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UniProtKB - P01891 (1A68_HUMAN)

UniProt

P01891 - 1A68_HUMAN

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Protein

HLA class I histocompatibility antigen, A-68 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-68 alpha chain
Alternative name(s):
Aw-68
HLA class I histocompatibility antigen, A-28 alpha chain
MHC class I antigen A*68
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-A.

Polymorphism and mutation databases

DMDMi13124681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-68 alpha chainPRO_0000018830Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei344 – 3441PhosphotyrosineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei359 – 3591PhosphoserineCombined sources

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP01891.
MaxQBiP01891.
PeptideAtlasiP01891.
PRIDEiP01891.

PTM databases

iPTMnetiP01891.
SwissPalmiP01891.

Expressioni

Gene expression databases

BgeeiENSG00000235657.
CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB

Protein-protein interaction databases

IntActiP01891. 5 interactions.
MINTiMINT-274751.

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10828Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi154 – 1618Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 2178Combined sources
Beta strandi219 – 23517Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi246 – 2483Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2963Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HSBX-ray1.90A25-294[»]
1TMCX-ray2.30A25-199[»]
2HLAX-ray2.60A25-294[»]
4HWZX-ray2.40A25-298[»]
4HX1X-ray1.80A25-296[»]
4I48X-ray2.80A25-296[»]
ProteinModelPortaliP01891.
SMRiP01891. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01891.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
InParanoidiP01891.
PhylomeDBiP01891.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01891-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFYTSVSRPG RGEPRFIAVG 
        60         70         80         90        100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDRNTRN VKAQSQTDRV 
       110        120        130        140        150
DLGTLRGYYN QSEAGSHTIQ MMYGCDVGSD GRFLRGYRQD AYDGKDYIAL 
       160        170        180        190        200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQW RAYLEGTCVE WLRRYLENGK 
       210        220        230        240        250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ 
       260        270        280        290        300
DTELVETRPA GDGTFQKWVA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP 
       310        320        330        340        350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSDRK GGSYSQAASS 
       360 
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,909
Last modified:February 21, 2001 - v4
Checksum:i78539C59DB8B1DFC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061T → A in AAF74211 (PubMed:10803837).Curated
Sequence conflicti231 – 2311S → G AA sequence (PubMed:6179086).Curated

Polymorphismi

The following alleles of A-68 are known: A*68:01 (Aw68.1), A*68:02, A*68:03. A*68:04, A*68:05, A*68:06, A*68:07, A*68:08, A*68:09, A*68:10, A*68:16 and A*68:17. The sequence shown is that of A*68:01.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → M in allele A*68:02. 3 Publications
VAR_004389
Natural varianti86 – 872RN → EE in allele A*68:10. 1 Publication
VAR_010362
Natural varianti89 – 891R → G.
Corresponds to variant rs1059459 [ dbSNP | Ensembl ].		VAR_056304
Natural varianti94 – 941Q → H in allele A*68:03, allele A*68:04 and allele A*68:05. 3 Publications
Corresponds to variant rs1059463 [ dbSNP | Ensembl ].		VAR_010363
Natural varianti97 – 971T → I in allele A*68:04.
VAR_010364
Natural varianti98 – 981D → H in allele A*68:05.
VAR_010365
Natural varianti101 – 1011D → N.
Corresponds to variant rs1136688 [ dbSNP | Ensembl ].		VAR_056305
Natural varianti121 – 1211M → R in allele A*68:02. 3 Publications
VAR_004390
Natural varianti129 – 1291S → P in allele A*68:02. 3 Publications
Corresponds to variant rs1136700 [ dbSNP | Ensembl ].		VAR_004391
Natural varianti133 – 1331F → L.
Corresponds to variant rs1059488 [ dbSNP | Ensembl ].		VAR_056306
Natural varianti138 – 1381R → E in allele A*68:06; requires 2 nucleotide substitutions. 1 Publication
VAR_010366
Natural varianti138 – 1381R → H in allele A*68:02. 3 Publications
VAR_004392
Natural varianti140 – 1401D → H in allele A*68:06 and allele A*68:07. 1 Publication
VAR_010367
Natural varianti140 – 1401D → V in allele A*68:17. 2 Publications
VAR_010368
Natural varianti140 – 1401D → Y in allele A*68:02. 3 Publications
VAR_004393
Natural varianti175 – 1751H → L in allele A*68:16. 1 Publication
VAR_010369
Natural varianti180 – 1801W → L in allele A*68:08. 1 Publication
VAR_010370
Natural varianti180 – 1801W → Q in allele A*68:09; requires 2 nucleotide substitutions.
VAR_010371

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03861 mRNA. Translation: AAA03602.1.
X03070 Genomic DNA. Translation: CAB56605.1.
X03071 Genomic DNA. Translation: CAB56606.1.
U41057 mRNA. Translation: AAB41292.1.
AJ315642 Genomic DNA. Translation: CAC44382.1.
AF144013 Genomic DNA. Translation: AAF74211.1.
AJ245567 Genomic DNA. Translation: CAB59722.1.
AH005127 Genomic DNA. Translation: AAB50567.1.
U89946 Genomic DNA. Translation: AAB82079.1.
U89947 Genomic DNA. Translation: AAB82080.1.
AJ001274 mRNA. Translation: CAA04647.1.
AH006296 Genomic DNA. Translation: AAC25782.1.
AH007538 Genomic DNA. Translation: AAD22270.1.
AH007605 Genomic DNA. Translation: AAD27539.1.
AJ223972 Genomic DNA. Translation: CAA11708.1.
AH007201 Genomic DNA. Translation: AAD02208.1.
AH009406 Genomic DNA. Translation: AAF73477.1.
PIRiA02187. HLHU28.
A24671. HLHUAW.
I38441.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03861 mRNA. Translation: AAA03602.1.
X03070 Genomic DNA. Translation: CAB56605.1.
X03071 Genomic DNA. Translation: CAB56606.1.
U41057 mRNA. Translation: AAB41292.1.
AJ315642 Genomic DNA. Translation: CAC44382.1.
AF144013 Genomic DNA. Translation: AAF74211.1.
AJ245567 Genomic DNA. Translation: CAB59722.1.
AH005127 Genomic DNA. Translation: AAB50567.1.
U89946 Genomic DNA. Translation: AAB82079.1.
U89947 Genomic DNA. Translation: AAB82080.1.
AJ001274 mRNA. Translation: CAA04647.1.
AH006296 Genomic DNA. Translation: AAC25782.1.
AH007538 Genomic DNA. Translation: AAD22270.1.
AH007605 Genomic DNA. Translation: AAD27539.1.
AJ223972 Genomic DNA. Translation: CAA11708.1.
AH007201 Genomic DNA. Translation: AAD02208.1.
AH009406 Genomic DNA. Translation: AAF73477.1.
PIRiA02187. HLHU28.
A24671. HLHUAW.
I38441.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HSBX-ray1.90A25-294[»]
1TMCX-ray2.30A25-199[»]
2HLAX-ray2.60A25-294[»]
4HWZX-ray2.40A25-298[»]
4HX1X-ray1.80A25-296[»]
4I48X-ray2.80A25-296[»]
ProteinModelPortaliP01891.
SMRiP01891. Positions 25-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01891. 5 interactions.
MINTiMINT-274751.

PTM databases

iPTMnetiP01891.
SwissPalmiP01891.

Polymorphism and mutation databases

DMDMi13124681.

Proteomic databases

EPDiP01891.
MaxQBiP01891.
PeptideAtlasiP01891.
PRIDEiP01891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457879; ENSP00000403575; ENSG00000235657.

Organism-specific databases

GeneCardsiHLA-A.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P01891.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
InParanoidiP01891.
PhylomeDBiP01891.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
EvolutionaryTraceiP01891.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000235657.
CleanExiHS_HLA-A.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1A68_HUMAN
AccessioniPrimary (citable) accession number: P01891
Secondary accession number(s): O19673
, O19695, O19794, O19795, O43907, O77938, O98010, P10315, P79505, Q9MYA5, Q9MYC4, Q9TQG7, Q9TQN5, Q9UIN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 164 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.