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Protein

Immunoglobulin heavy constant gamma 4

Gene

IGHG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-6785807. Interleukin-4 and 13 signaling.
R-HSA-977606. Regulation of Complement cascade.

Protein family/group databases

IMGT/GENE-DBIGHG4.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 42 Publications
Alternative name(s):
Ig gamma-4 chain C regionCurated
Gene namesi
Name:IGHG42 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000211892.3.
HGNCiHGNC:5528. IGHG4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000211892.

Polymorphism and mutation databases

DMDMi121047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153581‹1 – 327Immunoglobulin heavy constant gamma 4Add BLAST›327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi141 ↔ 201PROSITE-ProRule annotation
Glycosylationi177N-linked (GlcNAc...) (complex) asparagine2 Publications1
Disulfide bondi247 ↔ 305PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01861.
PeptideAtlasiP01861.
PRIDEiP01861.

PTM databases

PhosphoSitePlusiP01861.
UniCarbKBiP01861.

Expressioni

Gene expression databases

BgeeiENSG00000211892.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01861. 2 interactors.
MINTiMINT-1179376.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 11Combined sources4
Beta strandi21 – 29Combined sources9
Beta strandi31 – 35Combined sources5
Turni42 – 44Combined sources3
Beta strandi48 – 52Combined sources5
Beta strandi67 – 72Combined sources6
Beta strandi83 – 87Combined sources5
Turni88 – 91Combined sources4
Beta strandi92 – 96Combined sources5
Beta strandi119 – 123Combined sources5
Helixi127 – 131Combined sources5
Beta strandi138 – 146Combined sources9
Beta strandi148 – 150Combined sources3
Beta strandi153 – 159Combined sources7
Beta strandi162 – 164Combined sources3
Beta strandi167 – 169Combined sources3
Beta strandi173 – 175Combined sources3
Turni176 – 178Combined sources3
Beta strandi179 – 187Combined sources9
Helixi190 – 194Combined sources5
Beta strandi199 – 205Combined sources7
Beta strandi208 – 210Combined sources3
Beta strandi211 – 216Combined sources6
Beta strandi227 – 231Combined sources5
Helixi235 – 239Combined sources5
Beta strandi240 – 255Combined sources16
Beta strandi258 – 263Combined sources6
Beta strandi266 – 268Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi284 – 293Combined sources10
Helixi294 – 298Combined sources5
Beta strandi303 – 308Combined sources6
Helixi313 – 315Combined sources3
Beta strandi316 – 321Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ADQX-ray3.15A118-323[»]
1BBJX-ray3.10B/H1-98[»]
2FL5X-ray3.00B/D/F/H1-99[»]
3EO1X-ray3.10B/E/H/K1-105[»]
4B53X-ray1.80A/B223-327[»]
4C54X-ray1.90A/B114-327[»]
4C55X-ray2.35A/B110-327[»]
4D2NX-ray2.70A/B/C/D102-327[»]
5LG1X-ray2.70A/B114-327[»]
ProteinModelPortaliP01861.
SMRiP01861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01861.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Domaini118 – 217Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini226 – 322Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 220CH2Add BLAST110
Regioni221 – 327CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01861.
OMAiCSVVHEG.
PhylomeDBiP01861.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P01861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES
110 120 130 140 150
KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED
160 170 180 190 200
PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK
210 220 230 240 250
CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK
260 270 280 290 300
GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
310 320
NVFSCSVMHE ALHNHYTQKS LSLSLGK
Length:327
Mass (Da):35,941
Last modified:July 21, 1986 - v1
Checksum:i3EDBD811EF208E7A
GO

Sequence cautioni

The sequence AAB59394 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG4*04.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA90933. G4HU.
UniGeneiHs.510635.

Genome annotation databases

EnsembliENST00000390543; ENSP00000374985; ENSG00000211892.
ENST00000618981; ENSP00000483393; ENSG00000277016.
UCSCiuc059gcs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGHG4_HUMAN
AccessioniPrimary (citable) accession number: P01861
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full-length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references