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Protein

Ig gamma-2A chain C region secreted form

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region secreted form
Alternative name(s):
B allele
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153585‹1 – 335Ig gamma-2A chain C region secreted formAdd BLAST›335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi185N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP01864.
PeptideAtlasiP01864.
PRIDEiP01864.

Interactioni

Protein-protein interaction databases

MINTiMINT-1511331.
STRINGi10090.ENSMUSP00000100212.

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi10 – 12Combined sources3
Beta strandi18 – 27Combined sources10
Helixi29 – 31Combined sources3
Beta strandi34 – 40Combined sources7
Turni41 – 43Combined sources3
Beta strandi44 – 51Combined sources8
Turni53 – 55Combined sources3
Beta strandi58 – 60Combined sources3
Helixi62 – 64Combined sources3
Turni65 – 67Combined sources3
Beta strandi68 – 73Combined sources6
Turni74 – 77Combined sources4
Beta strandi78 – 83Combined sources6
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi99 – 102Combined sources4
Beta strandi106 – 110Combined sources5
Beta strandi119 – 123Combined sources5
Beta strandi133 – 147Combined sources15
Beta strandi150 – 153Combined sources4
Turni154 – 157Combined sources4
Beta strandi162 – 164Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi173 – 183Combined sources11
Turni184 – 189Combined sources6
Beta strandi193 – 198Combined sources6
Helixi199 – 201Combined sources3
Beta strandi203 – 208Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOGX-ray2.60B1-212[»]
1CFNX-ray2.65B1-101[»]
1CFQX-ray2.80B1-101[»]
1CFSX-ray2.75B1-101[»]
1CFTX-ray2.80B1-101[»]
1HH6X-ray2.60B1-101[»]
1HH9X-ray2.70B1-101[»]
1HI6X-ray2.55B1-101[»]
2IPTX-ray2.00H1-100[»]
2IQ9X-ray2.30H1-100[»]
2IQAX-ray2.00B/H1-100[»]
2VWEX-ray3.40E/L1-99[»]
ProteinModelPortaliP01864.
SMRiP01864.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01864.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini126 – 225Ig-like 2Add BLAST100
Domaini234 – 330Ig-like 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
PhylomeDBiP01864.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTAPSVYP LVPVCGGTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPALLQSG LYTLSSSVTV TSNTWPSQTI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
VPITQNPCPP HQRVPPCAAP DLLGGPSVFI FPPKIKDVLM ISLSPMVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTLRV VSALPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNRALPSPI EKTISKPRGP VRAPQVYVLP PPAEEMTKKE
260 270 280 290 300
FSLTCMITGF LPAEIAVDWT SNGRTEQNYK NTATVLDSDG SYFMYSKLRV
310 320 330
QKSTWERGSL FACSVVHEVL HNHLTTKTIS RSLGK
Note: Probably the major isoform.
Length:335
Mass (Da):36,596
Last modified:July 21, 1986 - v1
Checksum:iFA3382792CBB13C6
GO
Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01865.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00479 Genomic DNA. No translation available.
PIRiA02153. G2MSAB.

Genome annotation databases

UCSCiuc007pgl.2. mouse. [P01864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00479 Genomic DNA. No translation available.
PIRiA02153. G2MSAB.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BOGX-ray2.60B1-212[»]
1CFNX-ray2.65B1-101[»]
1CFQX-ray2.80B1-101[»]
1CFSX-ray2.75B1-101[»]
1CFTX-ray2.80B1-101[»]
1HH6X-ray2.60B1-101[»]
1HH9X-ray2.70B1-101[»]
1HI6X-ray2.55B1-101[»]
2IPTX-ray2.00H1-100[»]
2IQ9X-ray2.30H1-100[»]
2IQAX-ray2.00B/H1-100[»]
2VWEX-ray3.40E/L1-99[»]
ProteinModelPortaliP01864.
SMRiP01864.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1511331.
STRINGi10090.ENSMUSP00000100212.

Protein family/group databases

IMGTiSearch...

Proteomic databases

PaxDbiP01864.
PeptideAtlasiP01864.
PRIDEiP01864.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc007pgl.2. mouse. [P01864-1]

Phylogenomic databases

eggNOGiENOG410IJ6J. Eukaryota.
ENOG410YNB1. LUCA.
HOVERGENiHBG005814.
PhylomeDBiP01864.

Miscellaneous databases

EvolutionaryTraceiP01864.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCAB_MOUSE
AccessioniPrimary (citable) accession number: P01864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence differs from that of the a allele, from BALB/c mice, at 15% of the positions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.