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P01906

- DQA2_HUMAN

UniProt

P01906 - DQA2_HUMAN

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Protein

HLA class II histocompatibility antigen, DQ alpha 2 chain

Gene

HLA-DQA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.1 Publication

GO - Molecular functioni

  1. MHC class II receptor activity Source: UniProtKB

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. cytokine-mediated signaling pathway Source: Reactome
  3. immune response Source: UniProtKB
  4. interferon-gamma-mediated signaling pathway Source: Reactome
  5. T cell costimulation Source: Reactome
  6. T cell receptor signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DQ alpha 2 chain
Alternative name(s):
DX alpha chain
HLA class II histocompatibility antigen, DQ(6) alpha chain
HLA-DQA1
MHC class II DQA2
Gene namesi
Name:HLA-DQA2
Synonyms:HLA-DXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:4943. HLA-DQA2.

Subcellular locationi

Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 217194ExtracellularSequence AnalysisAdd
BLAST
Transmembranei218 – 24023HelicalSequence AnalysisAdd
BLAST
Topological domaini241 – 25515CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated endocytic vesicle membrane Source: Reactome
  2. endocytic vesicle membrane Source: Reactome
  3. endosome Source: UniProtKB-KW
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi membrane Source: Reactome
  6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  7. integral component of plasma membrane Source: UniProtKB
  8. lysosomal membrane Source: Reactome
  9. MHC class II protein complex Source: UniProtKB-KW
  10. plasma membrane Source: Reactome
  11. trans-Golgi network membrane Source: Reactome
  12. transport vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35067.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 255232HLA class II histocompatibility antigen, DQ alpha 2 chainPRO_0000018973Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi133 ↔ 189PROSITE-ProRule annotation
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01906.
PaxDbiP01906.
PRIDEiP01906.

PTM databases

PhosphoSiteiP01906.

Expressioni

Tissue specificityi

Restricted to skin Langerhans cells, although some expression at low levels may occur at the surface of B lymphoblastoid cells.2 Publications

Gene expression databases

BgeeiP01906.
CleanExiHS_HLA-DQA2.
ExpressionAtlasiP01906. baseline and differential.
GenevestigatoriP01906.

Organism-specific databases

HPAiHPA010967.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. Dimer formation with HLA-DQB2, but not with HLA-DQB1, is required for efficient exit from the endoplasmic reticulum (ER). In the ER, forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Association with HLA-DMA also occurs in skin Langerhans cells, in post-Golgi compartments.1 Publication

Protein-protein interaction databases

BioGridi109363. 1 interaction.
STRINGi9606.ENSP00000391434.

Structurei

3D structure databases

ProteinModelPortaliP01906.
SMRiP01906. Positions 25-208.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 20593Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 11087Alpha-1Add
BLAST
Regioni111 – 20494Alpha-2Add
BLAST
Regioni205 – 21713Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG26577.
GeneTreeiENSGT00760000118970.
HOGENOMiHOG000112076.
InParanoidiP01906.
KOiK06752.
OMAiVPEMALF.
OrthoDBiEOG7C2R26.
PhylomeDBiP01906.
TreeFamiTF333797.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01906-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILNKALLLG ALALTAVMSP CGGEDIVADH VASYGVNFYQ SHGPSGQYTH
60 70 80 90 100
EFDGDEEFYV DLETKETVWQ LPMFSKFISF DPQSALRNMA VGKHTLEFMM
110 120 130 140 150
RQSNSTAATN EVPEVTVFSK FPVTLGQPNT LICLVDNIFP PVVNITWLSN
160 170 180 190 200
GHSVTEGVSE TSFLSKSDHS FFKISYLTFL PSADEIYDCK VEHWGLDEPL
210 220 230 240 250
LKHWEPEIPA PMSELTETLV CALGLSVGLM GIVVGTVFII QGLRSVGASR

HQGLL
Length:255
Mass (Da):28,033
Last modified:February 1, 1991 - v2
Checksum:i85B13D9FDF2905FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 841S → T in AAA59834. (PubMed:3036828)Curated
Sequence conflicti101 – 1011R → G in CAM26196. (PubMed:14574404)Curated
Sequence conflicti101 – 1011R → G in CAM26195. (PubMed:14574404)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271V → A.1 Publication
Corresponds to variant rs9276436 [ dbSNP | Ensembl ].
VAR_033431
Natural varianti247 – 2471G → D.1 Publication
Corresponds to variant rs2071800 [ dbSNP | Ensembl ].
VAR_050392

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29615, M29614 Genomic DNA. Translation: AAA59834.1.
X00453
, X00454, X00455, X00456 Genomic DNA. Translation: CAA25142.1.
M17237, M17235 Genomic DNA. Translation: AAA59605.1.
CR759848 Genomic DNA. Translation: CAQ07531.1.
AL773543 Genomic DNA. Translation: CAI18490.1.
BX248406, BX927131 Genomic DNA. Translation: CAM26195.1.
BX927131, BX248406 Genomic DNA. Translation: CAM26196.1.
AL713890 Genomic DNA. Translation: CAI17623.1.
AL672104 Genomic DNA. Translation: CAI18437.1.
CR936921 Genomic DNA. Translation: CAQ07312.1.
CR753846 Genomic DNA. Translation: CAQ09761.1.
BX927160, BX927168 Genomic DNA. Translation: CAQ10975.1.
BX927168, BX927160 Genomic DNA. Translation: CAQ08754.1.
S71248 Genomic DNA. Translation: AAD14077.1.
CCDSiCCDS4753.1.
PIRiA02210. HLHUDX.
I54439.
RefSeqiNP_064440.1. NM_020056.4.
UniGeneiHs.591798.

Genome annotation databases

EnsembliENST00000241802; ENSP00000241802; ENSG00000206301.
ENST00000374940; ENSP00000364076; ENSG00000237541.
ENST00000415898; ENSP00000400695; ENSG00000231526.
ENST00000443184; ENSP00000405833; ENSG00000257473.
ENST00000446482; ENSP00000390725; ENSG00000225103.
ENST00000447735; ENSP00000393431; ENSG00000223793.
ENST00000449560; ENSP00000401098; ENSG00000233192.
ENST00000453672; ENSP00000387768; ENSG00000231823.
ENST00000546801; ENSP00000447668; ENSG00000233192.
ENST00000551533; ENSP00000448003; ENSG00000223793.
GeneIDi3118.
KEGGihsa:3118.
UCSCiuc003obx.3. human.

Polymorphism databases

DMDMi122192.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29615 , M29614 Genomic DNA. Translation: AAA59834.1 .
X00453
, X00454 , X00455 , X00456 Genomic DNA. Translation: CAA25142.1 .
M17237 , M17235 Genomic DNA. Translation: AAA59605.1 .
CR759848 Genomic DNA. Translation: CAQ07531.1 .
AL773543 Genomic DNA. Translation: CAI18490.1 .
BX248406 , BX927131 Genomic DNA. Translation: CAM26195.1 .
BX927131 , BX248406 Genomic DNA. Translation: CAM26196.1 .
AL713890 Genomic DNA. Translation: CAI17623.1 .
AL672104 Genomic DNA. Translation: CAI18437.1 .
CR936921 Genomic DNA. Translation: CAQ07312.1 .
CR753846 Genomic DNA. Translation: CAQ09761.1 .
BX927160 , BX927168 Genomic DNA. Translation: CAQ10975.1 .
BX927168 , BX927160 Genomic DNA. Translation: CAQ08754.1 .
S71248 Genomic DNA. Translation: AAD14077.1 .
CCDSi CCDS4753.1.
PIRi A02210. HLHUDX.
I54439.
RefSeqi NP_064440.1. NM_020056.4.
UniGenei Hs.591798.

3D structure databases

ProteinModelPortali P01906.
SMRi P01906. Positions 25-208.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109363. 1 interaction.
STRINGi 9606.ENSP00000391434.

Chemistry

DrugBanki DB00071. "Insulin.

PTM databases

PhosphoSitei P01906.

Polymorphism databases

DMDMi 122192.

Proteomic databases

MaxQBi P01906.
PaxDbi P01906.
PRIDEi P01906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000241802 ; ENSP00000241802 ; ENSG00000206301 .
ENST00000374940 ; ENSP00000364076 ; ENSG00000237541 .
ENST00000415898 ; ENSP00000400695 ; ENSG00000231526 .
ENST00000443184 ; ENSP00000405833 ; ENSG00000257473 .
ENST00000446482 ; ENSP00000390725 ; ENSG00000225103 .
ENST00000447735 ; ENSP00000393431 ; ENSG00000223793 .
ENST00000449560 ; ENSP00000401098 ; ENSG00000233192 .
ENST00000453672 ; ENSP00000387768 ; ENSG00000231823 .
ENST00000546801 ; ENSP00000447668 ; ENSG00000233192 .
ENST00000551533 ; ENSP00000448003 ; ENSG00000223793 .
GeneIDi 3118.
KEGGi hsa:3118.
UCSCi uc003obx.3. human.

Organism-specific databases

CTDi 3118.
GeneCardsi GC06P032709.
GC06Pi32694.
GC06Pj32632.
GC06Pk32688.
GC06Pl32862.
GC06Pm32742.
GC06Pn32637.
GC06Po32799.
H-InvDB HIX0058177.
HIX0166445.
HIX0166701.
HGNCi HGNC:4943. HLA-DQA2.
HPAi HPA010967.
MIMi 613503. gene.
neXtProti NX_P01906.
PharmGKBi PA35067.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG26577.
GeneTreei ENSGT00760000118970.
HOGENOMi HOG000112076.
InParanoidi P01906.
KOi K06752.
OMAi VPEMALF.
OrthoDBi EOG7C2R26.
PhylomeDBi P01906.
TreeFami TF333797.

Enzyme and pathway databases

Reactomei REACT_121399. MHC class II antigen presentation.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.
REACT_25078. Interferon gamma signaling.

Miscellaneous databases

GeneWikii HLA-DQA2.
GenomeRNAii 3118.
NextBioi 12376.
PROi P01906.
SOURCEi Search...

Gene expression databases

Bgeei P01906.
CleanExi HS_HLA-DQA2.
ExpressionAtlasi P01906. baseline and differential.
Genevestigatori P01906.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
    Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
    J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes."
    Auffray C., Lillie J.W., Arnot D., Grossberger D., Kappes D., Strominger J.L.
    Nature 308:327-333(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE LAMBDA DCH-10).
  3. "Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector."
    Auffray C., Lillie J.W., Korman A.J., Boss J.M., Frechin N., Guillemot F., Cooper J., Mulligan R.C., Strominger J.L.
    Immunogenetics 26:63-73(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANTS ALA-227 AND ASP-247.
  5. "Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer."
    Rudy G., Lew A.M.
    Hum. Immunol. 39:225-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-13.
  6. "Ancient roots for polymorphism at the HLA-DQ alpha locus in primates."
    Gyllensten U.B., Erlich H.A.
    Proc. Natl. Acad. Sci. U.S.A. 86:9986-9990(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-103.
  7. "The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells."
    Rudy G.B., Lew A.M.
    J. Immunol. 158:2116-2125(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Invariant chain structure and MHC class II function."
    Cresswell P.
    Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  9. "Presentation of antigens by MHC class II molecules: getting the most out of them."
    Villadangos J.A.
    Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "MHC class II molecules on the move for successful antigen presentation."
    Rocha N., Neefjes J.
    EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. "Autophagy in MHC class II presentation: sampling from within."
    Menendez-Benito V., Neefjes J.
    Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  12. "MHC class II transport at a glance."
    Berger A.C., Roche P.A.
    J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  13. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
    Beswick E.J., Reyes V.E.
    World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. "HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule."
    Lenormand C., Bausinger H., Gross F., Signorino-Gelo F., Koch S., Peressin M., Fricker D., Cazenave J.P., Bieber T., Hanau D., de la Salle H., Tourne S.
    J. Immunol. 188:3903-3911(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH CD74; HLA-DMA; HLA-DQB1 AND HLA-DQB2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDQA2_HUMAN
AccessioniPrimary (citable) accession number: P01906
Secondary accession number(s): A2BF37
, B0V0E7, O19789, Q5SQ94, Q5SR04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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