRNA. Translation: AAC41957.1 .
L34090 mRNA. Translation: AAC41958.1 .
L34092 mRNA. Translation: AAC41960.1 .
L34093 mRNA. Translation: AAC41961.1 .
L34094 mRNA. Translation: AAC41962.1 .
L42625 mRNA. Translation: AAA85334.1 .
AY197775 Genomic DNA. Translation: AAO45622.1 .
AY547314 Genomic DNA. Translation: AAS49496.1 .
AY206406 Genomic DNA. Translation: AAO47362.1 .
AY585236 Genomic DNA. Translation: AAT09985.1 .
M34997 Genomic DNA. Translation: AAA35772.1 .
M34999 Genomic DNA. Translation: AAA74633.1 .
U85035 Genomic DNA. Translation: AAB41891.1 .
AF109734 Genomic DNA. Translation: AAD56720.1 . Sequence problems.
U03675 Genomic DNA. Translation: AAB60341.1 .
M20506 mRNA. Translation: AAA59774.1 .
J00199 mRNA. No translation available.
M17846 mRNA. Translation: AAA59707.1 .
PIRi A02211. HLHUD1.
A02213. HLHUDQ.
A02214. HLHUD7.
A02215. HLHU3C.
A93326. HLHUDC.
B27628.
D34512.
RefSeqi NP_002113.2. NM_002122.3.
XP_003120317.1. XM_003120269.3.
XP_005275010.1. XM_005274953.2.
XP_005275165.1. XM_005275108.2.
XP_005275599.1. XM_005275542.2.
XP_005276137.1. XM_005276080.2.
XP_006725547.1. XM_006725484.1.
XP_006726062.1. XM_006725999.1.
UniGenei Hs.387679.
Hs.591798.
Hs.706240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JK8 X-ray 2.40 A 27-206 [» ]
1NBN model - A 27-206 [» ]
1S9V X-ray 2.22 A/D 24-216 [» ]
1UVQ X-ray 1.80 A 24-218 [» ]
2NNA X-ray 2.10 A 24-206 [» ]
4GG6 X-ray 3.20 A/C 24-206 [» ]
4OZF X-ray 2.70 A 24-206 [» ]
4OZG X-ray 3.00 A/C 24-206 [» ]
4OZH X-ray 2.80 A/C 24-206 [» ]
4OZI X-ray 3.20 A/C 24-206 [» ]
ProteinModelPortali P01909.
SMRi P01909. Positions 27-205.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109362. 29 interactions.
IntActi P01909. 11 interactions.

Polymorphism databases

DMDMi 122188.

Proteomic databases

PaxDbi P01909.
PRIDEi P01909.

Protocols and materials databases

DNASUi 3117.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343139 ; ENSP00000339398 ; ENSG00000196735 .
ENST00000374949 ; ENSP00000364087 ; ENSG00000196735 .
ENST00000383251 ; ENSP00000372738 ; ENSG00000206305 .
ENST00000395363 ; ENSP00000378767 ; ENSG00000196735 .
ENST00000399675 ; ENSP00000382583 ; ENSG00000206305 .
ENST00000399678 ; ENSP00000382586 ; ENSG00000206305 .
ENST00000418023 ; ENSP00000387892 ; ENSG00000232062 .
ENST00000444296 ; ENSP00000413237 ; ENSG00000232062 .
ENST00000548014 ; ENSP00000447970 ; ENSG00000206305 .
GeneIDi 100509457.
3117.
KEGGi hsa:100509457.
hsa:3117.
UCSCi uc011fnq.1. human.

Organism-specific databases

CTDi 3117.
GeneCardsi GC06P032595.
GC06Pn32538.
GC06Po32698.
GeneReviewsi HLA-DQA1.
HGNCi HGNC:4942. HLA-DQA1.
HPAi HPA012315.
MIMi 146880. gene.
neXtProti NX_P01909.
Orphaneti 555. Celiac disease.
243377. Diabetes mellitus type 1.
PharmGKBi PA35066.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26577.
GeneTreei ENSGT00760000118970.
HOVERGENi HBG006862.
InParanoidi P01909.
KOi K06752.
OMAi HWEPEIS.
PhylomeDBi P01909.
TreeFami TF333797.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSi HLA-DQA1. human.
EvolutionaryTracei P01909.
NextBioi 12366.
PROi P01909.
SOURCEi Search...

Gene expression databases

Bgeei P01909.
CleanExi HS_HLA-DQA1.
ExpressionAtlasi P01909. baseline and differential.
Genevestigatori P01909.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The heavy chain of human B-cell alloantigen HLA-DS has a variable N-terminal region and a constant immunoglobulin-like region."
    Chang H.-C., Moriuchi T., Silver J.
    Nature 305:813-815(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*02:01).
  2. "Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains."
    Schenning L., Larhammar D., Bill P., Wiman K., Jonsson A.-K., Rask L., Peterson P.A.
    EMBO J. 3:447-452(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*05:01).
  3. "Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes."
    Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D., Strominger J.L.
    Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DQA1*01:02 AND ALLELE DQA1*03:01).
  4. "Complete sequence of the HLA DQ alpha and DQ beta cDNA from a DR5/DQw3 cell line."
    Schiffenbauer J., Didier D.K., Klearman M., Rice K., Shuman S., Tieber V.L., Kittlesen D.J., Schwartz B.D.
    J. Immunol. 139:228-233(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DQA1*05:01).
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*05:01).
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:01; DQA1*01:02 AND DQA1*03:01).
  7. "Four novel human leukocyte antigen-DQA1 alleles identified in the Korean population."
    Lee K.W., Jung Y.A., Oh D.H.
    Tissue Antigens 68:167-172(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:02; DQA1*05:06; DQA1*05:07 AND DQA1*05:08).
  8. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
    Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
    J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*03:01).
  9. "Identification of a novel DQA1 allele, DQA1*01012, and confirmatory sequence of DQA1*01011."
    Ashdown M.L., Leas L., Gavrilidis A., Wood J.M., Simons M.J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE DQA1*01:01).
  10. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQA1*02:01).
  11. "New and confirmatory HLA sequences by SBT."
    Voorter C.E., van den Berg-Loonen E.M.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DQA1*01:02 AND DQA1*05:09).
  12. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE DQA1*01:01).
    Tissue: Trachea.
  13. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES DQA1*01:02; DQA1*03:01 AND DQA1*05:01).
  14. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DQA1*03:01 AND DQA1*05:01).
    Tissue: Lymph.
  15. "Sequence polymorphisms in HLA-DQA1 exon1."
    Yasunaga S., Kimura A., Sasazuki T.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-27 (ALLELES DQA1*01:01/DQA1*01:02/DQA1*01:03; DQA1*01:04; DQA1*01:05; DQA1*02:01/DQA1*03:01/DQA1*03:03; DQA1*04:01/DQA1*06:01 AND DQA1*05:01/DQA1*05:03/DQA1*05:05).
    Tissue: B-cell.
  16. "Nucleotide sequence of an HLA-DQ alpha chain derived from a DRw9 cell line: genetic and evolutionary implications."
    Moriuchi J., Moriuchi T., Silver J.
    Proc. Natl. Acad. Sci. U.S.A. 82:3420-3424(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-254 (ALLELE DQA1*03:02).
  17. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 23-254 (ALLELE DQA1*01:02).
  18. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
    Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
    Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-250 (ALLELE DQA1*03:02/DQA1*03:03) AND NUCLEOTIDE SEQUENCE [MRNA] OF 24-249 (ALLELES DQA1*01:01; DQA1*01:03; DQA1*01:04; DQA1*04:01; DQA1*05:03; DQA1*05:05 AND DQA1*06:01).
  19. Yasunaga S.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-249 (ALLELE DQA1*01:05).
  20. "Primary structure of human class II histocompatibility antigens 3rd communication. Amino acid sequence comparison between DR and DC subclass antigens derived from a lymphoblastoid B cell line homozygous at the HLA loci (HLA-A3,3; B7,7; Dw2,2; DR2,2: MT1,1; Dc1,1: MB1,1)."
    Goetz H., Kratzin H., Thinnes F.P., Yang C.-Y., Kruse T., Pauly E., Koelbel S., Egert G., Wernet P., Hilschmann N.
    Hoppe-Seyler's Z. Physiol. Chem. 364:749-755(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-89; 102-120 AND 164-212 (ALLELE DQA1*01:02).
  21. "Molecular analysis of the HLA class II genes in two DRw6-related haplotypes, DRw13 DQw1 and DRw14 DQw3."
    Kao H.T., Gregersen P.K., Tang J.C., Takahashi T., Wang C.Y., Silver J.
    J. Immunol. 142:1743-1747(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-209 (ALLELE DQA1*05:01).
  22. "High-resolution genotyping of HLA-DQA1 in the GoKinD study and identification of novel alleles HLA-DQA1*040102, HLA-DQA1*0402 and HLA-DQA1*0404."
    Cordovado S.K., Hancock L.N., Simone A.E., Hendrix M., Mueller P.W.
    Tissue Antigens 65:448-458(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELES DQA1*04:02 AND DQA1*04:04).
  23. "Identification of a novel HLA-DQA1*06 allele detected by sequence-based typing."
    Simone A.E., Cordovado S.K., Hendrix M.M., Mueller P.W.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELE DQA1*06:02).
  24. "Identification of a novel HLA-DQA1*01 allele detected by sequence-based typing."
    Hancock L.N., Cordovado S.K., Mueller P.W.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-203 (ALLELE DQA1*01:07).
  25. "Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals."
    Horn G.T., Bugawan T.L., Long C.M., Manos M.M., Erlich H.A.
    Hum. Immunol. 21:249-263(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-110 (ALLELE DQA1*01:02), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-109 (ALLELE DQA1*05:01).
  26. "DQA1 subtyping in Australian Aborigines. Additional evidence for heterogeneity."
    Trejaut J.A., Greville W.D., Dunckley H.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 29-109 (ALLELE DQA1*05:04).
  27. "Identification of a novel HLA-DQA1 allele (DQA1*0106) by sequence-based DQA1 typing."
    Luo M., Blanchard J., Maclean I., Brunham R.
    Tissue Antigens 53:595-596(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-109 (ALLELE DQA1*01:06).
  28. "HLA class II nucleotide sequences, 1992."
    Marsh S.G., Bodomer J.G.
    Tissue Antigens 40:229-243(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-74 (ALLELE DQA1*05:02).
  29. "Molecular studies of a rare DR2/LD-5a/DQw3 HLA class II haplotype. Multiple genetic mechanisms in the generation of polymorphic HLA class II genes."
    Liu C.P., Bach F.H., Wu S.K.
    J. Immunol. 140:3631-3639(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 36-254 (ALLELE DQA1*05:01).
  30. Erratum
    Liu C.P., Bach F.H., Wu S.K.
    J. Immunol. 144:15441-15441(1990)
  31. "cDNA clone for the heavy chain of the human B cell alloantigen DC1: strong sequence homology to the HLA-DR heavy chain."
    Auffray C., Korman A.J., Roux-Dosseto M., Bono R., Strominger J.L.
    Proc. Natl. Acad. Sci. U.S.A. 79:6337-6341(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 40-254 (ALLELE DQA1*03:01).
  32. "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates."
    Gyllensten U.B., Erlich H.A.
    Proc. Natl. Acad. Sci. U.S.A. 86:9986-9990(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-102 (ALLELE DQA1*05:01), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-103 (ALLELE DQA1*01:02).
  33. "Allelic forms of the alpha- and beta-chain genes encoding DQw1-positive heterodimers."
    Turco E., Care A., Compagnone-Post P., Robinson C., Cascino I., Trucco M.
    Immunogenetics 26:282-290(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 119-254 (ALLELE DQA1*01:02).
  34. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  35. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  36. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  37. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  38. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  39. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  40. "Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes."
    Lee K.H., Wucherpfennig K.W., Wiley D.C.
    Nat. Immunol. 2:501-507(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 27-207 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH INS PEPTIDE, SUBUNIT, GLYCOSYLATION AT ASN-103, DISULFIDE BOND.
  41. "Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."
    Siebold C., Hansen B.E., Wyer J.R., Harlos K., Esnouf R.E., Svejgaard A., Bell J.I., Strominger J.L., Jones E.Y., Fugger L.
    Proc. Natl. Acad. Sci. U.S.A. 101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 24-219 OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602) IN COMPLEX WITH HCRT PEPTIDE, POLYMORPHISM, SUBUNIT, DISULFIDE BOND.
  42. "Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease."
    Kim C.Y., Quarsten H., Bergseng E., Khosla C., Sollid L.M.
    Proc. Natl. Acad. Sci. U.S.A. 101:4175-4179(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 24-216 OF HLA-DQA1/HLA-DQB1 HETERODIMER (DQ2) IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN PEPTIDE, SUBUNIT, POLYMORPHISM.
  43. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 24-206 OF HLA-DQA1/HLA-DQB1 HETERODIMER IN COMPLEX WITH TRITICUM AESTIVUM ALPHA/BETA-GLIADIN, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiDQA1_HUMAN
AccessioniPrimary (citable) accession number: P01909
Secondary accession number(s): O19630
, O19706, P01907, P01908, P04225, P04226, P05536, P79553, Q06751, Q29876, Q29994, Q2Q6Y6, Q2Q6Y7, Q2Q6Y8, Q2WCM3, Q30064, Q30067, Q30068, Q30070, Q30071, Q30072, Q30073, Q30086, Q30101, Q5Y7D5, Q5Y7F5, Q6ICU6, Q6PR46, Q6QDB1, Q860W2, Q860W4, Q9BD37, Q9TPM3, Q9UM31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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