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Protein

Ig gamma-2B chain C region

Gene

Igh-3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: GO_Central
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: GO_Central
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2B chain C region
Gene namesi
Name:Igh-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96445. Igh-3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei351 – 368HelicalSequence analysisAdd BLAST18
Topological domaini369 – 404CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153588‹1 – 404Ig gamma-2B chain C regionAdd BLAST›404

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondi26 ↔ 81PROSITE-ProRule annotation
Glycosylationi104O-linked (GalNAc...)1 Publication1
Disulfide bondi108Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi111Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi114Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi117Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi149 ↔ 209PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi255 ↔ 313PROSITE-ProRule annotation

Post-translational modificationi

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with 2 sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01867.
PeptideAtlasiP01867.
PRIDEiP01867.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01867. 2 interactors.
MINTiMINT-1504211.

Structurei

Secondary structure

1404
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 5Combined sources3
Beta strandi6 – 10Combined sources5
Beta strandi14 – 16Combined sources3
Beta strandi20 – 31Combined sources12
Beta strandi37 – 41Combined sources5
Turni44 – 46Combined sources3
Beta strandi48 – 57Combined sources10
Beta strandi60 – 70Combined sources11
Helixi71 – 73Combined sources3
Turni74 – 76Combined sources3
Beta strandi80 – 85Combined sources6
Helixi86 – 88Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi104 – 107Combined sources4
Beta strandi111 – 115Combined sources5
Beta strandi127 – 131Combined sources5
Helixi135 – 139Combined sources5
Beta strandi146 – 154Combined sources9
Beta strandi155 – 158Combined sources4
Beta strandi161 – 167Combined sources7
Beta strandi170 – 172Combined sources3
Beta strandi173 – 175Combined sources3
Beta strandi176 – 182Combined sources7
Turni183 – 186Combined sources4
Beta strandi187 – 195Combined sources9
Helixi198 – 202Combined sources5
Helixi204 – 206Combined sources3
Beta strandi207 – 213Combined sources7
Beta strandi220 – 224Combined sources5
Beta strandi235 – 239Combined sources5
Helixi243 – 245Combined sources3
Beta strandi248 – 263Combined sources16
Beta strandi266 – 271Combined sources6
Beta strandi274 – 276Combined sources3
Beta strandi279 – 281Combined sources3
Beta strandi292 – 301Combined sources10
Helixi302 – 307Combined sources6
Beta strandi311 – 316Combined sources6
Helixi321 – 323Combined sources3
Beta strandi325 – 329Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CICX-ray2.50B1-217[»]
1ETZX-ray2.60B/H1-101[»]
1FJ1X-ray2.68B/D1-99[»]
1FL3X-ray2.45A/H1-97[»]
1HQ4X-ray2.70B/D1-98[»]
1MAMX-ray2.45H1-97[»]
1NBVX-ray2.00H1-97[»]
1OSPX-ray1.95H1-97[»]
1UB5X-ray2.00A/H1-97[»]
1UB6X-ray2.12A/H1-97[»]
1YNKX-ray2.10H1-102[»]
1YNLX-ray1.70H1-102[»]
1ZTXX-ray2.50H1-99[»]
2GJZX-ray2.65B/H1-98[»]
2GK0X-ray2.45B/H1-98[»]
2Q8AX-ray2.40H1-97[»]
2Q8BX-ray2.30H1-97[»]
2RGSX-ray2.13A/B117-334[»]
3CFDX-ray2.50B/H1-99[»]
3CFEX-ray2.99B/H1-99[»]
ProteinModelPortaliP01867.
SMRiP01867.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01867.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 97Ig-like 1Add BLAST93
Domaini126 – 225Ig-like 2Add BLAST100
Domaini234 – 330Ig-like 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01867.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01867-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
KTTPPSVYPL APGCGDTTGS SVTLGCLVKG YFPESVTVTW NSGSLSSSVH
60 70 80 90 100
TFPALLQSGL YTMSSSVTVP SSTWPSQTVT CSVAHPASST TVDKKLEPSG
110 120 130 140 150
PISTINPCPP CKECHKCPAP NLEGGPSVFI FPPNIKDVLM ISLTPKVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTIRV VSTLPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNKDLPSPI ERTISKIKGL VRAPQVYILP PPAEQLSRKD
260 270 280 290 300
VSLTCLVVGF NPGDISVEWT SNGHTEENYK DTAPVLDSDG SYFIYSKLNM
310 320 330 340 350
KTSKWEKTDS FSCNVRHEGL KNYYLKKTIS RSPGLDLDDI CAEAKDGELD
360 370 380 390 400
GLWTTITIFI SLFLLSVCYS ASVTLFKVKW IFSSVVELKQ KISPDYRNMI

GQGA
Length:404
Mass (Da):44,259
Last modified:February 1, 2005 - v3
Checksum:iAE17A03221F6EC0C
GO
Isoform 2 (identifier: P01867-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: L → K
     336-404: Missing.

Note: May be the major isoform.
Show »
Length:335
Mass (Da):36,588
Checksum:i557C4C96ED38965A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti24L → S (PubMed:117548).Curated1
Sequence conflicti24L → S (PubMed:117549).Curated1
Sequence conflicti35S → P (PubMed:117548).Curated1
Sequence conflicti35S → P (PubMed:117549).Curated1
Sequence conflicti238I → T (PubMed:117548).Curated1
Sequence conflicti238I → T (PubMed:117549).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti162Q → R in allele B. 1
Natural varianti193T → A in allele B. 1
Natural varianti299N → D in allele B. 1
Natural varianti300M → I in allele B. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034614335L → K in isoform 2. Curated1
Alternative sequenceiVSP_034615336 – 404Missing in isoform 2. CuratedAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00461, J00462 Genomic DNA. Translation: AAB59659.1.
PIRiC02154. G2MSBM.
S25057. G2MS11.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00461, J00462 Genomic DNA. Translation: AAB59659.1.
PIRiC02154. G2MSBM.
S25057. G2MS11.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CICX-ray2.50B1-217[»]
1ETZX-ray2.60B/H1-101[»]
1FJ1X-ray2.68B/D1-99[»]
1FL3X-ray2.45A/H1-97[»]
1HQ4X-ray2.70B/D1-98[»]
1MAMX-ray2.45H1-97[»]
1NBVX-ray2.00H1-97[»]
1OSPX-ray1.95H1-97[»]
1UB5X-ray2.00A/H1-97[»]
1UB6X-ray2.12A/H1-97[»]
1YNKX-ray2.10H1-102[»]
1YNLX-ray1.70H1-102[»]
1ZTXX-ray2.50H1-99[»]
2GJZX-ray2.65B/H1-98[»]
2GK0X-ray2.45B/H1-98[»]
2Q8AX-ray2.40H1-97[»]
2Q8BX-ray2.30H1-97[»]
2RGSX-ray2.13A/B117-334[»]
3CFDX-ray2.50B/H1-99[»]
3CFEX-ray2.99B/H1-99[»]
ProteinModelPortaliP01867.
SMRiP01867.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01867. 2 interactors.
MINTiMINT-1504211.

Protein family/group databases

IMGTiSearch...
Search...

Proteomic databases

MaxQBiP01867.
PeptideAtlasiP01867.
PRIDEiP01867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96445. Igh-3.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01867.

Miscellaneous databases

EvolutionaryTraceiP01867.
PROiP01867.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGG2B_MOUSE
AccessioniPrimary (citable) accession number: P01867
Secondary accession number(s): P01866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.