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P01863

- GCAA_MOUSE

UniProt

P01863 - GCAA_MOUSE

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Protein

Ig gamma-2A chain C region, A allele

Gene

Ighg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region, A allele
Alternative name(s):
Immunoglobulin heavy chain gamma polypeptide
Gene namesi
Name:Ighg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2144967. Ighg.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 330›330Ig gamma-2A chain C region, A allelePRO_0000153584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi15 – 15Interchain (with a light chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi27 ↔ 821 PublicationPROSITE-ProRule annotation
Disulfide bondi107 – 107Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi110 – 110Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi112 – 112Interchain (with a heavy chain)1 PublicationPROSITE-ProRule annotation
Disulfide bondi144 ↔ 2041 PublicationPROSITE-ProRule annotation
Glycosylationi180 – 1801N-linked (GlcNAc...)1 Publication
Disulfide bondi250 ↔ 3081 PublicationPROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP01863.

Expressioni

Gene expression databases

GenevestigatoriP01863.

Structurei

Secondary structure

1
330
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115
Beta strandi16 – 183
Turni19 – 213
Beta strandi22 – 3514
Beta strandi38 – 414
Helixi42 – 443
Beta strandi47 – 493
Beta strandi50 – 523
Beta strandi56 – 583
Beta strandi61 – 7111
Turni72 – 776
Beta strandi81 – 866
Helixi87 – 893
Beta strandi91 – 966
Beta strandi98 – 1069
Beta strandi114 – 1174
Beta strandi122 – 1265
Helixi130 – 1345
Beta strandi141 – 1499
Beta strandi157 – 1626
Beta strandi165 – 1673
Beta strandi171 – 1788
Turni179 – 1813
Beta strandi182 – 1909
Helixi193 – 1975
Beta strandi202 – 2076
Beta strandi215 – 2195
Beta strandi230 – 2345
Helixi238 – 2414
Beta strandi242 – 25817
Beta strandi261 – 2666
Beta strandi272 – 2765
Beta strandi287 – 29610
Helixi297 – 3015
Beta strandi306 – 3116
Helixi316 – 3183
Beta strandi319 – 3246

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHLX-ray2.40H1-99[»]
1GGIX-ray2.80H/J1-107[»]
1IGTX-ray2.80B/D2-326[»]
1KEGX-ray2.40H1-100[»]
1KN2X-ray1.90H1-99[»]
1KN4X-ray1.90H1-99[»]
1MH5X-ray2.10B/H1-111[»]
1MNUX-ray2.50H7-126[»]
1MPAX-ray2.60H1-104[»]
1OB1X-ray2.90B/E1-99[»]
1PG7X-ray2.50X/Z1-100[»]
1UYWX-ray2.00H/M1-100[»]
1YECX-ray1.90H1-99[»]
1YEFX-ray2.00H1-99[»]
1YEGX-ray2.00H1-99[»]
1YEHX-ray2.55H1-99[»]
1YEIX-ray1.90H1-99[»]
1YEJX-ray1.85H1-99[»]
1YEKX-ray2.10H1-99[»]
2IPUX-ray1.65G/H1-103[»]
2MPAX-ray2.60H1-104[»]
2R0WX-ray2.50H1-100[»]
2R0ZX-ray2.10H1-100[»]
2R29X-ray3.00H1-100[»]
2R69X-ray3.80H1-100[»]
2R6Pelectron microscopy24.00D/F1-100[»]
2VL5X-ray2.10A/C1-99[»]
2ZCHX-ray2.83H1-107[»]
2ZCKX-ray3.10H1-107[»]
2ZCLX-ray3.25H1-107[»]
3BGFX-ray3.00B/H1-99[»]
3ZO0X-ray1.99A120-326[»]
4F37X-ray2.57F/H1-100[»]
ProteinModelPortaliP01863.
SMRiP01863. Positions 1-326.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01863.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9893Ig-like 1Add
BLAST
Domaini121 – 220100Ig-like 2Add
BLAST
Domaini229 – 32597Ig-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01863.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
GPTIKPCPPC KCPAPNLLGG PSVFIFPPKI KDVLMISLSP IVTCVVVDVS
160 170 180 190 200
EDDPDVQISW FVNNVEVHTA QTQTHREDYN STLRVVSALP IQHQDWMSGK
210 220 230 240 250
EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE MTKKQVTLTC
260 270 280 290 300
MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW
310 320 330
VERNSYSCSV VHEGLHNHHT TKSFSRTPGK
Length:330
Mass (Da):36,389
Last modified:July 21, 1986 - v1
Checksum:iB84361C5445A6864
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00798 mRNA. Translation: CAA24178.1.
PIRiA02152. G2MSA.
UniGeneiMm.342177.
Mm.436014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00798 mRNA. Translation: CAA24178.1 .
PIRi A02152. G2MSA.
UniGenei Mm.342177.
Mm.436014.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1EHL X-ray 2.40 H 1-99 [» ]
1GGI X-ray 2.80 H/J 1-107 [» ]
1IGT X-ray 2.80 B/D 2-326 [» ]
1KEG X-ray 2.40 H 1-100 [» ]
1KN2 X-ray 1.90 H 1-99 [» ]
1KN4 X-ray 1.90 H 1-99 [» ]
1MH5 X-ray 2.10 B/H 1-111 [» ]
1MNU X-ray 2.50 H 7-126 [» ]
1MPA X-ray 2.60 H 1-104 [» ]
1OB1 X-ray 2.90 B/E 1-99 [» ]
1PG7 X-ray 2.50 X/Z 1-100 [» ]
1UYW X-ray 2.00 H/M 1-100 [» ]
1YEC X-ray 1.90 H 1-99 [» ]
1YEF X-ray 2.00 H 1-99 [» ]
1YEG X-ray 2.00 H 1-99 [» ]
1YEH X-ray 2.55 H 1-99 [» ]
1YEI X-ray 1.90 H 1-99 [» ]
1YEJ X-ray 1.85 H 1-99 [» ]
1YEK X-ray 2.10 H 1-99 [» ]
2IPU X-ray 1.65 G/H 1-103 [» ]
2MPA X-ray 2.60 H 1-104 [» ]
2R0W X-ray 2.50 H 1-100 [» ]
2R0Z X-ray 2.10 H 1-100 [» ]
2R29 X-ray 3.00 H 1-100 [» ]
2R69 X-ray 3.80 H 1-100 [» ]
2R6P electron microscopy 24.00 D/F 1-100 [» ]
2VL5 X-ray 2.10 A/C 1-99 [» ]
2ZCH X-ray 2.83 H 1-107 [» ]
2ZCK X-ray 3.10 H 1-107 [» ]
2ZCL X-ray 3.25 H 1-107 [» ]
3BGF X-ray 3.00 B/H 1-99 [» ]
3ZO0 X-ray 1.99 A 120-326 [» ]
4F37 X-ray 2.57 F/H 1-100 [» ]
ProteinModelPortali P01863.
SMRi P01863. Positions 1-326.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

IMGTi Search...

Proteomic databases

PRIDEi P01863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2144967. Ighg.

Phylogenomic databases

HOVERGENi HBG005814.
InParanoidi P01863.

Miscellaneous databases

EvolutionaryTracei P01863.
PROi P01863.
SOURCEi Search...

Gene expression databases

Genevestigatori P01863.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 3 hits.
[Graphical view ]
SMARTi SM00407. IGc1. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA."
    Sikorav J.-L., Auffray C., Rougeon F.
    Nucleic Acids Res. 8:3143-3155(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
    Yamawaki-Kataoka Y., Miyata T., Honjo T.
    Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family."
    Ollo R., Auffray C., Morchamps C., Rougeon F.
    Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Determination of the primary structure of a mouse IgG2a immunoglobulin: amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function."
    Bourgois A., Fougereau M., Rocca-Serra J.
    Eur. J. Biochem. 43:423-435(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYELOMA PROTEIN MOPC 173.
  5. "Determination of the primary structure of a mouse gamma G2a immunoglobulin. Identification of the disulfide bridges."
    de Preval C., Fougereau M.
    Eur. J. Biochem. 30:452-462(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISULFIDE BONDS.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiGCAA_MOUSE
AccessioniPrimary (citable) accession number: P01863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3