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Protein

Ig gamma-2A chain C region, membrane-bound form

Gene

Igh-1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibody-dependent cellular cytotoxicity Source: MGI
  • antigen processing and presentation Source: MGI
  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: GO_Central
  • early endosome to late endosome transport Source: MGI
  • endosome to lysosome transport Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: MGI
  • positive regulation of endocytosis Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • regulation of proteolysis Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region, membrane-bound form
Gene namesi
Name:Igh-1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96443. Igh-1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei345 – 362HelicalSequence analysisAdd BLAST18
Topological domaini363 – 398CytoplasmicSequence analysisAdd BLAST36

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153586‹1 – 398Ig gamma-2A chain C region, membrane-bound formAdd BLAST›398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi26 ↔ 81
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi111Interchain (with a heavy chain)
Disulfide bondi143 ↔ 203
Glycosylationi179N-linked (GlcNAc...)1 Publication1
Disulfide bondi249 ↔ 307

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01865.
PRIDEiP01865.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01865. 2 interactors.
MINTiMINT-132839.

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi14 – 16Combined sources3
Beta strandi17 – 34Combined sources18
Beta strandi37 – 40Combined sources4
Helixi41 – 43Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi60 – 70Combined sources11
Helixi71 – 73Combined sources3
Turni74 – 76Combined sources3
Beta strandi80 – 85Combined sources6
Helixi86 – 88Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi101 – 103Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi126 – 130Combined sources5
Beta strandi140 – 154Combined sources15
Beta strandi157 – 160Combined sources4
Turni161 – 164Combined sources4
Beta strandi169 – 171Combined sources3
Beta strandi181 – 190Combined sources10
Helixi191 – 193Combined sources3
Turni194 – 196Combined sources3
Beta strandi200 – 205Combined sources6
Turni206 – 209Combined sources4
Beta strandi210 – 215Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXTX-ray2.15H1-99[»]
1EGJX-ray2.80H1-218[»]
1FLRX-ray1.85H1-100[»]
1FPTX-ray3.00H1-99[»]
1GGBX-ray2.80H1-99[»]
1GGCX-ray2.80H1-99[»]
1KB5X-ray2.50H1-99[»]
1LO0X-ray2.00H/Y1-101[»]
1NBYX-ray1.80B1-96[»]
1NCAX-ray2.50H1-100[»]
1NCBX-ray2.50H1-100[»]
1NCCX-ray2.50H1-100[»]
1NCDX-ray2.90H1-100[»]
1ND0X-ray2.45B/D/F/H1-102[»]
1NDGX-ray1.90B1-96[»]
1NDMX-ray2.10B1-96[»]
1ORQX-ray3.20B1-99[»]
1PLGX-ray2.80H1-97[»]
1RU9X-ray2.50H1-102[»]
1RUAX-ray1.75H1-102[»]
1RUKX-ray1.40H1-102[»]
1RULX-ray1.88H1-102[»]
1RUMX-ray1.48H1-102[»]
1RUPX-ray1.40H1-102[»]
1YEEX-ray2.20H1-98[»]
4FABX-ray2.70H1-97[»]
4ZXBX-ray3.30C1-106[»]
ProteinModelPortaliP01865.
SMRiP01865.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01865.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 97Ig-like 1Add BLAST93
Domaini120 – 219Ig-like 2Add BLAST100
Domaini228 – 324Ig-like 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01865.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
KTTAPSVYPL APVCGDTTGS SVTLGCLVKG YFPEPVTLTW NSGSLSSGVH
60 70 80 90 100
TFPAVLQSDL YTLSSSVTVT SSTWPSQSIT CNVAHPASST KVDKKIEPRG
110 120 130 140 150
PTIKPCPPCK CPAPNLLGGP SVFIFPPKIK DVLMISLSPI VTCVVVDVSE
160 170 180 190 200
DDPDVQISWF VNNVEVHTAQ TQTHREDYNS TLRVVSALPI QHQDWMSGKE
210 220 230 240 250
FKCKVNNKDL PAPIERTISK PKGSVRAPQV YVLPPPEEEM TKKQVTLTCM
260 270 280 290 300
VTDFMPEDIY VEWTNNGKTE LNYKNTEPVL DSDGSYFMYS KLRVEKKNWV
310 320 330 340 350
ERNSYSCSVV HEGLHNHHTT KSFSRTPGLD LDDVCAEAQD GELDGLWTTI
360 370 380 390
TIFISLFLLS VCYSASVTLF KVKWIFSSVV ELKQTISPDY RNMIGQGA
Length:398
Mass (Da):43,949
Last modified:February 1, 2005 - v3
Checksum:iB9CE2EE11224D13B
GO
Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01864.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Probably the major isoform.
Length:335
Mass (Da):36,596
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00470, J00471 Genomic DNA. Translation: AAB59661.1.
M35032 Genomic DNA. Translation: AAA37919.1.
PIRiA02154. G2MSAM.
UniGeneiMm.342177.
Mm.436014.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00470, J00471 Genomic DNA. Translation: AAB59661.1.
M35032 Genomic DNA. Translation: AAA37919.1.
PIRiA02154. G2MSAM.
UniGeneiMm.342177.
Mm.436014.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXTX-ray2.15H1-99[»]
1EGJX-ray2.80H1-218[»]
1FLRX-ray1.85H1-100[»]
1FPTX-ray3.00H1-99[»]
1GGBX-ray2.80H1-99[»]
1GGCX-ray2.80H1-99[»]
1KB5X-ray2.50H1-99[»]
1LO0X-ray2.00H/Y1-101[»]
1NBYX-ray1.80B1-96[»]
1NCAX-ray2.50H1-100[»]
1NCBX-ray2.50H1-100[»]
1NCCX-ray2.50H1-100[»]
1NCDX-ray2.90H1-100[»]
1ND0X-ray2.45B/D/F/H1-102[»]
1NDGX-ray1.90B1-96[»]
1NDMX-ray2.10B1-96[»]
1ORQX-ray3.20B1-99[»]
1PLGX-ray2.80H1-97[»]
1RU9X-ray2.50H1-102[»]
1RUAX-ray1.75H1-102[»]
1RUKX-ray1.40H1-102[»]
1RULX-ray1.88H1-102[»]
1RUMX-ray1.48H1-102[»]
1RUPX-ray1.40H1-102[»]
1YEEX-ray2.20H1-98[»]
4FABX-ray2.70H1-97[»]
4ZXBX-ray3.30C1-106[»]
ProteinModelPortaliP01865.
SMRiP01865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01865. 2 interactors.
MINTiMINT-132839.

Protein family/group databases

IMGTiSearch...
Search...
Search...

Proteomic databases

MaxQBiP01865.
PRIDEiP01865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96443. Igh-1a.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01865.

Miscellaneous databases

EvolutionaryTraceiP01865.
PROiP01865.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCAM_MOUSE
AccessioniPrimary (citable) accession number: P01865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.