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Protein

Ig alpha-1 chain C region

Gene

IGHA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei352Multimeric 3-hydroxykynurenine chromophore (covalent); in form alpha-1-microglobulin complex1

GO - Molecular functioni

  • antigen binding Source: UniProtKB

GO - Biological processi

  • antibacterial humoral response Source: UniProtKB
  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: GO_Central
  • glomerular filtration Source: UniProtKB
  • immune response Source: UniProtKB
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: GO_Central
  • phagocytosis, recognition Source: GO_Central
  • positive regulation of B cell activation Source: GO_Central
  • positive regulation of respiratory burst Source: UniProtKB
  • protein-chromophore linkage Source: UniProtKB-KW
  • receptor-mediated endocytosis Source: Reactome
  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Chromophore

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181160-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig alpha-1 chain C region
Gene namesi
Name:IGHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5478. IGHA1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • monomeric IgA immunoglobulin complex Source: UniProtKB
  • secretory dimeric IgA immunoglobulin complex Source: UniProtKB
  • secretory IgA immunoglobulin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.

Organism-specific databases

DisGeNETi3493.
OpenTargetsiENSG00000211895.
ENSG00000282633.

Polymorphism and mutation databases

DMDMi113584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153566‹1 – 353Ig alpha-1 chain C regionAdd BLAST›353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with light chain)
Disulfide bondi26 ↔ 85
Disulfide bondi77 ↔ 101
Glycosylationi105O-linked (GalNAc...)1
Glycosylationi111O-linked (GalNAc...)1
Glycosylationi113O-linked (GalNAc...)1
Glycosylationi119O-linked (GalNAc...)1
Glycosylationi121O-linked (GalNAc...)1
Disulfide bondi122Interchain (with heavy chain)
Disulfide bondi123 ↔ 180Or C-123 with C-182
Glycosylationi144N-linked (GlcNAc...) (complex)4 Publications1
Disulfide bondi147 ↔ 204
Disulfide bondi182Interchain (with heavy chain) (or with C-180)
Disulfide bondi192Interchain (with heavy chain of another subunit)Curated
Disulfide bondi250 ↔ 313
Glycosylationi340N-linked (GlcNAc...) (complex)1 Publication1
Disulfide bondi352Interchain (with J chain); in oligomeric form

Post-translational modificationi

3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.
N- and O-glycosylated. N-glycan at Asn-144: Hex5HexNAc4.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01876.
PeptideAtlasiP01876.
PRIDEiP01876.

PTM databases

iPTMnetiP01876.
PhosphoSitePlusiP01876.
UniCarbKBiP01876.

Expressioni

Gene expression databases

BgeeiENSG00000211895.
GenevisibleiP01876. HS.

Interactioni

Subunit structurei

Monomeric or polymeric.

Protein-protein interaction databases

IntActiP01876. 47 interactors.

Structurei

Secondary structure

1353
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi128 – 130Combined sources3
Helixi134 – 139Combined sources6
Beta strandi146 – 149Combined sources4
Beta strandi162 – 164Combined sources3
Beta strandi185 – 188Combined sources4
Turni190 – 192Combined sources3
Helixi193 – 198Combined sources6
Beta strandi201 – 206Combined sources6
Beta strandi215 – 220Combined sources6
Beta strandi229 – 233Combined sources5
Turni237 – 241Combined sources5
Beta strandi242 – 258Combined sources17
Beta strandi261 – 266Combined sources6
Helixi273 – 275Combined sources3
Beta strandi276 – 278Combined sources3
Beta strandi287 – 289Combined sources3
Beta strandi292 – 301Combined sources10
Helixi302 – 307Combined sources6
Beta strandi311 – 316Combined sources6
Beta strandi323 – 325Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IGAX-ray-A/B1-353[»]
1OW0X-ray3.10A/B122-335[»]
2QEJX-ray3.20A/B123-336[»]
3CHNX-ray-A/B/C/D2-353[»]
ProteinModelPortaliP01876.
SMRiP01876.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini125 – 220Ig-like 2Add BLAST96
Domaini228 – 330Ig-like 3Add BLAST103

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01876.
OMAiHGKTFTC.
PhylomeDBiP01876.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASPTSPKVFP LSLCSTQPDG NVVIACLVQG FFPQEPLSVT WSESGQGVTA
60 70 80 90 100
RNFPPSQDAS GDLYTTSSQL TLPATQCLAG KSVTCHVKHY TNPSQDVTVP
110 120 130 140 150
CPVPSTPPTP SPSTPPTPSP SCCHPRLSLH RPALEDLLLG SEANLTCTLT
160 170 180 190 200
GLRDASGVTF TWTPSSGKSA VQGPPERDLC GCYSVSSVLP GCAEPWNHGK
210 220 230 240 250
TFTCTAAYPE SKTPLTATLS KSGNTFRPEV HLLPPPSEEL ALNELVTLTC
260 270 280 290 300
LARGFSPKDV LVRWLQGSQE LPREKYLTWA SRQEPSQGTT TFAVTSILRV
310 320 330 340 350
AAEDWKKGDT FSCMVGHEAL PLAFTQKTID RLAGKPTHVN VSVVMAEVDG

TCY
Length:353
Mass (Da):37,655
Last modified:February 1, 1991 - v2
Checksum:iEBA11ECB7E85DB21
GO

Sequence cautioni

The sequence AAC82528 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti163 – 165TPS → PST AA sequence (PubMed:107164).Curated3
Sequence conflicti176E → B AA sequence (PubMed:809331).Curated1
Sequence conflicti190P → S AA sequence (PubMed:809331).Curated1
Sequence conflicti227R → H AA sequence (PubMed:809331).Curated1
Sequence conflicti231H → R AA sequence (PubMed:809331).Curated1
Sequence conflicti290T → E AA sequence (PubMed:809331).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014602176E → D.Corresponds to variant rs1407dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00220 Genomic DNA. Translation: AAC82528.1. Different initiation.
PIRiA22360. A1HU.
UniGeneiHs.699841.

Genome annotation databases

EnsembliENST00000390547; ENSP00000374989; ENSG00000211895.
ENST00000633714; ENSP00000488021; ENSG00000282633.
UCSCiuc059gcy.1. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00220 Genomic DNA. Translation: AAC82528.1. Different initiation.
PIRiA22360. A1HU.
UniGeneiHs.699841.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IGAX-ray-A/B1-353[»]
1OW0X-ray3.10A/B122-335[»]
2QEJX-ray3.20A/B123-336[»]
3CHNX-ray-A/B/C/D2-353[»]
ProteinModelPortaliP01876.
SMRiP01876.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01876. 47 interactors.

Protein family/group databases

IMGTiSearch...

PTM databases

iPTMnetiP01876.
PhosphoSitePlusiP01876.
UniCarbKBiP01876.

Polymorphism and mutation databases

DMDMi113584.

Proteomic databases

EPDiP01876.
PeptideAtlasiP01876.
PRIDEiP01876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390547; ENSP00000374989; ENSG00000211895.
ENST00000633714; ENSP00000488021; ENSG00000282633.
UCSCiuc059gcy.1. human.

Organism-specific databases

DisGeNETi3493.
GeneCardsiIGHA1.
HGNCiHGNC:5478. IGHA1.
MIMi146900. gene.
neXtProtiNX_P01876.
OpenTargetsiENSG00000211895.
ENSG00000282633.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01876.
OMAiHGKTFTC.
PhylomeDBiP01876.
TreeFamiTF334176.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181160-MONOMER.
ReactomeiR-HSA-2168880. Scavenging of heme from plasma.

Miscellaneous databases

EvolutionaryTraceiP01876.
PROiP01876.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211895.
GenevisibleiP01876. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 2 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHA1_HUMAN
AccessioniPrimary (citable) accession number: P01876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1991
Last modified: November 2, 2016
This is version 169 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.