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P01889

- 1B07_HUMAN

UniProt

P01889 - 1B07_HUMAN

Protein

HLA class I histocompatibility antigen, B-7 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 3 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt
    2. receptor binding Source: BHF-UCL

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. immune response Source: UniProtKB
    7. interferon-gamma-mediated signaling pathway Source: Reactome
    8. positive regulation of T cell mediated cytotoxicity Source: InterPro
    9. protection from natural killer cell mediated cytotoxicity Source: UniProt
    10. regulation of dendritic cell differentiation Source: BHF-UCL
    11. regulation of immune response Source: Reactome
    12. regulation of interleukin-12 production Source: BHF-UCL
    13. regulation of interleukin-6 production Source: BHF-UCL
    14. regulation of T cell anergy Source: BHF-UCL
    15. type I interferon signaling pathway Source: Reactome
    16. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-7 alpha chain
    Alternative name(s):
    MHC class I antigen B*7
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. extracellular vesicular exosome Source: UniProt
    6. Golgi apparatus Source: UniProt
    7. Golgi membrane Source: Reactome
    8. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    9. integral component of plasma membrane Source: UniProtKB
    10. membrane Source: UniProtKB
    11. MHC class I protein complex Source: UniProt
    12. phagocytic vesicle membrane Source: Reactome
    13. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-7 alpha chainPRO_0000018833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
    Disulfide bondi125 ↔ 188
    Disulfide bondi227 ↔ 283

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiP01889.
    PaxDbiP01889.
    PRIDEiP01889.

    Expressioni

    Gene expression databases

    ArrayExpressiP01889.
    BgeeiP01889.
    CleanExiHS_HLA-B.
    GenevestigatoriP01889.

    Organism-specific databases

    HPAiCAB015418.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity. Interacts with HTLV-1 accessory protein p12I.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi109351. 33 interactions.
    IntActiP01889. 4 interactions.

    Structurei

    Secondary structure

    1
    362
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi27 – 3610
    Beta strandi45 – 528
    Beta strandi55 – 617
    Beta strandi64 – 663
    Helixi74 – 763
    Helixi81 – 10828
    Beta strandi118 – 12710
    Beta strandi133 – 14210
    Beta strandi145 – 1506
    Beta strandi157 – 1615
    Helixi162 – 17312
    Helixi176 – 18510
    Helixi187 – 19812
    Helixi200 – 2034
    Beta strandi210 – 23526
    Beta strandi238 – 2436
    Helixi249 – 2513
    Beta strandi252 – 2543
    Beta strandi261 – 2633
    Beta strandi265 – 27410
    Helixi278 – 2803
    Beta strandi281 – 2866
    Beta strandi290 – 2923
    Beta strandi294 – 2963

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VCLX-ray1.70A25-299[»]
    ProteinModelPortaliP01889.
    SMRiP01889. Positions 25-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 309285ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini334 – 36229CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei310 – 33324HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30911Connecting peptideAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42056.
    HOVERGENiHBG016709.
    KOiK06751.
    OMAiFLANTRM.
    OrthoDBiEOG7JT6WQ.
    PhylomeDBiP01889.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01889-1 [UniParc]FASTAAdd to Basket

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    MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE 100
    SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL 150
    NEDLRSWTAA DTAAQITQRK WEAAREAEQR RAYLEGECVE WLRRYLENGK 200
    DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,460
    Last modified:February 1, 1991 - v3
    Checksum:i5E5A7BDE031403D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 184AALA → GPW in AAA59622. (PubMed:2993161)Curated
    Sequence conflicti266 – 2661Q → E AA sequence (PubMed:518865)Curated
    Sequence conflicti268 – 2681W → S in AAA59622. (PubMed:2993161)Curated
    Sequence conflicti297 – 2971R → G in AAA59622. (PubMed:2993161)Curated
    Sequence conflicti314 – 3152GL → RP in AAA59622. (PubMed:2993161)Curated

    Polymorphismi

    The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41M → T.
    Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
    VAR_050332
    Natural varianti9 – 91V → L.
    Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
    VAR_050333
    Natural varianti17 – 171L → V.
    Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
    VAR_050334
    Natural varianti35 – 351S → A.
    Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
    VAR_050335
    Natural varianti36 – 361V → M.
    Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
    VAR_050336
    Natural varianti48 – 481S → A.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061386
    Natural varianti48 – 481S → P.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061387
    Natural varianti48 – 481S → T.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061388
    Natural varianti65 – 651A → T.1 Publication
    Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
    VAR_050337
    Natural varianti87 – 871N → D.
    Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
    VAR_050338
    Natural varianti87 – 871N → K.
    Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
    VAR_059467
    Natural varianti93 – 953AQA → TNT in allele B*07:03.
    VAR_016351
    Natural varianti97 – 971T → A.
    Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
    VAR_050339
    Natural varianti98 – 981D → Y.
    Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
    VAR_059468
    Natural varianti101 – 1011S → N.
    Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
    VAR_050340
    Natural varianti118 – 1192TL → II in allele B*07:18.
    VAR_016352
    Natural varianti121 – 1211S → R in allele B*07:18.
    VAR_016353
    Natural varianti137 – 1371H → Y.
    Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
    VAR_050341
    Natural varianti138 – 1381D → H.
    Corresponds to variant rs709055 [ dbSNP | Ensembl ].
    VAR_061389
    Natural varianti138 – 1381D → N in allele B*07:05 and allele B*07:06.
    Corresponds to variant rs709055 [ dbSNP | Ensembl ].
    VAR_016354
    Natural varianti155 – 1551R → S.
    Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
    VAR_050342
    Natural varianti180 – 1801R → D in allele B*07:04; requires 2 nucleotide substitutions.
    VAR_016355
    Natural varianti187 – 1871E → A.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059469
    Natural varianti187 – 1871E → G.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059470
    Natural varianti187 – 1871E → K.
    Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
    VAR_059471
    Natural varianti187 – 1871E → L in allele B*07:24; requires 2 nucleotide substitutions.
    VAR_016616
    Natural varianti187 – 1871E → Q.
    Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
    VAR_059472
    Natural varianti187 – 1871E → V.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059473
    Natural varianti195 – 1951Y → H.
    Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
    VAR_050343
    Natural varianti306 – 3061V → I in allele B*07:05.
    Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
    VAR_016356
    Natural varianti329 – 3291A → T.
    Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
    VAR_050344
    Natural varianti349 – 3491C → S.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061390
    Natural varianti349 – 3491C → Y.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061391

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32317 mRNA. Translation: AAA36230.1.
    M16102 mRNA. Translation: AAA59622.1. Sequence problems.
    U29057 mRNA. Translation: AAA91229.1.
    X64454 mRNA. Translation: CAA45785.1.
    U04245 mRNA. Translation: AAA87398.1.
    L33922 mRNA. Translation: AAA65639.1.
    U21052 mRNA. Translation: AAA92563.1.
    U21053 mRNA. Translation: AAA92564.1.
    X91749 mRNA. Translation: CAA62864.1.
    AF189017 mRNA. Translation: AAF01052.1.
    AJ309047 Genomic DNA. Translation: CAC35468.1.
    AJ292075 Genomic DNA. Translation: CAC33440.1.
    AL671883 Genomic DNA. Translation: CAI18148.1.
    AK313911 mRNA. Translation: BAG36634.1.
    AJ401222 Genomic DNA. Translation: CAC10402.1.
    CCDSiCCDS34394.1.
    PIRiB35997. HLHUB7.
    I54418.
    I59651.
    S60601.
    RefSeqiNP_005505.2. NM_005514.6.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
    GeneIDi3106.
    KEGGihsa:3106.
    UCSCiuc003ntg.1. human.

    Polymorphism databases

    DMDMi122162.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32317 mRNA. Translation: AAA36230.1 .
    M16102 mRNA. Translation: AAA59622.1 . Sequence problems.
    U29057 mRNA. Translation: AAA91229.1 .
    X64454 mRNA. Translation: CAA45785.1 .
    U04245 mRNA. Translation: AAA87398.1 .
    L33922 mRNA. Translation: AAA65639.1 .
    U21052 mRNA. Translation: AAA92563.1 .
    U21053 mRNA. Translation: AAA92564.1 .
    X91749 mRNA. Translation: CAA62864.1 .
    AF189017 mRNA. Translation: AAF01052.1 .
    AJ309047 Genomic DNA. Translation: CAC35468.1 .
    AJ292075 Genomic DNA. Translation: CAC33440.1 .
    AL671883 Genomic DNA. Translation: CAI18148.1 .
    AK313911 mRNA. Translation: BAG36634.1 .
    AJ401222 Genomic DNA. Translation: CAC10402.1 .
    CCDSi CCDS34394.1.
    PIRi B35997. HLHUB7.
    I54418.
    I59651.
    S60601.
    RefSeqi NP_005505.2. NM_005514.6.
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VCL X-ray 1.70 A 25-299 [» ]
    ProteinModelPortali P01889.
    SMRi P01889. Positions 25-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109351. 33 interactions.
    IntActi P01889. 4 interactions.

    Polymorphism databases

    DMDMi 122162.

    Proteomic databases

    MaxQBi P01889.
    PaxDbi P01889.
    PRIDEi P01889.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412585 ; ENSP00000399168 ; ENSG00000234745 .
    GeneIDi 3106.
    KEGGi hsa:3106.
    UCSCi uc003ntg.1. human.

    Organism-specific databases

    CTDi 3106.
    GeneCardsi GC06M031321.
    HGNCi HGNC:4932. HLA-B.
    HPAi CAB015418.
    MIMi 142830. gene.
    neXtProti NX_P01889.
    PharmGKBi PA35056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42056.
    HOVERGENi HBG016709.
    KOi K06751.
    OMAi FLANTRM.
    OrthoDBi EOG7JT6WQ.
    PhylomeDBi P01889.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    GeneWikii HLA-B.
    GenomeRNAii 3106.
    NextBioi 12323.
    PROi P01889.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01889.
    Bgeei P01889.
    CleanExi HS_HLA-B.
    Genevestigatori P01889.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification."
      Ennis P.D., Zemmour J., Salter R.D., Parham P.
      Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
    2. "Diversity of class I HLA molecules: functional and evolutionary interactions with T cells."
      Parham P., Benjamin R.J., Chen B.P., Clayberger C., Ennis P.D., Krensky A.M., Lawlor D.A., Littman D.R., Norment A.M., Orr H.T., Salter R.D., Zemmour J.
      Cold Spring Harb. Symp. Quant. Biol. 54:529-543(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
    4. Ellexson M.E., Zhang L., Hildebrand W.H.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
    5. "Complete nucleotide sequence of HLA-B*0703, a B7-variant (BPOT)."
      Bergmans A., Tijssen H., Lardy J., Reekers P.
      Hum. Immunol. 38:159-162(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:03).
    6. "Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, family studies and DNA sequence analysis."
      Kubens B.S., Arnett K.L., Adams E.J., Parham P., Grosse-Wilde H.
      Tissue Antigens 45:322-327(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:04).
    7. "Structure of a novel subtype of B7 (B*0705) isolated from a Chinese individual."
      Arnett K.L., Adams E.J., Domena J.D., Parham P.
      Tissue Antigens 44:318-321(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:05).
    8. "Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation."
      Smith K.D., Epperson D.F., Lutz C.T.
      Immunogenetics 43:27-37(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*07:03 AND B*07:05).
    9. "Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles."
      Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M.
      Tissue Antigens 47:329-332(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:06).
    10. "A new HLA-B allele."
      Bettinotti M.P., Hadzikadic L., Dhillon G., Barracchini K., Marincola F.M.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:18).
    11. "Intron sequences of HLA class I."
      Marsh S.G.E.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
    12. Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
      Tissue: Blood.
    13. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    14. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    15. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*07:24).
      Tissue: Peripheral blood.
    16. "Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies."
      Orr H.T., Lopez de Castro J.A., Lancet D., Strominger J.L.
      Biochemistry 18:5711-5720(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-295 (B*07:02).
    17. "Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein."
      Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G.
      J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
    18. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
      Tissue: Liver.
    19. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1B07_HUMAN
    AccessioniPrimary (citable) accession number: P01889
    Secondary accession number(s): Q29638
    , Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 153 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3