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P01865

- GCAM_MOUSE

UniProt

P01865 - GCAM_MOUSE

Protein

Ig gamma-2A chain C region, membrane-bound form

Gene

Igh-1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig gamma-2A chain C region, membrane-bound form
    Gene namesi
    Name:Igh-1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96443. Igh-1a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 398›398Ig gamma-2A chain C region, membrane-bound formPRO_0000153586Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi14 – 14Interchain (with a light chain)
    Disulfide bondi26 ↔ 81
    Disulfide bondi106 – 106Interchain (with a heavy chain)
    Disulfide bondi109 – 109Interchain (with a heavy chain)
    Disulfide bondi111 – 111Interchain (with a heavy chain)
    Disulfide bondi143 ↔ 203
    Glycosylationi179 – 1791N-linked (GlcNAc...)1 Publication
    Disulfide bondi249 ↔ 307

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP01865.
    PRIDEiP01865.

    Expressioni

    Gene expression databases

    GenevestigatoriP01865.

    Interactioni

    Protein-protein interaction databases

    IntActiP01865. 2 interactions.
    MINTiMINT-132839.

    Structurei

    Secondary structure

    1
    398
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 105
    Helixi14 – 163
    Beta strandi17 – 3418
    Beta strandi37 – 404
    Helixi41 – 433
    Beta strandi49 – 513
    Beta strandi55 – 573
    Beta strandi60 – 7011
    Helixi71 – 733
    Turni74 – 763
    Beta strandi80 – 856
    Helixi86 – 883
    Beta strandi90 – 956
    Beta strandi101 – 1033
    Beta strandi113 – 1175
    Beta strandi126 – 1305
    Beta strandi140 – 15415
    Beta strandi157 – 1604
    Turni161 – 1644
    Beta strandi169 – 1713
    Beta strandi181 – 19010
    Helixi191 – 1933
    Turni194 – 1963
    Beta strandi200 – 2056
    Turni206 – 2094
    Beta strandi210 – 2156

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AXTX-ray2.15H1-99[»]
    1EGJX-ray2.80H1-98[»]
    1FLRX-ray1.85H1-100[»]
    1FPTX-ray3.00H1-99[»]
    1GGBX-ray2.80H1-99[»]
    1GGCX-ray2.80H1-99[»]
    1KB5X-ray2.50H1-99[»]
    1LO0X-ray2.00H/Y1-101[»]
    1NBYX-ray1.80B1-96[»]
    1NCAX-ray2.50H1-100[»]
    1NCBX-ray2.50H1-100[»]
    1NCCX-ray2.50H1-100[»]
    1NCDX-ray2.90H1-100[»]
    1ND0X-ray2.45B/D/F/H1-102[»]
    1NDGX-ray1.90B1-96[»]
    1NDMX-ray2.10B1-96[»]
    1ORQX-ray3.20B1-99[»]
    1PLGX-ray2.80H1-97[»]
    1RU9X-ray2.50H1-102[»]
    1RUAX-ray1.75H1-102[»]
    1RUKX-ray1.40H1-102[»]
    1RULX-ray1.88H1-102[»]
    1RUMX-ray1.48H1-102[»]
    1RUPX-ray1.40H1-102[»]
    1YEEX-ray2.20H1-98[»]
    4FABX-ray2.70H1-97[»]
    ProteinModelPortaliP01865.
    SMRiP01865. Positions 1-325.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01865.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini363 – 39836CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei345 – 36218HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 9793Ig-like 1Add
    BLAST
    Domaini120 – 219100Ig-like 2Add
    BLAST
    Domaini228 – 32497Ig-like 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG005814.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 3 hits.
    [Graphical view]
    SMARTiSM00407. IGc1. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    KTTAPSVYPL APVCGDTTGS SVTLGCLVKG YFPEPVTLTW NSGSLSSGVH    50
    TFPAVLQSDL YTLSSSVTVT SSTWPSQSIT CNVAHPASST KVDKKIEPRG 100
    PTIKPCPPCK CPAPNLLGGP SVFIFPPKIK DVLMISLSPI VTCVVVDVSE 150
    DDPDVQISWF VNNVEVHTAQ TQTHREDYNS TLRVVSALPI QHQDWMSGKE 200
    FKCKVNNKDL PAPIERTISK PKGSVRAPQV YVLPPPEEEM TKKQVTLTCM 250
    VTDFMPEDIY VEWTNNGKTE LNYKNTEPVL DSDGSYFMYS KLRVEKKNWV 300
    ERNSYSCSVV HEGLHNHHTT KSFSRTPGLD LDDVCAEAQD GELDGLWTTI 350
    TIFISLFLLS VCYSASVTLF KVKWIFSSVV ELKQTISPDY RNMIGQGA 398
    Length:398
    Mass (Da):43,949
    Last modified:February 1, 2005 - v3
    Checksum:iB9CE2EE11224D13B
    GO
    Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P01864.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Probably the major isoform.

    Length:335
    Mass (Da):36,596
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00470, J00471 Genomic DNA. Translation: AAB59661.1.
    M35032 Genomic DNA. Translation: AAA37919.1.
    PIRiA02154. G2MSAM.
    UniGeneiMm.342177.
    Mm.436014.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00470 , J00471 Genomic DNA. Translation: AAB59661.1 .
    M35032 Genomic DNA. Translation: AAA37919.1 .
    PIRi A02154. G2MSAM.
    UniGenei Mm.342177.
    Mm.436014.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AXT X-ray 2.15 H 1-99 [» ]
    1EGJ X-ray 2.80 H 1-98 [» ]
    1FLR X-ray 1.85 H 1-100 [» ]
    1FPT X-ray 3.00 H 1-99 [» ]
    1GGB X-ray 2.80 H 1-99 [» ]
    1GGC X-ray 2.80 H 1-99 [» ]
    1KB5 X-ray 2.50 H 1-99 [» ]
    1LO0 X-ray 2.00 H/Y 1-101 [» ]
    1NBY X-ray 1.80 B 1-96 [» ]
    1NCA X-ray 2.50 H 1-100 [» ]
    1NCB X-ray 2.50 H 1-100 [» ]
    1NCC X-ray 2.50 H 1-100 [» ]
    1NCD X-ray 2.90 H 1-100 [» ]
    1ND0 X-ray 2.45 B/D/F/H 1-102 [» ]
    1NDG X-ray 1.90 B 1-96 [» ]
    1NDM X-ray 2.10 B 1-96 [» ]
    1ORQ X-ray 3.20 B 1-99 [» ]
    1PLG X-ray 2.80 H 1-97 [» ]
    1RU9 X-ray 2.50 H 1-102 [» ]
    1RUA X-ray 1.75 H 1-102 [» ]
    1RUK X-ray 1.40 H 1-102 [» ]
    1RUL X-ray 1.88 H 1-102 [» ]
    1RUM X-ray 1.48 H 1-102 [» ]
    1RUP X-ray 1.40 H 1-102 [» ]
    1YEE X-ray 2.20 H 1-98 [» ]
    4FAB X-ray 2.70 H 1-97 [» ]
    ProteinModelPortali P01865.
    SMRi P01865. Positions 1-325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01865. 2 interactions.
    MINTi MINT-132839.

    Chemistry

    DrugBanki DB00078. Ibritumomab.

    Protein family/group databases

    IMGTi Search...
    Search...
    Search...

    Proteomic databases

    MaxQBi P01865.
    PRIDEi P01865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:96443. Igh-1a.

    Phylogenomic databases

    HOVERGENi HBG005814.

    Miscellaneous databases

    EvolutionaryTracei P01865.
    PROi P01865.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P01865.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 3 hits.
    [Graphical view ]
    SMARTi SM00407. IGc1. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
      Yamawaki-Kataoka Y., Miyata T., Honjo T.
      Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains."
      Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.
      Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 329-398.
    3. "Sequence and polyadenylation site determination of the murine immunoglobulin gamma 2a membrane 3' untranslated region."
      Hall B., Milcarek C.
      Mol. Immunol. 26:819-826(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 372-398.
    4. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiGCAM_MOUSE
    AccessioniPrimary (citable) accession number: P01865
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3