Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01861

- IGHG4_HUMAN

UniProt

P01861 - IGHG4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ig gamma-4 chain C region

Gene

IGHG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB-KW

GO - Biological processi

  1. complement activation Source: Reactome
  2. complement activation, classical pathway Source: Reactome
  3. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  4. innate immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160274. FCGR activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-4 chain C region
Gene namesi
Name:IGHG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:5528. IGHG4.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProt
  4. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 327›327Ig gamma-4 chain C regionPRO_0000153581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi14 – 14Interchain (with a light chain)
Disulfide bondi27 ↔ 83
Disulfide bondi106 – 106Interchain (with a heavy chain)
Disulfide bondi109 – 109Interchain (with a heavy chain)
Disulfide bondi141 ↔ 201
Glycosylationi177 – 1771N-linked (GlcNAc...) (complex)2 Publications
Disulfide bondi247 ↔ 305

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01861.
PRIDEiP01861.

Expressioni

Gene expression databases

BgeeiP01861.
GenevestigatoriP01861.

Interactioni

Protein-protein interaction databases

MINTiMINT-1179376.
STRINGi9606.ENSP00000374985.

Structurei

Secondary structure

1
327
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi119 – 1235
Helixi127 – 1315
Beta strandi138 – 1469
Beta strandi148 – 1503
Beta strandi153 – 1597
Beta strandi162 – 1643
Turni165 – 1673
Beta strandi173 – 1753
Turni176 – 1783
Beta strandi179 – 1879
Helixi190 – 1945
Beta strandi199 – 2057
Beta strandi208 – 2103
Beta strandi211 – 2166
Beta strandi227 – 2315
Helixi235 – 2395
Beta strandi240 – 25516
Beta strandi258 – 2636
Beta strandi271 – 2733
Beta strandi284 – 29310
Helixi294 – 2985
Beta strandi303 – 3086
Helixi313 – 3153
Beta strandi316 – 3216

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ADQX-ray3.15A118-323[»]
1BBJX-ray3.10B/H1-98[»]
2FL5X-ray3.00B/D/F/H1-99[»]
4B53X-ray1.80A/B223-327[»]
4C54X-ray1.90A/B114-327[»]
4C55X-ray2.35A/B110-327[»]
4D2NX-ray2.70A/B/C/D102-327[»]
ProteinModelPortaliP01861.
SMRiP01861. Positions 1-327.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01861.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9898CH1Add
BLAST
Regioni99 – 11012HingeAdd
BLAST
Regioni111 – 220110CH2Add
BLAST
Regioni221 – 327107CH3Add
BLAST

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiNOG115036.
GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01861.
OMAiFSWFVDD.
PhylomeDBiP01861.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01861-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES
110 120 130 140 150
KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED
160 170 180 190 200
PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK
210 220 230 240 250
CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK
260 270 280 290 300
GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
310 320
NVFSCSVMHE ALHNHYTQKS LSLSLGK
Length:327
Mass (Da):35,941
Last modified:July 21, 1986 - v1
Checksum:i3EDBD811EF208E7A
GO

Sequence cautioni

The sequence AAB59394.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA90933. G4HU.
UniGeneiHs.510635.

Genome annotation databases

EnsembliENST00000390543; ENSP00000374985; ENSG00000211892.

Polymorphism databases

DMDMi121047.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
K01316 Genomic DNA. Translation: AAB59394.1 . Different initiation.
AL928742 Genomic DNA. No translation available.
PIRi A90933. G4HU.
UniGenei Hs.510635.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ADQ X-ray 3.15 A 118-323 [» ]
1BBJ X-ray 3.10 B/H 1-98 [» ]
2FL5 X-ray 3.00 B/D/F/H 1-99 [» ]
4B53 X-ray 1.80 A/B 223-327 [» ]
4C54 X-ray 1.90 A/B 114-327 [» ]
4C55 X-ray 2.35 A/B 110-327 [» ]
4D2N X-ray 2.70 A/B/C/D 102-327 [» ]
ProteinModelPortali P01861.
SMRi P01861. Positions 1-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1179376.
STRINGi 9606.ENSP00000374985.

Protein family/group databases

IMGTi Search...
Search...

Polymorphism databases

DMDMi 121047.

Proteomic databases

PaxDbi P01861.
PRIDEi P01861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000390543 ; ENSP00000374985 ; ENSG00000211892 .

Organism-specific databases

GeneCardsi GC14M106090.
HGNCi HGNC:5528. IGHG4.
MIMi 147130. gene.
neXtProti NX_P01861.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115036.
GeneTreei ENSGT00530000063726.
HOVERGENi HBG005814.
InParanoidi P01861.
OMAi FSWFVDD.
PhylomeDBi P01861.
TreeFami TF334176.

Enzyme and pathway databases

Reactomei REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160274. FCGR activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

EvolutionaryTracei P01861.
PROi P01861.
SOURCEi Search...

Gene expression databases

Bgeei P01861.
Genevestigatori P01861.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 3 hits.
[Graphical view ]
SMARTi SM00407. IGc1. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a human immunoglobulin C gamma 4 gene."
    Ellison J.W., Buxbaum J.N., Hood L.E.
    DNA 1:11-18(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain."
    Pink J.R.L., Buttery S.H., de Vries G.M., Milstein C.
    Biochem. J. 117:33-47(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-30 AND 81-326.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-177.
    Tissue: Liver.
  5. Cited for: GLYCOSYLATION AT ASN-177.

Entry informationi

Entry nameiIGHG4_HUMAN
AccessioniPrimary (citable) accession number: P01861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3