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P01887

- B2MG_MOUSE

UniProt

P01887 - B2MG_MOUSE

Protein

Beta-2-microglobulin

Gene

B2m

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
    2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    3. cellular defense response Source: MGI
    4. positive regulation of T cell mediated cytotoxicity Source: MGI
    5. protein refolding Source: MGI
    6. response to cadmium ion Source: Ensembl
    7. response to drug Source: Ensembl
    8. response to molecule of bacterial origin Source: MGI
    9. T cell differentiation in thymus Source: MGI

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_188185. DAP12 signaling.
    REACT_188188. DAP12 interactions.
    REACT_197102. ER-Phagosome pathway.
    REACT_198563. Amyloids.
    REACT_198660. Interferon gamma signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199112. Endosomal/Vacuolar pathway.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-2-microglobulin
    Gene namesi
    Name:B2m
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:88127. B2m.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. extracellular space Source: Ensembl
    3. MHC class I protein complex Source: UniProtKB-KW
    4. phagocytic vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    MHC I, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 20202 PublicationsAdd
    BLAST
    Chaini21 – 11999Beta-2-microglobulinPRO_0000018784Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi45 ↔ 100

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01887.
    PRIDEiP01887.

    2D gel databases

    SWISS-2DPAGEP01887.

    PTM databases

    PhosphoSiteiP01887.

    Miscellaneous databases

    PMAP-CutDBP01887.

    Expressioni

    Gene expression databases

    CleanExiMM_B2M.
    GenevestigatoriP01887.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

    Protein-protein interaction databases

    DIPiDIP-6111N.
    IntActiP01887. 5 interactions.
    MINTiMINT-1870185.
    STRINGi10090.ENSMUSP00000099534.

    Structurei

    Secondary structure

    1
    119
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi26 – 338
    Beta strandi37 – 393
    Beta strandi41 – 5313
    Beta strandi56 – 616
    Beta strandi70 – 767
    Turni78 – 803
    Beta strandi82 – 909
    Beta strandi94 – 963
    Beta strandi98 – 1036
    Beta strandi107 – 1093
    Beta strandi111 – 1144

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BIIX-ray2.40B1-119[»]
    1BQHX-ray2.80B/E21-119[»]
    1BZ9X-ray2.80B21-119[»]
    1CD1X-ray2.67B/D21-119[»]
    1DDHX-ray3.10B22-119[»]
    1FFNX-ray2.70B/E21-119[»]
    1FFOX-ray2.65B/E21-119[»]
    1FFPX-ray2.60B/E21-119[»]
    1FG2X-ray2.75B/E/H/K21-119[»]
    1FO0X-ray2.50L21-119[»]
    1FZJX-ray1.90B21-119[»]
    1FZKX-ray1.70B21-119[»]
    1FZMX-ray1.80B21-119[»]
    1FZOX-ray1.80B21-119[»]
    1G6RX-ray2.80L/M21-119[»]
    1G7PX-ray1.50B21-119[»]
    1G7QX-ray1.60B21-119[»]
    1HOCX-ray2.40B21-119[»]
    1INQX-ray2.20B21-119[»]
    1JPFX-ray2.18B21-119[»]
    1JPGX-ray2.20B21-119[»]
    1JUFX-ray2.00B21-119[»]
    1K8DX-ray2.30B21-119[»]
    1KBGX-ray2.20L21-119[»]
    1KJ2X-ray2.71L/M21-119[»]
    1KJ3X-ray2.30L/M21-119[»]
    1KPUX-ray1.50B21-119[»]
    1KPVX-ray1.71B21-119[»]
    1L6Qmodel-B21-119[»]
    1LD9X-ray2.40B/E21-119[»]
    1LDPX-ray3.10L21-119[»]
    1LEGX-ray1.75B21-119[»]
    1LEKX-ray2.15B21-119[»]
    1LK2X-ray1.35B21-119[»]
    1MHCX-ray2.10B/E21-119[»]
    1MWAX-ray2.40L/M21-119[»]
    1N3NX-ray3.00B/D/F/H21-119[»]
    1N59X-ray2.95B/D21-119[»]
    1N5AX-ray2.85B/E/H/K21-119[»]
    1NAMX-ray2.70L21-119[»]
    1NANX-ray2.30I/P21-119[»]
    1NEZX-ray2.10B21-119[»]
    1OSZX-ray2.10B21-119[»]
    1P1ZX-ray3.26B21-119[»]
    1P4LX-ray2.90B21-119[»]
    1PQZX-ray2.10B21-119[»]
    1QO3X-ray2.30B21-119[»]
    1RJYX-ray1.90B/E21-119[»]
    1RJZX-ray2.60B/E21-119[»]
    1RK0X-ray2.61B21-119[»]
    1RK1X-ray2.10B21-119[»]
    1S7QX-ray1.99B21-119[»]
    1S7RX-ray2.95B/E21-119[»]
    1S7SX-ray1.99B21-119[»]
    1S7TX-ray2.30B/E21-119[»]
    1S7UX-ray2.20B/E/H/K21-119[»]
    1S7VX-ray2.20B/E21-119[»]
    1S7WX-ray2.40B/E/H/K21-119[»]
    1S7XX-ray2.41B/E/H/K21-119[»]
    1T0MX-ray2.00B/E21-119[»]
    1T0NX-ray1.80B/E21-119[»]
    1U58X-ray1.90B21-119[»]
    1VACX-ray2.50B21-119[»]
    1VADX-ray2.50B21-119[»]
    1WBXX-ray1.90B21-119[»]
    1WBYX-ray2.30B21-119[»]
    1WBZX-ray2.00B/D21-119[»]
    1YN6X-ray2.20B21-119[»]
    1YN7X-ray2.20B21-119[»]
    1Z5LX-ray2.20B/D21-119[»]
    1ZHBX-ray2.70B/E/H/K21-119[»]
    1ZHNX-ray2.80B21-119[»]
    1ZT1X-ray2.50B21-119[»]
    1ZT7X-ray3.00B/D21-119[»]
    2AKRX-ray1.90B/D21-119[»]
    2CKBX-ray3.00L/M21-119[»]
    2CLVX-ray1.90B/P21-119[»]
    2CLZX-ray1.90B/P21-119[»]
    2FIKX-ray1.80B21-119[»]
    2FO4X-ray2.70B21-119[»]
    2FWOX-ray2.60B21-119[»]
    2GAZX-ray2.61B21-119[»]
    2MHAX-ray2.50B/D21-119[»]
    2OL3X-ray2.90L21-119[»]
    2Q7YX-ray1.95B/D21-119[»]
    2QRIX-ray2.00A/B21-119[»]
    2QRSX-ray2.00A/B21-119[»]
    2QRTX-ray1.80A/B21-119[»]
    2VAAX-ray2.30B21-119[»]
    2VABX-ray2.50B21-119[»]
    2VE6X-ray2.65B/E/H/K22-119[»]
    2ZOKX-ray2.10B/D/F/H21-119[»]
    2ZOLX-ray2.70B/D21-119[»]
    2ZSVX-ray1.80B/D21-119[»]
    2ZSWX-ray2.80B/D/F/H21-119[»]
    3ARBX-ray2.70B21-119[»]
    3ARDX-ray3.01B21-119[»]
    3AREX-ray2.80B21-119[»]
    3ARFX-ray2.90B21-119[»]
    3ARGX-ray3.00B21-119[»]
    3AU1X-ray2.50B21-119[»]
    3BUYX-ray2.60B21-119[»]
    3C8KX-ray2.90B21-119[»]
    3CC5X-ray1.91B/E21-119[»]
    3CCHX-ray2.60B/E/H/K21-119[»]
    3CH1X-ray2.30B/E/H/K21-119[»]
    3CPLX-ray2.50B/D21-119[»]
    3CVHX-ray2.90B/N21-119[»]
    3DMMX-ray2.60B21-119[»]
    3E6FX-ray2.41B22-119[»]
    3E6HX-ray2.10B21-119[»]
    3ECBX-ray1.70B21-119[»]
    3FOLX-ray2.50B21-119[»]
    3FOMX-ray2.10B21-119[»]
    3FONX-ray2.03B/D21-119[»]
    3FTGX-ray2.60B21-119[»]
    3G08X-ray1.60B21-119[»]
    3GMLX-ray1.70B21-119[»]
    3GMMX-ray1.80B21-119[»]
    3GMNX-ray1.70B21-119[»]
    3GMOX-ray1.60B21-119[»]
    3GMPX-ray1.70B21-119[»]
    3GMQX-ray1.80B21-119[»]
    3GMRX-ray1.90B21-119[»]
    3HE6X-ray2.90B21-119[»]
    3HE7X-ray2.80B21-119[»]
    3ILPX-ray1.85B21-119[»]
    3ILQX-ray2.05D21-119[»]
    3L3HX-ray2.70B21-119[»]
    3MA7X-ray2.29B/D21-119[»]
    3NWMX-ray2.70A21-119[»]
    3O8XX-ray2.74B21-119[»]
    3O9WX-ray2.80B21-119[»]
    3P4MX-ray2.50B/E21-119[»]
    3P4NX-ray2.50B/E21-119[»]
    3P4OX-ray2.30B/E21-119[»]
    3P9LX-ray2.00B/E21-119[»]
    3P9MX-ray2.00B/E21-119[»]
    3PABX-ray2.20B/E21-119[»]
    3PQYX-ray3.19B/G/L/Q21-119[»]
    3PWUX-ray1.90B21-119[»]
    3QI9X-ray2.30B21-119[»]
    3QUKX-ray2.41B/E21-119[»]
    3QULX-ray2.00B/E/H/K21-119[»]
    3QUXX-ray2.91B21-119[»]
    3QUYX-ray2.25B21-119[»]
    3QUZX-ray2.30B21-119[»]
    3RGVX-ray2.90D21-119[»]
    3ROLX-ray2.60B/D21-119[»]
    3ROOX-ray2.00B/D21-119[»]
    3RTQX-ray2.80B21-119[»]
    3RUGX-ray2.20B/D21-119[»]
    3RZCX-ray2.80B21-119[»]
    3SCMX-ray2.50B21-119[»]
    3SDAX-ray2.80B21-119[»]
    3SDCX-ray3.10B21-119[»]
    3SDDX-ray3.00B21-119[»]
    3T1FX-ray1.70B21-119[»]
    3TA3X-ray2.70B21-119[»]
    3TBSX-ray2.49B/E21-119[»]
    3TBTX-ray2.30B/E/H/K21-119[»]
    3TBVX-ray2.10B/D/F/H21-119[»]
    3TBWX-ray2.15B/D/F/H21-119[»]
    3TBYX-ray2.50B/E/H/K21-119[»]
    3TN0X-ray3.20B21-119[»]
    3TO4X-ray3.10B21-119[»]
    3TVMX-ray2.80B/F21-119[»]
    3UBXX-ray3.10B/E21-119[»]
    3VJ6X-ray1.90B21-119[»]
    3WS3X-ray2.34B/D21-119[»]
    3WS6X-ray1.98C/D21-119[»]
    4APQX-ray3.00B21-119[»]
    4EI5X-ray3.10B/F21-119[»]
    4ELMX-ray3.48B/D21-119[»]
    4HS3X-ray2.10B21-119[»]
    4HUUX-ray2.00B/E21-119[»]
    4HUVX-ray2.50B/E21-119[»]
    4HUWX-ray3.16B/D/F/H21-119[»]
    4HUXX-ray2.20B21-119[»]
    4HV8X-ray2.00B/D21-119[»]
    4IHOX-ray2.80B/E21-119[»]
    4IRJX-ray3.00B21-119[»]
    4IRSX-ray2.80B21-119[»]
    4L8BX-ray2.20B21-119[»]
    4L8CX-ray2.80B/D/F/H21-119[»]
    4L8DX-ray1.90B/D21-119[»]
    4MNGX-ray3.01B/D21-119[»]
    4MQ7X-ray2.60B21-119[»]
    4NSKX-ray2.60B21-119[»]
    4PV8X-ray2.31B/D21-119[»]
    4PV9X-ray2.00B/D21-119[»]
    ProteinModelPortaliP01887.
    SMRiP01887. Positions 21-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01887.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 11490Ig-like C1-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the beta-2-microglobulin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal

    Phylogenomic databases

    eggNOGiNOG40777.
    GeneTreeiENSGT00690000102227.
    HOGENOMiHOG000043084.
    HOVERGENiHBG006197.
    InParanoidiP01887.
    KOiK08055.
    OMAiFYLLVHT.
    OrthoDBiEOG7RFTKJ.
    TreeFamiTF334167.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01887-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF    50
    HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC 100
    RVKHASMAEP KTVYWDRDM 119
    Length:119
    Mass (Da):13,779
    Last modified:October 3, 2012 - v2
    Checksum:i94F649EBCF1D7A4E
    GO

    Polymorphismi

    The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti8 – 81V → I in allele W3.
    Natural varianti54 – 541H → Q in allele W4.
    Natural varianti64 – 641K → E in allele W3.
    Natural varianti101 – 1011R → T in allele W2.
    Natural varianti105 – 1051A → D in allele A.
    Natural varianti105 – 1051A → V in allele W2, W4 and W5.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01838 mRNA. Translation: CAA25970.1.
    M12485 Genomic DNA. No translation available.
    M84363 Genomic DNA. Translation: AAA39667.1.
    M84364 Genomic DNA. Translation: AAA39668.1.
    M84365 Genomic DNA. Translation: AAA39669.1.
    M84366 Genomic DNA. Translation: AAA39670.1.
    M84367 Genomic DNA. Translation: AAA39671.1.
    AK019389 mRNA. Translation: BAB31695.1.
    AK028378 mRNA. Translation: BAC25917.1.
    AK166067 mRNA. Translation: BAE38551.1.
    AL845457 Genomic DNA. Translation: CAM21783.1.
    CH466519 Genomic DNA. Translation: EDL28084.1.
    BC085164 mRNA. Translation: AAH85164.1.
    M10389 mRNA. Translation: AAA39536.1.
    M10416 mRNA. Translation: AAA39537.1.
    CCDSiCCDS16654.1.
    PIRiA90822. MGMSB2.
    RefSeqiNP_033865.2. NM_009735.3.
    UniGeneiMm.163.

    Genome annotation databases

    EnsembliENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802.
    GeneIDi12010.
    KEGGimmu:12010.
    UCSCiuc008maf.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01838 mRNA. Translation: CAA25970.1 .
    M12485 Genomic DNA. No translation available.
    M84363 Genomic DNA. Translation: AAA39667.1 .
    M84364 Genomic DNA. Translation: AAA39668.1 .
    M84365 Genomic DNA. Translation: AAA39669.1 .
    M84366 Genomic DNA. Translation: AAA39670.1 .
    M84367 Genomic DNA. Translation: AAA39671.1 .
    AK019389 mRNA. Translation: BAB31695.1 .
    AK028378 mRNA. Translation: BAC25917.1 .
    AK166067 mRNA. Translation: BAE38551.1 .
    AL845457 Genomic DNA. Translation: CAM21783.1 .
    CH466519 Genomic DNA. Translation: EDL28084.1 .
    BC085164 mRNA. Translation: AAH85164.1 .
    M10389 mRNA. Translation: AAA39536.1 .
    M10416 mRNA. Translation: AAA39537.1 .
    CCDSi CCDS16654.1.
    PIRi A90822. MGMSB2.
    RefSeqi NP_033865.2. NM_009735.3.
    UniGenei Mm.163.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BII X-ray 2.40 B 1-119 [» ]
    1BQH X-ray 2.80 B/E 21-119 [» ]
    1BZ9 X-ray 2.80 B 21-119 [» ]
    1CD1 X-ray 2.67 B/D 21-119 [» ]
    1DDH X-ray 3.10 B 22-119 [» ]
    1FFN X-ray 2.70 B/E 21-119 [» ]
    1FFO X-ray 2.65 B/E 21-119 [» ]
    1FFP X-ray 2.60 B/E 21-119 [» ]
    1FG2 X-ray 2.75 B/E/H/K 21-119 [» ]
    1FO0 X-ray 2.50 L 21-119 [» ]
    1FZJ X-ray 1.90 B 21-119 [» ]
    1FZK X-ray 1.70 B 21-119 [» ]
    1FZM X-ray 1.80 B 21-119 [» ]
    1FZO X-ray 1.80 B 21-119 [» ]
    1G6R X-ray 2.80 L/M 21-119 [» ]
    1G7P X-ray 1.50 B 21-119 [» ]
    1G7Q X-ray 1.60 B 21-119 [» ]
    1HOC X-ray 2.40 B 21-119 [» ]
    1INQ X-ray 2.20 B 21-119 [» ]
    1JPF X-ray 2.18 B 21-119 [» ]
    1JPG X-ray 2.20 B 21-119 [» ]
    1JUF X-ray 2.00 B 21-119 [» ]
    1K8D X-ray 2.30 B 21-119 [» ]
    1KBG X-ray 2.20 L 21-119 [» ]
    1KJ2 X-ray 2.71 L/M 21-119 [» ]
    1KJ3 X-ray 2.30 L/M 21-119 [» ]
    1KPU X-ray 1.50 B 21-119 [» ]
    1KPV X-ray 1.71 B 21-119 [» ]
    1L6Q model - B 21-119 [» ]
    1LD9 X-ray 2.40 B/E 21-119 [» ]
    1LDP X-ray 3.10 L 21-119 [» ]
    1LEG X-ray 1.75 B 21-119 [» ]
    1LEK X-ray 2.15 B 21-119 [» ]
    1LK2 X-ray 1.35 B 21-119 [» ]
    1MHC X-ray 2.10 B/E 21-119 [» ]
    1MWA X-ray 2.40 L/M 21-119 [» ]
    1N3N X-ray 3.00 B/D/F/H 21-119 [» ]
    1N59 X-ray 2.95 B/D 21-119 [» ]
    1N5A X-ray 2.85 B/E/H/K 21-119 [» ]
    1NAM X-ray 2.70 L 21-119 [» ]
    1NAN X-ray 2.30 I/P 21-119 [» ]
    1NEZ X-ray 2.10 B 21-119 [» ]
    1OSZ X-ray 2.10 B 21-119 [» ]
    1P1Z X-ray 3.26 B 21-119 [» ]
    1P4L X-ray 2.90 B 21-119 [» ]
    1PQZ X-ray 2.10 B 21-119 [» ]
    1QO3 X-ray 2.30 B 21-119 [» ]
    1RJY X-ray 1.90 B/E 21-119 [» ]
    1RJZ X-ray 2.60 B/E 21-119 [» ]
    1RK0 X-ray 2.61 B 21-119 [» ]
    1RK1 X-ray 2.10 B 21-119 [» ]
    1S7Q X-ray 1.99 B 21-119 [» ]
    1S7R X-ray 2.95 B/E 21-119 [» ]
    1S7S X-ray 1.99 B 21-119 [» ]
    1S7T X-ray 2.30 B/E 21-119 [» ]
    1S7U X-ray 2.20 B/E/H/K 21-119 [» ]
    1S7V X-ray 2.20 B/E 21-119 [» ]
    1S7W X-ray 2.40 B/E/H/K 21-119 [» ]
    1S7X X-ray 2.41 B/E/H/K 21-119 [» ]
    1T0M X-ray 2.00 B/E 21-119 [» ]
    1T0N X-ray 1.80 B/E 21-119 [» ]
    1U58 X-ray 1.90 B 21-119 [» ]
    1VAC X-ray 2.50 B 21-119 [» ]
    1VAD X-ray 2.50 B 21-119 [» ]
    1WBX X-ray 1.90 B 21-119 [» ]
    1WBY X-ray 2.30 B 21-119 [» ]
    1WBZ X-ray 2.00 B/D 21-119 [» ]
    1YN6 X-ray 2.20 B 21-119 [» ]
    1YN7 X-ray 2.20 B 21-119 [» ]
    1Z5L X-ray 2.20 B/D 21-119 [» ]
    1ZHB X-ray 2.70 B/E/H/K 21-119 [» ]
    1ZHN X-ray 2.80 B 21-119 [» ]
    1ZT1 X-ray 2.50 B 21-119 [» ]
    1ZT7 X-ray 3.00 B/D 21-119 [» ]
    2AKR X-ray 1.90 B/D 21-119 [» ]
    2CKB X-ray 3.00 L/M 21-119 [» ]
    2CLV X-ray 1.90 B/P 21-119 [» ]
    2CLZ X-ray 1.90 B/P 21-119 [» ]
    2FIK X-ray 1.80 B 21-119 [» ]
    2FO4 X-ray 2.70 B 21-119 [» ]
    2FWO X-ray 2.60 B 21-119 [» ]
    2GAZ X-ray 2.61 B 21-119 [» ]
    2MHA X-ray 2.50 B/D 21-119 [» ]
    2OL3 X-ray 2.90 L 21-119 [» ]
    2Q7Y X-ray 1.95 B/D 21-119 [» ]
    2QRI X-ray 2.00 A/B 21-119 [» ]
    2QRS X-ray 2.00 A/B 21-119 [» ]
    2QRT X-ray 1.80 A/B 21-119 [» ]
    2VAA X-ray 2.30 B 21-119 [» ]
    2VAB X-ray 2.50 B 21-119 [» ]
    2VE6 X-ray 2.65 B/E/H/K 22-119 [» ]
    2ZOK X-ray 2.10 B/D/F/H 21-119 [» ]
    2ZOL X-ray 2.70 B/D 21-119 [» ]
    2ZSV X-ray 1.80 B/D 21-119 [» ]
    2ZSW X-ray 2.80 B/D/F/H 21-119 [» ]
    3ARB X-ray 2.70 B 21-119 [» ]
    3ARD X-ray 3.01 B 21-119 [» ]
    3ARE X-ray 2.80 B 21-119 [» ]
    3ARF X-ray 2.90 B 21-119 [» ]
    3ARG X-ray 3.00 B 21-119 [» ]
    3AU1 X-ray 2.50 B 21-119 [» ]
    3BUY X-ray 2.60 B 21-119 [» ]
    3C8K X-ray 2.90 B 21-119 [» ]
    3CC5 X-ray 1.91 B/E 21-119 [» ]
    3CCH X-ray 2.60 B/E/H/K 21-119 [» ]
    3CH1 X-ray 2.30 B/E/H/K 21-119 [» ]
    3CPL X-ray 2.50 B/D 21-119 [» ]
    3CVH X-ray 2.90 B/N 21-119 [» ]
    3DMM X-ray 2.60 B 21-119 [» ]
    3E6F X-ray 2.41 B 22-119 [» ]
    3E6H X-ray 2.10 B 21-119 [» ]
    3ECB X-ray 1.70 B 21-119 [» ]
    3FOL X-ray 2.50 B 21-119 [» ]
    3FOM X-ray 2.10 B 21-119 [» ]
    3FON X-ray 2.03 B/D 21-119 [» ]
    3FTG X-ray 2.60 B 21-119 [» ]
    3G08 X-ray 1.60 B 21-119 [» ]
    3GML X-ray 1.70 B 21-119 [» ]
    3GMM X-ray 1.80 B 21-119 [» ]
    3GMN X-ray 1.70 B 21-119 [» ]
    3GMO X-ray 1.60 B 21-119 [» ]
    3GMP X-ray 1.70 B 21-119 [» ]
    3GMQ X-ray 1.80 B 21-119 [» ]
    3GMR X-ray 1.90 B 21-119 [» ]
    3HE6 X-ray 2.90 B 21-119 [» ]
    3HE7 X-ray 2.80 B 21-119 [» ]
    3ILP X-ray 1.85 B 21-119 [» ]
    3ILQ X-ray 2.05 D 21-119 [» ]
    3L3H X-ray 2.70 B 21-119 [» ]
    3MA7 X-ray 2.29 B/D 21-119 [» ]
    3NWM X-ray 2.70 A 21-119 [» ]
    3O8X X-ray 2.74 B 21-119 [» ]
    3O9W X-ray 2.80 B 21-119 [» ]
    3P4M X-ray 2.50 B/E 21-119 [» ]
    3P4N X-ray 2.50 B/E 21-119 [» ]
    3P4O X-ray 2.30 B/E 21-119 [» ]
    3P9L X-ray 2.00 B/E 21-119 [» ]
    3P9M X-ray 2.00 B/E 21-119 [» ]
    3PAB X-ray 2.20 B/E 21-119 [» ]
    3PQY X-ray 3.19 B/G/L/Q 21-119 [» ]
    3PWU X-ray 1.90 B 21-119 [» ]
    3QI9 X-ray 2.30 B 21-119 [» ]
    3QUK X-ray 2.41 B/E 21-119 [» ]
    3QUL X-ray 2.00 B/E/H/K 21-119 [» ]
    3QUX X-ray 2.91 B 21-119 [» ]
    3QUY X-ray 2.25 B 21-119 [» ]
    3QUZ X-ray 2.30 B 21-119 [» ]
    3RGV X-ray 2.90 D 21-119 [» ]
    3ROL X-ray 2.60 B/D 21-119 [» ]
    3ROO X-ray 2.00 B/D 21-119 [» ]
    3RTQ X-ray 2.80 B 21-119 [» ]
    3RUG X-ray 2.20 B/D 21-119 [» ]
    3RZC X-ray 2.80 B 21-119 [» ]
    3SCM X-ray 2.50 B 21-119 [» ]
    3SDA X-ray 2.80 B 21-119 [» ]
    3SDC X-ray 3.10 B 21-119 [» ]
    3SDD X-ray 3.00 B 21-119 [» ]
    3T1F X-ray 1.70 B 21-119 [» ]
    3TA3 X-ray 2.70 B 21-119 [» ]
    3TBS X-ray 2.49 B/E 21-119 [» ]
    3TBT X-ray 2.30 B/E/H/K 21-119 [» ]
    3TBV X-ray 2.10 B/D/F/H 21-119 [» ]
    3TBW X-ray 2.15 B/D/F/H 21-119 [» ]
    3TBY X-ray 2.50 B/E/H/K 21-119 [» ]
    3TN0 X-ray 3.20 B 21-119 [» ]
    3TO4 X-ray 3.10 B 21-119 [» ]
    3TVM X-ray 2.80 B/F 21-119 [» ]
    3UBX X-ray 3.10 B/E 21-119 [» ]
    3VJ6 X-ray 1.90 B 21-119 [» ]
    3WS3 X-ray 2.34 B/D 21-119 [» ]
    3WS6 X-ray 1.98 C/D 21-119 [» ]
    4APQ X-ray 3.00 B 21-119 [» ]
    4EI5 X-ray 3.10 B/F 21-119 [» ]
    4ELM X-ray 3.48 B/D 21-119 [» ]
    4HS3 X-ray 2.10 B 21-119 [» ]
    4HUU X-ray 2.00 B/E 21-119 [» ]
    4HUV X-ray 2.50 B/E 21-119 [» ]
    4HUW X-ray 3.16 B/D/F/H 21-119 [» ]
    4HUX X-ray 2.20 B 21-119 [» ]
    4HV8 X-ray 2.00 B/D 21-119 [» ]
    4IHO X-ray 2.80 B/E 21-119 [» ]
    4IRJ X-ray 3.00 B 21-119 [» ]
    4IRS X-ray 2.80 B 21-119 [» ]
    4L8B X-ray 2.20 B 21-119 [» ]
    4L8C X-ray 2.80 B/D/F/H 21-119 [» ]
    4L8D X-ray 1.90 B/D 21-119 [» ]
    4MNG X-ray 3.01 B/D 21-119 [» ]
    4MQ7 X-ray 2.60 B 21-119 [» ]
    4NSK X-ray 2.60 B 21-119 [» ]
    4PV8 X-ray 2.31 B/D 21-119 [» ]
    4PV9 X-ray 2.00 B/D 21-119 [» ]
    ProteinModelPortali P01887.
    SMRi P01887. Positions 21-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6111N.
    IntActi P01887. 5 interactions.
    MINTi MINT-1870185.
    STRINGi 10090.ENSMUSP00000099534.

    PTM databases

    PhosphoSitei P01887.

    2D gel databases

    SWISS-2DPAGE P01887.

    Proteomic databases

    PaxDbi P01887.
    PRIDEi P01887.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102476 ; ENSMUSP00000099534 ; ENSMUSG00000060802 .
    GeneIDi 12010.
    KEGGi mmu:12010.
    UCSCi uc008maf.1. mouse.

    Organism-specific databases

    CTDi 567.
    MGIi MGI:88127. B2m.

    Phylogenomic databases

    eggNOGi NOG40777.
    GeneTreei ENSGT00690000102227.
    HOGENOMi HOG000043084.
    HOVERGENi HBG006197.
    InParanoidi P01887.
    KOi K08055.
    OMAi FYLLVHT.
    OrthoDBi EOG7RFTKJ.
    TreeFami TF334167.

    Enzyme and pathway databases

    Reactomei REACT_188185. DAP12 signaling.
    REACT_188188. DAP12 interactions.
    REACT_197102. ER-Phagosome pathway.
    REACT_198563. Amyloids.
    REACT_198660. Interferon gamma signaling.
    REACT_199105. ER-Phagosome pathway.
    REACT_199112. Endosomal/Vacuolar pathway.
    REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    EvolutionaryTracei P01887.
    NextBioi 280211.
    PMAP-CutDB P01887.
    PROi P01887.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_B2M.
    Genevestigatori P01887.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells."
      Daniel F., Morello D., le Bail O., Chambon P., Cayre Y., Kourilsky P.
      EMBO J. 2:1061-1065(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A).
    2. "Structure of wild-type and mutant mouse beta 2-microglobulin genes."
      Parnes J.R., Seidman J.G.
      Cell 29:661-669(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ALLELE A).
      Strain: BALB/c.
    3. "Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection."
      Hermel E., Robinson P.J., She J.-X., Lindahl K.F.
      Immunogenetics 38:106-116(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES W2; W3; W4 AND W5).
      Tissue: Liver.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Lung and Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    8. "Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism."
      Gates F.T. III, Coligan J.E., Kindt T.J.
      Proc. Natl. Acad. Sci. U.S.A. 78:554-558(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 21-119 (ALLELES A AND B).
      Strain: BALB/c and C57BL/6.
    9. "Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs."
      Parnes J.R., Velan B., Felsenfeld A., Ramanathan L., Ferrini U., Appella E., Seidman J.G.
      Proc. Natl. Acad. Sci. U.S.A. 78:2253-2257(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-57 AND 86-119 (ALLELE A).
    10. "Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression."
      Kimura A., Israel A., le Bail O., Kourilsky P.
      Cell 44:261-272(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3 (ALLELE A).
    11. Cited for: PROTEIN SEQUENCE OF 21-60 (ALLELE A).
    12. "Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb."
      Fremont D.H., Matsumura M., Stura E.A., Peterson P.A., Wilson I.A.
      Science 257:919-927(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
    13. "The three-dimensional structure of H-2Db at 2.4-A resolution: implications for antigen-determinant selection."
      Young A.C.M., Zhang W., Sacchettini J.C., Nathenson S.G.
      Cell 76:39-50(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    14. "The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide."
      Balendiran G.K., Solheim J.C., Young A.C., Hansen T.H., Nathenson S.G., Sacchettini J.C.
      Proc. Natl. Acad. Sci. U.S.A. 94:6880-6885(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
    15. "The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK cell recognition."
      Achour A., Persson K., Harris R.A., Sundbaeck J., Sentman C.L., Lindqvist Y., Schneider G., Kaerre K.
      Immunity 9:199-208(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

    Entry informationi

    Entry nameiB2MG_MOUSE
    AccessioniPrimary (citable) accession number: P01887
    Secondary accession number(s): Q91XJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3