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P01889

- 1B07_HUMAN

UniProt

P01889 - 1B07_HUMAN

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Protein

HLA class I histocompatibility antigen, B-7 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt
  2. receptor binding Source: BHF-UCL

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. immune response Source: UniProtKB
  7. interferon-gamma-mediated signaling pathway Source: Reactome
  8. positive regulation of T cell mediated cytotoxicity Source: InterPro
  9. protection from natural killer cell mediated cytotoxicity Source: UniProt
  10. regulation of dendritic cell differentiation Source: BHF-UCL
  11. regulation of immune response Source: Reactome
  12. regulation of interleukin-12 production Source: BHF-UCL
  13. regulation of interleukin-6 production Source: BHF-UCL
  14. regulation of T cell anergy Source: BHF-UCL
  15. type I interferon signaling pathway Source: Reactome
  16. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-7 alpha chain
Alternative name(s):
MHC class I antigen B*7
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. extracellular vesicular exosome Source: UniProt
  6. Golgi apparatus Source: UniProt
  7. Golgi membrane Source: Reactome
  8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  9. integral component of plasma membrane Source: UniProtKB
  10. membrane Source: UniProtKB
  11. MHC class I protein complex Source: UniProt
  12. phagocytic vesicle membrane Source: Reactome
  13. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-7 alpha chainPRO_0000018833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi125 ↔ 188
Disulfide bondi227 ↔ 283

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiP01889.
PaxDbiP01889.
PRIDEiP01889.

Expressioni

Gene expression databases

BgeeiP01889.
CleanExiHS_HLA-B.
ExpressionAtlasiP01889. baseline.
GenevestigatoriP01889.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.By similarity1 Publication

Protein-protein interaction databases

BioGridi109351. 65 interactions.
IntActiP01889. 4 interactions.

Structurei

Secondary structure

1
362
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610
Beta strandi45 – 528
Beta strandi55 – 617
Beta strandi64 – 663
Helixi74 – 763
Helixi81 – 10828
Beta strandi118 – 12710
Beta strandi133 – 14210
Beta strandi145 – 1506
Beta strandi157 – 1615
Helixi162 – 17312
Helixi176 – 18510
Helixi187 – 19812
Helixi200 – 2034
Beta strandi210 – 23526
Beta strandi238 – 2436
Helixi249 – 2513
Beta strandi252 – 2543
Beta strandi261 – 2633
Beta strandi265 – 27410
Helixi278 – 2803
Beta strandi281 – 2866
Beta strandi290 – 2923
Beta strandi294 – 2963

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
ProteinModelPortaliP01889.
SMRiP01889. Positions 25-299.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 309285ExtracellularSequence AnalysisAdd
BLAST
Topological domaini334 – 36229CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei310 – 33324HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30911Connecting peptideAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42056.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiFLANTRM.
OrthoDBiEOG7JT6WQ.
PhylomeDBiP01889.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01889-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK
210 220 230 240 250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,460
Last modified:February 1, 1991 - v3
Checksum:i5E5A7BDE031403D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 184AALA → GPW in AAA59622. (PubMed:2993161)Curated
Sequence conflicti266 – 2661Q → E AA sequence (PubMed:518865)Curated
Sequence conflicti268 – 2681W → S in AAA59622. (PubMed:2993161)Curated
Sequence conflicti297 – 2971R → G in AAA59622. (PubMed:2993161)Curated
Sequence conflicti314 – 3152GL → RP in AAA59622. (PubMed:2993161)Curated

Polymorphismi

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_050332
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_050333
Natural varianti17 – 171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_050334
Natural varianti35 – 351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_050335
Natural varianti36 – 361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_050336
Natural varianti48 – 481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061386
Natural varianti48 – 481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061387
Natural varianti48 – 481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061388
Natural varianti65 – 651A → T.1 Publication
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_050337
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_050338
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059467
Natural varianti93 – 953AQA → TNT in allele B*07:03.
VAR_016351
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_050339
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059468
Natural varianti101 – 1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_050340
Natural varianti118 – 1192TL → II in allele B*07:18.
VAR_016352
Natural varianti121 – 1211S → R in allele B*07:18.
VAR_016353
Natural varianti137 – 1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_050341
Natural varianti138 – 1381D → H.
Corresponds to variant rs709055 [ dbSNP | Ensembl ].
VAR_061389
Natural varianti138 – 1381D → N in allele B*07:05 and allele B*07:06.
Corresponds to variant rs709055 [ dbSNP | Ensembl ].
VAR_016354
Natural varianti155 – 1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_050342
Natural varianti180 – 1801R → D in allele B*07:04; requires 2 nucleotide substitutions.
VAR_016355
Natural varianti187 – 1871E → A.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059469
Natural varianti187 – 1871E → G.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059470
Natural varianti187 – 1871E → K.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059471
Natural varianti187 – 1871E → L in allele B*07:24; requires 2 nucleotide substitutions.
VAR_016616
Natural varianti187 – 1871E → Q.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059472
Natural varianti187 – 1871E → V.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059473
Natural varianti195 – 1951Y → H.
Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
VAR_050343
Natural varianti306 – 3061V → I in allele B*07:05.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_016356
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_050344
Natural varianti349 – 3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061390
Natural varianti349 – 3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061391

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32317 mRNA. Translation: AAA36230.1.
M16102 mRNA. Translation: AAA59622.1. Sequence problems.
U29057 mRNA. Translation: AAA91229.1.
X64454 mRNA. Translation: CAA45785.1.
U04245 mRNA. Translation: AAA87398.1.
L33922 mRNA. Translation: AAA65639.1.
U21052 mRNA. Translation: AAA92563.1.
U21053 mRNA. Translation: AAA92564.1.
X91749 mRNA. Translation: CAA62864.1.
AF189017 mRNA. Translation: AAF01052.1.
AJ309047 Genomic DNA. Translation: CAC35468.1.
AJ292075 Genomic DNA. Translation: CAC33440.1.
AL671883 Genomic DNA. Translation: CAI18148.1.
AK313911 mRNA. Translation: BAG36634.1.
AJ401222 Genomic DNA. Translation: CAC10402.1.
CCDSiCCDS34394.1.
PIRiB35997. HLHUB7.
I54418.
I59651.
S60601.
RefSeqiNP_005505.2. NM_005514.6.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
GeneIDi3106.
KEGGihsa:3106.
UCSCiuc003ntg.1. human.

Polymorphism databases

DMDMi122162.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32317 mRNA. Translation: AAA36230.1 .
M16102 mRNA. Translation: AAA59622.1 . Sequence problems.
U29057 mRNA. Translation: AAA91229.1 .
X64454 mRNA. Translation: CAA45785.1 .
U04245 mRNA. Translation: AAA87398.1 .
L33922 mRNA. Translation: AAA65639.1 .
U21052 mRNA. Translation: AAA92563.1 .
U21053 mRNA. Translation: AAA92564.1 .
X91749 mRNA. Translation: CAA62864.1 .
AF189017 mRNA. Translation: AAF01052.1 .
AJ309047 Genomic DNA. Translation: CAC35468.1 .
AJ292075 Genomic DNA. Translation: CAC33440.1 .
AL671883 Genomic DNA. Translation: CAI18148.1 .
AK313911 mRNA. Translation: BAG36634.1 .
AJ401222 Genomic DNA. Translation: CAC10402.1 .
CCDSi CCDS34394.1.
PIRi B35997. HLHUB7.
I54418.
I59651.
S60601.
RefSeqi NP_005505.2. NM_005514.6.
UniGenei Hs.654404.
Hs.77961.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VCL X-ray 1.70 A 25-299 [» ]
ProteinModelPortali P01889.
SMRi P01889. Positions 25-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109351. 65 interactions.
IntActi P01889. 4 interactions.

Polymorphism databases

DMDMi 122162.

Proteomic databases

MaxQBi P01889.
PaxDbi P01889.
PRIDEi P01889.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412585 ; ENSP00000399168 ; ENSG00000234745 .
GeneIDi 3106.
KEGGi hsa:3106.
UCSCi uc003ntg.1. human.

Organism-specific databases

CTDi 3106.
GeneCardsi GC06M031321.
HGNCi HGNC:4932. HLA-B.
HPAi CAB015418.
MIMi 142830. gene.
neXtProti NX_P01889.
PharmGKBi PA35056.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42056.
GeneTreei ENSGT00760000118960.
HOVERGENi HBG016709.
KOi K06751.
OMAi FLANTRM.
OrthoDBi EOG7JT6WQ.
PhylomeDBi P01889.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
GeneWikii HLA-B.
GenomeRNAii 3106.
NextBioi 12323.
PROi P01889.
SOURCEi Search...

Gene expression databases

Bgeei P01889.
CleanExi HS_HLA-B.
ExpressionAtlasi P01889. baseline.
Genevestigatori P01889.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
    Ennis P.D., Zemmour J., Salter R.D., Parham P.
    Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
  2. "Diversity of class I HLA molecules: functional and evolutionary interactions with T cells."
    Parham P., Benjamin R.J., Chen B.P., Clayberger C., Ennis P.D., Krensky A.M., Lawlor D.A., Littman D.R., Norment A.M., Orr H.T., Salter R.D., Zemmour J.
    Cold Spring Harb. Symp. Quant. Biol. 54:529-543(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
  4. Ellexson M.E., Zhang L., Hildebrand W.H.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
  5. "Complete nucleotide sequence of HLA-B*0703, a B7-variant (BPOT)."
    Bergmans A., Tijssen H., Lardy J., Reekers P.
    Hum. Immunol. 38:159-162(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:03).
  6. "Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, family studies and DNA sequence analysis."
    Kubens B.S., Arnett K.L., Adams E.J., Parham P., Grosse-Wilde H.
    Tissue Antigens 45:322-327(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:04).
  7. "Structure of a novel subtype of B7 (B*0705) isolated from a Chinese individual."
    Arnett K.L., Adams E.J., Domena J.D., Parham P.
    Tissue Antigens 44:318-321(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:05).
  8. "Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation."
    Smith K.D., Epperson D.F., Lutz C.T.
    Immunogenetics 43:27-37(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*07:03 AND B*07:05).
  9. "Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles."
    Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M.
    Tissue Antigens 47:329-332(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:06).
  10. "A new HLA-B allele."
    Bettinotti M.P., Hadzikadic L., Dhillon G., Barracchini K., Marincola F.M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:18).
  11. "Intron sequences of HLA class I."
    Marsh S.G.E.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
  12. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
    Tissue: Blood.
  13. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  14. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  15. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*07:24).
    Tissue: Peripheral blood.
  16. "Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies."
    Orr H.T., Lopez de Castro J.A., Lancet D., Strominger J.L.
    Biochemistry 18:5711-5720(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-295 (B*07:02).
  17. "Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein."
    Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G.
    J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
  18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
    Tissue: Liver.
  19. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B07_HUMAN
AccessioniPrimary (citable) accession number: P01889
Secondary accession number(s): Q29638
, Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: October 29, 2014
This is version 154 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3