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Protein

H-2 class I histocompatibility antigen, K-D alpha chain

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • defense response to bacterium Source: MGI
  • inner ear development Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, K-D alpha chain
Short name:
H-2K(D)
Gene namesi
Name:H2-K1
Synonyms:H2-K
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95904 H2-K1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23
Topological domaini329 – 368CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001892922 – 368H-2 class I histocompatibility antigen, K-D alpha chainAdd BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi122 ↔ 185PROSITE-ProRule annotation
Glycosylationi197N-linked (GlcNAc...) asparagine1 PublicationSequence analysis1
Disulfide bondi224 ↔ 280PROSITE-ProRule annotation
Glycosylationi277N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei350PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP01902
MaxQBiP01902
PRIDEiP01902

PTM databases

iPTMnetiP01902
PhosphoSitePlusiP01902

Expressioni

Gene expression databases

CleanExiMM_H2-K1

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01902, 1 interactor

Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 35Combined sources12
Turni36 – 38Combined sources3
Beta strandi39 – 49Combined sources11
Beta strandi52 – 58Combined sources7
Beta strandi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Helixi71 – 73Combined sources3
Helixi78 – 105Combined sources28
Beta strandi110 – 112Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi129 – 139Combined sources11
Beta strandi142 – 147Combined sources6
Beta strandi154 – 158Combined sources5
Helixi159 – 171Combined sources13
Helixi173 – 182Combined sources10
Helixi184 – 195Combined sources12
Helixi197 – 200Combined sources4
Beta strandi202 – 204Combined sources3
Beta strandi207 – 214Combined sources8
Beta strandi216 – 232Combined sources17
Beta strandi235 – 240Combined sources6
Beta strandi243 – 245Combined sources3
Helixi246 – 248Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi262 – 271Combined sources10
Helixi275 – 277Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi287 – 289Combined sources3
Beta strandi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VGKX-ray2.06A22-295[»]
2FWOX-ray2.60A22-304[»]
3NWMX-ray2.70A22-295[»]
4WDIX-ray2.31A/D22-296[»]
4Z76X-ray1.88A/D22-296[»]
4Z77X-ray1.85A/D22-296[»]
4Z78X-ray2.30A/D/G22-296[»]
5GR7X-ray2.40A22-295[»]
5GSBX-ray1.80A22-295[»]
5GSRX-ray2.20A/C22-295[»]
5GSVX-ray2.00A22-295[»]
5GSXX-ray2.50A/D22-295[»]
ProteinModelPortaliP01902
SMRiP01902
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01902

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRFIAVGYVD
60 70 80 90 100
DTQFVRFDSD ADNPRFEPRA PWMEQEGPEY WEEQTQRAKS DEQWFRVSLR
110 120 130 140 150
TAQRYYNQSK GGSHTFQRMF GCDVGSDWRL LRGYQQFAYD GRDYIALNED
160 170 180 190 200
LKTWTAADTA ALITRRKWEQ AGDAEYYRAY LEGECVEWLR RYLELGNETL
210 220 230 240 250
LRTDSPKAHV TYHPRSQVDV TLRCWALGFY PADITLTWQL NGEDLTQDME
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PLGKEQNYTC HVHHKGLPEP LTLRWKLPPS
310 320 330 340 350
TVSNTVIIAV LVVLGAAIVT GAVVAFVMKM RRNTGGKGVN YALAPGSQTS
360
DLSLPDGKVM VHDPHSLA
Length:368
Mass (Da):41,490
Last modified:July 21, 1986 - v1
Checksum:i4C83897CBCF7C6E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135Q → H in AAA39652 (PubMed:6298749).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00402 mRNA Translation: AAA39652.1
L36065 mRNA Translation: AAA89205.1
U47329 mRNA Translation: AAB17607.1
PIRiA90977 HLMSKD
UniGeneiMm.422886
Mm.439675
Mm.440940
Mm.441651
Mm.466882

Similar proteinsi

Entry informationi

Entry nameiHA1D_MOUSE
AccessioniPrimary (citable) accession number: P01902
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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