P01861 (IGHG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig gamma-4 chain C region

Gene names

Name:

IGHG4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Sequence caution	The sequence AAB59394.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Immunoglobulin C region Immunoglobulin domain
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 327

›327

Ig gamma-4 chain C region

PRO_0000153581

Regions

Region

1 – 98

98

CH1

Region

99 – 110

12

Hinge

Region

111 – 220

110

CH2

Region

221 – 327

107

CH3

Amino acid modifications

Glycosylation

177

1

N-linked (GlcNAc...) Ref.4

Disulfide bond

14

Interchain (with a light chain)

Disulfide bond

27 ↔ 83

Disulfide bond

106

Interchain (with a heavy chain)

Disulfide bond

109

Interchain (with a heavy chain)

Disulfide bond

141 ↔ 201

Disulfide bond

247 ↔ 305

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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327

Helix Strand Turn

Details...

Beta strand

7 – 11

5

Beta strand

14 – 16

3

Beta strand

18 – 21

4

Beta strand

23 – 35

13

Beta strand

38 – 41

4

Helix

42 – 44

3

Beta strand

50 – 52

3

Beta strand

63 – 71

9

Helix

73 – 75

3

Beta strand

81 – 87

7

Helix

88 – 90

3

Beta strand

92 – 98

7

Beta strand

119 – 123

5

Helix

127 – 131

5

Beta strand

138 – 144

7

Beta strand

148 – 150

3

Turn

165 – 167

3

Beta strand

184 – 187

4

Helix

190 – 194

5

Beta strand

199 – 203

5

Beta strand

208 – 210

3

Beta strand

212 – 216

5

Beta strand

227 – 231

5

Helix

235 – 239

5

Beta strand

240 – 255

16

Beta strand

258 – 263

6

Beta strand

271 – 273

3

Beta strand

284 – 293

10

Helix

294 – 298

5

Beta strand

303 – 308

6

Helix

313 – 315

3

Beta strand

316 – 321

6

Sequences

	Sequence		Length	Mass (Da)
	P01861 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 3EDBD811EF208E7A	FASTA	327	35,941
	10 20 30 40 50 60 ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 70 80 90 100 110 120 GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV 130 140 150 160 170 180 FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY 190 200 210 220 230 240 RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK 250 260 270 280 290 300 NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG 310 320 NVFSCSVMHE ALHNHYTQKS LSLSLGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a human immunoglobulin C gamma 4 gene." Ellison J.W., Buxbaum J.N., Hood L.E. DNA 1:11-18(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain." Pink J.R.L., Buttery S.H., de Vries G.M., Milstein C. Biochem. J. 117:33-47(1970) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-30 AND 81-326.
[4]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-177, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.

IPI

IPI00930442.

PIR

G4HU. A90933.

UniGene

Hs.510635.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ADQ	X-ray	3.15	A	118-323	[»]
1BBJ	X-ray	3.10	B/H	1-98	[»]
2FL5	X-ray	3.00	B/D/F/H	1-99	[»]
4B53	X-ray	1.80	A/B	223-327	[»]

ProteinModelPortal

P01861.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-1179376.

STRING

9606.ENSP00000374985.

Protein family/group databases

IMGT

Search...
Search...

Polymorphism databases

DMDM

121047.

Proteomic databases

PaxDb

P01861.

PRIDE

P01861.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000390543; ENSP00000374985; ENSG00000211892.

Organism-specific databases

GeneCards

GC14M106090.

HGNC

HGNC:5528. IGHG4.

MIM

147130. gene.

neXtProt

NX_P01861.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG115036.

HOVERGEN

HBG005814.

OMA

KVDKKIG.

OrthoDB

EOG4RR6HW.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Bgee

P01861.

Genevestigator

P01861.

GermOnline

ENSG00000205402. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 3 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 3 hits.
[Graphical view]

SMART

SM00407. IGc1. 2 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01861.

SOURCE

Search...

Entry information

Entry name

IGHG4_HUMAN

Accession

Primary (citable) accession number: P01861

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.