Reviewed, UniProtKB/Swiss-Prot P01863 (GCAA_MOUSE)

Names and origin

Protein names

Recommended name:
    Ig gamma-2A chain C region, A allele
Alternative name(s):
    Immunoglobulin heavy chain gamma polypeptide

Gene names

Name:

Ighg

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 3 Ig-like (immunoglobulin-like) domains.

Ontologies

Keywords
Domain	Immunoglobulin C region Immunoglobulin domain Repeat
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 330

›330

Ig gamma-2A chain C region, A allele

PRO_0000153584

Regions

Domain

6 – 98

93

Ig-like 1

Domain

121 – 220

100

Ig-like 2

Domain

229 – 325

97

Ig-like 3

Amino acid modifications

Glycosylation

180

1

N-linked (GlcNAc...) Ref.6

Disulfide bond

15

Interchain (with a light chain) Ref.5

Disulfide bond

27 ↔ 82

Ref.5

Disulfide bond

107

Interchain (with a heavy chain) Ref.5

Disulfide bond

110

Interchain (with a heavy chain) Ref.5

Disulfide bond

112

Interchain (with a heavy chain) Ref.5

Disulfide bond

144 ↔ 204

Ref.5

Disulfide bond

250 ↔ 308

Ref.5

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

330

Helix Strand Turn

Details...

Beta strand

7 – 11

5

Beta strand

20 – 35

16

Beta strand

38 – 41

4

Helix

42 – 44

3

Beta strand

50 – 52

3

Beta strand

56 – 58

3

Beta strand

61 – 71

11

Turn

72 – 77

6

Beta strand

81 – 86

6

Helix

87 – 89

3

Beta strand

91 – 96

6

Sequences

	Sequence		Length	Mass (Da)
	P01863-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: B84361C5445A6864	FASTA	330	36,389
	10 20 30 40 50 60 AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV HTFPAVLQSD 70 80 90 100 110 120 LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR GPTIKPCPPC KCPAPNLLGG 130 140 150 160 170 180 PSVFIFPPKI KDVLMISLSP IVTCVVVDVS EDDPDVQISW FVNNVEVHTA QTQTHREDYN 190 200 210 220 230 240 STLRVVSALP IQHQDWMSGK EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE 250 260 270 280 290 300 MTKKQVTLTC MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW 310 320 330 VERNSYSCSV VHEGLHNHHT TKSFSRTPGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the constant and 3' untranslated regions of the murine Balb/c gamma 2a heavy chain messenger RNA." Sikorav J.-L., Auffray C., Rougeon F. Nucleic Acids Res. 8:3143-3155(1980) [PubMed: 6777755] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The complete nucleotide sequence of mouse immunoglobin gamma 2a gene and evolution of heavy chain genes: further evidence for intervening sequence-mediated domain transfer." Yamawaki-Kataoka Y., Miyata T., Honjo T. Nucleic Acids Res. 9:1365-1381(1981) [PubMed: 6262729] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Comparison of mouse immunoglobulin gamma 2a and gamma 2b chain genes suggests that exons can be exchanged between genes in a multigenic family." Ollo R., Auffray C., Morchamps C., Rougeon F. Proc. Natl. Acad. Sci. U.S.A. 78:2442-2446(1981) [PubMed: 6787604] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Determination of the primary structure of a mouse IgG2a immunoglobulin: amino-acid sequence of the Fc fragment. Implications for the evolution of immunoglobulin structure and function." Bourgois A., Fougereau M., Rocca-Serra J. Eur. J. Biochem. 43:423-435(1974) [PubMed: 4831970] [Abstract] Cited for: MYELOMA PROTEIN MOPC 173.
[5]	"Determination of the primary structure of a mouse gamma G2a immunoglobulin. Identification of the disulfide bridges." de Preval C., Fougereau M. Eur. J. Biochem. 30:452-462(1972) [PubMed: 4565406] [Abstract] Cited for: DISULFIDE BONDS.
[6]	"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides." Bernhard O.K., Kapp E.A., Simpson R.J. J. Proteome Res. 6:987-995(2007) [PubMed: 17330941] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180, MASS SPECTROMETRY. Tissue: Plasma.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

V00798 mRNA. Translation: CAA24178.1.

IPI

IPI00420972.

PIR

G2MSA. A02152.

UniGene

Mm.342177
Mm.436014

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EHL	X-ray	2.40	H	1-99	[»]
1GGI	X-ray	2.80	H/J	1-107	[»]
1KEG	X-ray	2.40	H	1-100	[»]
1KN2	X-ray	1.90	H	1-99	[»]
1KN4	X-ray	1.90	H	1-99	[»]
1MH5	X-ray	2.10	B/H	1-111	[»]
1MNU	X-ray	2.50	H	1-104	[»]
1MPA	X-ray	2.60	H	1-104	[»]
1OB1	X-ray	2.90	B/E	1-99	[»]
1PG7	X-ray	2.50	X/Z	1-100	[»]
1UYW	X-ray	2.00	H/M	1-100	[»]
1YEC	X-ray	1.90	H	1-99	[»]
1YEF	X-ray	2.00	H	1-99	[»]
1YEG	X-ray	2.00	H	1-99	[»]
1YEH	X-ray	2.55	H	1-99	[»]
1YEI	X-ray	1.90	H	1-99	[»]
1YEJ	X-ray	1.85	H	1-99	[»]
1YEK	X-ray	2.10	H	1-99	[»]
2IPU	X-ray	1.65	G/H	1-103	[»]
2MPA	X-ray	2.60	H	1-104	[»]
2R0W	X-ray	2.50	H	1-100	[»]
2R0Z	X-ray	2.10	H	1-100	[»]
2R29	X-ray	3.00	H	1-100	[»]
2R69	X-ray	3.80	H	1-100	[»]
2R6P	electron microscopy	24.00	D/F	1-100	[»]
2VL5	X-ray	2.10	A/C	1-99	[»]
2ZCH	X-ray	2.83	H	1-107	[»]
2ZCK	X-ray	3.10	H	1-107	[»]
2ZCL	X-ray	3.25	H	1-107	[»]
3BGF	X-ray	3.00	B/H	1-99	[»]

SMR

P01863. Positions 1-326.

ModBase

Search...

Protein family/group databases

IMGT

Search...

Proteomic databases

PRIDE

P01863.

Organism-specific databases

MGI

MGI:2144967. Ighg.

Phylogenomic databases

HOVERGEN

P01863.

Gene expression databases

Genevestigator

P01863.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

Pfam

PF07654. C1-set. 3 hits.
[Graphical view]

SMART

SM00407. IGc1. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

SOURCE

Search...

Entry information

Entry name

GCAA_MOUSE

Accession

Primary (citable) accession number: P01863

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	October 13, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)