P01892 (1A02_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, A-2 alpha chain

Alternative name(s):
MHC class I antigen A*2

Gene names

Name:	HLA-A
Synonyms:	HLAA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 accessory protein p12I. Ref.36 Ref.37
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.
Polymorphism	The following alleles of A-2 are known: A*02:01, A*02:02, A*02:03, A*02:04, A*02:05, A*02:06 (A2.4A), A*02:07, A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 (A*02SLU), A*02:16, A*02:17, A*02:18 (A2K), A*02:19, A*02:20, A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. The sequence shown is that of A*02:01.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Sequence caution	The sequence CAA41022.1 differs from that shown. Reason: The sequence differs from that shown extensively.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of defense response to virus by virus Traceable author statement. Source: Reactome regulation of immune response Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome phagocytic vesicle membrane Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Ref.7

Chain

25 – 365

341

HLA class I histocompatibility antigen, A-2 alpha chain

PRO_0000018814

Regions

Topological domain

25 – 308

284

Extracellular Potential

Transmembrane

309 – 332

24

Helical; Potential

Topological domain

333 – 365

33

Cytoplasmic Potential

Domain

209 – 295

87

Ig-like C1-type

Region

25 – 114

90

Alpha-1

Region

115 – 206

92

Alpha-2

Region

207 – 298

92

Alpha-3

Region

299 – 308

10

Connecting peptide

Amino acid modifications

Modified residue

356

1

Phosphoserine Ref.33

Glycosylation

110

1

N-linked (GlcNAc...) Ref.34

Disulfide bond

125 ↔ 188

Ref.38

Disulfide bond

227 ↔ 283

Ref.38

Natural variations

Natural variant

33

1

F → Y in allele A*02:05, allele A*02:06, allele A*02:08, allele A*02:10 and allele A*02:21.

VAR_004334

Natural variant

54

1

D → N in allele A*02:21.

VAR_004335

Natural variant

65

1

A → G in allele A*02:31.

VAR_016726

Natural variant

67

1

Q → R in allele A*02:02, allele A*02:05 and allele A*02:08.

VAR_004336

Natural variant

90

1

K → N in allele A*02:08 and allele A*02:20.

VAR_004337

Natural variant

94

1

H → Q in allele A*02:34 and allele A*02:35.

VAR_016727

Natural variant

97

1

T → I in allele A*02:11.

VAR_004338

Natural variant

98

1

H → D in allele A*02:11 and allele A*02:35.

VAR_016728

Natural variant

119

1

V → L in allele A*02:02, allele A*02:05, allele A*02:08 and allele A*02:17.

VAR_004339

Natural variant

121

1

R → M in allele A*02:04 and allele A*02:17.

VAR_004340

Natural variant

123

1

Y → C in allele A*02:07 and allele A*02:18.

VAR_004341

Natural variant

123

1

Y → F in allele A*02:10 and allele A*02:17.

VAR_004342

Natural variant

131

1

W → G in allele A*02:10.

VAR_004343

Natural variant

162

1

M → K in allele A*02:18.

VAR_004344

Natural variant

173

1

A → T in allele A*02:03.

VAR_004345

Natural variant

176

1

V → E in allele A*02:03 and allele A*02:13. Ref.40

VAR_004346

Natural variant

180

1

L → Q in allele A*02:12, allele A*02:13 and allele A*02:37.

VAR_004348

Natural variant

180

1

L → W in allele A*02:02, allele A*02:03, allele A*02:05 and allele A*02:08. Ref.40

VAR_004347

Natural variant

187

1

T → E in allele A*02:16; requires 2 nucleotide substitutions.

VAR_004349

Natural variant

190

1

E → D in allele A*02:36 and allele A*02:37.

VAR_016729

Natural variant

191

1

W → G in allele A*02:36 and allele A*02:37.

VAR_016730

Natural variant

260

1

A → E in allele A*02:09.

VAR_004350

Experimental info

Sequence conflict

115

1

G → V in AAA52656. Ref.4

Sequence conflict

140

1

Y → V in AAA52656. Ref.4

Sequence conflict

277

1

Q → E in AAA52656. Ref.4

Sequence conflict

318

1

F → L in AAA52656. Ref.4

Secondary structure

1

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365

Helix Strand Turn

Details...

Beta strand

27 – 36

10

Beta strand

41 – 43

3

Beta strand

45 – 52

8

Beta strand

55 – 61

7

Beta strand

64 – 66

3

Beta strand

70 – 73

4

Helix

74 – 78

5

Helix

81 – 108

28

Beta strand

113 – 115

3

Beta strand

118 – 127

10

Beta strand

131 – 142

12

Beta strand

145 – 150

6

Beta strand

157 – 159

3

Helix

162 – 173

12

Helix

176 – 184

9

Helix

187 – 198

12

Helix

200 – 203

4

Beta strand

210 – 235

26

Beta strand

238 – 243

6

Beta strand

246 – 248

3

Helix

249 – 251

3

Beta strand

252 – 254

3

Beta strand

261 – 263

3

Beta strand

265 – 274

10

Helix

278 – 280

3

Beta strand

281 – 286

6

Beta strand

290 – 292

3

Beta strand

294 – 297

4

Beta strand

348 – 350

3

Sequences

	Sequence		Length	Mass (Da)
	P01892 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: B54A97B24B337C08	FASTA	365	40,922
	10 20 30 40 50 60 MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ 130 140 150 160 170 180 RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL TACKV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level." Koller B.H., Orr H.T. J. Immunol. 134:2727-2733(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01).
[2]	"Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing." Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., Giannella G., Peschle C., Boncinelli E. Immunogenetics 29:80-91(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[3]	"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification." Ennis P.D., Zemmour J., Salter R.D., Parham P. Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[4]	"Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes." Davidson W.F., Kress M., Khoury G., Jay G. J. Biol. Chem. 260:13414-13423(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-365.
[5]	"Unusual HLA-B alleles in two tribes of Brazilian Indians." Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., Williams R.C., Luz R., Petzl-Erler M.L., Parham P. Nature 357:326-329(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:01; A*02:11 AND A*02:12).
[6]	"Unusual RNA splicing generates a secreted form of HLA-A2 in a mutagenized B lymphoblastoid cell line." Krangel M.S. EMBO J. 4:1205-1210(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-365 (ALLELE A*02:01).
[7]	"Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites." Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L., Strominger J.L. Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-295 (ALLELE A*02:01).
[8]	"Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism." Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T. Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION (ALLELE A*02:01).
[9]	"HLA class I allele (HLA-A2) expression defect associated with a mutation in its enhancer B inverted CAT box in two families." Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L. Hum. Immunol. 41:69-73(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01). Tissue: Blood.
[10]	Balas A. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[11]	"Confirmation of HLA-A*0201." Cox S.T. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[12]	"DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1." Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P., Biddison W.E. Immunogenetics 26:190-192(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELES A*02:02 AND A*02:03).
[13]	"Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules." Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P. J. Immunol. 139:936-941(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05).
[14]	Domena J.D. Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05).
[15]	"Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of HLA-A2 subtype polymorphism." Castano A.R., Lopez de Castro J.A. Immunogenetics 34:281-285(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:04).
[16]	"New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., Troup G.M., Hughes A.L., Letvin N.L. Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*02:04).
[17]	"Diversity and diversification of HLA-A,B,C alleles." Parham P., Lawlor D.A., Lomen C.E., Ennis P.D. J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:06).
[18]	"Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes." Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A., Lopez de Castro J.A. J. Immunol. 137:1642-1649(1986) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:06).
[19]	"Structural analysis of HLA-A2.4 functional variant KNE. Implications for the mapping of HLA-A2-specific T-cell epitopes." Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A. Immunogenetics 27:196-202(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:07).
[20]	"Molecular analysis of HLA-A2.4 functional variant KLO: close structural and evolutionary relatedness to the HLA-A2.2 subtype." Domenech N., Castano R., Goulmy E., Lopez de Castro J.A. Immunogenetics 28:143-152(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:08).
[21]	"An HLA-A2 population variant with structural polymorphism in the alpha 3 region." Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A. Immunogenetics 27:345-355(1988) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:09).
[22]	"An Oriental HLA-A2 subtype is closely related to a subset of Caucasoid HLA-A2 alleles." Epstein H., Kennedy L., Holmes N. Immunogenetics 29:112-116(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:10).
[23]	"Structure of the HLA-A*0211 (A2.5) subtype: further evidence for selection-driven diversification of HLA-A2 antigens." Castano A.R., Lopez de Castro J.A. Immunogenetics 35:344-346(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:11).
[24]	"Primary structure of a new HLA-A2 subtype: HLA-A*0213." Barber D.F., Fernandez J.M., Lopez de Castro J.A. Immunogenetics 39:378-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:13).
[25]	"Identification of a novel HLA-A2 subtype, HLA-A*0216." Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J. Immunogenetics 41:388-388(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:16).
[26]	"A novel subtype of A2 (A*0217) isolated from the South American Indian B-cell line AMALA." Selvakumar A., Granja C.B., Salazar M., Alosco S.M., Yunis E.J., Dupont B. Tissue Antigens 45:343-347(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:17). Tissue: Blood.
[27]	"A new A2 sequence HLA-A2K from Japanese." Kashiwase K., Tokunaga K., Ishikawa Y., Oohashi H., Hashimoto M., Akaza T., Tadokoro K., Juji T. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:18). Tissue: Blood.
[28]	"HLA-A*02 subtype distribution in Caucasians from northern Italy: identification of A*0220." Fleischhauer K., Zino E., Mazzi B., Severini G.M., Benazzi E., Bordignon C. Tissue Antigens 48:673-679(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:20). Tissue: Blood.
[29]	"Nucleotide sequence of a novel HLA-A2 gene." Szmania S., Baxter-Lowe L.A. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:21). Tissue: Blood.
[30]	"Frequencies of HLA-A2 alleles in five U.S. population groups. Predominance Of A*02011 and identification of HLA-A*0231." Ellis J.M., Henson V., Slack R., Ng J., Hartzman R.J., Hurley C.K. Hum. Immunol. 61:334-340(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*02:31).
[31]	"A new HLA-A*02 allele, A*0234, detected by polymerase chain reaction using sequence-specific primers (PCR-SSP)." Moses J.H., Greville W.D., Downes J., McClenahan W., Kennedy A., Dunckley H. Tissue Antigens 55:175-177(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE A*02:34).
[32]	"Seventeen more novel HLA-A locus alleles." Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K. Tissue Antigens 55:369-373(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*02:35; A*02:36 AND A*02:37).
[33]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, MASS SPECTROMETRY. Tissue: Platelet.
[34]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, MASS SPECTROMETRY. Tissue: Liver.
[35]	"Structure of the human class I histocompatibility antigen, HLA-A2." Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., Wiley D.C. Nature 329:506-512(1987) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF A*02:01.
[36]	"Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein." Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G. J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
[37]	"Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation." Hewitt E.W., Duncan L., Mufti D., Baker J., Stevenson P.G., Lehner P.J. EMBO J. 21:2418-2429(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HUMAN HERPESVIRUS 8 MIR1 PROTEIN, UBIQUITINATION.
[38]	"A structural basis for immunodominant human T cell receptor recognition." Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y. Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 25-300 OF HLA-A/B2M HETERODIMER IN COMPLEX WITH TRAC AND TRBC1, DISULFIDE BONDS.
[39]	"Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution." Saper M.A., Bjorkman P.J., Wiley D.C. J. Mol. Biol. 219:277-319(1991) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A*02:01.
[40]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-176, VARIANT [LARGE SCALE ANALYSIS] TRP-180, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

K02883 Genomic DNA. Translation: AAA98727.1.
M84379 mRNA. Translation: AAA59606.1.
X02457 mRNA. Translation: CAA26297.1.
M11887 mRNA. Translation: AAA52656.1.
M19670 Genomic DNA. Translation: AAA03683.2.
AH003586 Genomic DNA. Translation: AAB02120.1.
U03863 mRNA. Translation: AAA03604.1.
M86404 mRNA. No translation available.
X57954 mRNA. Translation: CAA41022.1. Sequence problems.
U02935 Genomic DNA. Translation: AAA76608.2.
AJ555412 Genomic DNA. Translation: CAD87771.1.
U03862 mRNA. Translation: AAA03603.1.
M24042 mRNA. Translation: AAA59653.1.
Z23071 mRNA. Translation: CAA80612.1.
M84377 mRNA. Translation: AAA59603.1.
X60764 mRNA. No translation available.
M84378 mRNA. Translation: AAA59604.1.
Z27120 mRNA. Translation: CAA81644.1.
Z46633 mRNA. Translation: CAA86602.1.
U18930 mRNA. Translation: AAA87076.1.
D83515 mRNA. Translation: BAA11935.1.
X96724 mRNA. Translation: CAA65501.1.
U56825 mRNA. Translation: AAB17465.1.
AH007560 Genomic DNA. Translation: AAD23437.1.
AH007704 Genomic DNA. Translation: AAD30272.1.
AH008013 Genomic DNA. Translation: AAD45690.1.
AH008012 Genomic DNA. Translation: AAD45689.1.
AH008007 Genomic DNA. Translation: AAD45324.1.

IPI

IPI00876963.

PIR

HLHU10. B24512.
I37470.
I37542.
I38418.
I38442.
I38443.
HLHUA2. I55948.
I61857.
I61902.
I84448.

UniGene

Hs.181244.
Hs.713441.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AKJ	X-ray	2.65	A	25-300	[»]
1AO7	X-ray	2.60	A	25-299	[»]
1AQD	X-ray	2.45	C/F/I/L	127-141	[»]
1B0G	X-ray	2.50	A/D	25-299	[»]
1B0R	X-ray	2.90	A	25-299	[»]
1BD2	X-ray	2.50	A	25-299	[»]
1DUY	X-ray	2.15	A/D	25-299	[»]
1DUZ	X-ray	1.80	A/D	25-299	[»]
1EEY	X-ray	2.25	A/D	25-299	[»]
1EEZ	X-ray	2.30	A/D	25-299	[»]
1HHG	X-ray	2.60	A/D	25-299	[»]
1HHH	X-ray	3.00	A	25-299	[»]
1HHI	X-ray	2.50	A/D	25-299	[»]
1HHJ	X-ray	2.50	A/D	25-299	[»]
1HHK	X-ray	2.50	A/D	25-299	[»]
1HLA	X-ray	3.50	A	25-294	[»]
1I1F	X-ray	2.80	A/D	25-299	[»]
1I1Y	X-ray	2.20	A/D	25-299	[»]
1I4F	X-ray	1.40	A	25-299	[»]
1I7R	X-ray	2.20	A/D	25-299	[»]
1I7T	X-ray	2.80	A/D	25-299	[»]
1I7U	X-ray	1.80	A/D	25-299	[»]
1IM3	X-ray	2.20	A/E/I/M	25-299	[»]
1JF1	X-ray	1.85	A	25-299	[»]
1JHT	X-ray	2.15	A	25-299	[»]
1LP9	X-ray	2.00	A/H	25-299	[»]
1OGA	X-ray	1.40	A	25-300	[»]
1P7Q	X-ray	3.40	A	25-300	[»]
1QEW	X-ray	2.20	A	25-299	[»]
1QR1	X-ray	2.40	A/D	25-299	[»]
1QRN	X-ray	2.80	A	25-298	[»]
1QSE	X-ray	2.80	A	25-298	[»]
1QSF	X-ray	2.80	A	25-298	[»]
1S8D	X-ray	2.20	A	25-299	[»]
1S9W	X-ray	2.20	A	25-298	[»]
1S9X	X-ray	2.50	A	25-298	[»]
1S9Y	X-ray	2.30	A	25-298	[»]
1T1W	X-ray	2.20	A	25-299	[»]
1T1X	X-ray	2.20	A	25-299	[»]
1T1Y	X-ray	2.00	A	25-299	[»]
1T1Z	X-ray	1.90	A	25-299	[»]
1T20	X-ray	2.20	A	25-299	[»]
1T21	X-ray	2.19	A	25-299	[»]
1T22	X-ray	2.20	A	25-299	[»]
1TVB	X-ray	1.80	A/D	25-299	[»]
1TVH	X-ray	1.80	A/D	25-299	[»]
1UR7	model	-	A	25-299	[»]
2AV1	X-ray	1.95	A/D	25-299	[»]
2AV7	X-ray	2.05	A/D	25-299	[»]
2BNQ	X-ray	1.70	A	25-300	[»]
2BNR	X-ray	1.90	A	25-300	[»]
2C7U	X-ray	2.38	A/D	25-300	[»]
2CLR	X-ray	2.00	A/D	25-299	[»]
2F53	X-ray	2.10	A	25-299	[»]
2F54	X-ray	2.70	A/F	25-298	[»]
2GIT	X-ray	1.70	A/D	25-299	[»]
2GJ6	X-ray	2.56	A	25-299	[»]
2GT9	X-ray	1.75	A/D	25-299	[»]
2GTW	X-ray	1.55	A/D	25-299	[»]
2GTZ	X-ray	1.70	A/D	25-299	[»]
2GUO	X-ray	1.90	A/D	25-299	[»]
2J8U	X-ray	2.88	A/H	25-299	[»]
2JCC	X-ray	2.50	A/H	25-299	[»]
2P5E	X-ray	1.89	A	25-300	[»]
2P5W	X-ray	2.20	A	25-300	[»]
2PYE	X-ray	2.30	A	25-300	[»]
2UWE	X-ray	2.40	A/H	25-299	[»]
2V2W	X-ray	1.60	A/D	25-300	[»]
2V2X	X-ray	1.60	A/D	25-300	[»]
2VLJ	X-ray	2.40	A	25-300	[»]
2VLK	X-ray	2.50	A	25-300	[»]
2VLL	X-ray	1.60	A/D	25-300	[»]
2VLR	X-ray	2.30	A/F	25-300	[»]
2X4N	X-ray	2.34	A/D	25-299	[»]
2X4O	X-ray	2.30	A/D	25-299	[»]
2X4P	X-ray	2.30	A/D	25-299	[»]
2X4Q	X-ray	1.90	A/D	25-299	[»]
2X4R	X-ray	2.30	A/D	25-299	[»]
2X4S	X-ray	2.55	A/D	25-299	[»]
2X4T	X-ray	2.30	A/D	25-299	[»]
2X4U	X-ray	2.10	A/D	25-299	[»]
2X70	X-ray	2.00	A/D	25-299	[»]
3BGM	X-ray	1.60	A	25-298	[»]
3BH8	X-ray	1.65	A	25-298	[»]
3BH9	X-ray	1.70	A	25-299	[»]
3BHB	X-ray	2.20	A	25-298	[»]
3D25	X-ray	1.30	A	25-298	[»]
3D39	X-ray	2.81	A	25-299	[»]
3D3V	X-ray	2.80	A	25-299	[»]
3FQN	X-ray	1.65	A	25-299	[»]
3FQR	X-ray	1.70	A	25-299	[»]
3FQT	X-ray	1.80	A	25-299	[»]
3FQU	X-ray	1.80	A	25-299	[»]
3FQW	X-ray	1.93	A	25-299	[»]
3FQX	X-ray	1.70	A	25-299	[»]
3FT2	X-ray	1.80	A	25-299	[»]
3FT3	X-ray	1.95	A	25-299	[»]
3FT4	X-ray	1.90	A	25-299	[»]
3GIV	X-ray	2.00	A/D	25-299	[»]
3GJF	X-ray	1.90	A/D	25-300	[»]
3GSN	X-ray	2.80	H	25-298	[»]
3GSO	X-ray	1.60	A	25-298	[»]
3GSQ	X-ray	2.12	A	25-298	[»]
3GSR	X-ray	1.95	A	25-298	[»]
3GSU	X-ray	1.80	A	25-299	[»]
3GSV	X-ray	1.90	A	25-299	[»]
3GSW	X-ray	1.81	A	25-298	[»]
3GSX	X-ray	2.10	A	25-298	[»]
3H7B	X-ray	1.88	A/D	25-299	[»]
3H9H	X-ray	2.00	A/D	25-299	[»]
3H9S	X-ray	2.70	A	25-299	[»]
3HAE	X-ray	2.90	A/D/J/P	25-300	[»]
3HG1	X-ray	3.00	A	25-300	[»]
3HLA	X-ray	2.60	A	25-294	[»]
3HPJ	X-ray	2.00	A/D	25-299	[»]
3I6G	X-ray	2.20	A/D	25-299	[»]
3I6K	X-ray	2.80	A/E	25-299	[»]
3IXA	X-ray	2.10	A/D	25-299	[»]
3KLA	X-ray	1.65	A/D	25-299	[»]
3MGO	X-ray	2.30	A/D/G/J	25-299	[»]
3MGT	X-ray	2.20	A/D/G/J	25-299	[»]
3MR9	X-ray	1.93	A	25-300	[»]
3MRB	X-ray	1.40	A	25-300	[»]
3MRC	X-ray	1.80	A	25-300	[»]
3MRD	X-ray	1.70	A	25-300	[»]
3MRE	X-ray	1.10	A	25-300	[»]
3MRF	X-ray	2.30	A	25-300	[»]
3MRG	X-ray	1.30	A	25-300	[»]
3MRH	X-ray	2.40	A	25-300	[»]
3MRI	X-ray	2.10	A	25-300	[»]
3MRJ	X-ray	1.87	A	25-300	[»]
3MRK	X-ray	1.40	A	25-300	[»]
3MRL	X-ray	2.41	A	25-300	[»]
3MRM	X-ray	1.90	A	25-300	[»]
3MRN	X-ray	2.30	A	25-300	[»]
3MRO	X-ray	2.35	A	25-300	[»]
3MRP	X-ray	2.10	A	25-300	[»]
3MRQ	X-ray	2.20	A	25-300	[»]
3MRR	X-ray	1.60	A	25-300	[»]
3MYJ	X-ray	1.89	A/D	25-299	[»]
3O3A	X-ray	1.80	A/D	25-299	[»]
3O3B	X-ray	1.90	A/D	25-299	[»]
3O3D	X-ray	1.70	A/D	25-299	[»]
3O3E	X-ray	1.85	A/D	25-299	[»]
3O4L	X-ray	2.54	A	25-300	[»]
3PWJ	X-ray	1.70	A/D	25-299	[»]
3PWL	X-ray	1.65	A/D	25-299	[»]
3PWN	X-ray	1.60	A/D	25-299	[»]
3PWP	X-ray	2.69	A	25-299	[»]
3QDG	X-ray	2.69	A	25-299	[»]
3QDJ	X-ray	2.30	A	25-299	[»]
3QDM	X-ray	2.80	A	25-299	[»]
3QEQ	X-ray	2.59	A	25-299	[»]
3QFD	X-ray	1.68	A/D	25-299	[»]
3QFJ	X-ray	2.29	A	25-299	[»]
3REW	X-ray	1.90	A/D	25-299	[»]
3TO2	X-ray	2.60	A	25-299	[»]
3UTQ	X-ray	1.67	A	25-300	[»]
3UTS	X-ray	2.71	A/F	25-300	[»]
3UTT	X-ray	2.60	A/F	25-299	[»]
3V5D	X-ray	2.00	A/D	25-299	[»]
3V5H	X-ray	1.63	A/D	25-299	[»]
3V5K	X-ray	2.31	A/D	25-299	[»]
4E5X	X-ray	1.95	A/D	25-299	[»]
4EMZ	X-ray	2.90	D/E	338-365	[»]
4EN2	X-ray	2.58	D/E	338-365	[»]
4GKN	X-ray	2.75	A/D	25-300	[»]
4GKS	X-ray	2.35	A/D	25-300	[»]
4I4W	X-ray	1.77	A	25-300	[»]

ProteinModelPortal

P01892.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6085N.

IntAct

P01892. 6 interactions.

MINT

MINT-5000859.

PTM databases

PhosphoSite

P01892.

Polymorphism databases

DMDM

122138.

Proteomic databases

PaxDb

P01892.

PRIDE

P01892.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000457879; ENSP00000403575; ENSG00000235657.
ENST00000547271; ENSP00000447962; ENSG00000235657.

Organism-specific databases

GeneCards

GC06P029933.
GC06Pk29899.

HGNC

HGNC:4931. HLA-A.

MIM

142800. gene.

neXtProt

NX_P01892.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42056.

HOVERGEN

HBG016709.

OrthoDB

EOG4F4SBG.

Enzyme and pathway databases

Reactome

REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P01892.

CleanEx

HS_HLA-A.

Genevestigator

P01892.

GermOnline

ENSG00000204632. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HLA-A. human.

EvolutionaryTrace

P01892.

SOURCE

Search...

Entry information

Entry name

1A02_HUMAN

Accession

Primary (citable) accession number: P01892
Secondary accession number(s): O19619 , P06338, P10313, P30444, P30445, P30446, P30514, Q29680, Q29837, Q29899, Q95352, Q95380, Q9TPX8, Q9TPX9, Q9TPY0, Q9TQH5, Q9TQI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 13, 1987
Last modified:	May 1, 2013
This is version 155 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.