UniProtKB - P01891 (1A68_HUMAN)
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Protein
HLA class I histocompatibility antigen, A-68 alpha chain
Gene
HLA-A
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Molecular functioni
- beta-2-microglobulin binding Source: UniProtKB
- peptide antigen binding Source: UniProtKB
- receptor binding Source: GO_Central
- RNA binding Source: UniProtKB
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
- antigen processing and presentation of peptide antigen via MHC class I Source: GO_Central
- interferon-gamma-mediated signaling pathway Source: Reactome
- regulation of immune response Source: Reactome
- type I interferon signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-1236974. ER-Phagosome pathway. R-HSA-1236977. Endosomal/Vacuolar pathway. R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. R-HSA-877300. Interferon gamma signaling. R-HSA-909733. Interferon alpha/beta signaling. R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC. |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class I histocompatibility antigen, A-68 alpha chainAlternative name(s): Aw-68 HLA class I histocompatibility antigen, A-28 alpha chain MHC class I antigen A*68 |
Gene namesi | Name:HLA-A Synonyms:HLAA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4931. HLA-A. |
MIMi | 142800. gene. |
neXtProti | NX_P01891. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 308 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 309 – 332 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 333 – 365 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Membrane, MHC IPathology & Biotechi
Organism-specific databases
DisGeNETi | 3105. |
MalaCardsi | HLA-A. |
Polymorphism and mutation databases
DMDMi | 13124681. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | 1 PublicationAdd BLAST | 24 | |
ChainiPRO_0000018830 | 25 – 365 | HLA class I histocompatibility antigen, A-68 alpha chainAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 125 ↔ 188 | |||
Disulfide bondi | 227 ↔ 283 | |||
Modified residuei | 343 | PhosphoserineBy similarity | 1 | |
Modified residuei | 344 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | PhosphoserineCombined sources | 1 | |
Modified residuei | 352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P01891. |
MaxQBi | P01891. |
PeptideAtlasi | P01891. |
PRIDEi | P01891. |
PTM databases
iPTMneti | P01891. |
SwissPalmi | P01891. |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity
GO - Molecular functioni
- beta-2-microglobulin binding Source: UniProtKB
- receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | P01891. 8 interactors. |
MINTi | P01891. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 27 – 36 | Combined sources | 10 | |
Beta strandi | 41 – 43 | Combined sources | 3 | |
Beta strandi | 45 – 52 | Combined sources | 8 | |
Beta strandi | 55 – 61 | Combined sources | 7 | |
Beta strandi | 64 – 66 | Combined sources | 3 | |
Helixi | 74 – 76 | Combined sources | 3 | |
Helixi | 81 – 108 | Combined sources | 28 | |
Beta strandi | 113 – 115 | Combined sources | 3 | |
Beta strandi | 118 – 127 | Combined sources | 10 | |
Beta strandi | 133 – 142 | Combined sources | 10 | |
Beta strandi | 145 – 150 | Combined sources | 6 | |
Beta strandi | 157 – 159 | Combined sources | 3 | |
Helixi | 162 – 173 | Combined sources | 12 | |
Helixi | 176 – 185 | Combined sources | 10 | |
Helixi | 187 – 198 | Combined sources | 12 | |
Helixi | 200 – 203 | Combined sources | 4 | |
Beta strandi | 210 – 235 | Combined sources | 26 | |
Beta strandi | 238 – 243 | Combined sources | 6 | |
Beta strandi | 246 – 248 | Combined sources | 3 | |
Beta strandi | 252 – 254 | Combined sources | 3 | |
Beta strandi | 261 – 263 | Combined sources | 3 | |
Beta strandi | 265 – 274 | Combined sources | 10 | |
Helixi | 278 – 280 | Combined sources | 3 | |
Beta strandi | 281 – 286 | Combined sources | 6 | |
Beta strandi | 290 – 292 | Combined sources | 3 | |
Beta strandi | 294 – 296 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HSB | X-ray | 1.90 | A | 25-294 | [»] | |
1TMC | X-ray | 2.30 | A | 25-199 | [»] | |
2HLA | X-ray | 2.60 | A | 25-294 | [»] | |
4HWZ | X-ray | 2.40 | A | 25-298 | [»] | |
4HX1 | X-ray | 1.80 | A | 25-296 | [»] | |
4I48 | X-ray | 2.80 | A | 25-296 | [»] | |
6EI2 | X-ray | 1.61 | A | 25-299 | [»] | |
ProteinModelPortali | P01891. | |||||
SMRi | P01891. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01891. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 295 | Ig-like C1-typeAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 206 | Alpha-2Add BLAST | 92 | |
Regioni | 207 – 298 | Alpha-3Add BLAST | 92 | |
Regioni | 299 – 308 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
HOVERGENi | HBG016709. |
InParanoidi | P01891. |
PhylomeDBi | P01891. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. 3.30.500.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR037055. MHC_I-like_Ag-recog_sf. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. |
Pfami | View protein in Pfam PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. |
PRINTSi | PR01638. MHCCLASSI. |
SMARTi | View protein in SMART SM00407. IGc1. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01891-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQW RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWVA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 206 | T → A in AAF74211 (PubMed:10803837).Curated | 1 | |
Sequence conflicti | 231 | S → G AA sequence (PubMed:6179086).Curated | 1 |
Polymorphismi
The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05, A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004389 | 36 | V → M in allele A*68:02. 3 Publications | 1 | |
Natural variantiVAR_010362 | 86 – 87 | RN → EE in allele A*68:10. 1 Publication | 2 | |
Natural variantiVAR_056304 | 89 | R → G. Corresponds to variant dbSNP:rs199474430Ensembl. | 1 | |
Natural variantiVAR_010363 | 94 | Q → H in allele A*68:03, allele A*68:04 and allele A*68:05. 3 PublicationsCorresponds to variant dbSNP:rs78306866Ensembl. | 1 | |
Natural variantiVAR_010364 | 97 | T → I in allele A*68:04. | 1 | |
Natural variantiVAR_010365 | 98 | D → H in allele A*68:05. | 1 | |
Natural variantiVAR_056305 | 101 | D → N. Corresponds to variant dbSNP:rs1136688Ensembl. | 1 | |
Natural variantiVAR_004390 | 121 | M → R in allele A*68:02. 3 Publications | 1 | |
Natural variantiVAR_004391 | 129 | S → P in allele A*68:02. 3 PublicationsCorresponds to variant dbSNP:rs1136700Ensembl. | 1 | |
Natural variantiVAR_056306 | 133 | F → L. Corresponds to variant dbSNP:rs1059488Ensembl. | 1 | |
Natural variantiVAR_010366 | 138 | R → E in allele A*68:06; requires 2 nucleotide substitutions. 1 Publication | 1 | |
Natural variantiVAR_004392 | 138 | R → H in allele A*68:02. 3 Publications | 1 | |
Natural variantiVAR_010367 | 140 | D → H in allele A*68:06 and allele A*68:07. 1 Publication | 1 | |
Natural variantiVAR_010368 | 140 | D → V in allele A*68:17. 2 Publications | 1 | |
Natural variantiVAR_004393 | 140 | D → Y in allele A*68:02. 3 Publications | 1 | |
Natural variantiVAR_010369 | 175 | H → L in allele A*68:16. 1 Publication | 1 | |
Natural variantiVAR_010370 | 180 | W → L in allele A*68:08. 1 Publication | 1 | |
Natural variantiVAR_010371 | 180 | W → Q in allele A*68:09; requires 2 nucleotide substitutions. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U03861 mRNA. Translation: AAA03602.1. X03070 Genomic DNA. Translation: CAB56605.1. X03071 Genomic DNA. Translation: CAB56606.1. U41057 mRNA. Translation: AAB41292.1. AJ315642 Genomic DNA. Translation: CAC44382.1. AF144013 Genomic DNA. Translation: AAF74211.1. AJ245567 Genomic DNA. Translation: CAB59722.1. AH005127 Genomic DNA. Translation: AAB50567.1. U89946 Genomic DNA. Translation: AAB82079.1. U89947 Genomic DNA. Translation: AAB82080.1. AJ001274 mRNA. Translation: CAA04647.1. AH006296 Genomic DNA. Translation: AAC25782.1. AH007538 Genomic DNA. Translation: AAD22270.1. AH007605 Genomic DNA. Translation: AAD27539.1. AJ223972 Genomic DNA. Translation: CAA11708.1. AH007201 Genomic DNA. Translation: AAD02208.1. AH009406 Genomic DNA. Translation: AAF73477.1. |
PIRi | A02187. HLHU28. A24671. HLHUAW. I38441. |
UniGenei | Hs.181244. Hs.713441. |
Genome annotation databases
Ensembli | ENST00000457879; ENSP00000403575; ENSG00000235657. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | 1A68_HUMAN | |
Accessioni | P01891Primary (citable) accession number: P01891 Secondary accession number(s): O19673 Q9UIN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 21, 2001 | |
Last modified: | March 28, 2018 | |
This is version 176 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |