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P01864 (GCAB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-2A chain C region secreted form
Alternative name(s):
B allele
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Isoform Secreted: Secreted Potential.

Miscellaneous

The sequence differs from that of the a allele, from BALB/c mice, at 15% of the positions.

Sequence similarities

Contains 3 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainImmunoglobulin C region
Immunoglobulin domain
Repeat
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionantigen binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform Secreted (identifier: P01864-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Probably the major isoform.
Isoform Membrane-bound (identifier: P01865-1)

The sequence of this isoform can be found in the external entry P01865.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 335›335Ig gamma-2A chain C region secreted form
PRO_0000153585

Regions

Domain6 – 9893Ig-like 1
Domain126 – 225100Ig-like 2
Domain234 – 33097Ig-like 3

Amino acid modifications

Glycosylation1851N-linked (GlcNAc...) Ref.3

Experimental info

Non-terminal residue11

Secondary structure

.................... 335
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Secreted [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: FA3382792CBB13C6

FASTA33536,596
        10         20         30         40         50         60 
AKTTAPSVYP LVPVCGGTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPALLQSG 

        70         80         90        100        110        120 
LYTLSSSVTV TSNTWPSQTI TCNVAHPASS TKVDKKIEPR VPITQNPCPP HQRVPPCAAP 

       130        140        150        160        170        180 
DLLGGPSVFI FPPKIKDVLM ISLSPMVTCV VVDVSEDDPD VQISWFVNNV EVHTAQTQTH 

       190        200        210        220        230        240 
REDYNSTLRV VSALPIQHQD WMSGKEFKCK VNNRALPSPI EKTISKPRGP VRAPQVYVLP 

       250        260        270        280        290        300 
PPAEEMTKKE FSLTCMITGF LPAEIAVDWT SNGRTEQNYK NTATVLDSDG SYFMYSKLRV 

       310        320        330 
QKSTWERGSL FACSVVHEVL HNHLTTKTIS RSLGK 

« Hide

Isoform Membrane-bound [UniParc].

See P01865.

References

« Hide 'large scale' references
[1]"Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse."
Schreier P.H., Bothwell A.L.M., Mueller-Hill B., Baltimore D.
Proc. Natl. Acad. Sci. U.S.A. 78:4495-4499(1981) [PubMed: 6170065] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
[2]"Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms."
Dognin M.J., Lauwereys M., Strosberg A.D.
Proc. Natl. Acad. Sci. U.S.A. 78:4031-4035(1981) [PubMed: 6794027] [Abstract]
Cited for: PROTEIN SEQUENCE.
[3]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed: 17330941] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00479 Genomic DNA. No translation available.
IPIIPI00831380.
PIRG2MSAB. A02153.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1BOGX-ray2.60B1-100[»]
1CFNX-ray2.65B1-101[»]
1CFQX-ray2.80B1-101[»]
1CFSX-ray2.75B1-101[»]
1CFTX-ray2.80B1-101[»]
1HH6X-ray2.60B1-101[»]
1HH9X-ray2.70B1-101[»]
1HI6X-ray2.55B1-101[»]
2IPTX-ray2.00H1-100[»]
2IQ9X-ray2.30H1-100[»]
2IQAX-ray2.00B/H1-100[»]
2VWEX-ray3.40E/L1-99[»]
ProteinModelPortalP01864.
SMRP01864. Positions 1-331.
ModBaseSearch...

Protein-protein interaction databases

STRINGP01864.

Protein family/group databases

IMGTSearch...

Proteomic databases

PRIDEP01864.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc007pgl.1. mouse.

Phylogenomic databases

eggNOGroNOG17146.
HOVERGENHBG005814.
InParanoidP01864.
OrthoDBEOG49W2HB.

Gene expression databases

ArrayExpressP01864.
BgeeP01864.
GenevestigatorP01864.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCAB_MOUSE
AccessionPrimary (citable) accession number: P01864
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 21, 2011
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families