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Protein

Ig gamma-2A chain C region, membrane-bound form

Gene

Igh-1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibody-dependent cellular cytotoxicity Source: MGI
  • antigen processing and presentation Source: MGI
  • B cell receptor signaling pathway Source: GO_Central
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: GO_Central
  • early endosome to late endosome transport Source: MGI
  • endosome to lysosome transport Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • innate immune response Source: GO_Central
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of B cell activation Source: MGI
  • positive regulation of endocytosis Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI
  • regulation of proteolysis Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region, membrane-bound form
Gene namesi
Name:Igh-1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96443 Igh-1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei345 – 362HelicalSequence analysisAdd BLAST18
Topological domaini363 – 398CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153586‹1 – 398Ig gamma-2A chain C region, membrane-bound formAdd BLAST›398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi26 ↔ 81
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi111Interchain (with a heavy chain)
Disulfide bondi143 ↔ 203
Glycosylationi179N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi249 ↔ 307

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01865
PRIDEiP01865

PTM databases

iPTMnetiP01865

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P018375EBI-1035270,EBI-1035302

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01865, 4 interactors
MINTiP01865

Structurei

Secondary structure

1398
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi14 – 16Combined sources3
Beta strandi17 – 34Combined sources18
Beta strandi37 – 40Combined sources4
Helixi41 – 43Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi55 – 57Combined sources3
Beta strandi60 – 70Combined sources11
Helixi71 – 73Combined sources3
Turni74 – 76Combined sources3
Beta strandi80 – 85Combined sources6
Helixi86 – 88Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi101 – 103Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi126 – 130Combined sources5
Beta strandi140 – 154Combined sources15
Beta strandi157 – 160Combined sources4
Turni161 – 164Combined sources4
Beta strandi169 – 171Combined sources3
Beta strandi181 – 190Combined sources10
Helixi191 – 193Combined sources3
Turni194 – 196Combined sources3
Beta strandi200 – 205Combined sources6
Turni206 – 209Combined sources4
Beta strandi210 – 215Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AXTX-ray2.15H1-99[»]
1DQJX-ray2.00B1-96[»]
1E4WX-ray1.95H1-98[»]
1EGJX-ray2.80H1-218[»]
1FLRX-ray1.85H1-100[»]
1FPTX-ray3.00H1-99[»]
1GGBX-ray2.80H1-99[»]
1GGCX-ray2.80H1-99[»]
1KB5X-ray2.50H1-99[»]
1LO0X-ray2.00H/Y1-101[»]
1NBYX-ray1.80B1-96[»]
1NCAX-ray2.50H1-100[»]
1NCBX-ray2.50H1-100[»]
1NCCX-ray2.50H1-100[»]
1NCDX-ray2.90H1-100[»]
1NCWX-ray1.30H1-102[»]
1ND0X-ray2.45B/D/F/H1-102[»]
1NDGX-ray1.90B1-96[»]
1NDMX-ray2.10B1-96[»]
1ORQX-ray3.20B1-99[»]
1PLGX-ray2.80H1-97[»]
1RU9X-ray2.50H1-102[»]
1RUAX-ray1.75H1-102[»]
1RUKX-ray1.40H1-102[»]
1RULX-ray1.88H1-102[»]
1RUMX-ray1.48H1-102[»]
1RUPX-ray1.40H1-102[»]
1YEEX-ray2.20H1-98[»]
3FO9X-ray1.90B/H1-99[»]
3J3Pelectron microscopy9.10H1-99[»]
4FABX-ray2.70H1-97[»]
4ZXBX-ray3.30C1-106[»]
ProteinModelPortaliP01865
SMRiP01865
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01865

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 97Ig-like 1Add BLAST93
Domaini120 – 219Ig-like 2Add BLAST100
Domaini228 – 324Ig-like 3Add BLAST97

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814
InParanoidiP01865

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
KTTAPSVYPL APVCGDTTGS SVTLGCLVKG YFPEPVTLTW NSGSLSSGVH
60 70 80 90 100
TFPAVLQSDL YTLSSSVTVT SSTWPSQSIT CNVAHPASST KVDKKIEPRG
110 120 130 140 150
PTIKPCPPCK CPAPNLLGGP SVFIFPPKIK DVLMISLSPI VTCVVVDVSE
160 170 180 190 200
DDPDVQISWF VNNVEVHTAQ TQTHREDYNS TLRVVSALPI QHQDWMSGKE
210 220 230 240 250
FKCKVNNKDL PAPIERTISK PKGSVRAPQV YVLPPPEEEM TKKQVTLTCM
260 270 280 290 300
VTDFMPEDIY VEWTNNGKTE LNYKNTEPVL DSDGSYFMYS KLRVEKKNWV
310 320 330 340 350
ERNSYSCSVV HEGLHNHHTT KSFSRTPGLD LDDVCAEAQD GELDGLWTTI
360 370 380 390
TIFISLFLLS VCYSASVTLF KVKWIFSSVV ELKQTISPDY RNMIGQGA
Length:398
Mass (Da):43,949
Last modified:February 1, 2005 - v3
Checksum:iB9CE2EE11224D13B
GO
Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01864.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Probably the major isoform.
Length:335
Mass (Da):36,596
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00470, J00471 Genomic DNA Translation: AAB59661.1
M35032 Genomic DNA Translation: AAA37919.1
PIRiA02154 G2MSAM
UniGeneiMm.342177
Mm.436014

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGCAM_MOUSE
AccessioniPrimary (citable) accession number: P01865
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: March 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health