P01893 (HLAH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative HLA class I histocompatibility antigen, alpha chain H

Alternative name(s):
HLA-12.4
HLA-AR
MHC class I antigen H

Gene names

Name:	HLA-H
Synonyms:	HLAH

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Uncertain

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
Subcellular location	Cell membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Caution	Could be the product of a pseudogene.
Sequence caution	The sequence AAA36218.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Immunity
Cellular component	Cell membrane MHC I Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	MHC class I receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24
	Chain	25 – 362	338	Putative HLA class I histocompatibility antigen, alpha chain H		PRO_0000018888
Regions
	Topological domain	25 – 308	284	Extracellular Potential
	Transmembrane	309 – 332	24	Helical; Potential
	Topological domain	333 – 362	30	Cytoplasmic Potential
	Domain	209 – 297	89	Ig-like C1-type
	Region	25 – 114	90	Alpha-1
	Region	115 – 206	92	Alpha-2
	Region	207 – 298	92	Alpha-3
	Region	299 – 308	10	Connecting peptide
Amino acid modifications
	Modified residue	350	1	Phosphoserine Ref.2
	Glycosylation	110	1	N-linked (GlcNAc...) By similarity
	Disulfide bond	227 ↔ 283		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01893 [UniParc]. Last modified October 5, 2010. Version 3. Checksum: 8ADFD2388FEC4645	FASTA	362	40,892
	10 20 30 40 50 60 MVLMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ 130 140 150 160 170 180 VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR 190 200 210 220 230 240 RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP 310 320 330 340 350 360 SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL TA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Exon/intron organization and complete nucleotide sequence of an HLA gene." Malissen M., Malissen B., Jordan B.R. Proc. Natl. Acad. Sci. U.S.A. 79:893-897(1982) [PubMed: 6461010] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350, MASS SPECTROMETRY. Tissue: Platelet.
[3]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J00191 Genomic DNA. Translation: AAA36218.1. Different initiation.
IPI	IPI00004672.
PIR	HLHU12. A02189.
UniGene	Hs.728808.
3D structure databases
ProteinModelPortal	P01893.
SMR	P01893. Positions 26-300.
ModBase	Search...
Protein-protein interaction databases
IntAct	P01893. 1 interaction.
PTM databases
PhosphoSite	P01893.
Polymorphism databases
DMDM	308153595.
Proteomic databases
PRIDE	P01893.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC06P029858.
HGNC	HGNC:4965. HLA-H.
MIM	142800. gene.
neXtProt	NX_P01893.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG016709.
InParanoid	P01893.
Gene expression databases
Genevestigator	P01893.
GermOnline	ENSG00000204632. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit. G3DSA:3.30.500.10. MHC_I-like_Ag-recog. 1 hit.
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

HLAH_HUMAN

Accession

Primary (citable) accession number: P01893

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 5, 2010
Last modified:	January 25, 2012
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.