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P01887

- B2MG_MOUSE

UniProt

P01887 - B2MG_MOUSE

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Protein

Beta-2-microglobulin

Gene
B2m
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
  2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  3. cellular defense response Source: MGI
  4. positive regulation of T cell mediated cytotoxicity Source: MGI
  5. protein refolding Source: MGI
  6. response to cadmium ion Source: Ensembl
  7. response to drug Source: Ensembl
  8. response to molecule of bacterial origin Source: MGI
  9. T cell differentiation in thymus Source: MGI
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.
REACT_197102. ER-Phagosome pathway.
REACT_198563. Amyloids.
REACT_198660. Interferon gamma signaling.
REACT_199105. ER-Phagosome pathway.
REACT_199112. Endosomal/Vacuolar pathway.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulin
Gene namesi
Name:B2m
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:88127. B2m.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. extracellular space Source: Ensembl
  3. MHC class I protein complex Source: UniProtKB-KW
  4. phagocytic vesicle membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

MHC I, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20202 PublicationsAdd
BLAST
Chaini21 – 11999Beta-2-microglobulinPRO_0000018784Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi45 ↔ 100

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01887.
PRIDEiP01887.

2D gel databases

SWISS-2DPAGEP01887.

PTM databases

PhosphoSiteiP01887.

Miscellaneous databases

PMAP-CutDBP01887.

Expressioni

Gene expression databases

CleanExiMM_B2M.
GenevestigatoriP01887.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.

Protein-protein interaction databases

DIPiDIP-6111N.
IntActiP01887. 5 interactions.
MINTiMINT-1870185.
STRINGi10090.ENSMUSP00000099534.

Structurei

Secondary structure

1
119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi26 – 338
Beta strandi37 – 393
Beta strandi41 – 5313
Beta strandi56 – 616
Beta strandi70 – 767
Turni78 – 803
Beta strandi82 – 909
Beta strandi94 – 963
Beta strandi98 – 1036
Beta strandi107 – 1093
Beta strandi111 – 1144

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BIIX-ray2.40B1-119[»]
1BQHX-ray2.80B/E21-119[»]
1BZ9X-ray2.80B21-119[»]
1CD1X-ray2.67B/D21-119[»]
1DDHX-ray3.10B22-119[»]
1FFNX-ray2.70B/E21-119[»]
1FFOX-ray2.65B/E21-119[»]
1FFPX-ray2.60B/E21-119[»]
1FG2X-ray2.75B/E/H/K21-119[»]
1FO0X-ray2.50L21-119[»]
1FZJX-ray1.90B21-119[»]
1FZKX-ray1.70B21-119[»]
1FZMX-ray1.80B21-119[»]
1FZOX-ray1.80B21-119[»]
1G6RX-ray2.80L/M21-119[»]
1G7PX-ray1.50B21-119[»]
1G7QX-ray1.60B21-119[»]
1HOCX-ray2.40B21-119[»]
1INQX-ray2.20B21-119[»]
1JPFX-ray2.18B21-119[»]
1JPGX-ray2.20B21-119[»]
1JUFX-ray2.00B21-119[»]
1K8DX-ray2.30B21-119[»]
1KBGX-ray2.20L21-119[»]
1KJ2X-ray2.71L/M21-119[»]
1KJ3X-ray2.30L/M21-119[»]
1KPUX-ray1.50B21-119[»]
1KPVX-ray1.71B21-119[»]
1L6Qmodel-B21-119[»]
1LD9X-ray2.40B/E21-119[»]
1LDPX-ray3.10L21-119[»]
1LEGX-ray1.75B21-119[»]
1LEKX-ray2.15B21-119[»]
1LK2X-ray1.35B21-119[»]
1MHCX-ray2.10B/E21-119[»]
1MWAX-ray2.40L/M21-119[»]
1N3NX-ray3.00B/D/F/H21-119[»]
1N59X-ray2.95B/D21-119[»]
1N5AX-ray2.85B/E/H/K21-119[»]
1NAMX-ray2.70L21-119[»]
1NANX-ray2.30I/P21-119[»]
1NEZX-ray2.10B21-119[»]
1OSZX-ray2.10B21-119[»]
1P1ZX-ray3.26B21-119[»]
1P4LX-ray2.90B21-119[»]
1PQZX-ray2.10B21-119[»]
1QO3X-ray2.30B21-119[»]
1RJYX-ray1.90B/E21-119[»]
1RJZX-ray2.60B/E21-119[»]
1RK0X-ray2.61B21-119[»]
1RK1X-ray2.10B21-119[»]
1S7QX-ray1.99B21-119[»]
1S7RX-ray2.95B/E21-119[»]
1S7SX-ray1.99B21-119[»]
1S7TX-ray2.30B/E21-119[»]
1S7UX-ray2.20B/E/H/K21-119[»]
1S7VX-ray2.20B/E21-119[»]
1S7WX-ray2.40B/E/H/K21-119[»]
1S7XX-ray2.41B/E/H/K21-119[»]
1T0MX-ray2.00B/E21-119[»]
1T0NX-ray1.80B/E21-119[»]
1U58X-ray1.90B21-119[»]
1VACX-ray2.50B21-119[»]
1VADX-ray2.50B21-119[»]
1WBXX-ray1.90B21-119[»]
1WBYX-ray2.30B21-119[»]
1WBZX-ray2.00B/D21-119[»]
1YN6X-ray2.20B21-119[»]
1YN7X-ray2.20B21-119[»]
1Z5LX-ray2.20B/D21-119[»]
1ZHBX-ray2.70B/E/H/K21-119[»]
1ZHNX-ray2.80B21-119[»]
1ZT1X-ray2.50B21-119[»]
1ZT7X-ray3.00B/D21-119[»]
2AKRX-ray1.90B/D21-119[»]
2CKBX-ray3.00L/M21-119[»]
2CLVX-ray1.90B/P21-119[»]
2CLZX-ray1.90B/P21-119[»]
2FIKX-ray1.80B21-119[»]
2FO4X-ray2.70B21-119[»]
2FWOX-ray2.60B21-119[»]
2GAZX-ray2.61B21-119[»]
2MHAX-ray2.50B/D21-119[»]
2OL3X-ray2.90L21-119[»]
2Q7YX-ray1.95B/D21-119[»]
2QRIX-ray2.00A/B21-119[»]
2QRSX-ray2.00A/B21-119[»]
2QRTX-ray1.80A/B21-119[»]
2VAAX-ray2.30B21-119[»]
2VABX-ray2.50B21-119[»]
2VE6X-ray2.65B/E/H/K22-119[»]
2ZOKX-ray2.10B/D/F/H21-119[»]
2ZOLX-ray2.70B/D21-119[»]
2ZSVX-ray1.80B/D21-119[»]
2ZSWX-ray2.80B/D/F/H21-119[»]
3ARBX-ray2.70B21-119[»]
3ARDX-ray3.01B21-119[»]
3AREX-ray2.80B21-119[»]
3ARFX-ray2.90B21-119[»]
3ARGX-ray3.00B21-119[»]
3AU1X-ray2.50B21-119[»]
3BUYX-ray2.60B21-119[»]
3C8KX-ray2.90B21-119[»]
3CC5X-ray1.91B/E21-119[»]
3CCHX-ray2.60B/E/H/K21-119[»]
3CH1X-ray2.30B/E/H/K21-119[»]
3CPLX-ray2.50B/D21-119[»]
3CVHX-ray2.90B/N21-119[»]
3DMMX-ray2.60B21-119[»]
3E6FX-ray2.41B22-119[»]
3E6HX-ray2.10B21-119[»]
3ECBX-ray1.70B21-119[»]
3FOLX-ray2.50B21-119[»]
3FOMX-ray2.10B21-119[»]
3FONX-ray2.03B/D21-119[»]
3FTGX-ray2.60B21-119[»]
3G08X-ray1.60B21-119[»]
3GMLX-ray1.70B21-119[»]
3GMMX-ray1.80B21-119[»]
3GMNX-ray1.70B21-119[»]
3GMOX-ray1.60B21-119[»]
3GMPX-ray1.70B21-119[»]
3GMQX-ray1.80B21-119[»]
3GMRX-ray1.90B21-119[»]
3HE6X-ray2.90B21-119[»]
3HE7X-ray2.80B21-119[»]
3ILPX-ray1.85B21-119[»]
3ILQX-ray2.05D21-119[»]
3L3HX-ray2.70B21-119[»]
3MA7X-ray2.29B/D21-119[»]
3NWMX-ray2.70A21-119[»]
3O8XX-ray2.74B21-119[»]
3O9WX-ray2.80B21-119[»]
3P4MX-ray2.50B/E21-119[»]
3P4NX-ray2.50B/E21-119[»]
3P4OX-ray2.30B/E21-119[»]
3P9LX-ray2.00B/E21-119[»]
3P9MX-ray2.00B/E21-119[»]
3PABX-ray2.20B/E21-119[»]
3PQYX-ray3.19B/G/L/Q21-119[»]
3PWUX-ray1.90B21-119[»]
3QI9X-ray2.30B21-119[»]
3QUKX-ray2.41B/E21-119[»]
3QULX-ray2.00B/E/H/K21-119[»]
3QUXX-ray2.91B21-119[»]
3QUYX-ray2.25B21-119[»]
3QUZX-ray2.30B21-119[»]
3RGVX-ray2.90D21-119[»]
3ROLX-ray2.60B/D21-119[»]
3ROOX-ray2.00B/D21-119[»]
3RTQX-ray2.80B21-119[»]
3RUGX-ray2.20B/D21-119[»]
3RZCX-ray2.80B21-119[»]
3SCMX-ray2.50B21-119[»]
3SDAX-ray2.80B21-119[»]
3SDCX-ray3.10B21-119[»]
3SDDX-ray3.00B21-119[»]
3T1FX-ray1.70B21-119[»]
3TA3X-ray2.70B21-119[»]
3TBSX-ray2.49B/E21-119[»]
3TBTX-ray2.30B/E/H/K21-119[»]
3TBVX-ray2.10B/D/F/H21-119[»]
3TBWX-ray2.15B/D/F/H21-119[»]
3TBYX-ray2.50B/E/H/K21-119[»]
3TN0X-ray3.20B21-119[»]
3TO4X-ray3.10B21-119[»]
3TVMX-ray2.80B/F21-119[»]
3UBXX-ray3.10B/E21-119[»]
3VJ6X-ray1.90B21-119[»]
3WS3X-ray2.34B/D21-119[»]
3WS6X-ray1.98C/D21-119[»]
4APQX-ray3.00B21-119[»]
4EI5X-ray3.10B/F21-119[»]
4ELMX-ray3.48B/D21-119[»]
4HS3X-ray2.10B21-119[»]
4HUUX-ray2.00B/E21-119[»]
4HUVX-ray2.50B/E21-119[»]
4HUWX-ray3.16B/D/F/H21-119[»]
4HUXX-ray2.20B21-119[»]
4HV8X-ray2.00B/D21-119[»]
4IHOX-ray2.80B/E21-119[»]
4IRJX-ray3.00B21-119[»]
4IRSX-ray2.80B21-119[»]
4L8BX-ray2.20B21-119[»]
4L8CX-ray2.80B/D/F/H21-119[»]
4L8DX-ray1.90B/D21-119[»]
4MNGX-ray3.01B/D21-119[»]
4MQ7X-ray2.60B21-119[»]
4NSKX-ray2.60B21-119[»]
4PV8X-ray2.31B/D21-119[»]
4PV9X-ray2.00B/D21-119[»]
ProteinModelPortaliP01887.
SMRiP01887. Positions 21-119.

Miscellaneous databases

EvolutionaryTraceiP01887.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 11490Ig-like C1-typeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiNOG40777.
GeneTreeiENSGT00690000102227.
HOGENOMiHOG000043084.
HOVERGENiHBG006197.
InParanoidiP01887.
KOiK08055.
OMAiFYLLVHT.
OrthoDBiEOG7RFTKJ.
TreeFamiTF334167.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01887-1 [UniParc]FASTAAdd to Basket

« Hide

MARSVTLVFL VLVSLTGLYA IQKTPQIQVY SRHPPENGKP NILNCYVTQF    50
HPPHIEIQML KNGKKIPKVE MSDMSFSKDW SFYILAHTEF TPTETDTYAC 100
RVKHASMAEP KTVYWDRDM 119
Length:119
Mass (Da):13,779
Last modified:October 3, 2012 - v2
Checksum:i94F649EBCF1D7A4E
GO

Polymorphismi

The following alleles of B2M are known: A, B, W2, W3, W4 and W5 (C). The sequence shown is that of allele B.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81V → I in allele W3.
Natural varianti54 – 541H → Q in allele W4.
Natural varianti64 – 641K → E in allele W3.
Natural varianti101 – 1011R → T in allele W2.
Natural varianti105 – 1051A → D in allele A.
Natural varianti105 – 1051A → V in allele W2, W4 and W5.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01838 mRNA. Translation: CAA25970.1.
M12485 Genomic DNA. No translation available.
M84363 Genomic DNA. Translation: AAA39667.1.
M84364 Genomic DNA. Translation: AAA39668.1.
M84365 Genomic DNA. Translation: AAA39669.1.
M84366 Genomic DNA. Translation: AAA39670.1.
M84367 Genomic DNA. Translation: AAA39671.1.
AK019389 mRNA. Translation: BAB31695.1.
AK028378 mRNA. Translation: BAC25917.1.
AK166067 mRNA. Translation: BAE38551.1.
AL845457 Genomic DNA. Translation: CAM21783.1.
CH466519 Genomic DNA. Translation: EDL28084.1.
BC085164 mRNA. Translation: AAH85164.1.
M10389 mRNA. Translation: AAA39536.1.
M10416 mRNA. Translation: AAA39537.1.
CCDSiCCDS16654.1.
PIRiA90822. MGMSB2.
RefSeqiNP_033865.2. NM_009735.3.
UniGeneiMm.163.

Genome annotation databases

EnsembliENSMUST00000102476; ENSMUSP00000099534; ENSMUSG00000060802.
GeneIDi12010.
KEGGimmu:12010.
UCSCiuc008maf.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X01838 mRNA. Translation: CAA25970.1 .
M12485 Genomic DNA. No translation available.
M84363 Genomic DNA. Translation: AAA39667.1 .
M84364 Genomic DNA. Translation: AAA39668.1 .
M84365 Genomic DNA. Translation: AAA39669.1 .
M84366 Genomic DNA. Translation: AAA39670.1 .
M84367 Genomic DNA. Translation: AAA39671.1 .
AK019389 mRNA. Translation: BAB31695.1 .
AK028378 mRNA. Translation: BAC25917.1 .
AK166067 mRNA. Translation: BAE38551.1 .
AL845457 Genomic DNA. Translation: CAM21783.1 .
CH466519 Genomic DNA. Translation: EDL28084.1 .
BC085164 mRNA. Translation: AAH85164.1 .
M10389 mRNA. Translation: AAA39536.1 .
M10416 mRNA. Translation: AAA39537.1 .
CCDSi CCDS16654.1.
PIRi A90822. MGMSB2.
RefSeqi NP_033865.2. NM_009735.3.
UniGenei Mm.163.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BII X-ray 2.40 B 1-119 [» ]
1BQH X-ray 2.80 B/E 21-119 [» ]
1BZ9 X-ray 2.80 B 21-119 [» ]
1CD1 X-ray 2.67 B/D 21-119 [» ]
1DDH X-ray 3.10 B 22-119 [» ]
1FFN X-ray 2.70 B/E 21-119 [» ]
1FFO X-ray 2.65 B/E 21-119 [» ]
1FFP X-ray 2.60 B/E 21-119 [» ]
1FG2 X-ray 2.75 B/E/H/K 21-119 [» ]
1FO0 X-ray 2.50 L 21-119 [» ]
1FZJ X-ray 1.90 B 21-119 [» ]
1FZK X-ray 1.70 B 21-119 [» ]
1FZM X-ray 1.80 B 21-119 [» ]
1FZO X-ray 1.80 B 21-119 [» ]
1G6R X-ray 2.80 L/M 21-119 [» ]
1G7P X-ray 1.50 B 21-119 [» ]
1G7Q X-ray 1.60 B 21-119 [» ]
1HOC X-ray 2.40 B 21-119 [» ]
1INQ X-ray 2.20 B 21-119 [» ]
1JPF X-ray 2.18 B 21-119 [» ]
1JPG X-ray 2.20 B 21-119 [» ]
1JUF X-ray 2.00 B 21-119 [» ]
1K8D X-ray 2.30 B 21-119 [» ]
1KBG X-ray 2.20 L 21-119 [» ]
1KJ2 X-ray 2.71 L/M 21-119 [» ]
1KJ3 X-ray 2.30 L/M 21-119 [» ]
1KPU X-ray 1.50 B 21-119 [» ]
1KPV X-ray 1.71 B 21-119 [» ]
1L6Q model - B 21-119 [» ]
1LD9 X-ray 2.40 B/E 21-119 [» ]
1LDP X-ray 3.10 L 21-119 [» ]
1LEG X-ray 1.75 B 21-119 [» ]
1LEK X-ray 2.15 B 21-119 [» ]
1LK2 X-ray 1.35 B 21-119 [» ]
1MHC X-ray 2.10 B/E 21-119 [» ]
1MWA X-ray 2.40 L/M 21-119 [» ]
1N3N X-ray 3.00 B/D/F/H 21-119 [» ]
1N59 X-ray 2.95 B/D 21-119 [» ]
1N5A X-ray 2.85 B/E/H/K 21-119 [» ]
1NAM X-ray 2.70 L 21-119 [» ]
1NAN X-ray 2.30 I/P 21-119 [» ]
1NEZ X-ray 2.10 B 21-119 [» ]
1OSZ X-ray 2.10 B 21-119 [» ]
1P1Z X-ray 3.26 B 21-119 [» ]
1P4L X-ray 2.90 B 21-119 [» ]
1PQZ X-ray 2.10 B 21-119 [» ]
1QO3 X-ray 2.30 B 21-119 [» ]
1RJY X-ray 1.90 B/E 21-119 [» ]
1RJZ X-ray 2.60 B/E 21-119 [» ]
1RK0 X-ray 2.61 B 21-119 [» ]
1RK1 X-ray 2.10 B 21-119 [» ]
1S7Q X-ray 1.99 B 21-119 [» ]
1S7R X-ray 2.95 B/E 21-119 [» ]
1S7S X-ray 1.99 B 21-119 [» ]
1S7T X-ray 2.30 B/E 21-119 [» ]
1S7U X-ray 2.20 B/E/H/K 21-119 [» ]
1S7V X-ray 2.20 B/E 21-119 [» ]
1S7W X-ray 2.40 B/E/H/K 21-119 [» ]
1S7X X-ray 2.41 B/E/H/K 21-119 [» ]
1T0M X-ray 2.00 B/E 21-119 [» ]
1T0N X-ray 1.80 B/E 21-119 [» ]
1U58 X-ray 1.90 B 21-119 [» ]
1VAC X-ray 2.50 B 21-119 [» ]
1VAD X-ray 2.50 B 21-119 [» ]
1WBX X-ray 1.90 B 21-119 [» ]
1WBY X-ray 2.30 B 21-119 [» ]
1WBZ X-ray 2.00 B/D 21-119 [» ]
1YN6 X-ray 2.20 B 21-119 [» ]
1YN7 X-ray 2.20 B 21-119 [» ]
1Z5L X-ray 2.20 B/D 21-119 [» ]
1ZHB X-ray 2.70 B/E/H/K 21-119 [» ]
1ZHN X-ray 2.80 B 21-119 [» ]
1ZT1 X-ray 2.50 B 21-119 [» ]
1ZT7 X-ray 3.00 B/D 21-119 [» ]
2AKR X-ray 1.90 B/D 21-119 [» ]
2CKB X-ray 3.00 L/M 21-119 [» ]
2CLV X-ray 1.90 B/P 21-119 [» ]
2CLZ X-ray 1.90 B/P 21-119 [» ]
2FIK X-ray 1.80 B 21-119 [» ]
2FO4 X-ray 2.70 B 21-119 [» ]
2FWO X-ray 2.60 B 21-119 [» ]
2GAZ X-ray 2.61 B 21-119 [» ]
2MHA X-ray 2.50 B/D 21-119 [» ]
2OL3 X-ray 2.90 L 21-119 [» ]
2Q7Y X-ray 1.95 B/D 21-119 [» ]
2QRI X-ray 2.00 A/B 21-119 [» ]
2QRS X-ray 2.00 A/B 21-119 [» ]
2QRT X-ray 1.80 A/B 21-119 [» ]
2VAA X-ray 2.30 B 21-119 [» ]
2VAB X-ray 2.50 B 21-119 [» ]
2VE6 X-ray 2.65 B/E/H/K 22-119 [» ]
2ZOK X-ray 2.10 B/D/F/H 21-119 [» ]
2ZOL X-ray 2.70 B/D 21-119 [» ]
2ZSV X-ray 1.80 B/D 21-119 [» ]
2ZSW X-ray 2.80 B/D/F/H 21-119 [» ]
3ARB X-ray 2.70 B 21-119 [» ]
3ARD X-ray 3.01 B 21-119 [» ]
3ARE X-ray 2.80 B 21-119 [» ]
3ARF X-ray 2.90 B 21-119 [» ]
3ARG X-ray 3.00 B 21-119 [» ]
3AU1 X-ray 2.50 B 21-119 [» ]
3BUY X-ray 2.60 B 21-119 [» ]
3C8K X-ray 2.90 B 21-119 [» ]
3CC5 X-ray 1.91 B/E 21-119 [» ]
3CCH X-ray 2.60 B/E/H/K 21-119 [» ]
3CH1 X-ray 2.30 B/E/H/K 21-119 [» ]
3CPL X-ray 2.50 B/D 21-119 [» ]
3CVH X-ray 2.90 B/N 21-119 [» ]
3DMM X-ray 2.60 B 21-119 [» ]
3E6F X-ray 2.41 B 22-119 [» ]
3E6H X-ray 2.10 B 21-119 [» ]
3ECB X-ray 1.70 B 21-119 [» ]
3FOL X-ray 2.50 B 21-119 [» ]
3FOM X-ray 2.10 B 21-119 [» ]
3FON X-ray 2.03 B/D 21-119 [» ]
3FTG X-ray 2.60 B 21-119 [» ]
3G08 X-ray 1.60 B 21-119 [» ]
3GML X-ray 1.70 B 21-119 [» ]
3GMM X-ray 1.80 B 21-119 [» ]
3GMN X-ray 1.70 B 21-119 [» ]
3GMO X-ray 1.60 B 21-119 [» ]
3GMP X-ray 1.70 B 21-119 [» ]
3GMQ X-ray 1.80 B 21-119 [» ]
3GMR X-ray 1.90 B 21-119 [» ]
3HE6 X-ray 2.90 B 21-119 [» ]
3HE7 X-ray 2.80 B 21-119 [» ]
3ILP X-ray 1.85 B 21-119 [» ]
3ILQ X-ray 2.05 D 21-119 [» ]
3L3H X-ray 2.70 B 21-119 [» ]
3MA7 X-ray 2.29 B/D 21-119 [» ]
3NWM X-ray 2.70 A 21-119 [» ]
3O8X X-ray 2.74 B 21-119 [» ]
3O9W X-ray 2.80 B 21-119 [» ]
3P4M X-ray 2.50 B/E 21-119 [» ]
3P4N X-ray 2.50 B/E 21-119 [» ]
3P4O X-ray 2.30 B/E 21-119 [» ]
3P9L X-ray 2.00 B/E 21-119 [» ]
3P9M X-ray 2.00 B/E 21-119 [» ]
3PAB X-ray 2.20 B/E 21-119 [» ]
3PQY X-ray 3.19 B/G/L/Q 21-119 [» ]
3PWU X-ray 1.90 B 21-119 [» ]
3QI9 X-ray 2.30 B 21-119 [» ]
3QUK X-ray 2.41 B/E 21-119 [» ]
3QUL X-ray 2.00 B/E/H/K 21-119 [» ]
3QUX X-ray 2.91 B 21-119 [» ]
3QUY X-ray 2.25 B 21-119 [» ]
3QUZ X-ray 2.30 B 21-119 [» ]
3RGV X-ray 2.90 D 21-119 [» ]
3ROL X-ray 2.60 B/D 21-119 [» ]
3ROO X-ray 2.00 B/D 21-119 [» ]
3RTQ X-ray 2.80 B 21-119 [» ]
3RUG X-ray 2.20 B/D 21-119 [» ]
3RZC X-ray 2.80 B 21-119 [» ]
3SCM X-ray 2.50 B 21-119 [» ]
3SDA X-ray 2.80 B 21-119 [» ]
3SDC X-ray 3.10 B 21-119 [» ]
3SDD X-ray 3.00 B 21-119 [» ]
3T1F X-ray 1.70 B 21-119 [» ]
3TA3 X-ray 2.70 B 21-119 [» ]
3TBS X-ray 2.49 B/E 21-119 [» ]
3TBT X-ray 2.30 B/E/H/K 21-119 [» ]
3TBV X-ray 2.10 B/D/F/H 21-119 [» ]
3TBW X-ray 2.15 B/D/F/H 21-119 [» ]
3TBY X-ray 2.50 B/E/H/K 21-119 [» ]
3TN0 X-ray 3.20 B 21-119 [» ]
3TO4 X-ray 3.10 B 21-119 [» ]
3TVM X-ray 2.80 B/F 21-119 [» ]
3UBX X-ray 3.10 B/E 21-119 [» ]
3VJ6 X-ray 1.90 B 21-119 [» ]
3WS3 X-ray 2.34 B/D 21-119 [» ]
3WS6 X-ray 1.98 C/D 21-119 [» ]
4APQ X-ray 3.00 B 21-119 [» ]
4EI5 X-ray 3.10 B/F 21-119 [» ]
4ELM X-ray 3.48 B/D 21-119 [» ]
4HS3 X-ray 2.10 B 21-119 [» ]
4HUU X-ray 2.00 B/E 21-119 [» ]
4HUV X-ray 2.50 B/E 21-119 [» ]
4HUW X-ray 3.16 B/D/F/H 21-119 [» ]
4HUX X-ray 2.20 B 21-119 [» ]
4HV8 X-ray 2.00 B/D 21-119 [» ]
4IHO X-ray 2.80 B/E 21-119 [» ]
4IRJ X-ray 3.00 B 21-119 [» ]
4IRS X-ray 2.80 B 21-119 [» ]
4L8B X-ray 2.20 B 21-119 [» ]
4L8C X-ray 2.80 B/D/F/H 21-119 [» ]
4L8D X-ray 1.90 B/D 21-119 [» ]
4MNG X-ray 3.01 B/D 21-119 [» ]
4MQ7 X-ray 2.60 B 21-119 [» ]
4NSK X-ray 2.60 B 21-119 [» ]
4PV8 X-ray 2.31 B/D 21-119 [» ]
4PV9 X-ray 2.00 B/D 21-119 [» ]
ProteinModelPortali P01887.
SMRi P01887. Positions 21-119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6111N.
IntActi P01887. 5 interactions.
MINTi MINT-1870185.
STRINGi 10090.ENSMUSP00000099534.

PTM databases

PhosphoSitei P01887.

2D gel databases

SWISS-2DPAGE P01887.

Proteomic databases

PaxDbi P01887.
PRIDEi P01887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102476 ; ENSMUSP00000099534 ; ENSMUSG00000060802 .
GeneIDi 12010.
KEGGi mmu:12010.
UCSCi uc008maf.1. mouse.

Organism-specific databases

CTDi 567.
MGIi MGI:88127. B2m.

Phylogenomic databases

eggNOGi NOG40777.
GeneTreei ENSGT00690000102227.
HOGENOMi HOG000043084.
HOVERGENi HBG006197.
InParanoidi P01887.
KOi K08055.
OMAi FYLLVHT.
OrthoDBi EOG7RFTKJ.
TreeFami TF334167.

Enzyme and pathway databases

Reactomei REACT_188185. DAP12 signaling.
REACT_188188. DAP12 interactions.
REACT_197102. ER-Phagosome pathway.
REACT_198563. Amyloids.
REACT_198660. Interferon gamma signaling.
REACT_199105. ER-Phagosome pathway.
REACT_199112. Endosomal/Vacuolar pathway.
REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTracei P01887.
NextBioi 280211.
PMAP-CutDB P01887.
PROi P01887.
SOURCEi Search...

Gene expression databases

CleanExi MM_B2M.
Genevestigatori P01887.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of the mouse beta 2-microglobulin gene isolated from somatic and non-expressing teratocarcinoma cells."
    Daniel F., Morello D., le Bail O., Chambon P., Cayre Y., Kourilsky P.
    EMBO J. 2:1061-1065(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE A).
  2. "Structure of wild-type and mutant mouse beta 2-microglobulin genes."
    Parnes J.R., Seidman J.G.
    Cell 29:661-669(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ALLELE A).
    Strain: BALB/c.
  3. "Sequence divergence of B2m alleles of wild Mus musculus and Mus spretus implies positive selection."
    Hermel E., Robinson P.J., She J.-X., Lindahl K.F.
    Immunogenetics 38:106-116(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES W2; W3; W4 AND W5).
    Tissue: Liver.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Lung and Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  8. "Complete amino acid sequence of murine beta 2-microglobulin: structural evidence for strain-related polymorphism."
    Gates F.T. III, Coligan J.E., Kindt T.J.
    Proc. Natl. Acad. Sci. U.S.A. 78:554-558(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-119 (ALLELES A AND B).
    Strain: BALB/c and C57BL/6.
  9. "Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs."
    Parnes J.R., Velan B., Felsenfeld A., Ramanathan L., Ferrini U., Appella E., Seidman J.G.
    Proc. Natl. Acad. Sci. U.S.A. 78:2253-2257(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-57 AND 86-119 (ALLELE A).
  10. "Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression."
    Kimura A., Israel A., le Bail O., Kourilsky P.
    Cell 44:261-272(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-3 (ALLELE A).
  11. Cited for: PROTEIN SEQUENCE OF 21-60 (ALLELE A).
  12. "Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb."
    Fremont D.H., Matsumura M., Stura E.A., Peterson P.A., Wilson I.A.
    Science 257:919-927(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
  13. "The three-dimensional structure of H-2Db at 2.4-A resolution: implications for antigen-determinant selection."
    Young A.C.M., Zhang W., Sacchettini J.C., Nathenson S.G.
    Cell 76:39-50(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  14. "The three-dimensional structure of an H-2Ld-peptide complex explains the unique interaction of Ld with beta-2 microglobulin and peptide."
    Balendiran G.K., Solheim J.C., Young A.C., Hansen T.H., Nathenson S.G., Sacchettini J.C.
    Proc. Natl. Acad. Sci. U.S.A. 94:6880-6885(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).
  15. "The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4-A resolution: implications for T cell and NK cell recognition."
    Achour A., Persson K., Harris R.A., Sundbaeck J., Sentman C.L., Lindqvist Y., Schneider G., Kaerre K.
    Immunity 9:199-208(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS).

Entry informationi

Entry nameiB2MG_MOUSE
AccessioniPrimary (citable) accession number: P01887
Secondary accession number(s): Q91XJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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