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Protein

Ig gamma-1 chain C region secreted form

Gene

Ighg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • antibody-dependent cellular cytotoxicity Source: MGI
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region secreted form
Gene namesi
Name:Ighg1
Synonyms:Igh-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96446. Ighg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153582‹1 – 324Ig gamma-1 chain C region secreted formAdd BLAST›324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation1 Publication
Disulfide bondi102Interchain (with a light chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi104Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi107Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi109Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi138 ↔ 198PROSITE-ProRule annotation1 Publication
GlycosylationiCAR_000055174N-linked (GlcNAc...)1
Disulfide bondi244 ↔ 302PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01868.
PRIDEiP01868.

PTM databases

UniCarbKBiP01868.

Interactioni

Protein-protein interaction databases

MINTiMINT-138391.

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Beta strandi21 – 35Combined sources15
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 72Combined sources12
Turni73 – 77Combined sources5
Beta strandi81 – 86Combined sources6
Helixi87 – 89Combined sources3
Beta strandi91 – 96Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00B/E-[»]
1AI1X-ray2.80H1-100[»]
1CLOX-ray2.10H1-101[»]
1DBAX-ray2.80H1-100[»]
1DBBX-ray2.70H1-100[»]
1DBJX-ray2.70H1-100[»]
1DBKX-ray3.00H1-100[»]
1DBMX-ray2.70H1-100[»]
1FBIX-ray3.00H/Q1-99[»]
1KELX-ray1.90H1-99[»]
1KEMX-ray2.20H1-99[»]
1NTLX-ray30.00A/B98-324[»]
1OPGX-ray2.00H1-102[»]
1SEQX-ray1.78H3-102[»]
1YEDX-ray3.10B/H1-102[»]
2ATYX-ray-A/B98-324[»]
2B2XX-ray2.20H/I1-102[»]
2DBLX-ray2.90H1-100[»]
3ZO0X-ray1.99A114-320[»]
ProteinModelPortaliP01868.
SMRiP01868.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01868.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97CH1Add BLAST97
Regioni98 – 110HingeAdd BLAST13
Regioni111 – 217CH2Add BLAST107
Regioni218 – 324CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV
160 170 180 190 200
QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV
210 220 230 240 250
NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF
260 270 280 290 300
PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320
TCSVLHEGLH NHHTEKSLSH SPGK
Note: May be the major isoform.
Length:324
Mass (Da):35,705
Last modified:July 21, 1986 - v1
Checksum:iA338812F3D1F2C93
GO
Isoform Membrane-bound (identifier: P01869-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01869.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:393
Mass (Da):43,387
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti276N → D AA sequence (PubMed:98524).Curated1
Sequence conflicti278N → D AA sequence (PubMed:98524).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. Translation: AAB59656.1.
V00795 mRNA. Translation: CAA24176.1.
PIRiA02159. G1MS.
UniGeneiMm.342177.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. Translation: AAB59656.1.
V00795 mRNA. Translation: CAA24176.1.
PIRiA02159. G1MS.
UniGeneiMm.342177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00B/E-[»]
1AI1X-ray2.80H1-100[»]
1CLOX-ray2.10H1-101[»]
1DBAX-ray2.80H1-100[»]
1DBBX-ray2.70H1-100[»]
1DBJX-ray2.70H1-100[»]
1DBKX-ray3.00H1-100[»]
1DBMX-ray2.70H1-100[»]
1FBIX-ray3.00H/Q1-99[»]
1KELX-ray1.90H1-99[»]
1KEMX-ray2.20H1-99[»]
1NTLX-ray30.00A/B98-324[»]
1OPGX-ray2.00H1-102[»]
1SEQX-ray1.78H3-102[»]
1YEDX-ray3.10B/H1-102[»]
2ATYX-ray-A/B98-324[»]
2B2XX-ray2.20H/I1-102[»]
2DBLX-ray2.90H1-100[»]
3ZO0X-ray1.99A114-320[»]
ProteinModelPortaliP01868.
SMRiP01868.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-138391.

Protein family/group databases

IMGTiSearch...
Search...

PTM databases

UniCarbKBiP01868.

Proteomic databases

PeptideAtlasiP01868.
PRIDEiP01868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96446. Ighg1.

Phylogenomic databases

HOVERGENiHBG005814.

Miscellaneous databases

EvolutionaryTraceiP01868.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG1_MOUSE
AccessioniPrimary (citable) accession number: P01868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.