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Protein

Ig gamma-2A chain C region secreted form

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region secreted form
Alternative name(s):
B allele
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 335›335Ig gamma-2A chain C region secreted formPRO_0000153585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi185 – 1851N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP01864.
PeptideAtlasiP01864.
PRIDEiP01864.

Interactioni

Protein-protein interaction databases

MINTiMINT-1511331.
STRINGi10090.ENSMUSP00000100212.

Structurei

Secondary structure

1
335
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 64Combined sources
Beta strandi10 – 123Combined sources
Beta strandi18 – 2710Combined sources
Helixi29 – 313Combined sources
Beta strandi34 – 407Combined sources
Turni41 – 433Combined sources
Beta strandi44 – 518Combined sources
Turni53 – 553Combined sources
Beta strandi58 – 603Combined sources
Helixi62 – 643Combined sources
Turni65 – 673Combined sources
Beta strandi68 – 736Combined sources
Turni74 – 774Combined sources
Beta strandi78 – 836Combined sources
Helixi88 – 903Combined sources
Beta strandi92 – 976Combined sources
Beta strandi99 – 1024Combined sources
Beta strandi106 – 1105Combined sources
Beta strandi119 – 1235Combined sources
Beta strandi133 – 14715Combined sources
Beta strandi150 – 1534Combined sources
Turni154 – 1574Combined sources
Beta strandi162 – 1643Combined sources
Beta strandi168 – 1703Combined sources
Beta strandi173 – 18311Combined sources
Turni184 – 1896Combined sources
Beta strandi193 – 1986Combined sources
Helixi199 – 2013Combined sources
Beta strandi203 – 2086Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BOGX-ray2.60B1-212[»]
1CFNX-ray2.65B1-101[»]
1CFQX-ray2.80B1-101[»]
1CFSX-ray2.75B1-101[»]
1CFTX-ray2.80B1-101[»]
1HH6X-ray2.60B1-101[»]
1HH9X-ray2.70B1-101[»]
1HI6X-ray2.55B1-101[»]
2IPTX-ray2.00H1-100[»]
2IQ9X-ray2.30H1-100[»]
2IQAX-ray2.00B/H1-100[»]
2VWEX-ray3.40E/L1-99[»]
ProteinModelPortaliP01864.
SMRiP01864. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01864.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9893Ig-like 1Add
BLAST
Domaini126 – 225100Ig-like 2Add
BLAST
Domaini234 – 33097Ig-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
PhylomeDBiP01864.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTAPSVYP LVPVCGGTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPALLQSG LYTLSSSVTV TSNTWPSQTI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
VPITQNPCPP HQRVPPCAAP DLLGGPSVFI FPPKIKDVLM ISLSPMVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTLRV VSALPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNRALPSPI EKTISKPRGP VRAPQVYVLP PPAEEMTKKE
260 270 280 290 300
FSLTCMITGF LPAEIAVDWT SNGRTEQNYK NTATVLDSDG SYFMYSKLRV
310 320 330
QKSTWERGSL FACSVVHEVL HNHLTTKTIS RSLGK
Note: Probably the major isoform.
Length:335
Mass (Da):36,596
Last modified:July 21, 1986 - v1
Checksum:iFA3382792CBB13C6
GO
Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P01865.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,949
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00479 Genomic DNA. No translation available.
PIRiA02153. G2MSAB.

Genome annotation databases

UCSCiuc007pgl.2. mouse. [P01864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00479 Genomic DNA. No translation available.
PIRiA02153. G2MSAB.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BOGX-ray2.60B1-212[»]
1CFNX-ray2.65B1-101[»]
1CFQX-ray2.80B1-101[»]
1CFSX-ray2.75B1-101[»]
1CFTX-ray2.80B1-101[»]
1HH6X-ray2.60B1-101[»]
1HH9X-ray2.70B1-101[»]
1HI6X-ray2.55B1-101[»]
2IPTX-ray2.00H1-100[»]
2IQ9X-ray2.30H1-100[»]
2IQAX-ray2.00B/H1-100[»]
2VWEX-ray3.40E/L1-99[»]
ProteinModelPortaliP01864.
SMRiP01864. Positions 1-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1511331.
STRINGi10090.ENSMUSP00000100212.

Protein family/group databases

IMGTiSearch...

Proteomic databases

PaxDbiP01864.
PeptideAtlasiP01864.
PRIDEiP01864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007pgl.2. mouse. [P01864-1]

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
PhylomeDBiP01864.

Miscellaneous databases

EvolutionaryTraceiP01864.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse."
    Schreier P.H., Bothwell A.L.M., Mueller-Hill B., Baltimore D.
    Proc. Natl. Acad. Sci. U.S.A. 78:4495-4499(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms."
    Dognin M.J., Lauwereys M., Strosberg A.D.
    Proc. Natl. Acad. Sci. U.S.A. 78:4031-4035(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
  3. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185.
    Strain: C57BL/6J.
    Tissue: Plasma.

Entry informationi

Entry nameiGCAB_MOUSE
AccessioniPrimary (citable) accession number: P01864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence differs from that of the a allele, from BALB/c mice, at 15% of the positions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.