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Protein

HLA class I histocompatibility antigen, A-68 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-68 alpha chain
Alternative name(s):
Aw-68
HLA class I histocompatibility antigen, A-28 alpha chain
MHC class I antigen A*68
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 365CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3105.
MalaCardsiHLA-A.

Polymorphism and mutation databases

DMDMi13124681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001883025 – 365HLA class I histocompatibility antigen, A-68 alpha chainAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)1 Publication1
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283
Modified residuei343PhosphoserineBy similarity1
Modified residuei344PhosphotyrosineBy similarity1
Modified residuei345PhosphoserineBy similarity1
Modified residuei349PhosphoserineBy similarity1
Modified residuei350PhosphoserineCombined sources1
Modified residuei352PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP01891.
MaxQBiP01891.
PeptideAtlasiP01891.
PRIDEiP01891.

PTM databases

iPTMnetiP01891.
SwissPalmiP01891.

Expressioni

Gene expression databases

BgeeiENSG00000235657.
CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB

Protein-protein interaction databases

IntActiP01891. 5 interactors.
MINTiMINT-274751.

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi154 – 161Combined sources8
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSBX-ray1.90A25-294[»]
1TMCX-ray2.30A25-199[»]
2HLAX-ray2.60A25-294[»]
4HWZX-ray2.40A25-298[»]
4HX1X-ray1.80A25-296[»]
4I48X-ray2.80A25-296[»]
ProteinModelPortaliP01891.
SMRiP01891.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01891.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
InParanoidiP01891.
PhylomeDBiP01891.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQW RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWVA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,909
Last modified:February 21, 2001 - v4
Checksum:i78539C59DB8B1DFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206T → A in AAF74211 (PubMed:10803837).Curated1
Sequence conflicti231S → G AA sequence (PubMed:6179086).Curated1

Polymorphismi

The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05, A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00438936V → M in allele A*68:02. 3 Publications1
Natural variantiVAR_01036286 – 87RN → EE in allele A*68:10. 1 Publication2
Natural variantiVAR_05630489R → G.Corresponds to variant rs1059459dbSNPEnsembl.1
Natural variantiVAR_01036394Q → H in allele A*68:03, allele A*68:04 and allele A*68:05. 3 PublicationsCorresponds to variant rs1059463dbSNPEnsembl.1
Natural variantiVAR_01036497T → I in allele A*68:04. 1
Natural variantiVAR_01036598D → H in allele A*68:05. 1
Natural variantiVAR_056305101D → N.Corresponds to variant rs1136688dbSNPEnsembl.1
Natural variantiVAR_004390121M → R in allele A*68:02. 3 Publications1
Natural variantiVAR_004391129S → P in allele A*68:02. 3 PublicationsCorresponds to variant rs1136700dbSNPEnsembl.1
Natural variantiVAR_056306133F → L.Corresponds to variant rs1059488dbSNPEnsembl.1
Natural variantiVAR_010366138R → E in allele A*68:06; requires 2 nucleotide substitutions. 1 Publication1
Natural variantiVAR_004392138R → H in allele A*68:02. 3 Publications1
Natural variantiVAR_010367140D → H in allele A*68:06 and allele A*68:07. 1 Publication1
Natural variantiVAR_010368140D → V in allele A*68:17. 2 Publications1
Natural variantiVAR_004393140D → Y in allele A*68:02. 3 Publications1
Natural variantiVAR_010369175H → L in allele A*68:16. 1 Publication1
Natural variantiVAR_010370180W → L in allele A*68:08. 1 Publication1
Natural variantiVAR_010371180W → Q in allele A*68:09; requires 2 nucleotide substitutions. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03861 mRNA. Translation: AAA03602.1.
X03070 Genomic DNA. Translation: CAB56605.1.
X03071 Genomic DNA. Translation: CAB56606.1.
U41057 mRNA. Translation: AAB41292.1.
AJ315642 Genomic DNA. Translation: CAC44382.1.
AF144013 Genomic DNA. Translation: AAF74211.1.
AJ245567 Genomic DNA. Translation: CAB59722.1.
AH005127 Genomic DNA. Translation: AAB50567.1.
U89946 Genomic DNA. Translation: AAB82079.1.
U89947 Genomic DNA. Translation: AAB82080.1.
AJ001274 mRNA. Translation: CAA04647.1.
AH006296 Genomic DNA. Translation: AAC25782.1.
AH007538 Genomic DNA. Translation: AAD22270.1.
AH007605 Genomic DNA. Translation: AAD27539.1.
AJ223972 Genomic DNA. Translation: CAA11708.1.
AH007201 Genomic DNA. Translation: AAD02208.1.
AH009406 Genomic DNA. Translation: AAF73477.1.
PIRiA02187. HLHU28.
A24671. HLHUAW.
I38441.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03861 mRNA. Translation: AAA03602.1.
X03070 Genomic DNA. Translation: CAB56605.1.
X03071 Genomic DNA. Translation: CAB56606.1.
U41057 mRNA. Translation: AAB41292.1.
AJ315642 Genomic DNA. Translation: CAC44382.1.
AF144013 Genomic DNA. Translation: AAF74211.1.
AJ245567 Genomic DNA. Translation: CAB59722.1.
AH005127 Genomic DNA. Translation: AAB50567.1.
U89946 Genomic DNA. Translation: AAB82079.1.
U89947 Genomic DNA. Translation: AAB82080.1.
AJ001274 mRNA. Translation: CAA04647.1.
AH006296 Genomic DNA. Translation: AAC25782.1.
AH007538 Genomic DNA. Translation: AAD22270.1.
AH007605 Genomic DNA. Translation: AAD27539.1.
AJ223972 Genomic DNA. Translation: CAA11708.1.
AH007201 Genomic DNA. Translation: AAD02208.1.
AH009406 Genomic DNA. Translation: AAF73477.1.
PIRiA02187. HLHU28.
A24671. HLHUAW.
I38441.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSBX-ray1.90A25-294[»]
1TMCX-ray2.30A25-199[»]
2HLAX-ray2.60A25-294[»]
4HWZX-ray2.40A25-298[»]
4HX1X-ray1.80A25-296[»]
4I48X-ray2.80A25-296[»]
ProteinModelPortaliP01891.
SMRiP01891.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01891. 5 interactors.
MINTiMINT-274751.

PTM databases

iPTMnetiP01891.
SwissPalmiP01891.

Polymorphism and mutation databases

DMDMi13124681.

Proteomic databases

EPDiP01891.
MaxQBiP01891.
PeptideAtlasiP01891.
PRIDEiP01891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657.

Organism-specific databases

DisGeNETi3105.
GeneCardsiHLA-A.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P01891.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
InParanoidiP01891.
PhylomeDBiP01891.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
EvolutionaryTraceiP01891.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000235657.
CleanExiHS_HLA-A.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1A68_HUMAN
AccessioniPrimary (citable) accession number: P01891
Secondary accession number(s): O19673
, O19695, O19794, O19795, O43907, O77938, O98010, P10315, P79505, Q9MYA5, Q9MYC4, Q9TQG7, Q9TQN5, Q9UIN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 21, 2001
Last modified: November 2, 2016
This is version 166 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.