P01889 (1B07_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
HLA class I histocompatibility antigen, B-7 alpha chain

Alternative name(s):
MHC class I antigen B*7

Gene names

Name:	HLA-B
Synonyms:	HLAB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity. Interacts with HTLV-1 accessory protein p12I. Ref.17
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.
Polymorphism	The following alleles of B-7 are known: B*07:02 (B7.2), B*07:03 (BPOT), B*07:04, B*07:05, B*07:06 (B7_L79), B*07:18 and B*07:24. The sequence shown is B*07:02.
Sequence similarities	Belongs to the MHC class I family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Host-virus interaction Immunity
Cellular component	MHC I Membrane
Coding sequence diversity	Polymorphism
Domain	Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Traceable author statement. Source: Reactome antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Traceable author statement. Source: Reactome interferon-gamma-mediated signaling pathway Traceable author statement. Source: Reactome regulation of T cell anergy Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL regulation of dendritic cell differentiation Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL regulation of immune response Traceable author statement. Source: Reactome regulation of interleukin-12 production Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL regulation of interleukin-6 production Inferred from mutant phenotype PubMed 20008523. Source: BHF-UCL type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ER to Golgi transport vesicle membrane Traceable author statement. Source: Reactome Golgi membrane Traceable author statement. Source: Reactome MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW early endosome membrane Traceable author statement. Source: Reactome integral to lumenal side of endoplasmic reticulum membrane Traceable author statement. Source: Reactome integral to plasma membrane Non-traceable author statement Ref.16. Source: UniProtKB phagocytic vesicle membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Ref.16

Chain

25 – 362

338

HLA class I histocompatibility antigen, B-7 alpha chain

PRO_0000018833

Regions

Topological domain

25 – 309

285

Extracellular Potential

Transmembrane

310 – 333

24

Helical; Potential

Topological domain

334 – 362

29

Cytoplasmic Potential

Domain

209 – 295

87

Ig-like C1-type

Region

25 – 114

90

Alpha-1

Region

115 – 206

92

Alpha-2

Region

207 – 298

92

Alpha-3

Region

299 – 309

11

Connecting peptide

Amino acid modifications

Glycosylation

110

1

N-linked (GlcNAc...) Ref.18

Disulfide bond

125 ↔ 188

Disulfide bond

227 ↔ 283

Natural variations

Natural variant

4

1

M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].

VAR_050332

Natural variant

9

1

V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].

VAR_050333

Natural variant

17

1

L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].

VAR_050334

Natural variant

35

1

S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].

VAR_050335

Natural variant

36

1

V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].

VAR_050336

Natural variant

48

1

S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061386

Natural variant

48

1

S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061387

Natural variant

48

1

S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].

VAR_061388

Natural variant

65

1

A → T. Ref.19
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].

VAR_050337

Natural variant

87

1

N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].

VAR_050338

Natural variant

87

1

N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].

VAR_059467

Natural variant

93 – 95

3

AQA → TNT in allele B*07:03.

VAR_016351

Natural variant

97

1

T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].

VAR_050339

Natural variant

98

1

D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].

VAR_059468

Natural variant

101

1

S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].

VAR_050340

Natural variant

118 – 119

2

TL → II in allele B*07:18.

VAR_016352

Natural variant

121

1

S → R in allele B*07:18.

VAR_016353

Natural variant

137

1

H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].

VAR_050341

Natural variant

138

1

D → H.
Corresponds to variant rs709055 [ dbSNP | Ensembl ].

VAR_061389

Natural variant

138

1

D → N in allele B*07:05 and allele B*07:06.

VAR_016354

Natural variant

155

1

R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].

VAR_050342

Natural variant

180

1

R → D in allele B*07:04; requires 2 nucleotide substitutions.

VAR_016355

Natural variant

187

1

E → A.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].

VAR_059469

Natural variant

187

1

E → G.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].

VAR_059470

Natural variant

187

1

E → K.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].

VAR_059471

Natural variant

187

1

E → L in allele B*07:24; requires 2 nucleotide substitutions.

VAR_016616

Natural variant

187

1

E → Q.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].

VAR_059472

Natural variant

187

1

E → V.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].

VAR_059473

Natural variant

195

1

Y → H.
Corresponds to variant rs1050696 [ dbSNP | Ensembl ].

VAR_050343

Natural variant

306

1

V → I in allele B*07:05.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].

VAR_016356

Natural variant

329

1

A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].

VAR_050344

Natural variant

349

1

C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061390

Natural variant

349

1

C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].

VAR_061391

Experimental info

Sequence conflict

15 – 18

4

AALA → GPW in AAA59622. Ref.3

Sequence conflict

266

1

Q → E AA sequence Ref.16

Sequence conflict

268

1

W → S in AAA59622. Ref.3

Sequence conflict

297

1

R → G in AAA59622. Ref.3

Sequence conflict

314 – 315

2

GL → RP in AAA59622. Ref.3

Secondary structure

1

.

.

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362

Helix Strand Turn

Details...

Beta strand

27 – 36

10

Beta strand

45 – 52

8

Beta strand

55 – 61

7

Beta strand

64 – 66

3

Helix

74 – 76

3

Helix

81 – 108

28

Beta strand

118 – 127

10

Beta strand

133 – 142

10

Beta strand

145 – 150

6

Beta strand

157 – 161

5

Helix

162 – 173

12

Helix

176 – 185

10

Helix

187 – 198

12

Helix

200 – 203

4

Beta strand

210 – 235

26

Beta strand

238 – 243

6

Helix

249 – 251

3

Beta strand

252 – 254

3

Beta strand

261 – 263

3

Beta strand

265 – 274

10

Helix

278 – 280

3

Beta strand

281 – 286

6

Beta strand

290 – 292

3

Beta strand

294 – 296

3

Sequences

	Sequence		Length	Mass (Da)
	P01889 [UniParc]. Last modified February 1, 1991. Version 3. Checksum: 5E5A7BDE031403D6	FASTA	362	40,460
	10 20 30 40 50 60 MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 130 140 150 160 170 180 SMYGCDVGPD GRLLRGHDQY AYDGKDYIAL NEDLRSWTAA DTAAQITQRK WEAAREAEQR 190 200 210 220 230 240 RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDRTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 310 320 330 340 350 360 SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL TA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification." Ennis P.D., Zemmour J., Salter R.D., Parham P. Proc. Natl. Acad. Sci. U.S.A. 87:2833-2837(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
[2]	"Diversity of class I HLA molecules: functional and evolutionary interactions with T cells." Parham P., Benjamin R.J., Chen B.P., Clayberger C., Ennis P.D., Krensky A.M., Lawlor D.A., Littman D.R., Norment A.M., Orr H.T., Salter R.D., Zemmour J. Cold Spring Harb. Symp. Quant. Biol. 54:529-543(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[3]	"Structure and polymorphism of class I MHC antigen mRNA." Sood A.K., Pan J., Biro P.A., Pereira D., Srivastava R., Reddy V.B., Duceman B.W., Weissman S.M. Immunogenetics 22:101-121(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:02).
[4]	Ellexson M.E., Zhang L., Hildebrand W.H. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[5]	"Complete nucleotide sequence of HLA-B*0703, a B7-variant (BPOT)." Bergmans A., Tijssen H., Lardy J., Reekers P. Hum. Immunol. 38:159-162(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:03).
[6]	"Definition of a new HLA-B7 subtype (B*0704) by isoelectric focusing, family studies and DNA sequence analysis." Kubens B.S., Arnett K.L., Adams E.J., Parham P., Grosse-Wilde H. Tissue Antigens 45:322-327(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:04).
[7]	"Structure of a novel subtype of B7 (B*0705) isolated from a Chinese individual." Arnett K.L., Adams E.J., Domena J.D., Parham P. Tissue Antigens 44:318-321(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:05).
[8]	"Alloreactive cytotoxic T-lymphocyte-defined HLA-B7 subtypes differ in peptide antigen presentation." Smith K.D., Epperson D.F., Lutz C.T. Immunogenetics 43:27-37(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*07:03 AND B*07:05).
[9]	"Haplotypic association of two new HLA class I alleles: Cw*15052 and B*0706: evolutionary relationships of HLA-Cw*15 alleles." Sanz L., Vilches C., de Pablo R., Bunce M., Moreno M.E., Kreisler M. Tissue Antigens 47:329-332(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*07:06).
[10]	"A new HLA-B allele." Bettinotti M.P., Hadzikadic L., Dhillon G., Barracchini K., Marincola F.M. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:18).
[11]	"Intron sequences of HLA class I." Marsh S.G.E. Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02).
[12]	"Cloning and sequencing full-length HLA-B and -C genes." Cox S.T., McWhinnie A.J., Robinson J., Marsh S.G.E., Parham P., Madrigal J.A., Little A.-M. Tissue Antigens 61:20-48(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (ALLELE B*07:02). Tissue: Blood.
[13]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Subthalamic nucleus.
[14]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[15]	"Characterisation of a new HLA-B allele, HLA-B*0724." Middleton D., Curran M.D., Anholts J.D., Reilly E.R., Schreuder G.M. Tissue Antigens 57:471-473(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE B*07:24). Tissue: Peripheral blood.
[16]	"Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies." Orr H.T., Lopez de Castro J.A., Lancet D., Strominger J.L. Biochemistry 18:5711-5720(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 25-295 (B*07:02).
[17]	"Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein." Johnson J.M., Nicot C., Fullen J., Ciminale V., Casareto L., Mulloy J.C., Jacobson S., Franchini G. J. Virol. 75:6086-6094(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
[18]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110, MASS SPECTROMETRY. Tissue: Liver.
[19]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M32317 mRNA. Translation: AAA36230.1.
M16102 mRNA. Translation: AAA59622.1. Sequence problems.
U29057 mRNA. Translation: AAA91229.1.
X64454 mRNA. Translation: CAA45785.1.
U04245 mRNA. Translation: AAA87398.1.
L33922 mRNA. Translation: AAA65639.1.
U21052 mRNA. Translation: AAA92563.1.
U21053 mRNA. Translation: AAA92564.1.
X91749 mRNA. Translation: CAA62864.1.
AF189017 mRNA. Translation: AAF01052.1.
AJ309047 Genomic DNA. Translation: CAC35468.1.
AJ292075 Genomic DNA. Translation: CAC33440.1.
AL671883 Genomic DNA. Translation: CAI18148.1.
AK313911 mRNA. Translation: BAG36634.1.
AJ401222 Genomic DNA. Translation: CAC10402.1.

IPI

IPI00004657.

PIR

HLHUB7. B35997.
I54418.
I59651.
S60601.

RefSeq

NP_005505.2. NM_005514.6.

UniGene

Hs.654404.
Hs.77961.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3VCL	X-ray	1.70	A	25-299	[»]

ProteinModelPortal

P01889.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01889. 4 interactions.

Polymorphism databases

DMDM

122162.

Proteomic databases

PaxDb

P01889.

PRIDE

P01889.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000412585; ENSP00000399168; ENSG00000234745.

GeneID

3106.

KEGG

hsa:3106.

UCSC

uc003ntg.1. human.

Organism-specific databases

CTD

3106.

GeneCards

GC06M031321.

HGNC

HGNC:4932. HLA-B.

HPA

CAB015418.

MIM

142830. gene.

neXtProt

NX_P01889.

PharmGKB

PA35056.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG42056.

HOVERGEN

HBG016709.

KO

K06751.

OMA

WEAARWA.

OrthoDB

EOG4F4SBG.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P01889.

Bgee

P01889.

CleanEx

HS_HLA-B.

Genevestigator

P01889.

GermOnline

ENSG00000204523. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.
3.30.500.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]

PRINTS

PR01638. MHCCLASSI.

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

SUPFAM

SSF54452. MHC_I/II-like_Ag-recog. 1 hit.

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HLA-B. human.

GenomeRNAi

3106.

NextBio

12323.

SOURCE

Search...

Entry information

Entry name

1B07_HUMAN

Accession

Primary (citable) accession number: P01889
Secondary accession number(s): Q29638 , Q29681, Q29854, Q29861, Q31613, Q5SRJ2, Q9GIX1, Q9TP95

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1991
Last modified:	May 1, 2013
This is version 140 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.