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Protein

Ig gamma-2A chain C region, A allele

Gene

Ighg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: AgBase

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region, A allele
Alternative name(s):
Immunoglobulin heavy chain gamma polypeptide
Gene namesi
Name:Ighg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2144967. Ighg.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153584‹1 – 330Ig gamma-2A chain C region, A alleleAdd BLAST›330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi15Interchain (with a light chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation1 Publication
Disulfide bondi107Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi110Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi112Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi144 ↔ 204PROSITE-ProRule annotation1 Publication
Glycosylationi180N-linked (GlcNAc...)1 Publication1
Disulfide bondi250 ↔ 308PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01863.
PeptideAtlasiP01863.
PRIDEiP01863.

Interactioni

GO - Molecular functioni

  • immunoglobulin receptor binding Source: AgBase

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Beta strandi16 – 18Combined sources3
Turni19 – 21Combined sources3
Beta strandi22 – 35Combined sources14
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi47 – 49Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 71Combined sources11
Turni72 – 77Combined sources6
Beta strandi81 – 86Combined sources6
Helixi87 – 89Combined sources3
Beta strandi91 – 96Combined sources6
Beta strandi98 – 106Combined sources9
Beta strandi114 – 117Combined sources4
Beta strandi122 – 126Combined sources5
Helixi130 – 134Combined sources5
Beta strandi141 – 149Combined sources9
Beta strandi157 – 162Combined sources6
Beta strandi165 – 167Combined sources3
Beta strandi171 – 178Combined sources8
Turni179 – 181Combined sources3
Beta strandi182 – 190Combined sources9
Helixi193 – 197Combined sources5
Beta strandi202 – 207Combined sources6
Beta strandi215 – 219Combined sources5
Beta strandi230 – 234Combined sources5
Helixi238 – 241Combined sources4
Beta strandi242 – 258Combined sources17
Beta strandi261 – 266Combined sources6
Beta strandi272 – 276Combined sources5
Beta strandi287 – 296Combined sources10
Helixi297 – 301Combined sources5
Beta strandi306 – 311Combined sources6
Helixi316 – 318Combined sources3
Beta strandi319 – 324Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHLX-ray2.40H1-99[»]
1GGIX-ray2.80H/J1-107[»]
1IGTX-ray2.80B/D2-326[»]
1KEGX-ray2.40H1-100[»]
1KN2X-ray1.90H1-99[»]
1KN4X-ray1.90H1-99[»]
1MH5X-ray2.10B/H1-111[»]
1MNUX-ray2.50H7-126[»]
1MPAX-ray2.60H1-104[»]
1OB1X-ray2.90B/E1-99[»]
1PG7X-ray2.50X/Z1-100[»]
1UYWX-ray2.00H/M1-100[»]
1YECX-ray1.90H1-99[»]
1YEFX-ray2.00H1-99[»]
1YEGX-ray2.00H1-99[»]
1YEHX-ray2.55H1-99[»]
1YEIX-ray1.90H1-99[»]
1YEJX-ray1.85H1-99[»]
1YEKX-ray2.10H1-99[»]
2IPUX-ray1.65G/H1-103[»]
2MPAX-ray2.60H1-104[»]
2R0WX-ray2.50H1-100[»]
2R0ZX-ray2.10H1-100[»]
2R29X-ray3.00H1-100[»]
2R69X-ray3.80H1-100[»]
2R6Pelectron microscopy24.00D/F1-100[»]
2VL5X-ray2.10A/C1-99[»]
2ZCHX-ray2.83H1-107[»]
2ZCKX-ray3.10H1-107[»]
2ZCLX-ray3.25H1-107[»]
3BGFX-ray3.00B/H1-99[»]
3ZO0X-ray1.99A120-326[»]
4F37X-ray2.57F/H1-100[»]
ProteinModelPortaliP01863.
SMRiP01863.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01863.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini121 – 220Ig-like 2Add BLAST100
Domaini229 – 325Ig-like 3Add BLAST97

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01863.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01863-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
GPTIKPCPPC KCPAPNLLGG PSVFIFPPKI KDVLMISLSP IVTCVVVDVS
160 170 180 190 200
EDDPDVQISW FVNNVEVHTA QTQTHREDYN STLRVVSALP IQHQDWMSGK
210 220 230 240 250
EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE MTKKQVTLTC
260 270 280 290 300
MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW
310 320 330
VERNSYSCSV VHEGLHNHHT TKSFSRTPGK
Length:330
Mass (Da):36,389
Last modified:July 21, 1986 - v1
Checksum:iB84361C5445A6864
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00798 mRNA. Translation: CAA24178.1.
PIRiA02152. G2MSA.
UniGeneiMm.342177.
Mm.436014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00798 mRNA. Translation: CAA24178.1.
PIRiA02152. G2MSA.
UniGeneiMm.342177.
Mm.436014.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EHLX-ray2.40H1-99[»]
1GGIX-ray2.80H/J1-107[»]
1IGTX-ray2.80B/D2-326[»]
1KEGX-ray2.40H1-100[»]
1KN2X-ray1.90H1-99[»]
1KN4X-ray1.90H1-99[»]
1MH5X-ray2.10B/H1-111[»]
1MNUX-ray2.50H7-126[»]
1MPAX-ray2.60H1-104[»]
1OB1X-ray2.90B/E1-99[»]
1PG7X-ray2.50X/Z1-100[»]
1UYWX-ray2.00H/M1-100[»]
1YECX-ray1.90H1-99[»]
1YEFX-ray2.00H1-99[»]
1YEGX-ray2.00H1-99[»]
1YEHX-ray2.55H1-99[»]
1YEIX-ray1.90H1-99[»]
1YEJX-ray1.85H1-99[»]
1YEKX-ray2.10H1-99[»]
2IPUX-ray1.65G/H1-103[»]
2MPAX-ray2.60H1-104[»]
2R0WX-ray2.50H1-100[»]
2R0ZX-ray2.10H1-100[»]
2R29X-ray3.00H1-100[»]
2R69X-ray3.80H1-100[»]
2R6Pelectron microscopy24.00D/F1-100[»]
2VL5X-ray2.10A/C1-99[»]
2ZCHX-ray2.83H1-107[»]
2ZCKX-ray3.10H1-107[»]
2ZCLX-ray3.25H1-107[»]
3BGFX-ray3.00B/H1-99[»]
3ZO0X-ray1.99A120-326[»]
4F37X-ray2.57F/H1-100[»]
ProteinModelPortaliP01863.
SMRiP01863.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01863.
PeptideAtlasiP01863.
PRIDEiP01863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2144967. Ighg.

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01863.

Miscellaneous databases

EvolutionaryTraceiP01863.
PROiP01863.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCAA_MOUSE
AccessioniPrimary (citable) accession number: P01863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.