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Protein

Ig gamma-1 chain C region, membrane-bound form

Gene

Ighg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • antibody-dependent cellular cytotoxicity Source: MGI
  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: GO_Central
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region, membrane-bound form
Gene namesi
Name:Ighg1
Synonyms:Igh-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96446. Ighg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei340 – 357HelicalSequence analysisAdd BLAST18
Topological domaini358 – 393CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153583‹1 – 393Ig gamma-1 chain C region, membrane-bound formAdd BLAST›393

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82
Disulfide bondi102Interchain (with a light chain)
Disulfide bondi104Interchain (with a heavy chain)
Disulfide bondi107Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi138 ↔ 198
Glycosylationi174N-linked (GlcNAc...)1
Disulfide bondi244 ↔ 302

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01869.
PRIDEiP01869.

Interactioni

GO - Molecular functioni

  • immunoglobulin receptor binding Source: AgBase

Protein-protein interaction databases

IntActiP01869. 1 interactor.
MINTiMINT-1852472.

Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi7 – 11Combined sources5
Beta strandi15 – 17Combined sources3
Beta strandi20 – 35Combined sources16
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi50 – 52Combined sources3
Turni53 – 55Combined sources3
Beta strandi56 – 71Combined sources16
Turni72 – 77Combined sources6
Beta strandi81 – 86Combined sources6
Helixi87 – 89Combined sources3
Beta strandi91 – 96Combined sources6
Beta strandi113 – 117Combined sources5
Beta strandi126 – 130Combined sources5
Helixi131 – 135Combined sources5
Beta strandi139 – 154Combined sources16
Beta strandi157 – 160Combined sources4
Turni161 – 164Combined sources4
Beta strandi167 – 171Combined sources5
Beta strandi175 – 179Combined sources5
Beta strandi181 – 190Combined sources10
Turni191 – 196Combined sources6
Beta strandi199 – 205Combined sources7
Turni206 – 209Combined sources4
Beta strandi210 – 216Combined sources7
Beta strandi226 – 228Combined sources3
Beta strandi232 – 250Combined sources19
Beta strandi254 – 260Combined sources7
Beta strandi277 – 279Combined sources3
Beta strandi281 – 290Combined sources10
Helixi291 – 295Combined sources5
Beta strandi300 – 306Combined sources7
Helixi310 – 312Combined sources3
Beta strandi314 – 318Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50H2-217[»]
1ACYX-ray3.00H1-100[»]
1AE6X-ray3.00H1-98[»]
1CICX-ray2.50D1-218[»]
1CL7X-ray3.00I21-102[»]
1F11X-ray3.00B/D1-102[»]
1F58X-ray2.00H1-102[»]
1IGYX-ray3.20B/D1-320[»]
1KC5X-ray2.50H1-101[»]
1KCRX-ray2.90H1-102[»]
1KENX-ray3.50H/T1-101[»]
1ORSX-ray1.90B1-103[»]
1S5IX-ray2.70H1-102[»]
25C8X-ray2.00H2-217[»]
2AJSX-ray1.70H1-100[»]
2AJUX-ray1.50H1-100[»]
2AJVX-ray1.50H1-100[»]
2AJXX-ray1.85H1-100[»]
2AJYX-ray2.10H1-100[»]
2AJZX-ray2.30B/H1-100[»]
2AK1X-ray1.85H1-100[»]
ProteinModelPortaliP01869.
SMRiP01869.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01869.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97CH1Add BLAST97
Regioni98 – 110HingeAdd BLAST13
Regioni111 – 217CH2Add BLAST107
Regioni218 – 324CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01869.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Membrane-bound (identifier: P01869-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV
160 170 180 190 200
QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV
210 220 230 240 250
NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF
260 270 280 290 300
PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320 330 340 350
TCSVLHEGLH NHHTEKSLSH SPGLQLDETC AEAQDGELDG LWTTITIFIS
360 370 380 390
LFLLSVCYSA AVTLFKVKWI FSSVVELKQT LVPEYKNMIG QAP
Length:393
Mass (Da):43,387
Last modified:August 1, 1991 - v2
Checksum:i4CC88343B7A1CE27
GO
Isoform Secreted (identifier: P01868-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01868.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: May be the major isoform.
Length:324
Mass (Da):35,705
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. No translation available.
PIRiB02159. G1MSM.
UniGeneiMm.342177.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. No translation available.
PIRiB02159. G1MSM.
UniGeneiMm.342177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
15C8X-ray2.50H2-217[»]
1ACYX-ray3.00H1-100[»]
1AE6X-ray3.00H1-98[»]
1CICX-ray2.50D1-218[»]
1CL7X-ray3.00I21-102[»]
1F11X-ray3.00B/D1-102[»]
1F58X-ray2.00H1-102[»]
1IGYX-ray3.20B/D1-320[»]
1KC5X-ray2.50H1-101[»]
1KCRX-ray2.90H1-102[»]
1KENX-ray3.50H/T1-101[»]
1ORSX-ray1.90B1-103[»]
1S5IX-ray2.70H1-102[»]
25C8X-ray2.00H2-217[»]
2AJSX-ray1.70H1-100[»]
2AJUX-ray1.50H1-100[»]
2AJVX-ray1.50H1-100[»]
2AJXX-ray1.85H1-100[»]
2AJYX-ray2.10H1-100[»]
2AJZX-ray2.30B/H1-100[»]
2AK1X-ray1.85H1-100[»]
ProteinModelPortaliP01869.
SMRiP01869.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01869. 1 interactor.
MINTiMINT-1852472.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01869.
PRIDEiP01869.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96446. Ighg1.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01869.

Miscellaneous databases

EvolutionaryTraceiP01869.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGH1M_MOUSE
AccessioniPrimary (citable) accession number: P01869
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1991
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.