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Protein

Ig gamma-2B chain C region

Gene

Igh-3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: GO_Central
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: GO_Central
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2B chain C region
Gene namesi
Name:Igh-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96445. Igh-3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei351 – 36818HelicalSequence analysisAdd
BLAST
Topological domaini369 – 40436CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 404›404Ig gamma-2B chain C regionPRO_0000153588Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi14 – 14Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondi26 ↔ 81PROSITE-ProRule annotation
Glycosylationi104 – 1041O-linked (GalNAc...)1 Publication
Disulfide bondi108 – 108Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi111 – 111Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi114 – 114Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi117 – 117Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondi149 ↔ 209PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi255 ↔ 313PROSITE-ProRule annotation

Post-translational modificationi

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with 2 sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01867.
PeptideAtlasiP01867.
PRIDEiP01867.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01867. 2 interactions.
MINTiMINT-1504211.

Structurei

Secondary structure

1
404
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi6 – 105Combined sources
Beta strandi14 – 163Combined sources
Beta strandi20 – 3112Combined sources
Beta strandi37 – 415Combined sources
Turni44 – 463Combined sources
Beta strandi48 – 5710Combined sources
Beta strandi60 – 7011Combined sources
Helixi71 – 733Combined sources
Turni74 – 763Combined sources
Beta strandi80 – 856Combined sources
Helixi86 – 883Combined sources
Beta strandi90 – 956Combined sources
Beta strandi104 – 1074Combined sources
Beta strandi111 – 1155Combined sources
Beta strandi127 – 1315Combined sources
Helixi135 – 1395Combined sources
Beta strandi146 – 1549Combined sources
Beta strandi155 – 1584Combined sources
Beta strandi161 – 1677Combined sources
Beta strandi170 – 1723Combined sources
Beta strandi173 – 1753Combined sources
Beta strandi176 – 1827Combined sources
Turni183 – 1864Combined sources
Beta strandi187 – 1959Combined sources
Helixi198 – 2025Combined sources
Helixi204 – 2063Combined sources
Beta strandi207 – 2137Combined sources
Beta strandi220 – 2245Combined sources
Beta strandi235 – 2395Combined sources
Helixi243 – 2453Combined sources
Beta strandi248 – 26316Combined sources
Beta strandi266 – 2716Combined sources
Beta strandi274 – 2763Combined sources
Beta strandi279 – 2813Combined sources
Beta strandi292 – 30110Combined sources
Helixi302 – 3076Combined sources
Beta strandi311 – 3166Combined sources
Helixi321 – 3233Combined sources
Beta strandi325 – 3295Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CICX-ray2.50B1-217[»]
1ETZX-ray2.60B/H1-101[»]
1FJ1X-ray2.68B/D1-99[»]
1FL3X-ray2.45A/H1-97[»]
1HQ4X-ray2.70B/D1-98[»]
1MAMX-ray2.45H1-97[»]
1NBVX-ray2.00H1-97[»]
1OSPX-ray1.95H1-97[»]
1UB5X-ray2.00A/H1-97[»]
1UB6X-ray2.12A/H1-97[»]
1YNKX-ray2.10H1-102[»]
1YNLX-ray1.70H1-102[»]
1ZTXX-ray2.50H1-99[»]
2GJZX-ray2.65B/H1-98[»]
2GK0X-ray2.45B/H1-98[»]
2Q8AX-ray2.40H1-97[»]
2Q8BX-ray2.30H1-97[»]
2RGSX-ray2.13A/B117-334[»]
3CFDX-ray2.50B/H1-99[»]
3CFEX-ray2.99B/H1-99[»]
ProteinModelPortaliP01867.
SMRiP01867. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01867.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9793Ig-like 1Add
BLAST
Domaini126 – 225100Ig-like 2Add
BLAST
Domaini234 – 33097Ig-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01867.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01867-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
KTTPPSVYPL APGCGDTTGS SVTLGCLVKG YFPESVTVTW NSGSLSSSVH
60 70 80 90 100
TFPALLQSGL YTMSSSVTVP SSTWPSQTVT CSVAHPASST TVDKKLEPSG
110 120 130 140 150
PISTINPCPP CKECHKCPAP NLEGGPSVFI FPPNIKDVLM ISLTPKVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTIRV VSTLPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNKDLPSPI ERTISKIKGL VRAPQVYILP PPAEQLSRKD
260 270 280 290 300
VSLTCLVVGF NPGDISVEWT SNGHTEENYK DTAPVLDSDG SYFIYSKLNM
310 320 330 340 350
KTSKWEKTDS FSCNVRHEGL KNYYLKKTIS RSPGLDLDDI CAEAKDGELD
360 370 380 390 400
GLWTTITIFI SLFLLSVCYS ASVTLFKVKW IFSSVVELKQ KISPDYRNMI

GQGA
Length:404
Mass (Da):44,259
Last modified:February 1, 2005 - v3
Checksum:iAE17A03221F6EC0C
GO
Isoform 2 (identifier: P01867-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: L → K
     336-404: Missing.

Note: May be the major isoform.
Show »
Length:335
Mass (Da):36,588
Checksum:i557C4C96ED38965A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti24 – 241L → S (PubMed:117548).Curated
Sequence conflicti24 – 241L → S (PubMed:117549).Curated
Sequence conflicti35 – 351S → P (PubMed:117548).Curated
Sequence conflicti35 – 351S → P (PubMed:117549).Curated
Sequence conflicti238 – 2381I → T (PubMed:117548).Curated
Sequence conflicti238 – 2381I → T (PubMed:117549).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti162 – 1621Q → R in allele B.
Natural varianti193 – 1931T → A in allele B.
Natural varianti299 – 2991N → D in allele B.
Natural varianti300 – 3001M → I in allele B.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei335 – 3351L → K in isoform 2. CuratedVSP_034614
Alternative sequencei336 – 40469Missing in isoform 2. CuratedVSP_034615Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00461, J00462 Genomic DNA. Translation: AAB59659.1.
PIRiC02154. G2MSBM.
S25057. G2MS11.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00461, J00462 Genomic DNA. Translation: AAB59659.1.
PIRiC02154. G2MSBM.
S25057. G2MS11.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CICX-ray2.50B1-217[»]
1ETZX-ray2.60B/H1-101[»]
1FJ1X-ray2.68B/D1-99[»]
1FL3X-ray2.45A/H1-97[»]
1HQ4X-ray2.70B/D1-98[»]
1MAMX-ray2.45H1-97[»]
1NBVX-ray2.00H1-97[»]
1OSPX-ray1.95H1-97[»]
1UB5X-ray2.00A/H1-97[»]
1UB6X-ray2.12A/H1-97[»]
1YNKX-ray2.10H1-102[»]
1YNLX-ray1.70H1-102[»]
1ZTXX-ray2.50H1-99[»]
2GJZX-ray2.65B/H1-98[»]
2GK0X-ray2.45B/H1-98[»]
2Q8AX-ray2.40H1-97[»]
2Q8BX-ray2.30H1-97[»]
2RGSX-ray2.13A/B117-334[»]
3CFDX-ray2.50B/H1-99[»]
3CFEX-ray2.99B/H1-99[»]
ProteinModelPortaliP01867.
SMRiP01867. Positions 1-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01867. 2 interactions.
MINTiMINT-1504211.

Protein family/group databases

IMGTiSearch...
Search...

Proteomic databases

MaxQBiP01867.
PeptideAtlasiP01867.
PRIDEiP01867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96445. Igh-3.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01867.

Miscellaneous databases

EvolutionaryTraceiP01867.
PROiP01867.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGG2B_MOUSE
AccessioniPrimary (citable) accession number: P01867
Secondary accession number(s): P01866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.