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Protein

Ig gamma-1 chain C region secreted form

Gene

Ighg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • antibody-dependent cellular cytotoxicity Source: MGI
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region secreted form
Gene namesi
Name:Ighg1
Synonyms:Igh-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96446. Ighg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 324›324Ig gamma-1 chain C region secreted formPRO_0000153582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation1 Publication
Disulfide bondi102 – 102Interchain (with a light chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi104 – 104Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi107 – 107Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi109 – 109Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi138 ↔ 198PROSITE-ProRule annotation1 Publication
Glycosylationi174 – 1741N-linked (GlcNAc...)CAR_000055
Disulfide bondi244 ↔ 302PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01868.
PRIDEiP01868.

PTM databases

UniCarbKBiP01868.

Interactioni

Protein-protein interaction databases

MINTiMINT-138391.

Structurei

Secondary structure

1
324
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Beta strandi21 – 3515Combined sources
Beta strandi38 – 414Combined sources
Helixi42 – 443Combined sources
Beta strandi50 – 523Combined sources
Beta strandi56 – 583Combined sources
Beta strandi61 – 7212Combined sources
Turni73 – 775Combined sources
Beta strandi81 – 866Combined sources
Helixi87 – 893Combined sources
Beta strandi91 – 966Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00B/E-[»]
1AI1X-ray2.80H1-100[»]
1CLOX-ray2.10H1-101[»]
1DBAX-ray2.80H1-100[»]
1DBBX-ray2.70H1-100[»]
1DBJX-ray2.70H1-100[»]
1DBKX-ray3.00H1-100[»]
1DBMX-ray2.70H1-100[»]
1FBIX-ray3.00H/Q1-99[»]
1KELX-ray1.90H1-99[»]
1KEMX-ray2.20H1-99[»]
1OPGX-ray2.00H1-102[»]
1SEQX-ray1.78H3-102[»]
1YEDX-ray3.10B/H1-102[»]
2ATYX-ray-A/B98-324[»]
2B2XX-ray2.20H/I1-102[»]
2DBLX-ray2.90H1-100[»]
3ZO0X-ray1.99A114-320[»]
ProteinModelPortaliP01868.
SMRiP01868. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01868.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797CH1Add
BLAST
Regioni98 – 11013HingeAdd
BLAST
Regioni111 – 217107CH2Add
BLAST
Regioni218 – 324107CH3Add
BLAST

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV
160 170 180 190 200
QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV
210 220 230 240 250
NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF
260 270 280 290 300
PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320
TCSVLHEGLH NHHTEKSLSH SPGK
Note: May be the major isoform.
Length:324
Mass (Da):35,705
Last modified:July 21, 1986 - v1
Checksum:iA338812F3D1F2C93
GO
Isoform Membrane-bound (identifier: P01869-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P01869.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:393
Mass (Da):43,387
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti276 – 2761N → D AA sequence (PubMed:98524).Curated
Sequence conflicti278 – 2781N → D AA sequence (PubMed:98524).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. Translation: AAB59656.1.
V00795 mRNA. Translation: CAA24176.1.
PIRiA02159. G1MS.
UniGeneiMm.342177.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA. Translation: AAB59656.1.
V00795 mRNA. Translation: CAA24176.1.
PIRiA02159. G1MS.
UniGeneiMm.342177.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHWX-ray3.00B/E-[»]
1AI1X-ray2.80H1-100[»]
1CLOX-ray2.10H1-101[»]
1DBAX-ray2.80H1-100[»]
1DBBX-ray2.70H1-100[»]
1DBJX-ray2.70H1-100[»]
1DBKX-ray3.00H1-100[»]
1DBMX-ray2.70H1-100[»]
1FBIX-ray3.00H/Q1-99[»]
1KELX-ray1.90H1-99[»]
1KEMX-ray2.20H1-99[»]
1OPGX-ray2.00H1-102[»]
1SEQX-ray1.78H3-102[»]
1YEDX-ray3.10B/H1-102[»]
2ATYX-ray-A/B98-324[»]
2B2XX-ray2.20H/I1-102[»]
2DBLX-ray2.90H1-100[»]
3ZO0X-ray1.99A114-320[»]
ProteinModelPortaliP01868.
SMRiP01868. Positions 1-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-138391.

Protein family/group databases

IMGTiSearch...
Search...

PTM databases

UniCarbKBiP01868.

Proteomic databases

EPDiP01868.
PRIDEiP01868.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96446. Ighg1.

Phylogenomic databases

HOVERGENiHBG005814.

Miscellaneous databases

EvolutionaryTraceiP01868.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and complete nucleotide sequence of mouse immunoglobulin gamma 1 chain gene."
    Honjo T., Obata M., Yamawaki-Kataoka Y., Kataoka T., Kawakami T., Takahashi N., Mano Y.
    Cell 18:559-568(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid."
    Obata M., Yamawaki-Kataoka Y., Takahashi N., Kataoka T., Shimizu A., Mano Y., Seidman J.G., Peterlin B.M., Leder P., Honjo T.
    Gene 9:87-97(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 76-324 (MYELOMA PROTEIN MOPC 31C).
  3. "Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain."
    Rogers J., Clarke P., Salser W.
    Nucleic Acids Res. 6:3305-3321(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 70-322 (MYELOMA PROTEIN MOPC 21).
  4. "Evolution of immunoglobulin subclasses. Primary structure of a murine myeloma gamma1 chain."
    Adetugbo K.
    J. Biol. Chem. 253:6068-6075(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (MYELOMA PROTEIN MOPC 21).
  5. "The disulphide bridges of a mouse immunoglobulin G1 protein."
    Svasti J., Milstein C.
    Biochem. J. 126:837-850(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS (MOPC 21).
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiIGHG1_MOUSE
AccessioniPrimary (citable) accession number: P01868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.