Ig gamma-2A chain C region secreted form

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Preferred order of sections

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

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P01864 (GCAB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names	Recommended name: Ig gamma-2A chain C region secreted form Alternative name(s): B allele
Organism	Mus musculus (Mouse)
Taxonomic identifier	10090 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Subcellular location	Isoform Secreted: Secreted Potential.
Miscellaneous	The sequence differs from that of the a allele, from BALB/c mice, at 15% of the positions.
Sequence similarities	Contains 3 Ig-like (immunoglobulin-like) domains.

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin C region Immunoglobulin domain Repeat
PTM	Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

‹1 – 335

›335

Ig gamma-2A chain C region secreted form

PRO_0000153585

Domain

6 – 98

Ig-like 1

Domain

126 – 225

100

Ig-like 2

Domain

234 – 330

Ig-like 3

Glycosylation

185

N-linked (GlcNAc...) Ref.3

Non-terminal residue

335

Helix Strand Turn

Details...

Sequence

Length

Mass (Da)

Tools

Isoform Secreted [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: FA3382792CBB13C6
Show »

FASTA

335

36,596

        10         20         30         40         50         60 
AKTTAPSVYP LVPVCGGTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPALLQSG 

        70         80         90        100        110        120 
LYTLSSSVTV TSNTWPSQTI TCNVAHPASS TKVDKKIEPR VPITQNPCPP HQRVPPCAAP 

       130        140        150        160        170        180 
DLLGGPSVFI FPPKIKDVLM ISLSPMVTCV VVDVSEDDPD VQISWFVNNV EVHTAQTQTH 

       190        200        210        220        230        240 
REDYNSTLRV VSALPIQHQD WMSGKEFKCK VNNRALPSPI EKTISKPRGP VRAPQVYVLP 

       250        260        270        280        290        300 
PPAEEMTKKE FSLTCMITGF LPAEIAVDWT SNGRTEQNYK NTATVLDSDG SYFMYSKLRV 

       310        320        330 
QKSTWERGSL FACSVVHEVL HNHLTTKTIS RSLGK

« Hide

Isoform Membrane-bound [UniParc].

See P01865.

–

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse." Schreier P.H., Bothwell A.L.M., Mueller-Hill B., Baltimore D. Proc. Natl. Acad. Sci. U.S.A. 78:4495-4499(1981) [PubMed: 6170065] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C57BL/6.
[2]	"Multiple amino acid substitutions between murine gamma 2a heavy chain Fc regions of Ig1a and Ig1b allotypic forms." Dognin M.J., Lauwereys M., Strosberg A.D. Proc. Natl. Acad. Sci. U.S.A. 78:4031-4035(1981) [PubMed: 6794027] [Abstract] Cited for: PROTEIN SEQUENCE.
[3]	"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res. 6:987-995(2007) [PubMed: 17330941] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Plasma.
+	Additional computationally mapped references.

EMBL
GenBank
DDBJ

J00479 Genomic DNA. No translation available.

IPI

IPI00831380.

PIR

G2MSAB. A02153.

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BOG	X-ray	2.60	B	1-100	[»]
1CFN	X-ray	2.65	B	1-101	[»]
1CFQ	X-ray	2.80	B	1-101	[»]
1CFS	X-ray	2.75	B	1-101	[»]
1CFT	X-ray	2.80	B	1-101	[»]
1HH6	X-ray	2.60	B	1-101	[»]
1HH9	X-ray	2.70	B	1-101	[»]
1HI6	X-ray	2.55	B	1-101	[»]
2IPT	X-ray	2.00	H	1-100	[»]
2IQ9	X-ray	2.30	H	1-100	[»]
2IQA	X-ray	2.00	B/H	1-100	[»]
2VWE	X-ray	3.40	E/L	1-99	[»]

ProteinModelPortal

P01864.

SMR

P01864. Positions 1-331.

ModBase

Search...

STRING

P01864.

IMGT

Search...

PRIDE

P01864.

StructuralBiologyKnowledgebase

Search...

UCSC

uc007pgl.1. mouse.

eggNOG

roNOG17146.

HOVERGEN

HBG005814.

InParanoid

P01864.

OrthoDB

EOG49W2HB.

ArrayExpress

P01864.

Bgee

P01864.

Genevestigator

P01864.

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

Pfam

PF07654. C1-set. 3 hits.
[Graphical view]

SMART

SM00407. IGc1. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry name

GCAB_MOUSE

Accession

Primary (citable) accession number: P01864

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 21, 2011
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Secreted (identifier: P01864-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Probably the major isoform.

Isoform Membrane-bound (identifier: P01865-1)

The sequence of this isoform can be found in the external entry P01865.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.