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Protein

Ig gamma-1 chain C region, membrane-bound form

Gene

Ighg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • antibody-dependent cellular cytotoxicity Source: MGI
  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: GO_Central
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region, membrane-bound form
Gene namesi
Name:Ighg1
Synonyms:Igh-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96446. Ighg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei340 – 35718HelicalSequence analysisAdd
BLAST
Topological domaini358 – 39336CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 393›393Ig gamma-1 chain C region, membrane-bound formPRO_0000153583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 82
Disulfide bondi102 – 102Interchain (with a light chain)
Disulfide bondi104 – 104Interchain (with a heavy chain)
Disulfide bondi107 – 107Interchain (with a heavy chain)
Disulfide bondi109 – 109Interchain (with a heavy chain)
Disulfide bondi138 ↔ 198
Glycosylationi174 – 1741N-linked (GlcNAc...)
Disulfide bondi244 ↔ 302

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01869.
PRIDEiP01869.

Interactioni

GO - Molecular functioni

  • immunoglobulin receptor binding Source: AgBase

Protein-protein interaction databases

IntActiP01869. 1 interaction.
MINTiMINT-1852472.

Structurei

Secondary structure

1
393
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Beta strandi7 – 115Combined sources
Beta strandi15 – 173Combined sources
Beta strandi20 – 3516Combined sources
Beta strandi38 – 414Combined sources
Helixi42 – 443Combined sources
Beta strandi50 – 523Combined sources
Turni53 – 553Combined sources
Beta strandi56 – 7116Combined sources
Turni72 – 776Combined sources
Beta strandi81 – 866Combined sources
Helixi87 – 893Combined sources
Beta strandi91 – 966Combined sources
Beta strandi113 – 1175Combined sources
Beta strandi126 – 1305Combined sources
Helixi131 – 1355Combined sources
Beta strandi139 – 15416Combined sources
Beta strandi157 – 1604Combined sources
Turni161 – 1644Combined sources
Beta strandi167 – 1715Combined sources
Beta strandi175 – 1795Combined sources
Beta strandi181 – 19010Combined sources
Turni191 – 1966Combined sources
Beta strandi199 – 2057Combined sources
Turni206 – 2094Combined sources
Beta strandi210 – 2167Combined sources
Beta strandi226 – 2283Combined sources
Beta strandi232 – 25019Combined sources
Beta strandi254 – 2607Combined sources
Beta strandi277 – 2793Combined sources
Beta strandi281 – 29010Combined sources
Helixi291 – 2955Combined sources
Beta strandi300 – 3067Combined sources
Helixi310 – 3123Combined sources
Beta strandi314 – 3185Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50H2-217[»]
1ACYX-ray3.00H1-100[»]
1AE6X-ray3.00H1-98[»]
1CICX-ray2.50D1-218[»]
1CL7X-ray3.00I21-102[»]
1F11X-ray3.00B/D1-102[»]
1F58X-ray2.00H1-102[»]
1IGYX-ray3.20B/D1-320[»]
1KC5X-ray2.50H1-101[»]
1KCRX-ray2.90H1-102[»]
1KENX-ray3.50H/T1-101[»]
1ORSX-ray1.90B1-103[»]
1S5IX-ray2.70H1-102[»]
25C8X-ray2.00H2-217[»]
2AJSX-ray1.70H1-100[»]
2AJUX-ray1.50H1-100[»]
2AJVX-ray1.50H1-100[»]
2AJXX-ray1.85H1-100[»]
2AJYX-ray2.10H1-100[»]
2AJZX-ray2.30B/H1-100[»]
2AK1X-ray1.85H1-100[»]
ProteinModelPortaliP01869.
SMRiP01869. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01869.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797CH1Add
BLAST
Regioni98 – 11013HingeAdd
BLAST
Regioni111 – 217107CH2Add
BLAST
Regioni218 – 324107CH3Add
BLAST

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01869.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Membrane-bound (identifier: P01869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV
160 170 180 190 200
QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV
210 220 230 240 250
NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF
260 270 280 290 300
PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320 330 340 350
TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS
360 370 380 390
LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP
Length:393
Mass (Da):43,387
Last modified:August 1, 1991 - v2
Checksum:i4CC88343B7A1CE27
GO
Isoform Secreted (identifier: P01868-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01868.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: May be the major isoform.
Length:324
Mass (Da):35,705
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. No translation available.
PIRiB02159. G1MSM.
UniGeneiMm.342177.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. No translation available.
PIRiB02159. G1MSM.
UniGeneiMm.342177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50H2-217[»]
1ACYX-ray3.00H1-100[»]
1AE6X-ray3.00H1-98[»]
1CICX-ray2.50D1-218[»]
1CL7X-ray3.00I21-102[»]
1F11X-ray3.00B/D1-102[»]
1F58X-ray2.00H1-102[»]
1IGYX-ray3.20B/D1-320[»]
1KC5X-ray2.50H1-101[»]
1KCRX-ray2.90H1-102[»]
1KENX-ray3.50H/T1-101[»]
1ORSX-ray1.90B1-103[»]
1S5IX-ray2.70H1-102[»]
25C8X-ray2.00H2-217[»]
2AJSX-ray1.70H1-100[»]
2AJUX-ray1.50H1-100[»]
2AJVX-ray1.50H1-100[»]
2AJXX-ray1.85H1-100[»]
2AJYX-ray2.10H1-100[»]
2AJZX-ray2.30B/H1-100[»]
2AK1X-ray1.85H1-100[»]
ProteinModelPortaliP01869.
SMRiP01869. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01869. 1 interaction.
MINTiMINT-1852472.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01869.
PRIDEiP01869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96446. Ighg1.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01869.

Miscellaneous databases

EvolutionaryTraceiP01869.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGH1M_MOUSE
AccessioniPrimary (citable) accession number: P01869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1991
Last modified: September 7, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.