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P01863

- GCAA_MOUSE

UniProt

P01863 - GCAA_MOUSE

Protein

Ig gamma-2A chain C region, A allele

Gene

Ighg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig gamma-2A chain C region, A allele
    Alternative name(s):
    Immunoglobulin heavy chain gamma polypeptide
    Gene namesi
    Name:Ighg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2144967. Ighg.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 330›330Ig gamma-2A chain C region, A allelePRO_0000153584Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi15 – 15Interchain (with a light chain)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi27 ↔ 821 PublicationPROSITE-ProRule annotation
    Disulfide bondi107 – 107Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi110 – 110Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi112 – 112Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
    Disulfide bondi144 ↔ 2041 PublicationPROSITE-ProRule annotation
    Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication
    Disulfide bondi250 ↔ 3081 PublicationPROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP01863.

    Expressioni

    Gene expression databases

    GenevestigatoriP01863.

    Structurei

    Secondary structure

    1
    330
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi7 – 115
    Beta strandi16 – 183
    Turni19 – 213
    Beta strandi22 – 3514
    Beta strandi38 – 414
    Helixi42 – 443
    Beta strandi47 – 493
    Beta strandi50 – 523
    Beta strandi56 – 583
    Beta strandi61 – 7111
    Turni72 – 776
    Beta strandi81 – 866
    Helixi87 – 893
    Beta strandi91 – 966
    Beta strandi98 – 1069
    Beta strandi114 – 1174
    Beta strandi122 – 1265
    Helixi130 – 1345
    Beta strandi141 – 1499
    Beta strandi157 – 1626
    Beta strandi165 – 1673
    Beta strandi171 – 1788
    Turni179 – 1813
    Beta strandi182 – 1909
    Helixi193 – 1975
    Beta strandi202 – 2076
    Beta strandi215 – 2195
    Beta strandi230 – 2345
    Helixi238 – 2414
    Beta strandi242 – 25817
    Beta strandi261 – 2666
    Beta strandi272 – 2765
    Beta strandi287 – 29610
    Helixi297 – 3015
    Beta strandi306 – 3116
    Helixi316 – 3183
    Beta strandi319 – 3246

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EHLX-ray2.40H1-99[»]
    1GGIX-ray2.80H/J1-107[»]
    1IGTX-ray2.80B/D2-326[»]
    1KEGX-ray2.40H1-100[»]
    1KN2X-ray1.90H1-99[»]
    1KN4X-ray1.90H1-99[»]
    1MH5X-ray2.10B/H1-111[»]
    1MNUX-ray2.50H7-126[»]
    1MPAX-ray2.60H1-104[»]
    1OB1X-ray2.90B/E1-99[»]
    1PG7X-ray2.50X/Z1-100[»]
    1UYWX-ray2.00H/M1-100[»]
    1YECX-ray1.90H1-99[»]
    1YEFX-ray2.00H1-99[»]
    1YEGX-ray2.00H1-99[»]
    1YEHX-ray2.55H1-99[»]
    1YEIX-ray1.90H1-99[»]
    1YEJX-ray1.85H1-99[»]
    1YEKX-ray2.10H1-99[»]
    2IPUX-ray1.65G/H1-103[»]
    2MPAX-ray2.60H1-104[»]
    2R0WX-ray2.50H1-100[»]
    2R0ZX-ray2.10H1-100[»]
    2R29X-ray3.00H1-100[»]
    2R69X-ray3.80H1-100[»]
    2R6Pelectron microscopy24.00D/F1-100[»]
    2VL5X-ray2.10A/C1-99[»]
    2ZCHX-ray2.83H1-107[»]
    2ZCKX-ray3.10H1-107[»]
    2ZCLX-ray3.25H1-107[»]
    3BGFX-ray3.00B/H1-99[»]
    3ZO0X-ray1.99A120-326[»]
    4F37X-ray2.57F/H1-100[»]
    ProteinModelPortaliP01863.
    SMRiP01863. Positions 1-326.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01863.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 9893Ig-like 1Add
    BLAST
    Domaini121 – 220100Ig-like 2Add
    BLAST
    Domaini229 – 32597Ig-like 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain, Repeat

    Phylogenomic databases

    HOVERGENiHBG005814.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 3 hits.
    [Graphical view]
    SMARTiSM00407. IGc1. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01863-1 [UniParc]FASTAAdd to Basket

    « Hide

    AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV    50
    HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR 100
    GPTIKPCPPC KCPAPNLLGG PSVFIFPPKI KDVLMISLSP IVTCVVVDVS 150
    EDDPDVQISW FVNNVEVHTA QTQTHREDYN STLRVVSALP IQHQDWMSGK 200
    EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE MTKKQVTLTC 250
    MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW 300
    VERNSYSCSV VHEGLHNHHT TKSFSRTPGK 330
    Length:330
    Mass (Da):36,389
    Last modified:July 21, 1986 - v1
    Checksum:iB84361C5445A6864
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00798 mRNA. Translation: CAA24178.1.
    PIRiA02152. G2MSA.
    UniGeneiMm.342177.
    Mm.436014.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00798 mRNA. Translation: CAA24178.1 .
    PIRi A02152. G2MSA.
    UniGenei Mm.342177.
    Mm.436014.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EHL X-ray 2.40 H 1-99 [» ]
    1GGI X-ray 2.80 H/J 1-107 [» ]
    1IGT X-ray 2.80 B/D 2-326 [» ]
    1KEG X-ray 2.40 H 1-100 [» ]
    1KN2 X-ray 1.90 H 1-99 [» ]
    1KN4 X-ray 1.90 H 1-99 [» ]
    1MH5 X-ray 2.10 B/H 1-111 [» ]
    1MNU X-ray 2.50 H 7-126 [» ]
    1MPA X-ray 2.60 H 1-104 [» ]
    1OB1 X-ray 2.90 B/E 1-99 [» ]
    1PG7 X-ray 2.50 X/Z 1-100 [» ]
    1UYW X-ray 2.00 H/M 1-100 [» ]
    1YEC X-ray 1.90 H 1-99 [» ]
    1YEF X-ray 2.00 H 1-99 [» ]
    1YEG X-ray 2.00 H 1-99 [» ]
    1YEH X-ray 2.55 H 1-99 [» ]
    1YEI X-ray 1.90 H 1-99 [» ]
    1YEJ X-ray 1.85 H 1-99 [» ]
    1YEK X-ray 2.10 H 1-99 [» ]
    2IPU X-ray 1.65 G/H 1-103 [» ]
    2MPA X-ray 2.60 H 1-104 [» ]
    2R0W X-ray 2.50 H 1-100 [» ]
    2R0Z X-ray 2.10 H 1-100 [» ]
    2R29 X-ray 3.00 H 1-100 [» ]
    2R69 X-ray 3.80 H 1-100 [» ]
    2R6P electron microscopy 24.00 D/F 1-100 [» ]
    2VL5 X-ray 2.10 A/C 1-99 [» ]
    2ZCH X-ray 2.83 H 1-107 [» ]
    2ZCK X-ray 3.10 H 1-107 [» ]
    2ZCL X-ray 3.25 H 1-107 [» ]
    3BGF X-ray 3.00 B/H 1-99 [» ]
    3ZO0 X-ray 1.99 A 120-326 [» ]
    4F37 X-ray 2.57 F/H 1-100 [» ]
    ProteinModelPortali P01863.
    SMRi P01863. Positions 1-326.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    IMGTi Search...

    Proteomic databases

    PRIDEi P01863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:2144967. Ighg.

    Phylogenomic databases

    HOVERGENi HBG005814.

    Miscellaneous databases

    EvolutionaryTracei P01863.
    PROi P01863.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P01863.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 3 hits.
    [Graphical view ]
    SMARTi SM00407. IGc1. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA."
      Sikorav J.-L., Auffray C., Rougeon F.
      Nucleic Acids Res. 8:3143-3155(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
      Yamawaki-Kataoka Y., Miyata T., Honjo T.
      Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family."
      Ollo R., Auffray C., Morchamps C., Rougeon F.
      Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Determination of the primary structure of a mouse IgG2a immunoglobulin: amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function."
      Bourgois A., Fougereau M., Rocca-Serra J.
      Eur. J. Biochem. 43:423-435(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: MYELOMA PROTEIN MOPC 173.
    5. "Determination of the primary structure of a mouse gamma G2a immunoglobulin. Identification of the disulfide bridges."
      de Preval C., Fougereau M.
      Eur. J. Biochem. 30:452-462(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISULFIDE BONDS.
    6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
      Bernhard O.K., Kapp E.A., Simpson R.J.
      J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180.
      Strain: C57BL/6.
      Tissue: Plasma.

    Entry informationi

    Entry nameiGCAA_MOUSE
    AccessioniPrimary (citable) accession number: P01863
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3