P01869 (IGH1M_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig gamma-1 chain C region, membrane-bound form

Gene names

Name:	Ighg1
Synonyms:	Igh-4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin C region Immunoglobulin domain Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Membrane-bound (identifier: P01869-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Secreted (identifier: P01868-1)

The sequence of this isoform can be found in the external entry P01868.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: May be the major isoform.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 393

›393

Ig gamma-1 chain C region, membrane-bound form

PRO_0000153583

Regions

Transmembrane

340 – 357

18

Helical; Potential

Topological domain

358 – 393

36

Cytoplasmic Potential

Region

1 – 97

97

CH1

Region

98 – 110

13

Hinge

Region

111 – 217

107

CH2

Region

218 – 324

107

CH3

Amino acid modifications

Glycosylation

174

1

N-linked (GlcNAc...)

Disulfide bond

27 ↔ 82

Disulfide bond

102

Interchain (with a light chain)

Disulfide bond

104

Interchain (with a heavy chain)

Disulfide bond

107

Interchain (with a heavy chain)

Disulfide bond

109

Interchain (with a heavy chain)

Disulfide bond

138 ↔ 198

Disulfide bond

244 ↔ 302

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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393

Helix Strand Turn

Details...

Beta strand

7 – 11

5

Beta strand

20 – 35

16

Beta strand

38 – 41

4

Helix

42 – 44

3

Beta strand

50 – 52

3

Beta strand

56 – 71

16

Turn

72 – 77

6

Beta strand

81 – 86

6

Helix

87 – 89

3

Beta strand

91 – 96

6

Beta strand

112 – 114

3

Beta strand

117 – 120

4

Helix

124 – 128

5

Beta strand

135 – 140

6

Beta strand

154 – 158

5

Beta strand

174 – 176

3

Helix

187 – 192

6

Beta strand

226 – 228

3

Beta strand

232 – 250

19

Beta strand

254 – 260

7

Beta strand

277 – 279

3

Beta strand

281 – 290

10

Helix

291 – 295

5

Beta strand

300 – 306

7

Helix

310 – 312

3

Beta strand

314 – 318

5

Sequences

	Sequence		Length	Mass (Da)
	Isoform Membrane-bound [UniParc]. Last modified August 1, 1991. Version 2. Checksum: 4CC88343B7A1CE27	FASTA	393	43,387
	10 20 30 40 50 60 AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD 70 80 90 100 110 120 LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF 130 140 150 160 170 180 PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV 190 200 210 220 230 240 SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV 250 260 270 280 290 300 SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF 310 320 330 340 350 360 TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS LFLLSVCYSA 370 380 390 AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP
	Isoform Secreted [UniParc]. See P01868.		–	–

References

[1]	"Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene." Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., Takahashi N., Mano Y. Cell 18:559-568(1979) [PubMed: 115593] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain." Tyler B.M., Cowman A.F., Gerondakis S.D., Adams J.M., Bernard O. Proc. Natl. Acad. Sci. U.S.A. 79:2008-2012(1982) [PubMed: 6804950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-393.
[3]	"Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains." Rogers J., Choi E., Souza L., Carter C., Word C.J., Kuehl M., Eisenberg D., Wall R. Cell 26:19-27(1981) [PubMed: 6799207] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 323-366.
[4]	"Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains." Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T. Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982) [PubMed: 6283537] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-44.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J00453 Genomic DNA. No translation available.

IPI

IPI00308213.

PIR

G1MSM. B02159.

UniGene

Mm.342177.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
15C8	X-ray	2.50	H	2-98	[»]
1ACY	X-ray	3.00	H	1-100	[»]
1AE6	X-ray	3.00	H	1-98	[»]
1CIC	X-ray	2.50	D	3-102	[»]
1CL7	X-ray	3.00	I	21-102	[»]
1F11	X-ray	3.00	B/D	1-102	[»]
1F58	X-ray	2.00	H	1-102	[»]
1IGY	X-ray	3.20	B/D	1-320	[»]
1KC5	X-ray	2.50	H	1-101	[»]
1KCR	X-ray	2.90	H	3-102	[»]
1KEN	X-ray	3.50	H/T	1-101	[»]
1ORS	X-ray	1.90	B	1-103	[»]
1S5I	X-ray	2.70	H	1-102	[»]
25C8	X-ray	2.00	H	2-98	[»]
2AJS	X-ray	1.70	H	1-100	[»]
2AJU	X-ray	1.50	H	1-100	[»]
2AJV	X-ray	1.50	H	1-100	[»]
2AJX	X-ray	1.85	H	1-100	[»]
2AJY	X-ray	2.10	H	1-100	[»]
2AJZ	X-ray	2.30	B/H	1-100	[»]
2AK1	X-ray	1.85	H	1-100	[»]

ProteinModelPortal

P01869.

SMR

P01869. Positions 1-320.

ModBase

Search...

Protein-protein interaction databases

STRING

P01869.

Protein family/group databases

IMGT

Search...

Proteomic databases

PRIDE

P01869.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

UCSC

uc007pgo.1. mouse.

Organism-specific databases

MGI

MGI:96446. Ighg1.

Phylogenomic databases

GeneTree

ENSGT00530000063726.

HOGENOM

HBG505540.

HOVERGEN

HBG005814.

InParanoid

P01869.

OrthoDB

EOG4RXZ0H.

Gene expression databases

ArrayExpress

P01869.

Genevestigator

P01869.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

Pfam

PF07654. C1-set. 3 hits.
[Graphical view]

SMART

SM00407. IGc1. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. False negative.
[Graphical view]

ProtoNet

Search...

Other

SOURCE

Search...

Entry information

Entry name

IGH1M_MOUSE

Accession

Primary (citable) accession number: P01869

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 1, 1991
Last modified:	September 21, 2011
This is version 100 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program