Skip Header

Contribute Send feedback
Read comments (?) or add your own

P01868 (IGHG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-1 chain C region secreted form
Gene names
Name:Ighg1
Synonyms:Igh-4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Isoform Secreted: Secreted.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin C region
Immunoglobulin domain
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionantigen binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Secreted (identifier: P01868-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: May be the major isoform.
Isoform Membrane-bound (identifier: P01869-1)

The sequence of this isoform can be found in the external entry P01869.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 324›324Ig gamma-1 chain C region secreted form
PRO_0000153582

Regions

Region1 – 9797CH1
Region98 – 11013Hinge
Region111 – 217107CH2
Region218 – 324107CH3

Amino acid modifications

Glycosylation1741N-linked (GlcNAc...)
CAR_000055
Disulfide bond27 ↔ 82 Ref.5
Disulfide bond102Interchain (with a light chain) Ref.5
Disulfide bond104Interchain (with a heavy chain) Ref.5
Disulfide bond107Interchain (with a heavy chain) Ref.5
Disulfide bond109Interchain (with a heavy chain) Ref.5
Disulfide bond138 ↔ 198 Ref.5
Disulfide bond244 ↔ 302 Ref.5

Experimental info

Sequence conflict2761N → D AA sequence Ref.4
Sequence conflict2781N → D AA sequence Ref.4
Non-terminal residue11

Secondary structure

1 .................... 324
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Secreted [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: A338812F3D1F2C93

FASTA32435,705
        10         20         30         40         50         60 
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV HTFPAVLQSD 

        70         80         90        100        110        120 
LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR DCGCKPCICT VPEVSSVFIF 

       130        140        150        160        170        180 
PPKPKDVLTI TLTPKVTCVV VDISKDDPEV QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV 

       190        200        210        220        230        240 
SELPIMHQDW LNGKEFKCRV NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV 

       250        260        270        280        290        300 
SLTCMITDFF PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF 

       310        320 
TCSVLHEGLH NHHTEKSLSH SPGK

« Hide

Isoform Membrane-bound [UniParc].

See P01869.

––

References

[1]"Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene."
Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., Takahashi N., Mano Y.
Cell 18:559-568(1979) [PubMed: 115593] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid."
Obata M., Yamawaki-Kataoka Y., Takahashi N., Kataoka T., Shimizu A., Mano Y., Seidman J.G., Peterlin B.M., Leder P., Honjo T.
Gene 9:87-97(1980) [PubMed: 6769752] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-324 (MYELOMA PROTEIN MOPC 31C).
[3]"Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain."
Rogers J., Clarke P., Salser W.
Nucleic Acids Res. 6:3305-3321(1979) [PubMed: 113776] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 70-322 (MYELOMA PROTEIN MOPC 21).
[4]"Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain."
Adetugbo K.
J. Biol. Chem. 253:6068-6075(1978) [PubMed: 98524] [Abstract]
Cited for: PROTEIN SEQUENCE (MYELOMA PROTEIN MOPC 21).
[5]"The disulphide bridges of a mouse immunoglobulin G1 protein."
Svasti J., Milstein C.
Biochem. J. 126:837-850(1972) [PubMed: 5073237] [Abstract]
Cited for: DISULFIDE BONDS (MOPC 21).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J00453 Genomic DNA. Translation: AAB59656.1.
V00795 mRNA. Translation: CAA24176.1.
IPIIPI00830215.
PIRG1MS. A02159.
UniGeneMm.342177.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00B/E-[»]
1AI1X-ray2.80H1-100[»]
1CLOX-ray2.10H1-101[»]
1DBAX-ray2.80H1-100[»]
1DBBX-ray2.70H1-100[»]
1DBJX-ray2.70H1-100[»]
1DBKX-ray3.00H1-100[»]
1DBMX-ray2.70H1-100[»]
1FBIX-ray3.00H/Q1-99[»]
1KELX-ray1.90H1-99[»]
1KEMX-ray2.20H1-99[»]
1OPGX-ray2.00H1-102[»]
1YEDX-ray3.10B/H1-102[»]
2ATYX-ray-A/B98-324[»]
2B2XX-ray2.20H/I1-102[»]
2DBLX-ray2.90H1-100[»]
2VOLX-ray1.95A114-320[»]
ProteinModelPortalP01868.
SMRP01868. Positions 1-320.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-138391.
STRINGP01868.

Protein family/group databases

IMGTSearch...
Search...

PTM databases

GlycoSuiteDBP01868.

Proteomic databases

PRIDEP01868.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96446. Ighg1.

Phylogenomic databases

eggNOGroNOG17146.
HOVERGENHBG005814.

Gene expression databases

ArrayExpressP01868.
BgeeP01868.
GenevestigatorP01868.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. False negative.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameIGHG1_MOUSE
AccessionPrimary (citable) accession number: P01868
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 21, 2011
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents