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P01863 (GCAA_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-2A chain C region, A allele
Alternative name(s):
Immunoglobulin heavy chain gamma polypeptide
Gene names
Name:Ighg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 3 Ig-like (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 330›330Ig gamma-2A chain C region, A allele
PRO_0000153584

Regions

Domain6 – 9893Ig-like 1
Domain121 – 220100Ig-like 2
Domain229 – 32597Ig-like 3

Amino acid modifications

Glycosylation1801N-linked (GlcNAc...) Ref.6
Disulfide bond15Interchain (with a light chain) Ref.5
Disulfide bond27 ↔ 82 Ref.5
Disulfide bond107Interchain (with a heavy chain) Ref.5
Disulfide bond110Interchain (with a heavy chain) Ref.5
Disulfide bond112Interchain (with a heavy chain) Ref.5
Disulfide bond144 ↔ 204 Ref.5
Disulfide bond250 ↔ 308 Ref.5

Experimental info

Non-terminal residue11

Secondary structure

................................................................ 330
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01863 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: B84361C5445A6864

FASTA33036,389
        10         20         30         40         50         60 
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD 

        70         80         90        100        110        120 
LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNLLGG 

       130        140        150        160        170        180 
PSVFIFPPKI KDVLMISLSP IVTCVVVDVS EDDPDVQISW FVNNVEVHTA QTQTHREDYN 

       190        200        210        220        230        240 
STLRVVSALP IQHQDWMSGK EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE 

       250        260        270        280        290        300 
MTKKQVTLTC MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW 

       310        320        330 
VERNSYSCSV VHEGLHNHHT TKSFSRTPGK 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA."
Sikorav J.-L., Auffray C., Rougeon F.
Nucleic Acids Res. 8:3143-3155(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer."
Yamawaki-Kataoka Y., Miyata T., Honjo T.
Nucleic Acids Res. 9:1365-1381(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family."
Ollo R., Auffray C., Morchamps C., Rougeon F.
Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Determination of the primary structure of a mouse IgG2a immunoglobulin: amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function."
Bourgois A., Fougereau M., Rocca-Serra J.
Eur. J. Biochem. 43:423-435(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: MYELOMA PROTEIN MOPC 173.
[5]"Determination of the primary structure of a mouse gamma G2a immunoglobulin. Identification of the disulfide bridges."
de Preval C., Fougereau M.
Eur. J. Biochem. 30:452-462(1972) [PubMed] [Europe PMC] [Abstract]
Cited for: DISULFIDE BONDS.
[6]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00798 mRNA. Translation: CAA24178.1.
PIRG2MSA. A02152.
UniGeneMm.342177.
Mm.436014.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1EHLX-ray2.40H1-99[»]
1GGIX-ray2.80H/J1-107[»]
1IGTX-ray2.80B/D2-326[»]
1KEGX-ray2.40H1-100[»]
1KN2X-ray1.90H1-99[»]
1KN4X-ray1.90H1-99[»]
1MH5X-ray2.10B/H1-111[»]
1MNUX-ray2.50H7-126[»]
1MPAX-ray2.60H1-104[»]
1OB1X-ray2.90B/E1-99[»]
1PG7X-ray2.50X/Z1-100[»]
1UYWX-ray2.00H/M1-100[»]
1YECX-ray1.90H1-99[»]
1YEFX-ray2.00H1-99[»]
1YEGX-ray2.00H1-99[»]
1YEHX-ray2.55H1-99[»]
1YEIX-ray1.90H1-99[»]
1YEJX-ray1.85H1-99[»]
1YEKX-ray2.10H1-99[»]
2IPUX-ray1.65G/H1-103[»]
2MPAX-ray2.60H1-104[»]
2R0WX-ray2.50H1-100[»]
2R0ZX-ray2.10H1-100[»]
2R29X-ray3.00H1-100[»]
2R69X-ray3.80H1-100[»]
2R6Pelectron microscopy24.00D/F1-100[»]
2VL5X-ray2.10A/C1-99[»]
2ZCHX-ray2.83H1-107[»]
2ZCKX-ray3.10H1-107[»]
2ZCLX-ray3.25H1-107[»]
3BGFX-ray3.00B/H1-99[»]
3ZO0X-ray1.99A120-326[»]
4F37X-ray2.57F/H1-100[»]
ProteinModelPortalP01863.
SMRP01863. Positions 1-326.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

IMGTSearch...

Proteomic databases

PRIDEP01863.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:2144967. Ighg.

Phylogenomic databases

HOVERGENHBG005814.

Gene expression databases

GenevestigatorP01863.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01863.
PROP01863.
SOURCESearch...

Entry information

Entry nameGCAA_MOUSE
AccessionPrimary (citable) accession number: P01863
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot