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P01897 (HA1L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H-2 class I histocompatibility antigen, L-D alpha chain
Gene names
Name:H2-L
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence CAA24126.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338H-2 class I histocompatibility antigen, L-D alpha chain
PRO_0000018932

Regions

Topological domain25 – 309285Extracellular Potential
Transmembrane310 – 33122Helical; Potential
Topological domain332 – 36231Cytoplasmic Potential
Domain209 – 29789Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30911Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...)
Glycosylation2001N-linked (GlcNAc...)
Glycosylation2801N-linked (GlcNAc...) Probable
Disulfide bond125 ↔ 188
Disulfide bond227 ↔ 283

Experimental info

Sequence conflict17 – 248LAPTQTRA → WPDSDPR Ref.2
Sequence conflict17 – 248LAPTQTRA → WPDSDPR Ref.3
Sequence conflict17 – 248LAPTQTRA → WPDSDPR Ref.4
Sequence conflict351Missing Ref.2
Sequence conflict351Missing Ref.3
Sequence conflict1451C → R Ref.2
Sequence conflict1451C → R Ref.3
Sequence conflict1451C → R Ref.4
Sequence conflict2201K → E Ref.5
Sequence conflict2921E → H in CAA24129. Ref.4
Sequence conflict2921E → H in AAA39661. Ref.4
Sequence conflict3031S → F Ref.5

Secondary structure

........................................................... 362
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01897 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: A5EFDEE31177BF22

FASTA36240,711
        10         20         30         40         50         60 
MGAMAPRTLL LLLAAALAPT QTRAGPHSMR YFETAVSRPG LGEPRYISVG YVDNKEFVRF 

        70         80         90        100        110        120 
DSDAENPRYE PQAPWMEQEG PEYWERITQI AKGQEQWFRV NLRTLLGYYN QSAGGTHTLQ 

       130        140        150        160        170        180 
WMYGCDVGSD GRLLRGYEQF AYDGCDYIAL NEDLKTWTAA DMAAQITRRK WEQAGAAEYY 

       190        200        210        220        230        240 
RAYLEGECVE WLHRYLKNGN ATLLRTDSPK AHVTHHPRSK GEVTLRCWAL GFYPADITLT 

       250        260        270        280        290        300 
WQLNGEELTQ DMELVETRPA GDGTFQKWAS VVVPLGKEQN YTCRVYHEGL PEPLTLRWEP 

       310        320        330        340        350        360 
PPSTDSYMVI VAVLGVLGAM AIIGAVVAFV MKRRRNTGGK GGDYALAPGS QSSEMSLRDC 


KA 

« Hide

References

[1]"Generation of a functional cDNA encoding the LdH2 class-I molecule by using a single-LTR retroviral shuttle vector."
Joly E., Oldstone M.B.
Gene 97:213-221(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen."
Moore K.W., Sher B.T., Sun Y.H., Eakle K.A., Hood L.E.
Science 215:679-682(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (CLONE 27.5).
Strain: BALB/c.
Tissue: Sperm.
[3]"Expression and function of transplantation antigens with altered or deleted cytoplasmic domains."
Zuniga M.C., Malissen B., McMillan M., Brayton P.R., Clark S.S., Forman J., Hood L.E.
Cell 34:535-544(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
Tissue: Sperm.
[4]"Structure and expression of a mouse major histocompatibility antigen gene, H-2Ld."
Evans G.A., Margulies D.H., Camerini-Otero R.D., Ozato K., Seidman J.G.
Proc. Natl. Acad. Sci. U.S.A. 79:1994-1998(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-311 AND 339-348.
[5]"Structure of C-terminal half of two H-2 antigens from cloned mRNA."
Bregegere F., Abastado J.P., Kvist S., Rask L., Lalanne J.-L., Garoff H., Cami B., Wiman K.G., Larhammar D., Peterson P.A., Gachelin G., Kourilsky P., Dobberstein B.
Nature 292:78-81(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-362 (CLONE PH-2D-3).
[6]"The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide."
Balendiran G.K., Solheim J.C., Young A.C., Hansen T.H., Nathenson S.G., Sacchettini J.C.
Proc. Natl. Acad. Sci. U.S.A. 94:6880-6885(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 25-293.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M33151 mRNA. Translation: AAA39659.1.
V00749 Genomic DNA. Translation: CAA24126.1. Different initiation.
V00750 Genomic DNA. Translation: CAA24127.1.
V00751 Genomic DNA. Translation: CAA24128.1.
V00752 Genomic DNA. Translation: CAA24129.1. Sequence problems.
L00129 Genomic DNA. Translation: AAA39662.1.
J00394 mRNA. Translation: AAA39578.1.
L00128, L00127 Genomic DNA. Translation: AAA39661.1.
PIRB60854.
C60854.
HLMSLD. I54069.
UniGeneMm.439675.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LD9X-ray2.40A/D25-292[»]
1LDPX-ray3.10H25-296[»]
2E7LX-ray2.50E/F25-205[»]
2OI9X-ray2.35A25-203[»]
3E2HX-ray3.80A25-199[»]
3E3QX-ray2.95A/B/H/L/P/U/Y/c25-199[»]
3ERYX-ray1.95A/B25-198[»]
3TF7X-ray2.75A/E25-203[»]
3TFKX-ray2.75A25-203[»]
3TJHX-ray2.12A25-203[»]
3TPUX-ray3.10E/I/K/Q25-203[»]
3UO1X-ray1.64P70-78[»]
3UYRX-ray1.70P70-77[»]
3V4UX-ray1.64P70-78[»]
3V52X-ray1.70P70-77[»]
3VJ6X-ray1.90P3-11[»]
ProteinModelPortalP01897.
SMRP01897. Positions 25-292.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01897. 2 interactions.
MINTMINT-1535330.

Proteomic databases

PRIDEP01897.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95912. H2-L.

Phylogenomic databases

HOVERGENHBG016709.
InParanoidP01897.

Gene expression databases

GenevestigatorP01897.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01897.
PROP01897.
SOURCESearch...

Entry information

Entry nameHA1L_MOUSE
AccessionPrimary (citable) accession number: P01897
Secondary accession number(s): Q31195, Q31196, Q31197
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: June 11, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot