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Protein

H-2 class II histocompatibility antigen, E-D alpha chain

Gene

H2-Ea

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class II histocompatibility antigen, E-D alpha chain
Short name:
H2-IE-alpha
Gene namesi
Name:H2-Ea
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95900. H2-Ea.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 216ExtracellularSequence analysisAdd BLAST191
Transmembranei217 – 242HelicalSequence analysisAdd BLAST26
Topological domaini243 – 255CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000001897826 – 255H-2 class II histocompatibility antigen, E-D alpha chainAdd BLAST230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi132 ↔ 188PROSITE-ProRule annotation
Glycosylationi143N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01904.

Interactioni

Protein-protein interaction databases

IntActiP01904. 1 interactor.
MINTiMINT-4097192.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 40Combined sources11
Turni41 – 43Combined sources3
Beta strandi44 – 51Combined sources8
Beta strandi54 – 60Combined sources7
Turni61 – 64Combined sources4
Beta strandi65 – 70Combined sources6
Helixi71 – 75Combined sources5
Helixi81 – 101Combined sources21
Turni102 – 104Combined sources3
Beta strandi113 – 120Combined sources8
Beta strandi128 – 140Combined sources13
Beta strandi143 – 148Combined sources6
Beta strandi151 – 153Combined sources3
Beta strandi155 – 159Combined sources5
Beta strandi166 – 168Combined sources3
Beta strandi170 – 178Combined sources9
Beta strandi185 – 191Combined sources7
Beta strandi199 – 204Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IEAX-ray2.30A/C26-217[»]
1IEBX-ray2.70A/C26-217[»]
1KT2X-ray2.80A/C26-207[»]
1KTDX-ray2.40A/C26-207[»]
ProteinModelPortaliP01904.
SMRiP01904.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01904.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 204Ig-like C1-typeAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 109Alpha-1Add BLAST84
Regioni110 – 203Alpha-2Add BLAST94
Regioni204 – 216Connecting peptideAdd BLAST13

Sequence similaritiesi

Belongs to the MHC class II family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG006862.
InParanoidiP01904.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01904-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIGALVLR FFFIAVLMSS QKSWAIKEEH TIIQAEFYLL PDKRGEFMFD
60 70 80 90 100
FDGDEIFHVD IEKSETIWRL EEFAKFASFE AQGALANIAV DKANLDVMKE
110 120 130 140 150
RSNNTPDANV APEVTVLSRS PVNLGEPNIL ICFIDKFSPP VVNVTWLRNG
160 170 180 190 200
RPVTEGVSET VFLPRDDHLF RKFHYLTFLP STDDFYDCEV DHWGLEEPLR
210 220 230 240 250
KTWEFEEKTL LPETKENVMC ALGLFVGLVG IVVGIILIMK GIKKRNVVER

RQGAL
Length:255
Mass (Da):29,117
Last modified:January 1, 1990 - v2
Checksum:i0852EA3AA4EE2674
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti155E → T in AAA39582 (PubMed:6815800).Curated1
Sequence conflicti202T → A in AAA39582 (PubMed:6815800).Curated1
Sequence conflicti239M → A no nucleotide entry (PubMed:6415003).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00971 Genomic DNA. Translation: AAA98624.1.
J00396 Genomic DNA. Translation: AAA39582.1.
PIRiB91743. HLMSED.
UniGeneiMm.15680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K00971 Genomic DNA. Translation: AAA98624.1.
J00396 Genomic DNA. Translation: AAA39582.1.
PIRiB91743. HLMSED.
UniGeneiMm.15680.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IEAX-ray2.30A/C26-217[»]
1IEBX-ray2.70A/C26-217[»]
1KT2X-ray2.80A/C26-207[»]
1KTDX-ray2.40A/C26-207[»]
ProteinModelPortaliP01904.
SMRiP01904.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01904. 1 interactor.
MINTiMINT-4097192.

Proteomic databases

PRIDEiP01904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95900. H2-Ea.

Phylogenomic databases

HOVERGENiHBG006862.
InParanoidiP01904.

Miscellaneous databases

EvolutionaryTraceiP01904.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA21_MOUSE
AccessioniPrimary (citable) accession number: P01904
Secondary accession number(s): Q31157
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.