Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01892 (1A02_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 165. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, A-2 alpha chain
Alternative name(s):
MHC class I antigen A*2
Gene names
Name:HLA-A
Synonyms:HLAA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Dimer of alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein. Interacts with HTLV-1 accessory protein p12I. Ref.37 Ref.38

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment through interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system.

Polymorphism

The following alleles of A-2 are known: A*02:01, A*02:02, A*02:03, A*02:04, A*02:05, A*02:06 (A2.4A), A*02:07, A*02:08, A*02:09, A*02:10, A*02:11 (A2.5), A*02:12, A*02:13 (A*02SLU), A*02:16, A*02:17, A*02:18 (A2K), A*02:19, A*02:20, A*02:21, A*02:31, A*02:34 (A*AAT), A*02:35, A*02:36 and A*02:37. The sequence shown is that of A*02:01.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence caution

The sequence CAA41022.1 differs from that shown. Reason: The sequence differs from that shown extensively.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

Inferred from direct assay PubMed 22031944. Source: UniProt

antigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from direct assay PubMed 22031944. Source: UniProt

positive regulation of interferon-gamma production

Inferred from direct assay PubMed 22031944. Source: UniProt

positive regulation of memory T cell activation

Inferred from direct assay PubMed 22031944. Source: UniProt

regulation of defense response to virus by virus

Traceable author statement. Source: Reactome

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Traceable author statement. Source: Reactome

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from direct assay PubMed 22031944. Source: UniProt

cell surface

Inferred from direct assay PubMed 22031944. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionTAP binding

Inferred from direct assay PubMed 8617941. Source: UniProt

peptide antigen binding

Inferred from direct assay PubMed 22031944. Source: UniProt

poly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

receptor binding

Inferred from physical interaction PubMed 19124746. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.7
Chain25 – 365341HLA class I histocompatibility antigen, A-2 alpha chain
PRO_0000018814

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36533Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Modified residue3561Phosphoserine Ref.33
Glycosylation1101N-linked (GlcNAc...) Ref.35
Disulfide bond125 ↔ 188 Ref.39
Disulfide bond227 ↔ 283 Ref.39

Natural variations

Natural variant331F → Y in allele A*02:05, allele A*02:06, allele A*02:08, allele A*02:10 and allele A*02:21.
VAR_004334
Natural variant541D → N in allele A*02:21.
VAR_004335
Natural variant651A → G in allele A*02:31.
VAR_016726
Natural variant671Q → R in allele A*02:02, allele A*02:05 and allele A*02:08.
VAR_004336
Natural variant901K → N in allele A*02:08 and allele A*02:20.
VAR_004337
Natural variant941H → Q in allele A*02:34 and allele A*02:35.
VAR_016727
Natural variant971T → I in allele A*02:11.
VAR_004338
Natural variant981H → D in allele A*02:11 and allele A*02:35.
VAR_016728
Natural variant1191V → L in allele A*02:02, allele A*02:05, allele A*02:08 and allele A*02:17.
VAR_004339
Natural variant1211R → M in allele A*02:04 and allele A*02:17.
VAR_004340
Natural variant1231Y → C in allele A*02:07 and allele A*02:18.
VAR_004341
Natural variant1231Y → F in allele A*02:10 and allele A*02:17.
VAR_004342
Natural variant1311W → G in allele A*02:10.
VAR_004343
Natural variant1621M → K in allele A*02:18.
VAR_004344
Natural variant1731A → T in allele A*02:03.
VAR_004345
Natural variant1761V → E in allele A*02:03 and allele A*02:13. Ref.41
VAR_004346
Natural variant1801L → Q in allele A*02:12, allele A*02:13 and allele A*02:37.
VAR_004348
Natural variant1801L → W in allele A*02:02, allele A*02:03, allele A*02:05 and allele A*02:08. Ref.41
VAR_004347
Natural variant1871T → E in allele A*02:16; requires 2 nucleotide substitutions.
VAR_004349
Natural variant1901E → D in allele A*02:36 and allele A*02:37.
VAR_016729
Natural variant1911W → G in allele A*02:36 and allele A*02:37.
VAR_016730
Natural variant2601A → E in allele A*02:09.
VAR_004350

Experimental info

Sequence conflict1151G → V in AAA52656. Ref.4
Sequence conflict1401Y → V in AAA52656. Ref.4
Sequence conflict2771Q → E in AAA52656. Ref.4
Sequence conflict3181F → L in AAA52656. Ref.4

Secondary structure

....................................................... 365
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01892 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: B54A97B24B337C08

FASTA36540,922
        10         20         30         40         50         60 
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV DLGTLRGYYN QSEAGSHTVQ 

       130        140        150        160        170        180 
RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS DSAQGSDVSL 


TACKV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level."
Koller B.H., Orr H.T.
J. Immunol. 134:2727-2733(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01).
[2]"Three new class I HLA alleles: structure of mRNAs and alternative mechanisms of processing."
Cianetti L., Testa U., Scotto L., la Valle R., Simeone A., Boccoli G., Giannella G., Peschle C., Boncinelli E.
Immunogenetics 29:80-91(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[3]"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
Ennis P.D., Zemmour J., Salter R.D., Parham P.
Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[4]"Comparison of HLA class I gene sequences. Derivation of locus-specific oligonucleotide probes specific for HLA-A, HLA-B, and HLA-C genes."
Davidson W.F., Kress M., Khoury G., Jay G.
J. Biol. Chem. 260:13414-13423(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-365.
[5]"Unusual HLA-B alleles in two tribes of Brazilian Indians."
Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., Williams R.C., Luz R., Petzl-Erler M.L., Parham P.
Nature 357:326-329(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:01; A*02:11 AND A*02:12).
[6]"Unusual RNA splicing generates a secreted form of HLA-A2 in a mutagenized B lymphoblastoid cell line."
Krangel M.S.
EMBO J. 4:1205-1210(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-365 (ALLELE A*02:01).
[7]"Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites."
Orr H.T., Lopez de Castro J.A., Parham P., Ploegh H.L., Strominger J.L.
Proc. Natl. Acad. Sci. U.S.A. 76:4395-4399(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-295 (ALLELE A*02:01).
[8]"Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism."
Lopez de Castro J.A., Strominger J.L., Strong D.M., Orr H.T.
Proc. Natl. Acad. Sci. U.S.A. 79:3813-3817(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION (ALLELE A*02:01).
[9]"HLA class I allele (HLA-A2) expression defect associated with a mutation in its enhancer B inverted CAT box in two families."
Balas A., Garcia-Sanchez F., Gomez-Reino F., Vicario J.L.
Hum. Immunol. 41:69-73(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*02:01).
Tissue: Blood.
[10]Balas A.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[11]"Confirmation of HLA-A*0201."
Cox S.T.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:01).
[12]"DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1."
Mattson D.H., Handy D.E., Bradley D.A., Coligan J.E., Cowan E.P., Biddison W.E.
Immunogenetics 26:190-192(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELES A*02:02 AND A*02:03).
[13]"Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules."
Holmes N., Ennis P., Wan A.M., Denney D.W., Parham P.
J. Immunol. 139:936-941(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05).
[14]Domena J.D.
Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELES A*02:03 AND A*02:05).
[15]"Structure of the HLA-A*0204 antigen, found in South American Indians. Spatial clustering of HLA-A2 subtype polymorphism."
Castano A.R., Lopez de Castro J.A.
Immunogenetics 34:281-285(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:04).
[16]"New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci."
Watkins D.I., McAdam S.N., Liu X., Stang C.R., Milford E.L., Levine C.G., Garber T.L., Dogon A.L., Lord C.I., Ghim S.H., Troup G.M., Hughes A.L., Letvin N.L.
Nature 357:329-333(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 9-365 (ALLELE A*02:04).
[17]"Diversity and diversification of HLA-A,B,C alleles."
Parham P., Lawlor D.A., Lomen C.E., Ennis P.D.
J. Immunol. 142:3937-3950(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:06).
[18]"Molecular analysis of an HLA-A2 functional variant CLA defined by cytolytic T lymphocytes."
Ezquerra A., Domenech N., van der Poel J., Strominger J.L., Vega M.A., Lopez de Castro J.A.
J. Immunol. 137:1642-1649(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:06).
[19]"Structural analysis of HLA-A2.4 functional variant KNE. Implications for the mapping of HLA-A2-specific T-cell epitopes."
Domenech N., Ezquerra A., Castano R., Lopez de Castro J.A.
Immunogenetics 27:196-202(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:07).
[20]"Molecular analysis of HLA-A2.4 functional variant KLO: close structural and evolutionary relatedness to the HLA-A2.2 subtype."
Domenech N., Castano R., Goulmy E., Lopez de Castro J.A.
Immunogenetics 28:143-152(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:08).
[21]"An HLA-A2 population variant with structural polymorphism in the alpha 3 region."
Castano R., Ezquerra A., Domenech N., Lopez de Castro J.A.
Immunogenetics 27:345-355(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE (ALLELE A*02:09).
[22]"An Oriental HLA-A2 subtype is closely related to a subset of Caucasoid HLA-A2 alleles."
Epstein H., Kennedy L., Holmes N.
Immunogenetics 29:112-116(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:10).
[23]"Structure of the HLA-A*0211 (A2.5) subtype: further evidence for selection-driven diversification of HLA-A2 antigens."
Castano A.R., Lopez de Castro J.A.
Immunogenetics 35:344-346(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-365 (ALLELE A*02:11).
[24]"Primary structure of a new HLA-A2 subtype: HLA-A*0213."
Barber D.F., Fernandez J.M., Lopez de Castro J.A.
Immunogenetics 39:378-378(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:13).
[25]"Identification of a novel HLA-A2 subtype, HLA-A*0216."
Barouch D., Krausa P., Bodmer J., Browning M.J., McMichael A.J.
Immunogenetics 41:388-388(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:16).
[26]"A novel subtype of A2 (A*0217) isolated from the South American Indian B-cell line AMALA."
Selvakumar A., Granja C.B., Salazar M., Alosco S.M., Yunis E.J., Dupont B.
Tissue Antigens 45:343-347(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:17).
Tissue: Blood.
[27]"A new A2 sequence HLA-A2K from Japanese."
Kashiwase K., Tokunaga K., Ishikawa Y., Oohashi H., Hashimoto M., Akaza T., Tadokoro K., Juji T.
Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:18).
Tissue: Blood.
[28]"HLA-A*02 subtype distribution in Caucasians from northern Italy: identification of A*0220."
Fleischhauer K., Zino E., Mazzi B., Severini G.M., Benazzi E., Bordignon C.
Tissue Antigens 48:673-679(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A*02:20).
Tissue: Blood.
[29]"Nucleotide sequence of a novel HLA-A2 gene."
Szmania S., Baxter-Lowe L.A.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*02:21).
Tissue: Blood.
[30]"Frequencies of HLA-A2 alleles in five U.S. population groups. Predominance Of A*02011 and identification of HLA-A*0231."
Ellis J.M., Henson V., Slack R., Ng J., Hartzman R.J., Hurley C.K.
Hum. Immunol. 61:334-340(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELE A*02:31).
[31]"A new HLA-A*02 allele, A*0234, detected by polymerase chain reaction using sequence-specific primers (PCR-SSP)."
Moses J.H., Greville W.D., Downes J., McClenahan W., Kennedy A., Dunckley H.
Tissue Antigens 55:175-177(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-298 (ALLELE A*02:34).
[32]"Seventeen more novel HLA-A locus alleles."
Ellis J., Steiner N.K., Kosman C., Henson V., Mitton W., Koester R., Ng J., Hartzman R.J., Hurley C.K.
Tissue Antigens 55:369-373(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 26-206 (ALLELES A*02:35; A*02:36 AND A*02:37).
[33]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[34]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[35]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
Tissue: Liver.
[36]"Structure of the human class I histocompatibility antigen, HLA-A2."
Bjorkman P.J., Saper M.A., Samraoui B., Bennett W.S., Strominger J.L., Wiley D.C.
Nature 329:506-512(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF A*02:01.
[37]"Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein."
Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G.
J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
[38]"Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation."
Hewitt E.W., Duncan L., Mufti D., Baker J., Stevenson P.G., Lehner P.J.
EMBO J. 21:2418-2429(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HUMAN HERPESVIRUS 8 MIR1 PROTEIN, UBIQUITINATION.
[39]"A structural basis for immunodominant human T cell receptor recognition."
Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 25-300 OF HLA-A/B2M HETERODIMER IN COMPLEX WITH TRAC AND TRBC1, DISULFIDE BONDS.
[40]"Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution."
Saper M.A., Bjorkman P.J., Wiley D.C.
J. Mol. Biol. 219:277-319(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF A*02:01.
[41]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-176, VARIANT [LARGE SCALE ANALYSIS] TRP-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K02883 Genomic DNA. Translation: AAA98727.1.
M84379 mRNA. Translation: AAA59606.1.
X02457 mRNA. Translation: CAA26297.1.
M11887 mRNA. Translation: AAA52656.1.
M19670 Genomic DNA. Translation: AAA03683.2.
AH003586 Genomic DNA. Translation: AAB02120.1.
U03863 mRNA. Translation: AAA03604.1.
M86404 mRNA. No translation available.
X57954 mRNA. Translation: CAA41022.1. Sequence problems.
U02935 Genomic DNA. Translation: AAA76608.2.
AJ555412 Genomic DNA. Translation: CAD87771.1.
U03862 mRNA. Translation: AAA03603.1.
M24042 mRNA. Translation: AAA59653.1.
Z23071 mRNA. Translation: CAA80612.1.
M84377 mRNA. Translation: AAA59603.1.
X60764 mRNA. No translation available.
M84378 mRNA. Translation: AAA59604.1.
Z27120 mRNA. Translation: CAA81644.1.
Z46633 mRNA. Translation: CAA86602.1.
U18930 mRNA. Translation: AAA87076.1.
D83515 mRNA. Translation: BAA11935.1.
X96724 mRNA. Translation: CAA65501.1.
U56825 mRNA. Translation: AAB17465.1.
AH007560 Genomic DNA. Translation: AAD23437.1.
AH007704 Genomic DNA. Translation: AAD30272.1.
AH008013 Genomic DNA. Translation: AAD45690.1.
AH008012 Genomic DNA. Translation: AAD45689.1.
AH008007 Genomic DNA. Translation: AAD45324.1.
PIRHLHU10. B24512.
I37470.
I37542.
I38418.
I38442.
I38443.
HLHUA2. I55948.
I61857.
I61902.
I84448.
UniGeneHs.181244.
Hs.713441.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AKJX-ray2.65A25-300[»]
1AO7X-ray2.60A25-299[»]
1AQDX-ray2.45C/F/I/L127-141[»]
1B0GX-ray2.50A/D25-299[»]
1B0RX-ray2.90A25-299[»]
1BD2X-ray2.50A25-299[»]
1DUYX-ray2.15A/D25-299[»]
1DUZX-ray1.80A/D25-299[»]
1EEYX-ray2.25A/D25-299[»]
1EEZX-ray2.30A/D25-299[»]
1HHGX-ray2.60A/D25-299[»]
1HHHX-ray3.00A25-299[»]
1HHIX-ray2.50A/D25-299[»]
1HHJX-ray2.50A/D25-299[»]
1HHKX-ray2.50A/D25-299[»]
1HLAX-ray3.50A25-294[»]
1I1FX-ray2.80A/D25-299[»]
1I1YX-ray2.20A/D25-299[»]
1I4FX-ray1.40A25-299[»]
1I7RX-ray2.20A/D25-299[»]
1I7TX-ray2.80A/D25-299[»]
1I7UX-ray1.80A/D25-299[»]
1IM3X-ray2.20A/E/I/M25-299[»]
1JF1X-ray1.85A25-299[»]
1JHTX-ray2.15A25-299[»]
1LP9X-ray2.00A/H25-299[»]
1OGAX-ray1.40A25-300[»]
1P7QX-ray3.40A25-300[»]
1QEWX-ray2.20A25-299[»]
1QR1X-ray2.40A/D25-299[»]
1QRNX-ray2.80A25-298[»]
1QSEX-ray2.80A25-298[»]
1QSFX-ray2.80A25-298[»]
1S8DX-ray2.20A25-299[»]
1S9WX-ray2.20A25-298[»]
1S9XX-ray2.50A25-298[»]
1S9YX-ray2.30A25-298[»]
1T1WX-ray2.20A25-299[»]
1T1XX-ray2.20A25-299[»]
1T1YX-ray2.00A25-299[»]
1T1ZX-ray1.90A25-299[»]
1T20X-ray2.20A25-299[»]
1T21X-ray2.19A25-299[»]
1T22X-ray2.20A25-299[»]
1TVBX-ray1.80A/D25-299[»]
1TVHX-ray1.80A/D25-299[»]
1UR7model-A25-299[»]
2AV1X-ray1.95A/D25-299[»]
2AV7X-ray2.05A/D25-299[»]
2BNQX-ray1.70A25-300[»]
2BNRX-ray1.90A25-300[»]
2C7UX-ray2.38A/D25-300[»]
2CLRX-ray2.00A/D25-299[»]
2F53X-ray2.10A25-299[»]
2F54X-ray2.70A/F25-298[»]
2GITX-ray1.70A/D25-299[»]
2GJ6X-ray2.56A25-299[»]
2GT9X-ray1.75A/D25-299[»]
2GTWX-ray1.55A/D25-299[»]
2GTZX-ray1.70A/D25-299[»]
2GUOX-ray1.90A/D25-299[»]
2J8UX-ray2.88A/H25-299[»]
2JCCX-ray2.50A/H25-299[»]
2P5EX-ray1.89A25-300[»]
2P5WX-ray2.20A25-300[»]
2PYEX-ray2.30A25-300[»]
2UWEX-ray2.40A/H25-299[»]
2V2WX-ray1.60A/D25-300[»]
2V2XX-ray1.60A/D25-300[»]
2VLJX-ray2.40A25-300[»]
2VLKX-ray2.50A25-300[»]
2VLLX-ray1.60A/D25-300[»]
2VLRX-ray2.30A/F25-300[»]
2X4NX-ray2.34A/D25-299[»]
2X4OX-ray2.30A/D25-299[»]
2X4PX-ray2.30A/D25-299[»]
2X4QX-ray1.90A/D25-299[»]
2X4RX-ray2.30A/D25-299[»]
2X4SX-ray2.55A/D25-299[»]
2X4TX-ray2.30A/D25-299[»]
2X4UX-ray2.10A/D25-299[»]
2X70X-ray2.00A/D25-299[»]
3BGMX-ray1.60A25-298[»]
3BH8X-ray1.65A25-298[»]
3BH9X-ray1.70A25-299[»]
3BHBX-ray2.20A25-298[»]
3D25X-ray1.30A25-298[»]
3D39X-ray2.81A25-299[»]
3D3VX-ray2.80A25-299[»]
3FQNX-ray1.65A25-299[»]
3FQRX-ray1.70A25-299[»]
3FQTX-ray1.80A25-299[»]
3FQUX-ray1.80A25-299[»]
3FQWX-ray1.93A25-299[»]
3FQXX-ray1.70A25-299[»]
3FT2X-ray1.80A25-299[»]
3FT3X-ray1.95A25-299[»]
3FT4X-ray1.90A25-299[»]
3GIVX-ray2.00A/D25-299[»]
3GJFX-ray1.90A/D25-300[»]
3GSNX-ray2.80H25-298[»]
3GSOX-ray1.60A25-298[»]
3GSQX-ray2.12A25-298[»]
3GSRX-ray1.95A25-298[»]
3GSUX-ray1.80A25-299[»]
3GSVX-ray1.90A25-299[»]
3GSWX-ray1.81A25-298[»]
3GSXX-ray2.10A25-298[»]
3H7BX-ray1.88A/D25-299[»]
3H9HX-ray2.00A/D25-299[»]
3H9SX-ray2.70A25-299[»]
3HAEX-ray2.90A/D/J/P25-300[»]
3HG1X-ray3.00A25-300[»]
3HLAX-ray2.60A25-294[»]
3HPJX-ray2.00A/D25-299[»]
3I6GX-ray2.20A/D25-299[»]
3I6KX-ray2.80A/E25-299[»]
3IXAX-ray2.10A/D25-299[»]
3KLAX-ray1.65A/D25-299[»]
3MGOX-ray2.30A/D/G/J25-299[»]
3MGTX-ray2.20A/D/G/J25-299[»]
3MR9X-ray1.93A25-300[»]
3MRBX-ray1.40A25-300[»]
3MRCX-ray1.80A25-300[»]
3MRDX-ray1.70A25-300[»]
3MREX-ray1.10A25-300[»]
3MRFX-ray2.30A25-300[»]
3MRGX-ray1.30A25-300[»]
3MRHX-ray2.40A25-300[»]
3MRIX-ray2.10A25-300[»]
3MRJX-ray1.87A25-300[»]
3MRKX-ray1.40A25-300[»]
3MRLX-ray2.41A25-300[»]
3MRMX-ray1.90A25-300[»]
3MRNX-ray2.30A25-300[»]
3MROX-ray2.35A25-300[»]
3MRPX-ray2.10A25-300[»]
3MRQX-ray2.20A25-300[»]
3MRRX-ray1.60A25-300[»]
3MYJX-ray1.89A/D25-299[»]
3O3AX-ray1.80A/D25-299[»]
3O3BX-ray1.90A/D25-299[»]
3O3DX-ray1.70A/D25-299[»]
3O3EX-ray1.85A/D25-299[»]
3O4LX-ray2.54A25-300[»]
3PWJX-ray1.70A/D25-299[»]
3PWLX-ray1.65A/D25-299[»]
3PWNX-ray1.60A/D25-299[»]
3PWPX-ray2.69A25-299[»]
3QDGX-ray2.69A25-299[»]
3QDJX-ray2.30A25-299[»]
3QDMX-ray2.80A25-299[»]
3QEQX-ray2.59A25-299[»]
3QFDX-ray1.68A/D25-299[»]
3QFJX-ray2.29A25-299[»]
3REWX-ray1.90A/D25-299[»]
3TO2X-ray2.60A25-299[»]
3UTQX-ray1.67A25-300[»]
3UTSX-ray2.71A/F25-300[»]
3UTTX-ray2.60A/F25-299[»]
3V5DX-ray2.00A/D25-299[»]
3V5HX-ray1.63A/D25-299[»]
3V5KX-ray2.31A/D25-299[»]
4E5XX-ray1.95A/D25-299[»]
4EMZX-ray2.90D/E338-365[»]
4EN2X-ray2.58D/E338-365[»]
4EUPX-ray2.88A/D25-299[»]
4EUQX-ray2.69A/D25-299[»]
4FTVX-ray2.74A25-299[»]
4GKNX-ray2.75A/D25-300[»]
4GKSX-ray2.35A/D25-300[»]
4I4WX-ray1.77A25-300[»]
4JFDX-ray2.46A25-300[»]
4JFEX-ray2.70A25-300[»]
4JFFX-ray2.43A25-300[»]
4JFOX-ray2.11A/D25-299[»]
4JFPX-ray1.91A/D25-300[»]
4JFQX-ray1.90A/D25-300[»]
4K7FX-ray2.00A/D25-299[»]
4L29X-ray3.09A/C/E/G/I/K/M/O/Q/S/U/W/Y/a25-300[»]
4L3CX-ray2.64A/C/E/G/I/K/M/O/Q/S/U/W/Y/a25-300[»]
4MNQX-ray2.74A25-300[»]
ProteinModelPortalP01892.
SMRP01892. Positions 25-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6085N.
IntActP01892. 12 interactions.
MINTMINT-5000859.

PTM databases

PhosphoSiteP01892.

Polymorphism databases

DMDM122138.

Proteomic databases

PaxDbP01892.
PRIDEP01892.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000457879; ENSP00000403575; ENSG00000235657.
ENST00000547271; ENSP00000447962; ENSG00000235657.

Organism-specific databases

GeneCardsGC06P029949.
GC06Pk29899.
HGNCHGNC:4931. HLA-A.
MIM142800. gene.
neXtProtNX_P01892.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42056.
HOVERGENHBG016709.

Enzyme and pathway databases

ReactomeREACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-A.
GenevestigatorP01892.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-A. human.
EvolutionaryTraceP01892.
SOURCESearch...

Entry information

Entry name1A02_HUMAN
AccessionPrimary (citable) accession number: P01892
Secondary accession number(s): O19619 expand/collapse secondary AC list , P06338, P10313, P30444, P30445, P30446, P30514, Q29680, Q29837, Q29899, Q95352, Q95380, Q9TPX8, Q9TPX9, Q9TPY0, Q9TQH5, Q9TQI3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: April 16, 2014
This is version 165 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM