Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01888 (B2MG_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-2-microglobulin
Alternative name(s):
Lactollin
Gene names
Name:B2M
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

Subcellular location

Secreted.

Sequence similarities

Belongs to the beta-2-microglobulin family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.4
Chain21 – 11898Beta-2-microglobulin
PRO_0000018756

Regions

Domain25 – 11288Ig-like C1-type

Amino acid modifications

Disulfide bond45 ↔ 99 Ref.6

Experimental info

Sequence conflict371D → N AA sequence Ref.4
Sequence conflict921N → D AA sequence Ref.4
Sequence conflict961Q → E AA sequence Ref.4

Secondary structure

...................... 118
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01888 [UniParc].

Last modified February 1, 1994. Version 2.
Checksum: 140854676D3332E6

FASTA11813,677
        10         20         30         40         50         60 
MARFVALVLL GLLSLSGLDA IQRPPKIQVY SRHPPEDGKP NYLNCYVYGF HPPQIEIDLL 

        70         80         90        100        110 
KNGEKIKSEQ SDLSFSKDWS FYLLSHAEFT PNSKDQYSCR VKHVTLEQPR IVKWDRDL 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of cattle beta 2-microglobulin cDNA."
Ellis S.A., Braem K.A., Payne L.
Immunogenetics 38:310-310(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Analysis of sequences obtained from constructed full-length bovine cDNA libraries."
Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymphoid epithelium.
[3]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal cerebellum.
[4]"Complete amino acid sequence of bovine beta 2-microglobulin."
Groves M.L., Greenberg R.
J. Biol. Chem. 257:2619-2626(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-118.
[5]"Three-dimensional structure of beta 2-microglobulin."
Becker J.W., Reeke G.N. Jr.
Proc. Natl. Acad. Sci. U.S.A. 82:4225-4229(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
[6]"The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins."
Lopez-Sagaseta J., Dulberger C.L., Crooks J.E., Parks C.D., Luoma A.M., McFedries A., Van Rhijn I., Saghatelian A., Adams E.J.
Proc. Natl. Acad. Sci. U.S.A. 110:E1771-E1778(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.86 ANGSTROMS) OF 21-118 IN COMPLEX WITH MR1, DISULFIDE BOND.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69084 mRNA. Translation: CAA48828.1.
AY911322 mRNA. Translation: AAW82090.1.
BC118352 mRNA. Translation: AAI18353.1.
PIRMGBOB2. I46000.
RefSeqNP_776318.1. NM_173893.3.
XP_001251108.1. XM_001251107.4.
XP_002691165.1. XM_002691119.2.
UniGeneBt.64557.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BMGX-ray2.50A21-118[»]
2XFXX-ray1.90B20-118[»]
3L9RX-ray2.30B/D/F/H21-118[»]
3PWVX-ray2.70B/E21-118[»]
4F7CX-ray2.86B/D21-118[»]
4F7EX-ray2.40B21-118[»]
4IIQX-ray2.86C21-118[»]
4L8SX-ray2.90C21-118[»]
4L9LX-ray3.40C21-118[»]
4LCCX-ray3.26C21-118[»]
ProteinModelPortalP01888.
SMRP01888. Positions 21-118.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbP01888.
PRIDEP01888.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000016359; ENSBTAP00000016359; ENSBTAG00000012330.
GeneID280729.
783680.
KEGGbta:280729.
bta:783680.

Organism-specific databases

CTD567.

Phylogenomic databases

eggNOGNOG40777.
GeneTreeENSGT00690000102227.
HOGENOMHOG000043084.
HOVERGENHBG006197.
InParanoidP01888.
KOK08055.
OMAPNFLNCY.
OrthoDBEOG7RFTKJ.
TreeFamTF334167.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR015707. B2Microglobulin.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PANTHERPTHR19944:SF16. PTHR19944:SF16. 1 hit.
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01888.
NextBio20804904.

Entry information

Entry nameB2MG_BOVIN
AccessionPrimary (citable) accession number: P01888
Secondary accession number(s): Q148G6, Q56K05
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1994
Last modified: April 16, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references