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P01865

- GCAM_MOUSE

UniProt

P01865 - GCAM_MOUSE

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Protein
Ig gamma-2A chain C region, membrane-bound form
Gene
Igh-1a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region, membrane-bound form
Gene namesi
Name:Igh-1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96443. Igh-1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei345 – 36218Helical; Reviewed prediction
Add
BLAST
Topological domaini363 – 39836Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 398›398Ig gamma-2A chain C region, membrane-bound form
PRO_0000153586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi14 – 14Interchain (with a light chain)
Disulfide bondi26 ↔ 81
Disulfide bondi106 – 106Interchain (with a heavy chain)
Disulfide bondi109 – 109Interchain (with a heavy chain)
Disulfide bondi111 – 111Interchain (with a heavy chain)
Disulfide bondi143 ↔ 203
Glycosylationi179 – 1791N-linked (GlcNAc...)1 Publication
Disulfide bondi249 ↔ 307

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01865.
PRIDEiP01865.

Expressioni

Gene expression databases

GenevestigatoriP01865.

Interactioni

Protein-protein interaction databases

IntActiP01865. 2 interactions.
MINTiMINT-132839.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 105
Helixi14 – 163
Beta strandi17 – 3418
Beta strandi37 – 404
Helixi41 – 433
Beta strandi49 – 513
Beta strandi55 – 573
Beta strandi60 – 7011
Helixi71 – 733
Turni74 – 763
Beta strandi80 – 856
Helixi86 – 883
Beta strandi90 – 956
Beta strandi101 – 1033
Beta strandi113 – 1175
Beta strandi126 – 1305
Beta strandi140 – 15415
Beta strandi157 – 1604
Turni161 – 1644
Beta strandi169 – 1713
Beta strandi181 – 19010
Helixi191 – 1933
Turni194 – 1963
Beta strandi200 – 2056
Turni206 – 2094
Beta strandi210 – 2156

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AXTX-ray2.15H1-99[»]
1EGJX-ray2.80H1-98[»]
1FLRX-ray1.85H1-100[»]
1FPTX-ray3.00H1-99[»]
1GGBX-ray2.80H1-99[»]
1GGCX-ray2.80H1-99[»]
1KB5X-ray2.50H1-99[»]
1LO0X-ray2.00H/Y1-101[»]
1NBYX-ray1.80B1-96[»]
1NCAX-ray2.50H1-100[»]
1NCBX-ray2.50H1-100[»]
1NCCX-ray2.50H1-100[»]
1NCDX-ray2.90H1-100[»]
1ND0X-ray2.45B/D/F/H1-102[»]
1NDGX-ray1.90B1-96[»]
1NDMX-ray2.10B1-96[»]
1ORQX-ray3.20B1-99[»]
1PLGX-ray2.80H1-97[»]
1RU9X-ray2.50H1-102[»]
1RUAX-ray1.75H1-102[»]
1RUKX-ray1.40H1-102[»]
1RULX-ray1.88H1-102[»]
1RUMX-ray1.48H1-102[»]
1RUPX-ray1.40H1-102[»]
1YEEX-ray2.20H1-98[»]
4FABX-ray2.70H1-97[»]
ProteinModelPortaliP01865.
SMRiP01865. Positions 1-325.

Miscellaneous databases

EvolutionaryTraceiP01865.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 9793Ig-like 1
Add
BLAST
Domaini120 – 219100Ig-like 2
Add
BLAST
Domaini228 – 32497Ig-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005814.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

KTTAPSVYPL APVCGDTTGS SVTLGCLVKG YFPEPVTLTW NSGSLSSGVH    50
TFPAVLQSDL YTLSSSVTVT SSTWPSQSIT CNVAHPASST KVDKKIEPRG 100
PTIKPCPPCK CPAPNLLGGP SVFIFPPKIK DVLMISLSPI VTCVVVDVSE 150
DDPDVQISWF VNNVEVHTAQ TQTHREDYNS TLRVVSALPI QHQDWMSGKE 200
FKCKVNNKDL PAPIERTISK PKGSVRAPQV YVLPPPEEEM TKKQVTLTCM 250
VTDFMPEDIY VEWTNNGKTE LNYKNTEPVL DSDGSYFMYS KLRVEKKNWV 300
ERNSYSCSVV HEGLHNHHTT KSFSRTPGLD LDDVCAEAQD GELDGLWTTI 350
TIFISLFLLS VCYSASVTLF KVKWIFSSVV ELKQTISPDY RNMIGQGA 398
Length:398
Mass (Da):43,949
Last modified:February 1, 2005 - v3
Checksum:iB9CE2EE11224D13B
GO
Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P01864.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Probably the major isoform.

Length:335
Mass (Da):36,596
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00470, J00471 Genomic DNA. Translation: AAB59661.1.
M35032 Genomic DNA. Translation: AAA37919.1.
PIRiA02154. G2MSAM.
UniGeneiMm.342177.
Mm.436014.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00470 , J00471 Genomic DNA. Translation: AAB59661.1 .
M35032 Genomic DNA. Translation: AAA37919.1 .
PIRi A02154. G2MSAM.
UniGenei Mm.342177.
Mm.436014.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AXT X-ray 2.15 H 1-99 [» ]
1EGJ X-ray 2.80 H 1-98 [» ]
1FLR X-ray 1.85 H 1-100 [» ]
1FPT X-ray 3.00 H 1-99 [» ]
1GGB X-ray 2.80 H 1-99 [» ]
1GGC X-ray 2.80 H 1-99 [» ]
1KB5 X-ray 2.50 H 1-99 [» ]
1LO0 X-ray 2.00 H/Y 1-101 [» ]
1NBY X-ray 1.80 B 1-96 [» ]
1NCA X-ray 2.50 H 1-100 [» ]
1NCB X-ray 2.50 H 1-100 [» ]
1NCC X-ray 2.50 H 1-100 [» ]
1NCD X-ray 2.90 H 1-100 [» ]
1ND0 X-ray 2.45 B/D/F/H 1-102 [» ]
1NDG X-ray 1.90 B 1-96 [» ]
1NDM X-ray 2.10 B 1-96 [» ]
1ORQ X-ray 3.20 B 1-99 [» ]
1PLG X-ray 2.80 H 1-97 [» ]
1RU9 X-ray 2.50 H 1-102 [» ]
1RUA X-ray 1.75 H 1-102 [» ]
1RUK X-ray 1.40 H 1-102 [» ]
1RUL X-ray 1.88 H 1-102 [» ]
1RUM X-ray 1.48 H 1-102 [» ]
1RUP X-ray 1.40 H 1-102 [» ]
1YEE X-ray 2.20 H 1-98 [» ]
4FAB X-ray 2.70 H 1-97 [» ]
ProteinModelPortali P01865.
SMRi P01865. Positions 1-325.
ModBasei Search...

Protein-protein interaction databases

IntActi P01865. 2 interactions.
MINTi MINT-132839.

Chemistry

DrugBanki DB00078. Ibritumomab.

Protein family/group databases

IMGTi Search...
Search...
Search...

Proteomic databases

MaxQBi P01865.
PRIDEi P01865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:96443. Igh-1a.

Phylogenomic databases

HOVERGENi HBG005814.

Miscellaneous databases

EvolutionaryTracei P01865.
PROi P01865.
SOURCEi Search...

Gene expression databases

Genevestigatori P01865.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 3 hits.
[Graphical view ]
SMARTi SM00407. IGc1. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
    Yamawaki-Kataoka Y., Miyata T., Honjo T.
    Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains."
    Yamawaki-Kataoka Y., Nakai S., Miyata T., Honjo T.
    Proc. Natl. Acad. Sci. U.S.A. 79:2623-2627(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 329-398.
  3. "Sequence and polyadenylation site determination of the murine immunoglobulin gamma 2a membrane 3' untranslated region."
    Hall B., Milcarek C.
    Mol. Immunol. 26:819-826(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 372-398.
  4. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiGCAM_MOUSE
AccessioniPrimary (citable) accession number: P01865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: May 14, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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