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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Biological processi

  1. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: Ensembl
  2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  3. iron ion homeostasis Source: Ensembl
  4. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  5. protein refolding Source: Ensembl
  6. response to molecule of bacterial origin Source: Ensembl
  7. retina homeostasis Source: Ensembl
  8. T cell differentiation in thymus Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_276477. ER-Phagosome pathway.
REACT_287904. DAP12 signaling.
REACT_298541. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_304742. DAP12 interactions.
REACT_319915. Endosomal/Vacuolar pathway.
REACT_325565. Amyloids.
REACT_347565. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Alternative name(s):
Lactollin
Gene namesi
Name:B2M
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
  4. focal adhesion Source: Ensembl
  5. Golgi apparatus Source: Ensembl
  6. MHC class I protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 11898Beta-2-microglobulinPRO_0000018756Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 99PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01888.
PRIDEiP01888.

Expressioni

Gene expression databases

ExpressionAtlasiP01888. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.1 Publication

Structurei

Secondary structure

1
118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 338Combined sources
Beta strandi41 – 5313Combined sources
Beta strandi56 – 616Combined sources
Beta strandi68 – 703Combined sources
Beta strandi74 – 763Combined sources
Turni77 – 793Combined sources
Beta strandi81 – 899Combined sources
Beta strandi97 – 1026Combined sources
Beta strandi110 – 1134Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMGX-ray2.50A21-118[»]
2XFXX-ray1.90B20-118[»]
3L9RX-ray2.30B/D/F/H21-118[»]
3PWVX-ray2.70B/E21-118[»]
4F7CX-ray2.86B/D21-118[»]
4F7EX-ray2.40B21-118[»]
4IIQX-ray2.86C21-118[»]
4L8SX-ray2.90C21-118[»]
4L9LX-ray3.40C21-118[»]
4LCCX-ray3.26C21-118[»]
ProteinModelPortaliP01888.
SMRiP01888. Positions 21-118.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11288Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40777.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP01888.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF
60 70 80 90 100
HPPQIEIDLL KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR
110
VKHVTLEQPR IVKWDRDL
Length:118
Mass (Da):13,677
Last modified:February 1, 1994 - v2
Checksum:i140854676D3332E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371D → N AA sequence (PubMed:6174509).Curated
Sequence conflicti92 – 921N → D AA sequence (PubMed:6174509).Curated
Sequence conflicti96 – 961Q → E AA sequence (PubMed:6174509).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.
PIRiI46000. MGBOB2.
RefSeqiNP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.4.
XP_002691165.1. XM_002691119.2.
UniGeneiBt.64557.

Genome annotation databases

EnsembliENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
GeneIDi280729.
783680.
KEGGibta:280729.
bta:783680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.
PIRiI46000. MGBOB2.
RefSeqiNP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.4.
XP_002691165.1. XM_002691119.2.
UniGeneiBt.64557.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMGX-ray2.50A21-118[»]
2XFXX-ray1.90B20-118[»]
3L9RX-ray2.30B/D/F/H21-118[»]
3PWVX-ray2.70B/E21-118[»]
4F7CX-ray2.86B/D21-118[»]
4F7EX-ray2.40B21-118[»]
4IIQX-ray2.86C21-118[»]
4L8SX-ray2.90C21-118[»]
4L9LX-ray3.40C21-118[»]
4LCCX-ray3.26C21-118[»]
ProteinModelPortaliP01888.
SMRiP01888. Positions 21-118.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP01888.
PRIDEiP01888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
GeneIDi280729.
783680.
KEGGibta:280729.
bta:783680.

Organism-specific databases

CTDi567.

Phylogenomic databases

eggNOGiNOG40777.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP01888.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG7RFTKJ.
TreeFamiTF334167.

Enzyme and pathway databases

ReactomeiREACT_276477. ER-Phagosome pathway.
REACT_287904. DAP12 signaling.
REACT_298541. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.
REACT_304742. DAP12 interactions.
REACT_319915. Endosomal/Vacuolar pathway.
REACT_325565. Amyloids.
REACT_347565. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP01888.
NextBioi20804904.

Gene expression databases

ExpressionAtlasiP01888. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cattle beta 2-microglobulin cDNA."
    Ellis S.A., Braem K.A., Payne L.
    Immunogenetics 38:310-310(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
    Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymphoid epithelium.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal cerebellum.
  4. "Complete amino acid sequence of bovine beta 2-microglobulin."
    Groves M.L., Greenberg R.
    J. Biol. Chem. 257:2619-2626(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-118.
  5. "Three-dimensional structure of beta 2-microglobulin."
    Becker J.W., Reeke G.N. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 82:4225-4229(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 21-118 IN COMPLEX WITH MR1, DISULFIDE BOND.

Entry informationi

Entry nameiB2MG_BOVIN
AccessioniPrimary (citable) accession number: P01888
Secondary accession number(s): Q148G6, Q56K05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1994
Last modified: April 1, 2015
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.