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P01900 (HA12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H-2 class I histocompatibility antigen, D-D alpha chain
Short name=H-2D(D)
Gene names
Name:H2-D1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.5
Chain25 – 365341H-2 class I histocompatibility antigen, D-D alpha chain
PRO_0000018924

Regions

Topological domain25 – 311287Extracellular Potential
Transmembrane312 – 33423Helical; Potential
Topological domain335 – 36531Cytoplasmic Potential
Domain209 – 29789Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 31113Connecting peptide

Amino acid modifications

Modified residue2021Phosphothreonine Ref.6
Modified residue3561Phosphoserine By similarity
Modified residue3591Phosphoserine By similarity
Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Secondary structure

1 ........................................................ 365
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01900 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: D127F5A4F0E79513

FASTA36541,110
        10         20         30         40         50         60 
MGAMAPRTLL LLLAAALGPT QTRAGSHSLR YFVTAVSRPG FGEPRYMEVG YVDNTEFVRF 

        70         80         90        100        110        120 
DSDAENPRYE PRARWIEQEG PEYWERETRR AKGNEQSFRV DLRTALRYYN QSAGGSHTLQ 

       130        140        150        160        170        180 
WMAGCDVESD GRLLRGYWQF AYDGCDYIAL NEDLKTWTAA DMAAQITRRK WEQAGAAERD 

       190        200        210        220        230        240 
RAYLEGECVE WLRRYLKNGN ATLLRTDPPK AHVTHHRRPE GDVTLRCWAL GFYPADITLT 

       250        260        270        280        290        300 
WQLNGEELTQ EMELVETRPA GDGTFQKWAS VVVPLGKEQK YTCHVEHEGL PEPLTLRWGK 

       310        320        330        340        350        360 
EEPPSSTKTN TVIIAVPVVL GAVVILGAVM AFVMKRRRNT GGKGGDYALA PGSQSSDMSL 


PDCKV

« Hide

References

« Hide 'large scale' references
[1]"Expression of H-2Dd and H-2Ld mouse major histocompatibility antigen genes in L cells after DNA-mediated gene transfer."
Margulies D.H., Evans G.A., Ozato K., Camerini-Otero R.D., Tanaka K., Appella E., Seidman J.G.
J. Immunol. 130:463-470(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Partial nucleotide sequence of H-2Dd major histocompatibility antigen gene."
Margulies D.H., Evans G.A., Ozato K., Camerini-Otero R.D., Tanaka K., Appella E., Seidman J.G.
J. Immunol. 135:1537-1537(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"DNA sequence of the mouse H-2Dd transplantation antigen gene."
Sher B.T., Nairn R., Coligan J.E., Hood L.E.
Proc. Natl. Acad. Sci. U.S.A. 82:1175-1179(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"Nucleotide sequences of three H-2K and three H-2D complementary DNA clones coding mouse class I MHC heavy chain proteins."
Wang M., Stepkowski S.M., Hebert J.S., Tian L., Yu J., Kahan B.D.
Ann. Transplant. 1:26-31(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[5]"Amino acid sequence of cyanogen bromide fragment CN-C (residues 24-98) of the mouse histocompatibility antigen H-2Dd. A comparison of the amino-terminal 100 residues of H-2Dd, Dd, Kd, and Kb reveals discrete areas of diversity."
Nairn R., Nathenson S.G., Coligan J.E.
Biochemistry 20:4739-4745(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-125.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-202, MASS SPECTROMETRY.
Tissue: Macrophage.
[7]"The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK cell recognition."
Achour A., Persson K., Harris R.A., Sundbaeck J., Sentman C.L., Lindqvist Y., Schneider G., Kaerre K.
Immunity 9:199-208(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L29190 Genomic DNA. Translation: AAA39581.1.
U47326 mRNA. Translation: AAB17604.1.
IPIIPI00110805.
RefSeqXP_003946485.1. XM_003946436.1.
UniGeneMm.422886.
Mm.439675.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BIIX-ray2.40A1-365[»]
1DDHX-ray3.10A26-298[»]
1QO3X-ray2.30A26-301[»]
3DMMX-ray2.60A26-299[»]
3E6FX-ray2.41A26-298[»]
3E6HX-ray2.10A26-299[»]
3ECBX-ray1.70A26-301[»]
ProteinModelPortalP01900.
SMRP01900. Positions 26-298.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-6110N.
MINTMINT-1539026.

Proteomic databases

PRIDEP01900.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID101056446.
KEGGmmu:101056446.

Organism-specific databases

CTD14964.
MGIMGI:95896. H2-D1.

Phylogenomic databases

HOVERGENHBG016709.
KOK06751.

Enzyme and pathway databases

ReactomeREACT_102124. Immune System.
REACT_107772. Immune System.

Gene expression databases

CleanExMM_H2-D1.
GenevestigatorP01900.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01900.
SOURCESearch...

Entry information

Entry nameHA12_MOUSE
AccessionPrimary (citable) accession number: P01900
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: May 29, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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