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Protein

H-2 class I histocompatibility antigen, L-D alpha chain

Gene

H2-L

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
H-2 class I histocompatibility antigen, L-D alpha chain
Gene namesi
Name:H2-L
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95912. H2-L.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 331HelicalSequence analysisAdd BLAST22
Topological domaini332 – 362CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001893225 – 362H-2 class I histocompatibility antigen, L-D alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)1
Disulfide bondi125 ↔ 188
Glycosylationi200N-linked (GlcNAc...)1
Disulfide bondi227 ↔ 283
Glycosylationi280N-linked (GlcNAc...)Curated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01897.
PaxDbiP01897.
PeptideAtlasiP01897.
PRIDEiP01897.

PTM databases

iPTMnetiP01897.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01897. 2 interactors.
MINTiMINT-1535330.
STRINGi10090.ENSMUSP00000134570.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi39 – 42Combined sources4
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Beta strandi70 – 73Combined sources4
Turni74 – 76Combined sources3
Helixi81 – 107Combined sources27
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi129 – 131Combined sources3
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Turni152 – 155Combined sources4
Beta strandi157 – 159Combined sources3
Helixi162 – 174Combined sources13
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi201 – 204Combined sources4
Beta strandi215 – 217Combined sources3
Turni219 – 221Combined sources3
Beta strandi223 – 228Combined sources6
Beta strandi231 – 235Combined sources5
Beta strandi238 – 247Combined sources10
Turni249 – 251Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi268 – 273Combined sources6
Turni275 – 277Combined sources3
Helixi278 – 280Combined sources3
Beta strandi282 – 286Combined sources5
Beta strandi288 – 290Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LD9X-ray2.40A/D25-292[»]
1LDPX-ray3.10H25-296[»]
2E7LX-ray2.50E/F25-205[»]
2OI9X-ray2.35A25-203[»]
3E2HX-ray3.80A25-199[»]
3E3QX-ray2.95A/B/H/L/P/U/Y/c25-199[»]
3ERYX-ray1.95A/B25-198[»]
3TF7X-ray2.75A/E25-203[»]
3TFKX-ray2.75A25-203[»]
3TJHX-ray2.12A25-203[»]
3TPUX-ray3.10E/I/K/Q25-203[»]
3UO1X-ray1.64P70-78[»]
3UYRX-ray1.70P70-77[»]
3V4UX-ray1.64P70-78[»]
3V52X-ray1.70P70-77[»]
3VJ6X-ray1.90P3-11[»]
4MS8X-ray1.92A25-203[»]
4MVBX-ray3.09A25-203[»]
4MXQX-ray2.60A25-203[»]
4N0CX-ray2.90A/E25-203[»]
4N5EX-ray3.06A25-203[»]
4NHUX-ray2.90E/G25-204[»]
ProteinModelPortaliP01897.
SMRiP01897.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01897.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 297Ig-like C1-typeAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
InParanoidiP01897.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LGEPRYISVG
60 70 80 90 100
YVDNKEFVRF DSDAENPRYE PQAPWMEQEG PEYWERITQI AKGQEQWFRV
110 120 130 140 150
NLRTLLGYYN QSAGGTHTLQ WMYGCDVGSD GRLLRGYEQF AYDGCDYIAL
160 170 180 190 200
NEDLKTWTAA DMAAQITRRK WEQAGAAEYY RAYLEGECVE WLHRYLKNGN
210 220 230 240 250
ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT WQLNGEELTQ
260 270 280 290 300
DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP
310 320 330 340 350
PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS
360
QSSEMSLRDC KA
Length:362
Mass (Da):40,711
Last modified:July 15, 1998 - v2
Checksum:iA5EFDEE31177BF22
GO

Sequence cautioni

The sequence CAA24126 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 24LAPTQTRA → WPDSDPR (PubMed:7058332).Curated8
Sequence conflicti17 – 24LAPTQTRA → WPDSDPR (PubMed:6604582).Curated8
Sequence conflicti17 – 24LAPTQTRA → WPDSDPR (PubMed:6952248).Curated8
Sequence conflicti35Missing (PubMed:7058332).Curated1
Sequence conflicti35Missing (PubMed:6604582).Curated1
Sequence conflicti145C → R (PubMed:7058332).Curated1
Sequence conflicti145C → R (PubMed:6604582).Curated1
Sequence conflicti145C → R (PubMed:6952248).Curated1
Sequence conflicti220K → E (PubMed:6895103).Curated1
Sequence conflicti292E → H in CAA24129 (PubMed:6952248).Curated1
Sequence conflicti292E → H in AAA39661 (PubMed:6952248).Curated1
Sequence conflicti303S → F (PubMed:6895103).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33151 mRNA. Translation: AAA39659.1.
V00749 Genomic DNA. Translation: CAA24126.1. Different initiation.
V00750 Genomic DNA. Translation: CAA24127.1.
V00751 Genomic DNA. Translation: CAA24128.1.
V00752 Genomic DNA. Translation: CAA24129.1. Sequence problems.
L00129 Genomic DNA. Translation: AAA39662.1.
J00394 mRNA. Translation: AAA39578.1.
L00128, L00127 Genomic DNA. Translation: AAA39661.1.
PIRiB60854.
C60854.
I54069. HLMSLD.
UniGeneiMm.439675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M33151 mRNA. Translation: AAA39659.1.
V00749 Genomic DNA. Translation: CAA24126.1. Different initiation.
V00750 Genomic DNA. Translation: CAA24127.1.
V00751 Genomic DNA. Translation: CAA24128.1.
V00752 Genomic DNA. Translation: CAA24129.1. Sequence problems.
L00129 Genomic DNA. Translation: AAA39662.1.
J00394 mRNA. Translation: AAA39578.1.
L00128, L00127 Genomic DNA. Translation: AAA39661.1.
PIRiB60854.
C60854.
I54069. HLMSLD.
UniGeneiMm.439675.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LD9X-ray2.40A/D25-292[»]
1LDPX-ray3.10H25-296[»]
2E7LX-ray2.50E/F25-205[»]
2OI9X-ray2.35A25-203[»]
3E2HX-ray3.80A25-199[»]
3E3QX-ray2.95A/B/H/L/P/U/Y/c25-199[»]
3ERYX-ray1.95A/B25-198[»]
3TF7X-ray2.75A/E25-203[»]
3TFKX-ray2.75A25-203[»]
3TJHX-ray2.12A25-203[»]
3TPUX-ray3.10E/I/K/Q25-203[»]
3UO1X-ray1.64P70-78[»]
3UYRX-ray1.70P70-77[»]
3V4UX-ray1.64P70-78[»]
3V52X-ray1.70P70-77[»]
3VJ6X-ray1.90P3-11[»]
4MS8X-ray1.92A25-203[»]
4MVBX-ray3.09A25-203[»]
4MXQX-ray2.60A25-203[»]
4N0CX-ray2.90A/E25-203[»]
4N5EX-ray3.06A25-203[»]
4NHUX-ray2.90E/G25-204[»]
ProteinModelPortaliP01897.
SMRiP01897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01897. 2 interactors.
MINTiMINT-1535330.
STRINGi10090.ENSMUSP00000134570.

PTM databases

iPTMnetiP01897.

Proteomic databases

MaxQBiP01897.
PaxDbiP01897.
PeptideAtlasiP01897.
PRIDEiP01897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95912. H2-L.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
InParanoidiP01897.

Enzyme and pathway databases

ReactomeiR-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTraceiP01897.
PROiP01897.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHA1L_MOUSE
AccessioniPrimary (citable) accession number: P01897
Secondary accession number(s): Q31195, Q31196, Q31197
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.