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Protein

HLA class I histocompatibility antigen, B-7 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • peptide antigen binding Source: UniProtKB
  • receptor binding Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  • antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  • immune response Source: UniProtKB
  • interferon-gamma-mediated signaling pathway Source: Reactome
  • protection from natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of dendritic cell differentiation Source: BHF-UCL
  • regulation of immune response Source: Reactome
  • regulation of interleukin-12 production Source: BHF-UCL
  • regulation of interleukin-6 production Source: BHF-UCL
  • regulation of T cell anergy Source: BHF-UCL
  • type I interferon signaling pathway Source: Reactome
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180202-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-7 alpha chain
Alternative name(s):
MHC class I antigen B*7
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 309ExtracellularSequence analysisAdd BLAST285
Transmembranei310 – 333HelicalSequence analysisAdd BLAST24
Topological domaini334 – 362CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • early endosome membrane Source: Reactome
  • endoplasmic reticulum Source: UniProtKB
  • ER to Golgi transport vesicle membrane Source: Reactome
  • extracellular exosome Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • Golgi membrane Source: Reactome
  • integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  • integral component of plasma membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • MHC class I protein complex Source: UniProtKB
  • phagocytic vesicle membrane Source: Reactome
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

DisGeNETi3106.
MalaCardsiHLA-B.
OpenTargetsiENSG00000234745.
PharmGKBiPA35056.

Polymorphism and mutation databases

BioMutaiZCCHC6.
DMDMi122162.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001883325 – 362HLA class I histocompatibility antigen, B-7 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)1 Publication1
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiP01889.
MaxQBiP01889.
PaxDbiP01889.
PeptideAtlasiP01889.
PRIDEiP01889.

PTM databases

iPTMnetiP01889.
SwissPalmiP01889.

Expressioni

Gene expression databases

BgeeiENSG00000234745.
CleanExiHS_HLA-B.
ExpressionAtlasiP01889. baseline and differential.
GenevisibleiP01889. HS.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.By similarity1 Publication

GO - Molecular functioni

  • receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109351. 72 interactors.
IntActiP01889. 4 interactors.
STRINGi9606.ENSP00000399168.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Beta strandi70 – 73Combined sources4
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 198Combined sources12
Helixi200 – 203Combined sources4
Beta strandi210 – 235Combined sources26
Beta strandi238 – 243Combined sources6
Helixi249 – 251Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi290 – 292Combined sources3
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
4U1HX-ray1.59A25-300[»]
4U1KX-ray2.09A/D25-300[»]
5EO0X-ray1.70A25-299[»]
5EO1X-ray1.85A25-299[»]
ProteinModelPortaliP01889.
SMRiP01889.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 309Connecting peptideAdd BLAST11

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiQSTITIM.
OrthoDBiEOG091G09OH.
PhylomeDBiP01889.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK
210 220 230 240 250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,460
Last modified:February 1, 1991 - v3
Checksum:i5E5A7BDE031403D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 18AALA → GPW in AAA59622 (PubMed:2993161).Curated4
Sequence conflicti266Q → E AA sequence (PubMed:518865).Curated1
Sequence conflicti268W → S in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti297R → G in AAA59622 (PubMed:2993161).Curated1
Sequence conflicti314 – 315GL → RP in AAA59622 (PubMed:2993161).Curated2

Polymorphismi

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0503324M → T.Corresponds to variant rs1050458dbSNPEnsembl.1
Natural variantiVAR_0503339V → L.Corresponds to variant rs1050462dbSNPEnsembl.1
Natural variantiVAR_05033417L → V.Corresponds to variant rs1131165dbSNPEnsembl.1
Natural variantiVAR_05033535S → A.Corresponds to variant rs1131170dbSNPEnsembl.1
Natural variantiVAR_05033636V → M.Corresponds to variant rs1050486dbSNPEnsembl.1
Natural variantiVAR_06138648S → A.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06138748S → P.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06138848S → T.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_05033765A → T.Combined sourcesCorresponds to variant rs1050529dbSNPEnsembl.1
Natural variantiVAR_05033887N → D.Corresponds to variant rs1050570dbSNPEnsembl.1
Natural variantiVAR_05946787N → K.Corresponds to variant rs1065386dbSNPEnsembl.1
Natural variantiVAR_01635193 – 95AQA → TNT in allele B*07:03. 3
Natural variantiVAR_05033997T → A.Corresponds to variant rs1050393dbSNPEnsembl.1
Natural variantiVAR_05946898D → Y.Corresponds to variant rs1131215dbSNPEnsembl.1
Natural variantiVAR_050340101S → N.Corresponds to variant rs1050388dbSNPEnsembl.1
Natural variantiVAR_016352118 – 119TL → II in allele B*07:18. Corresponds to variant rs796332753dbSNPEnsembl.2
Natural variantiVAR_016353121S → R in allele B*07:18. Corresponds to variant rs1140412dbSNPEnsembl.1
Natural variantiVAR_050341137H → Y.Corresponds to variant rs1050379dbSNPEnsembl.1
Natural variantiVAR_061389138D → H.Corresponds to variant rs709055dbSNPEnsembl.1
Natural variantiVAR_016354138D → N in allele B*07:05 and allele B*07:06. Combined sourcesCorresponds to variant rs709055dbSNPEnsembl.1
Natural variantiVAR_050342155R → S.Combined sourcesCorresponds to variant rs1050654dbSNPEnsembl.1
Natural variantiVAR_016355180R → D in allele B*07:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059469187E → A.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_059470187E → G.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_059471187E → K.Corresponds to variant rs2523600dbSNPEnsembl.1
Natural variantiVAR_016616187E → L in allele B*07:24; requires 2 nucleotide substitutions. 1
Natural variantiVAR_059472187E → Q.Corresponds to variant rs2523600dbSNPEnsembl.1
Natural variantiVAR_059473187E → V.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_050343195Y → H.Corresponds to variant rs1050696dbSNPEnsembl.1
Natural variantiVAR_016356306V → I in allele B*07:05. Corresponds to variant rs1131500dbSNPEnsembl.1
Natural variantiVAR_050344329A → T.Corresponds to variant rs1051488dbSNPEnsembl.1
Natural variantiVAR_061390349C → S.Corresponds to variant rs2308655dbSNPEnsembl.1
Natural variantiVAR_061391349C → Y.Corresponds to variant rs2308655dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32317 mRNA. Translation: AAA36230.1.
M16102 mRNA. Translation: AAA59622.1. Sequence problems.
U29057 mRNA. Translation: AAA91229.1.
X64454 mRNA. Translation: CAA45785.1.
U04245 mRNA. Translation: AAA87398.1.
L33922 mRNA. Translation: AAA65639.1.
U21052 mRNA. Translation: AAA92563.1.
U21053 mRNA. Translation: AAA92564.1.
X91749 mRNA. Translation: CAA62864.1.
AF189017 mRNA. Translation: AAF01052.1.
AJ309047 Genomic DNA. Translation: CAC35468.1.
AJ292075 Genomic DNA. Translation: CAC33440.1.
AL671883 Genomic DNA. Translation: CAI18148.1.
AK313911 mRNA. Translation: BAG36634.1.
AJ401222 Genomic DNA. Translation: CAC10402.1.
CCDSiCCDS34394.1.
PIRiB35997. HLHUB7.
I54418.
I59651.
S60601.
RefSeqiNP_005505.2. NM_005514.7.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
GeneIDi3106.
KEGGihsa:3106.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32317 mRNA. Translation: AAA36230.1.
M16102 mRNA. Translation: AAA59622.1. Sequence problems.
U29057 mRNA. Translation: AAA91229.1.
X64454 mRNA. Translation: CAA45785.1.
U04245 mRNA. Translation: AAA87398.1.
L33922 mRNA. Translation: AAA65639.1.
U21052 mRNA. Translation: AAA92563.1.
U21053 mRNA. Translation: AAA92564.1.
X91749 mRNA. Translation: CAA62864.1.
AF189017 mRNA. Translation: AAF01052.1.
AJ309047 Genomic DNA. Translation: CAC35468.1.
AJ292075 Genomic DNA. Translation: CAC33440.1.
AL671883 Genomic DNA. Translation: CAI18148.1.
AK313911 mRNA. Translation: BAG36634.1.
AJ401222 Genomic DNA. Translation: CAC10402.1.
CCDSiCCDS34394.1.
PIRiB35997. HLHUB7.
I54418.
I59651.
S60601.
RefSeqiNP_005505.2. NM_005514.7.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
4U1HX-ray1.59A25-300[»]
4U1KX-ray2.09A/D25-300[»]
5EO0X-ray1.70A25-299[»]
5EO1X-ray1.85A25-299[»]
ProteinModelPortaliP01889.
SMRiP01889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109351. 72 interactors.
IntActiP01889. 4 interactors.
STRINGi9606.ENSP00000399168.

PTM databases

iPTMnetiP01889.
SwissPalmiP01889.

Polymorphism and mutation databases

BioMutaiZCCHC6.
DMDMi122162.

Proteomic databases

EPDiP01889.
MaxQBiP01889.
PaxDbiP01889.
PeptideAtlasiP01889.
PRIDEiP01889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
GeneIDi3106.
KEGGihsa:3106.

Organism-specific databases

CTDi3106.
DisGeNETi3106.
GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
HPAiCAB015418.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_P01889.
OpenTargetsiENSG00000234745.
PharmGKBiPA35056.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiQSTITIM.
OrthoDBiEOG091G09OH.
PhylomeDBiP01889.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000180202-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-6798695. Neutrophil degranulation.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
GeneWikiiHLA-B.
GenomeRNAii3106.
PROiP01889.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000234745.
CleanExiHS_HLA-B.
ExpressionAtlasiP01889. baseline and differential.
GenevisibleiP01889. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B07_HUMAN
AccessioniPrimary (citable) accession number: P01889
Secondary accession number(s): Q29638
, Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: November 30, 2016
This is version 175 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.