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P01889 (1B07_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 149. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-7 alpha chain
Alternative name(s):
MHC class I antigen B*7
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity. Interacts with HTLV-1 accessory protein p12I. Ref.17

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

immune response

Non-traceable author statement Ref.16. Source: UniProtKB

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of T cell anergy

Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL

regulation of dendritic cell differentiation

Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL

regulation of immune response

Traceable author statement. Source: Reactome

regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL

regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

extracellular vesicular exosome

Inferred from direct assay PubMed 12519789PubMed 19056867PubMed 20458337. Source: UniProt

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

integral component of plasma membrane

Non-traceable author statement Ref.16. Source: UniProtKB

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

receptor binding

Inferred from physical interaction PubMed 20008523. Source: BHF-UCL

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.16
Chain25 – 362338HLA class I histocompatibility antigen, B-7 alpha chain
PRO_0000018833

Regions

Topological domain25 – 309285Extracellular Potential
Transmembrane310 – 33324Helical; Potential
Topological domain334 – 36229Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30911Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Ref.18
Disulfide bond125 ↔ 188
Disulfide bond227 ↔ 283

Natural variations

Natural variant41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_050332
Natural variant91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_050333
Natural variant171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_050334
Natural variant351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_050335
Natural variant361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_050336
Natural variant481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061386
Natural variant481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061387
Natural variant481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061388
Natural variant651A → T. Ref.19
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_050337
Natural variant871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_050338
Natural variant871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059467
Natural variant93 – 953AQA → TNT in allele B*07:03.
VAR_016351
Natural variant971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_050339
Natural variant981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059468
Natural variant1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_050340
Natural variant118 – 1192TL → II in allele B*07:18.
VAR_016352
Natural variant1211S → R in allele B*07:18.
VAR_016353
Natural variant1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_050341
Natural variant1381D → H.
Corresponds to variant rs709055 [ dbSNP | Ensembl ].
VAR_061389
Natural variant1381D → N in allele B*07:05 and allele B*07:06.
Corresponds to variant rs709055 [ dbSNP | Ensembl ].
VAR_016354
Natural variant1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_050342
Natural variant1801R → D in allele B*07:04; requires 2 nucleotide substitutions.
VAR_016355
Natural variant1871E → A.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059469
Natural variant1871E → G.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059470
Natural variant1871E → K.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059471
Natural variant1871E → L in allele B*07:24; requires 2 nucleotide substitutions.
VAR_016616
Natural variant1871E → Q.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059472
Natural variant1871E → V.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059473
Natural variant1951Y → H.
Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
VAR_050343
Natural variant3061V → I in allele B*07:05.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_016356
Natural variant3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_050344
Natural variant3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061390
Natural variant3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061391

Experimental info

Sequence conflict15 – 184AALA → GPW in AAA59622. Ref.3
Sequence conflict2661Q → E AA sequence Ref.16
Sequence conflict2681W → S in AAA59622. Ref.3
Sequence conflict2971R → G in AAA59622. Ref.3
Sequence conflict314 – 3152GL → RP in AAA59622. Ref.3

Secondary structure

.............................................. 362
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01889 [UniParc].

Last modified February 1, 1991. Version 3.
Checksum: 5E5A7BDE031403D6

FASTA36240,460
        10         20         30         40         50         60 
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR 

       190        200        210        220        230        240 
RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
Ennis P.D., Zemmour J., Salter R.D., Parham P.
Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
[2]"Diversity of class I HLA molecules: functional and evolutionary interactions with T cells."
Parham P., Benjamin R.J., Chen B.P., Clayberger C., Ennis P.D., Krensky A.M., Lawlor D.A., Littman D.R., Norment A.M., Orr H.T., Salter R.D., Zemmour J.
Cold Spring Harb. Symp. Quant. Biol. 54:529-543(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[3]"Structure and polymorphism of class I MHC antigen mRNA."
Sood A.K., Pan J., Biro P.A., Pereira D., Srivastava R., Reddy V.B., Duceman B.W., Weissman S.M.
Immunogenetics 22:101-121(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
[4]Ellexson M.E., Zhang L., Hildebrand W.H.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[5]"Complete nucleotide sequence of HLA-B*0703, a B7-variant (BPOT)."
Bergmans A., Tijssen H., Lardy J., Reekers P.
Hum. Immunol. 38:159-162(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:03).
[6]"Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, family studies and DNA sequence analysis."
Kubens B.S., Arnett K.L., Adams E.J., Parham P., Grosse-Wilde H.
Tissue Antigens 45:322-327(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:04).
[7]"Structure of a novel subtype of B7 (B*0705) isolated from a Chinese individual."
Arnett K.L., Adams E.J., Domena J.D., Parham P.
Tissue Antigens 44:318-321(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:05).
[8]"Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation."
Smith K.D., Epperson D.F., Lutz C.T.
Immunogenetics 43:27-37(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*07:03 AND B*07:05).
[9]"Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles."
Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M.
Tissue Antigens 47:329-332(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:06).
[10]"A new HLA-B allele."
Bettinotti M.P., Hadzikadic L., Dhillon G., Barracchini K., Marincola F.M.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:18).
[11]"Intron sequences of HLA class I."
Marsh S.G.E.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[12]"Cloning and sequencing full-length HLA-B and -C genes."
Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M.
Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
Tissue: Blood.
[13]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Subthalamic nucleus.
[14]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]"Characterisation of a new HLA-B allele, HLA-B*0724."
Middleton D., Curran M.D., Anholts J.D., Reilly E.R., Schreuder G.M.
Tissue Antigens 57:471-473(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*07:24).
Tissue: Peripheral blood.
[16]"Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies."
Orr H.T., Lopez de Castro J.A., Lancet D., Strominger J.L.
Biochemistry 18:5711-5720(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 25-295 (B*07:02).
[17]"Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein."
Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G.
J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
[18]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
Tissue: Liver.
[19]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32317 mRNA. Translation: AAA36230.1.
M16102 mRNA. Translation: AAA59622.1. Sequence problems.
U29057 mRNA. Translation: AAA91229.1.
X64454 mRNA. Translation: CAA45785.1.
U04245 mRNA. Translation: AAA87398.1.
L33922 mRNA. Translation: AAA65639.1.
U21052 mRNA. Translation: AAA92563.1.
U21053 mRNA. Translation: AAA92564.1.
X91749 mRNA. Translation: CAA62864.1.
AF189017 mRNA. Translation: AAF01052.1.
AJ309047 Genomic DNA. Translation: CAC35468.1.
AJ292075 Genomic DNA. Translation: CAC33440.1.
AL671883 Genomic DNA. Translation: CAI18148.1.
AK313911 mRNA. Translation: BAG36634.1.
AJ401222 Genomic DNA. Translation: CAC10402.1.
PIRHLHUB7. B35997.
I54418.
I59651.
S60601.
RefSeqNP_005505.2. NM_005514.6.
UniGeneHs.654404.
Hs.77961.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VCLX-ray1.70A25-299[»]
ProteinModelPortalP01889.
SMRP01889. Positions 25-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109351. 31 interactions.
IntActP01889. 4 interactions.

Polymorphism databases

DMDM122162.

Proteomic databases

PaxDbP01889.
PRIDEP01889.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412585; ENSP00000399168; ENSG00000234745.
GeneID3106.
KEGGhsa:3106.
UCSCuc003ntg.1. human.

Organism-specific databases

CTD3106.
GeneCardsGC06M031321.
HGNCHGNC:4932. HLA-B.
HPACAB015418.
MIM142830. gene.
neXtProtNX_P01889.
PharmGKBPA35056.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42056.
HOVERGENHBG016709.
KOK06751.
OMAKANTRIY.
OrthoDBEOG7JT6WQ.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP01889.
BgeeP01889.
CleanExHS_HLA-B.
GenevestigatorP01889.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
GeneWikiHLA-B.
GenomeRNAi3106.
NextBio12323.
PROP01889.
SOURCESearch...

Entry information

Entry name1B07_HUMAN
AccessionPrimary (citable) accession number: P01889
Secondary accession number(s): Q29638 expand/collapse secondary AC list , Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: April 16, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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