Beta-2-microglobulin precursor - Bos taurus (Bovine)

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P01888 (B2MG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Beta-2-microglobulin

Alternative name(s):
Lactollin

Gene names

Name:

B2M

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	118 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Subunit structure	Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.
Subcellular location	Secreted.
Sequence similarities	Belongs to the beta-2-microglobulin family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I Secreted
Domain	Immunoglobulin domain Signal
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation in thymus Inferred from electronic annotation. Source: Compara antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Inferred from electronic annotation. Source: Compara antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro positive regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara protein refolding Inferred from electronic annotation. Source: Compara response to molecule of bacterial origin Inferred from electronic annotation. Source: Compara
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW external side of plasma membrane Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Ref.4

Chain

21 – 118

Beta-2-microglobulin

PRO_0000018756

Regions

Domain

25 – 112

Ig-like C1-type

Amino acid modifications

Disulfide bond

45 ↔ 99

Experimental info

Sequence conflict

D → N AA sequence Ref.4

Sequence conflict

N → D AA sequence Ref.4

Sequence conflict

Q → E AA sequence Ref.4

Secondary structure

118

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P01888 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: 140854676D3332E6
Show »

FASTA

118

13,677

        10         20         30         40         50         60 
MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF HPPQIEIDLL 

        70         80         90        100        110 
KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR VKHVTLEQPR IVKWDRDL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of cattle beta 2-microglobulin cDNA." Ellis S.A., Braem K.A., Payne L. Immunogenetics 38:310-310(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Analysis of sequences obtained from constructed full-length bovine cDNA libraries." Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymphoid epithelium.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal cerebellum.
[4]	"Complete amino acid sequence of bovine beta 2-microglobulin." Groves M.L., Greenberg R. J. Biol. Chem. 257:2619-2626(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 21-118.
[5]	"Three-dimensional structure of beta 2-microglobulin." Becker J.W., Reeke G.N. Jr. Proc. Natl. Acad. Sci. U.S.A. 82:4225-4229(1985) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.

IPI

IPI00686769.

PIR

MGBOB2. I46000.

RefSeq

NP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.3.
XP_002691165.1. XM_002691119.1.

UniGene

Bt.5269.
Bt.64557.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BMG	X-ray	2.50	A	21-118	[»]
2XFX	X-ray	1.90	B	20-118	[»]
3L9R	X-ray	2.30	B/D/F/H	21-118	[»]
3PWV	X-ray	2.70	B/E	21-118	[»]
4F7C	X-ray	2.86	B/D	21-118	[»]
4F7E	X-ray	2.40	B	21-118	[»]

ProteinModelPortal

P01888.

SMR

P01888. Positions 21-118.

ModBase

Search...

Proteomic databases

PaxDb

P01888.

PRIDE

P01888.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.

GeneID

280729.
783680.

KEGG

bta:280729.
bta:783680.

Organism-specific databases

CTD

567.

Phylogenomic databases

eggNOG

NOG40777.

GeneTree

ENSGT00690000102227.

HOGENOM

HOG000043084.

HOVERGEN

HBG006197.

InParanoid

P01888.

K08055.

OMA

PNFLNCY.

Gene expression databases

ArrayExpress

P01888.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

PANTHER

PTHR19944:SF16. PTHR19944:SF16. 1 hit.

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01888.

NextBio

20804904.

Entry information

Entry name

B2MG_BOVIN

Accession

Primary (citable) accession number: P01888
Secondary accession number(s): Q148G6, Q56K05

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	February 1, 1994
Last modified:	April 3, 2013
This is version 107 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents