Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01865 (GCAM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-2A chain C region, membrane-bound form
Gene names
Name:Igh-1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length398 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 3 Ig-like (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Membrane-bound (identifier: P01865-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Secreted (identifier: P01864-1)

The sequence of this isoform can be found in the external entry P01864.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Probably the major isoform.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 398›398Ig gamma-2A chain C region, membrane-bound form
PRO_0000153586

Regions

Transmembrane345 – 36218Helical; Potential
Topological domain363 – 39836Cytoplasmic Potential
Domain5 – 9793Ig-like 1
Domain120 – 219100Ig-like 2
Domain228 – 32497Ig-like 3

Amino acid modifications

Glycosylation1791N-linked (GlcNAc...) Ref.4
Disulfide bond14Interchain (with a light chain)
Disulfide bond26 ↔ 81
Disulfide bond106Interchain (with a heavy chain)
Disulfide bond109Interchain (with a heavy chain)
Disulfide bond111Interchain (with a heavy chain)
Disulfide bond143 ↔ 203
Disulfide bond249 ↔ 307

Experimental info

Non-terminal residue11

Secondary structure

........................................... 398
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Membrane-bound [UniParc].

Last modified February 1, 2005. Version 3.
Checksum: B9CE2EE11224D13B

FASTA39843,949
        10         20         30         40         50         60 
KTTAPSVYPL APVCGDTTGS SVTLGCLVKG YFPEPVTLTW NSGSLSSGVH TFPAVLQSDL 

        70         80         90        100        110        120 
YTLSSSVTVT SSTWPSQSIT CNVAHPASST KVDKKIEPRG PTIKPCPPCK CPAPNLLGGP 

       130        140        150        160        170        180 
SVFIFPPKIK DVLMISLSPI VTCVVVDVSE DDPDVQISWF VNNVEVHTAQ TQTHREDYNS 

       190        200        210        220        230        240 
TLRVVSALPI QHQDWMSGKE FKCKVNNKDL PAPIERTISK PKGSVRAPQV YVLPPPEEEM 

       250        260        270        280        290        300 
TKKQVTLTCM VTDFMPEDIY VEWTNNGKTE LNYKNTEPVL DSDGSYFMYS KLRVEKKNWV 

       310        320        330        340        350        360 
ERNSYSCSVV HEGLHNHHTT KSFSRTPGLD LDDVCAEAQD GELDGLWTTI TIFISLFLLS 

       370        380        390 
VCYSASVTLF KVKWIFSSVV ELKQTISPDY RNMIGQGA 

« Hide

Isoform Secreted [UniParc].

See P01864.

References

« Hide 'large scale' references
[1]"The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
Yamawaki-Kataoka Y., Miyata T., Honjo T.
Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains."
Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.
Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 329-398.
[3]"Sequence and polyadenylation site determination of the murine immunoglobulin gamma 2a membrane 3' untranslated region."
Hall B., Milcarek C.
Mol. Immunol. 26:819-826(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 372-398.
[4]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00470, J00471 Genomic DNA. Translation: AAB59661.1.
M35032 Genomic DNA. Translation: AAA37919.1.
PIRG2MSAM. A02154.
UniGeneMm.342177.
Mm.436014.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AXTX-ray2.15H1-99[»]
1EGJX-ray2.80H1-98[»]
1FLRX-ray1.85H1-100[»]
1FPTX-ray3.00H1-99[»]
1GGBX-ray2.80H1-99[»]
1GGCX-ray2.80H1-99[»]
1KB5X-ray2.50H1-99[»]
1LO0X-ray2.00H/Y1-101[»]
1NBYX-ray1.80B1-96[»]
1NCAX-ray2.50H1-100[»]
1NCBX-ray2.50H1-100[»]
1NCCX-ray2.50H1-100[»]
1NCDX-ray2.90H1-100[»]
1ND0X-ray2.45B/D/F/H1-102[»]
1NDGX-ray1.90B1-96[»]
1NDMX-ray2.10B1-96[»]
1ORQX-ray3.20B1-99[»]
1PLGX-ray2.80H1-97[»]
1RU9X-ray2.50H1-102[»]
1RUAX-ray1.75H1-102[»]
1RUKX-ray1.40H1-102[»]
1RULX-ray1.88H1-102[»]
1RUMX-ray1.48H1-102[»]
1RUPX-ray1.40H1-102[»]
1YEEX-ray2.20H1-98[»]
4FABX-ray2.70H1-97[»]
ProteinModelPortalP01865.
SMRP01865. Positions 1-325.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01865. 2 interactions.
MINTMINT-132839.

Chemistry

DrugBankDB00078. Ibritumomab.

Protein family/group databases

IMGTSearch...
Search...
Search...

Proteomic databases

MaxQBP01865.
PRIDEP01865.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:96443. Igh-1a.

Phylogenomic databases

HOVERGENHBG005814.

Gene expression databases

GenevestigatorP01865.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01865.
PROP01865.
SOURCESearch...

Entry information

Entry nameGCAM_MOUSE
AccessionPrimary (citable) accession number: P01865
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot