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Protein

H-2 class I histocompatibility antigen, K-B alpha chain

Gene

H2-K1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent Source: MGI
  • antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
  • defense response to bacterium Source: MGI
  • immune response Source: InterPro
  • inner ear development Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • positive regulation of T cell mediated cytotoxicity Source: MGI

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-1236974 ER-Phagosome pathway
R-MMU-1236977 Endosomal/Vacuolar pathway
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-6798695 Neutrophil degranulation
R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, K-B alpha chain
Short name:
H-2K(B)
Gene namesi
Name:H2-K1
Synonyms:H2-K
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95904 H2-K1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 305ExtracellularSequence analysisAdd BLAST284
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23
Topological domaini329 – 369CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001892822 – 369H-2 class I histocompatibility antigen, K-B alpha chainAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi107N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi122 ↔ 185
Glycosylationi197N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi224 ↔ 280
Modified residuei351PhosphoserineBy similarity1
Modified residuei354PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP01901
PaxDbiP01901
PeptideAtlasiP01901
PRIDEiP01901

PTM databases

iPTMnetiP01901
PhosphoSitePlusiP01901
SwissPalmiP01901

Expressioni

Gene expression databases

BgeeiENSMUSG00000061232
CleanExiMM_H2-K1
ExpressionAtlasiP01901 baseline and differential
GenevisibleiP01901 MM

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FesP168793EBI-1265227,EBI-771815

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200155, 1 interactor
DIPiDIP-6189N
IntActiP01901, 5 interactors
MINTiP01901
STRINGi10090.ENSMUSP00000025181

Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 33Combined sources10
Beta strandi38 – 40Combined sources3
Beta strandi42 – 49Combined sources8
Beta strandi52 – 58Combined sources7
Beta strandi61 – 63Combined sources3
Beta strandi67 – 70Combined sources4
Helixi71 – 75Combined sources5
Helixi78 – 105Combined sources28
Beta strandi110 – 112Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi126 – 128Combined sources3
Beta strandi130 – 139Combined sources10
Beta strandi142 – 147Combined sources6
Turni149 – 152Combined sources4
Beta strandi154 – 158Combined sources5
Helixi159 – 171Combined sources13
Helixi173 – 182Combined sources10
Helixi184 – 195Combined sources12
Helixi197 – 200Combined sources4
Beta strandi207 – 214Combined sources8
Beta strandi216 – 232Combined sources17
Beta strandi235 – 240Combined sources6
Beta strandi243 – 245Combined sources3
Turni246 – 248Combined sources3
Beta strandi249 – 251Combined sources3
Beta strandi258 – 260Combined sources3
Beta strandi262 – 271Combined sources10
Helixi275 – 277Combined sources3
Beta strandi278 – 283Combined sources6
Beta strandi287 – 289Combined sources3
Beta strandi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BQHX-ray2.80A/D22-295[»]
1FO0X-ray2.50H22-296[»]
1FZJX-ray1.90A22-295[»]
1FZKX-ray1.70A22-295[»]
1FZMX-ray1.80A22-295[»]
1FZOX-ray1.80A22-295[»]
1G6RX-ray2.80H/I22-295[»]
1G7PX-ray1.50A22-295[»]
1G7QX-ray1.60A22-295[»]
1KBGX-ray2.20H22-295[»]
1KJ2X-ray2.71H/I22-298[»]
1KJ3X-ray2.30H/I22-299[»]
1KPUX-ray1.50A22-295[»]
1KPVX-ray1.71A22-295[»]
1LEGX-ray1.75A22-295[»]
1LEKX-ray2.15A22-295[»]
1LK2X-ray1.35A22-295[»]
1MWAX-ray2.40H/I22-295[»]
1N59X-ray2.95A/C22-297[»]
1NAMX-ray2.70H22-296[»]
1NANX-ray2.30H/L22-299[»]
1OSZX-ray2.10A22-295[»]
1P1ZX-ray3.26A22-295[»]
1P4LX-ray2.90A22-295[»]
1RJYX-ray1.90A/D22-301[»]
1RJZX-ray2.60A/D22-301[»]
1RK0X-ray2.61A22-295[»]
1RK1X-ray2.10A22-295[»]
1S7QX-ray1.99A22-369[»]
1S7RX-ray2.95A/D22-369[»]
1S7SX-ray1.99A22-369[»]
1S7TX-ray2.30A/D22-369[»]
1T0MX-ray2.00A/D22-299[»]
1T0NX-ray1.80A/D22-299[»]
1VACX-ray2.50A22-295[»]
1VADX-ray2.50A22-295[»]
1WBZX-ray2.00A/C22-296[»]
2CKBX-ray3.00H/I22-295[»]
2CLVX-ray1.90A/H22-300[»]
2CLZX-ray1.90A/H22-300[»]
2FO4X-ray2.70A22-295[»]
2MHAX-ray2.50A/C22-291[»]
2OL3X-ray2.90H22-300[»]
2QRIX-ray2.00A/B22-301[»]
2QRSX-ray2.00A/B22-301[»]
2QRTX-ray1.80A/B22-301[»]
2VAAX-ray2.30A22-295[»]
2VABX-ray2.50A22-295[»]
2ZSVX-ray1.80A/C22-299[»]
2ZSWX-ray2.80A/C/E/G22-299[»]
3C8KX-ray2.90A22-295[»]
3CVHX-ray2.90A/M22-295[»]
3P4MX-ray2.50A/D22-298[»]
3P4NX-ray2.50A/D22-298[»]
3P4OX-ray2.30A/D22-298[»]
3P9LX-ray2.00A/D22-299[»]
3P9MX-ray2.00A/D22-298[»]
3PABX-ray2.20A/D22-299[»]
3RGVX-ray2.90C22-296[»]
3ROLX-ray2.60A/C22-296[»]
3ROOX-ray2.00A/C22-296[»]
3TIDX-ray1.65A22-297[»]
3TIEX-ray2.25A/D22-297[»]
4HKJX-ray3.00A/E/I/M22-301[»]
4HS3X-ray2.10A22-297[»]
4PG9X-ray2.40A22-299[»]
4PGBX-ray2.80A/D22-299[»]
4PGCX-ray2.30A/D22-299[»]
4PGDX-ray2.70A22-299[»]
4PGEX-ray2.00A22-299[»]
4PV8X-ray2.31A/C22-299[»]
4PV9X-ray2.00A/C22-299[»]
5OQFX-ray2.27A/B23-304[»]
5OQGX-ray1.90A/B22-304[»]
5OQHX-ray2.05A/B22-304[»]
5OQIX-ray2.40A/B22-304[»]
ProteinModelPortaliP01901
SMRiP01901
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01901

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni22 – 111Alpha-1Add BLAST90
Regioni112 – 203Alpha-2Add BLAST92
Regioni204 – 295Alpha-3Add BLAST92
Regioni296 – 305Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
GeneTreeiENSGT00760000118960
HOVERGENiHBG016709
InParanoidiP01901
KOiK06751
OMAiVHEIHER
OrthoDBiEOG091G09OH
PhylomeDBiP01901
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPCTLLLLL AAALAPTQTR AGPHSLRYFV TAVSRPGLGE PRYMEVGYVD
60 70 80 90 100
DTEFVRFDSD AENPRYEPRA RWMEQEGPEY WERETQKAKG NEQSFRVDLR
110 120 130 140 150
TLLGYYNQSK GGSHTIQVIS GCEVGSDGRL LRGYQQYAYD GCDYIALNED
160 170 180 190 200
LKTWTAADMA ALITKHKWEQ AGEAERLRAY LEGTCVEWLR RYLKNGNATL
210 220 230 240 250
LRTDSPKAHV THHSRPEDKV TLRCWALGFY PADITLTWQL NGEELIQDME
260 270 280 290 300
LVETRPAGDG TFQKWASVVV PLGKEQYYTC HVYHQGLPEP LTLRWEPPPS
310 320 330 340 350
TVSNMATVAV LVVLGAAIVT GAVVAFVMKM RRRNTGGKGG DYALAPGSQT
360
SDLSLPDCKV MVHDPHSLA
Length:369
Mass (Da):41,302
Last modified:July 21, 1986 - v1
Checksum:i3D2F125318193443
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti217E → D AA sequence (PubMed:7306483).Curated1
Sequence conflicti289E → Q AA sequence (PubMed:7306483).Curated1
Sequence conflicti334N → A AA sequence (PubMed:7306483).Curated1
Sequence conflicti364D → P AA sequence (PubMed:7306483).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00400 mRNA Translation: AAA39648.1
U47328 mRNA Translation: AAB17606.1
V00746, V00747 Genomic DNA Translation: CAA24119.2
CCDSiCCDS50069.1
PIRiA90980 HLMSKB
RefSeqiNP_001001892.2, NM_001001892.2
UniGeneiMm.422886
Mm.439675
Mm.440940
Mm.441651
Mm.466882

Genome annotation databases

EnsembliENSMUST00000025181; ENSMUSP00000025181; ENSMUSG00000061232
GeneIDi14972
KEGGimmu:14972
UCSCiuc008cap.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHA1B_MOUSE
AccessioniPrimary (citable) accession number: P01901
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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