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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-BTA-1236974. ER-Phagosome pathway.
R-BTA-1236977. Endosomal/Vacuolar pathway.
R-BTA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-BTA-2172127. DAP12 interactions.
R-BTA-2424491. DAP12 signaling.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-877300. Interferon gamma signaling.
R-BTA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Alternative name(s):
Lactollin
Gene namesi
Name:B2M
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000001875621 – 118Beta-2-microglobulinAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 99PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01888.
PeptideAtlasiP01888.
PRIDEiP01888.

Expressioni

Gene expression databases

BgeeiENSBTAG00000012330.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016359.

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 33Combined sources8
Beta strandi41 – 53Combined sources13
Beta strandi56 – 61Combined sources6
Beta strandi68 – 70Combined sources3
Beta strandi74 – 76Combined sources3
Turni77 – 79Combined sources3
Beta strandi81 – 89Combined sources9
Beta strandi97 – 102Combined sources6
Beta strandi110 – 113Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMGX-ray2.50A21-118[»]
2XFXX-ray1.90B20-118[»]
3L9RX-ray2.30B/D/F/H21-118[»]
3PWVX-ray2.70B/E21-118[»]
4F7CX-ray2.86B/D21-118[»]
4F7EX-ray2.40B21-118[»]
4IIQX-ray2.86C21-118[»]
4L8SX-ray2.90C21-118[»]
4L9LX-ray3.40C21-118[»]
4LCCX-ray3.26C21-118[»]
ProteinModelPortaliP01888.
SMRiP01888.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01888.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 112Ig-like C1-typeAdd BLAST88

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP01888.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG091G0ZOW.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF
60 70 80 90 100
HPPQIEIDLL KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR
110
VKHVTLEQPR IVKWDRDL
Length:118
Mass (Da):13,677
Last modified:February 1, 1994 - v2
Checksum:i140854676D3332E6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37D → N AA sequence (PubMed:6174509).Curated1
Sequence conflicti92N → D AA sequence (PubMed:6174509).Curated1
Sequence conflicti96Q → E AA sequence (PubMed:6174509).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.
PIRiI46000. MGBOB2.
RefSeqiNP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.5.
XP_002691165.1. XM_002691119.3.
UniGeneiBt.64557.

Genome annotation databases

EnsembliENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
GeneIDi280729.
783680.
KEGGibta:280729.
bta:783680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.
PIRiI46000. MGBOB2.
RefSeqiNP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.5.
XP_002691165.1. XM_002691119.3.
UniGeneiBt.64557.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BMGX-ray2.50A21-118[»]
2XFXX-ray1.90B20-118[»]
3L9RX-ray2.30B/D/F/H21-118[»]
3PWVX-ray2.70B/E21-118[»]
4F7CX-ray2.86B/D21-118[»]
4F7EX-ray2.40B21-118[»]
4IIQX-ray2.86C21-118[»]
4L8SX-ray2.90C21-118[»]
4L9LX-ray3.40C21-118[»]
4LCCX-ray3.26C21-118[»]
ProteinModelPortaliP01888.
SMRiP01888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000016359.

Proteomic databases

PaxDbiP01888.
PeptideAtlasiP01888.
PRIDEiP01888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
GeneIDi280729.
783680.
KEGGibta:280729.
bta:783680.

Organism-specific databases

CTDi567.

Phylogenomic databases

eggNOGiENOG410J15A. Eukaryota.
ENOG410YTDG. LUCA.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP01888.
KOiK08055.
OMAiPNFLNCY.
OrthoDBiEOG091G0ZOW.
TreeFamiTF334167.

Enzyme and pathway databases

ReactomeiR-BTA-1236974. ER-Phagosome pathway.
R-BTA-1236977. Endosomal/Vacuolar pathway.
R-BTA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-BTA-2172127. DAP12 interactions.
R-BTA-2424491. DAP12 signaling.
R-BTA-6798695. Neutrophil degranulation.
R-BTA-877300. Interferon gamma signaling.
R-BTA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

EvolutionaryTraceiP01888.

Gene expression databases

BgeeiENSBTAG00000012330.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERiPTHR19944:SF62. PTHR19944:SF62. 1 hit.
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2MG_BOVIN
AccessioniPrimary (citable) accession number: P01888
Secondary accession number(s): Q148G6, Q56K05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.