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P01888

- B2MG_BOVIN

UniProt

P01888 - B2MG_BOVIN

Protein

Beta-2-microglobulin

Gene

B2M

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    GO - Biological processi

    1. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
    2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    3. positive regulation of T cell mediated cytotoxicity Source: Ensembl
    4. protein refolding Source: Ensembl
    5. response to molecule of bacterial origin Source: Ensembl
    6. T cell differentiation in thymus Source: Ensembl

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_206540. Amyloids.
    REACT_218212. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-2-microglobulin
    Alternative name(s):
    Lactollin
    Gene namesi
    Name:B2M
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 10

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    MHC I, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20201 PublicationAdd
    BLAST
    Chaini21 – 11898Beta-2-microglobulinPRO_0000018756Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 991 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01888.
    PRIDEiP01888.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.1 Publication

    Structurei

    Secondary structure

    1
    118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 338
    Beta strandi37 – 393
    Beta strandi41 – 5313
    Beta strandi56 – 616
    Beta strandi64 – 663
    Beta strandi68 – 703
    Beta strandi74 – 763
    Turni77 – 793
    Beta strandi81 – 899
    Beta strandi97 – 1026
    Beta strandi110 – 1134

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BMGX-ray2.50A21-118[»]
    2XFXX-ray1.90B20-118[»]
    3L9RX-ray2.30B/D/F/H21-118[»]
    3PWVX-ray2.70B/E21-118[»]
    4F7CX-ray2.86B/D21-118[»]
    4F7EX-ray2.40B21-118[»]
    4IIQX-ray2.86C21-118[»]
    4L8SX-ray2.90C21-118[»]
    4L9LX-ray3.40C21-118[»]
    4LCCX-ray3.26C21-118[»]
    ProteinModelPortaliP01888.
    SMRiP01888. Positions 21-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01888.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11288Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-2-microglobulin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40777.
    GeneTreeiENSGT00690000102227.
    HOGENOMiHOG000043084.
    HOVERGENiHBG006197.
    InParanoidiP01888.
    KOiK08055.
    OMAiFYLLVHT.
    OrthoDBiEOG7RFTKJ.
    TreeFamiTF334167.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01888-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF    50
    HPPQIEIDLL KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR 100
    VKHVTLEQPR IVKWDRDL 118
    Length:118
    Mass (Da):13,677
    Last modified:February 1, 1994 - v2
    Checksum:i140854676D3332E6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371D → N AA sequence (PubMed:6174509)Curated
    Sequence conflicti92 – 921N → D AA sequence (PubMed:6174509)Curated
    Sequence conflicti96 – 961Q → E AA sequence (PubMed:6174509)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69084 mRNA. Translation: CAA48828.1.
    AY911322 mRNA. Translation: AAW82090.1.
    BC118352 mRNA. Translation: AAI18353.1.
    PIRiI46000. MGBOB2.
    RefSeqiNP_776318.1. NM_173893.3.
    XP_001251108.1. XM_001251107.4.
    XP_002691165.1. XM_002691119.2.
    UniGeneiBt.64557.

    Genome annotation databases

    EnsembliENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
    GeneIDi280729.
    783680.
    KEGGibta:280729.
    bta:783680.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69084 mRNA. Translation: CAA48828.1 .
    AY911322 mRNA. Translation: AAW82090.1 .
    BC118352 mRNA. Translation: AAI18353.1 .
    PIRi I46000. MGBOB2.
    RefSeqi NP_776318.1. NM_173893.3.
    XP_001251108.1. XM_001251107.4.
    XP_002691165.1. XM_002691119.2.
    UniGenei Bt.64557.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BMG X-ray 2.50 A 21-118 [» ]
    2XFX X-ray 1.90 B 20-118 [» ]
    3L9R X-ray 2.30 B/D/F/H 21-118 [» ]
    3PWV X-ray 2.70 B/E 21-118 [» ]
    4F7C X-ray 2.86 B/D 21-118 [» ]
    4F7E X-ray 2.40 B 21-118 [» ]
    4IIQ X-ray 2.86 C 21-118 [» ]
    4L8S X-ray 2.90 C 21-118 [» ]
    4L9L X-ray 3.40 C 21-118 [» ]
    4LCC X-ray 3.26 C 21-118 [» ]
    ProteinModelPortali P01888.
    SMRi P01888. Positions 21-118.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi P01888.
    PRIDEi P01888.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000016359 ; ENSBTAP00000016359 ; ENSBTAG00000012330 .
    GeneIDi 280729.
    783680.
    KEGGi bta:280729.
    bta:783680.

    Organism-specific databases

    CTDi 567.

    Phylogenomic databases

    eggNOGi NOG40777.
    GeneTreei ENSGT00690000102227.
    HOGENOMi HOG000043084.
    HOVERGENi HBG006197.
    InParanoidi P01888.
    KOi K08055.
    OMAi FYLLVHT.
    OrthoDBi EOG7RFTKJ.
    TreeFami TF334167.

    Enzyme and pathway databases

    Reactomei REACT_206540. Amyloids.
    REACT_218212. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    EvolutionaryTracei P01888.
    NextBioi 20804904.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of cattle beta 2-microglobulin cDNA."
      Ellis S.A., Braem K.A., Payne L.
      Immunogenetics 38:310-310(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
      Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lymphoid epithelium.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal cerebellum.
    4. "Complete amino acid sequence of bovine beta 2-microglobulin."
      Groves M.L., Greenberg R.
      J. Biol. Chem. 257:2619-2626(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-118.
    5. "Three-dimensional structure of beta 2-microglobulin."
      Becker J.W., Reeke G.N. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 82:4225-4229(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
    6. Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 21-118 IN COMPLEX WITH MR1, DISULFIDE BOND.

    Entry informationi

    Entry nameiB2MG_BOVIN
    AccessioniPrimary (citable) accession number: P01888
    Secondary accession number(s): Q148G6, Q56K05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3