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Protein

H-2 class I histocompatibility antigen, K-D alpha chain

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, K-D alpha chain
Short name:
H-2K(D)
Gene namesi
Name:H2-K1
Synonyms:H2-K
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95904. H2-K1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 305284ExtracellularSequence analysisAdd
BLAST
Transmembranei306 – 32823HelicalSequence analysisAdd
BLAST
Topological domaini329 – 36840CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 368347H-2 class I histocompatibility antigen, K-D alpha chainPRO_0000018929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)2 Publications
Disulfide bondi122 ↔ 185PROSITE-ProRule annotation
Glycosylationi197 – 1971N-linked (GlcNAc...)1 PublicationSequence analysis
Disulfide bondi224 ↔ 280PROSITE-ProRule annotation
Glycosylationi277 – 2771N-linked (GlcNAc...)1 Publication
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP01902.
MaxQBiP01902.
PRIDEiP01902.

PTM databases

iPTMnetiP01902.

Expressioni

Gene expression databases

CleanExiMM_H2-K1.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Structurei

Secondary structure

1
368
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi24 – 3310Combined sources
Turni36 – 383Combined sources
Beta strandi42 – 498Combined sources
Beta strandi52 – 587Combined sources
Beta strandi61 – 633Combined sources
Beta strandi67 – 704Combined sources
Helixi71 – 755Combined sources
Helixi78 – 10528Combined sources
Beta strandi110 – 1123Combined sources
Beta strandi115 – 12410Combined sources
Beta strandi130 – 13910Combined sources
Beta strandi142 – 1476Combined sources
Beta strandi154 – 1563Combined sources
Helixi159 – 17113Combined sources
Helixi173 – 1819Combined sources
Helixi184 – 19512Combined sources
Helixi197 – 2004Combined sources
Beta strandi202 – 2043Combined sources
Beta strandi207 – 2148Combined sources
Beta strandi216 – 23217Combined sources
Beta strandi235 – 2406Combined sources
Helixi246 – 2483Combined sources
Beta strandi249 – 2513Combined sources
Beta strandi258 – 2603Combined sources
Beta strandi262 – 27110Combined sources
Helixi275 – 2773Combined sources
Beta strandi278 – 2836Combined sources
Beta strandi287 – 2893Combined sources
Beta strandi291 – 2933Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VGKX-ray2.06A22-295[»]
2FWOX-ray2.60A22-304[»]
3NWMX-ray2.70A22-295[»]
4WDIX-ray2.31A/D22-296[»]
4Z76X-ray1.88A/D22-296[»]
4Z77X-ray1.85A/D22-296[»]
4Z78X-ray2.30A/D/G22-296[»]
ProteinModelPortaliP01902.
SMRiP01902. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01902.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini206 – 29489Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni22 – 11190Alpha-1Add
BLAST
Regioni112 – 20392Alpha-2Add
BLAST
Regioni204 – 29592Alpha-3Add
BLAST
Regioni296 – 30510Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01902-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRFIAVGYVD
60 70 80 90 100
DTQFVRFDSD ADNPRFEPRA PWMEQEGPEY WEEQTQRAKS DEQWFRVSLR
110 120 130 140 150
TAQRYYNQSK GGSHTFQRMF GCDVGSDWRL LRGYQQFAYD GRDYIALNED
160 170 180 190 200
LKTWTAADTA ALITRRKWEQ AGDAEYYRAY LEGECVEWLR RYLELGNETL
210 220 230 240 250
LRTDSPKAHV TYHPRSQVDV TLRCWALGFY PADITLTWQL NGEDLTQDME
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PLGKEQNYTC HVHHKGLPEP LTLRWKLPPS
310 320 330 340 350
TVSNTVIIAV LVVLGAAIVT GAVVAFVMKM RRNTGGKGVN YALAPGSQTS
360
DLSLPDGKVM VHDPHSLA
Length:368
Mass (Da):41,490
Last modified:July 21, 1986 - v1
Checksum:i4C83897CBCF7C6E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351Q → H in AAA39652 (PubMed:6298749).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00402 mRNA. Translation: AAA39652.1.
L36065 mRNA. Translation: AAA89205.1.
U47329 mRNA. Translation: AAB17607.1.
PIRiA90977. HLMSKD.
RefSeqiXP_011241831.1. XM_011243529.1.
UniGeneiMm.422886.
Mm.439675.
Mm.440940.
Mm.441651.
Mm.466882.

Genome annotation databases

GeneIDi101056305.
KEGGimmu:101056305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00402 mRNA. Translation: AAA39652.1.
L36065 mRNA. Translation: AAA89205.1.
U47329 mRNA. Translation: AAB17607.1.
PIRiA90977. HLMSKD.
RefSeqiXP_011241831.1. XM_011243529.1.
UniGeneiMm.422886.
Mm.439675.
Mm.440940.
Mm.441651.
Mm.466882.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VGKX-ray2.06A22-295[»]
2FWOX-ray2.60A22-304[»]
3NWMX-ray2.70A22-295[»]
4WDIX-ray2.31A/D22-296[»]
4Z76X-ray1.88A/D22-296[»]
4Z77X-ray1.85A/D22-296[»]
4Z78X-ray2.30A/D/G22-296[»]
ProteinModelPortaliP01902.
SMRiP01902. Positions 22-296.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP01902.

Proteomic databases

EPDiP01902.
MaxQBiP01902.
PRIDEiP01902.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101056305.
KEGGimmu:101056305.

Organism-specific databases

MGIiMGI:95904. H2-K1.

Phylogenomic databases

HOVERGENiHBG016709.
KOiK06751.

Enzyme and pathway databases

ReactomeiR-GGA-1236974. ER-Phagosome pathway.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiH2-K1. mouse.
EvolutionaryTraceiP01902.
SOURCEiSearch...

Gene expression databases

CleanExiMM_H2-K1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA1D_MOUSE
AccessioniPrimary (citable) accession number: P01902
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.