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P01861

- IGHG4_HUMAN

UniProt

P01861 - IGHG4_HUMAN

Protein

Ig gamma-4 chain C region

Gene

IGHG4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB-KW

    GO - Biological processi

    1. complement activation Source: Reactome
    2. complement activation, classical pathway Source: Reactome
    3. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    4. innate immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160274. FCGR activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig gamma-4 chain C region
    Gene namesi
    Name:IGHG4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:5528. IGHG4.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 327›327Ig gamma-4 chain C regionPRO_0000153581Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi14 – 14Interchain (with a light chain)
    Disulfide bondi27 ↔ 83
    Disulfide bondi106 – 106Interchain (with a heavy chain)
    Disulfide bondi109 – 109Interchain (with a heavy chain)
    Disulfide bondi141 ↔ 201
    Glycosylationi177 – 1771N-linked (GlcNAc...) (complex)2 Publications
    Disulfide bondi247 ↔ 305

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01861.
    PRIDEiP01861.

    Expressioni

    Gene expression databases

    BgeeiP01861.
    GenevestigatoriP01861.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1179376.
    STRINGi9606.ENSP00000374985.

    Structurei

    Secondary structure

    1
    327
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi119 – 1235
    Helixi127 – 1315
    Beta strandi138 – 1469
    Beta strandi148 – 1503
    Beta strandi153 – 1597
    Beta strandi162 – 1643
    Turni165 – 1673
    Beta strandi173 – 1753
    Turni176 – 1783
    Beta strandi179 – 1879
    Helixi190 – 1945
    Beta strandi199 – 2057
    Beta strandi208 – 2103
    Beta strandi211 – 2166
    Beta strandi227 – 2315
    Helixi235 – 2395
    Beta strandi240 – 25516
    Beta strandi258 – 2636
    Beta strandi271 – 2733
    Beta strandi284 – 29310
    Helixi294 – 2985
    Beta strandi303 – 3086
    Helixi313 – 3153
    Beta strandi316 – 3216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ADQX-ray3.15A118-323[»]
    1BBJX-ray3.10B/H1-98[»]
    2FL5X-ray3.00B/D/F/H1-99[»]
    4B53X-ray1.80A/B223-327[»]
    4C54X-ray1.90A/B114-327[»]
    4C55X-ray2.35A/B110-327[»]
    ProteinModelPortaliP01861.
    SMRiP01861. Positions 1-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01861.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9898CH1Add
    BLAST
    Regioni99 – 11012HingeAdd
    BLAST
    Regioni111 – 220110CH2Add
    BLAST
    Regioni221 – 327107CH3Add
    BLAST

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain

    Phylogenomic databases

    eggNOGiNOG115036.
    HOVERGENiHBG005814.
    OMAiFSWFVDD.
    PhylomeDBiP01861.
    TreeFamiTF334176.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 3 hits.
    [Graphical view]
    SMARTiSM00407. IGc1. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01861-1 [UniParc]FASTAAdd to Basket

    « Hide

    ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV    50
    HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES 100
    KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED 150
    PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK 200
    CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK 250
    GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG 300
    NVFSCSVMHE ALHNHYTQKS LSLSLGK 327
    Length:327
    Mass (Da):35,941
    Last modified:July 21, 1986 - v1
    Checksum:i3EDBD811EF208E7A
    GO

    Sequence cautioni

    The sequence AAB59394.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
    AL928742 Genomic DNA. No translation available.
    PIRiA90933. G4HU.
    UniGeneiHs.510635.

    Genome annotation databases

    EnsembliENST00000390543; ENSP00000374985; ENSG00000211892.

    Polymorphism databases

    DMDMi121047.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01316 Genomic DNA. Translation: AAB59394.1 . Different initiation.
    AL928742 Genomic DNA. No translation available.
    PIRi A90933. G4HU.
    UniGenei Hs.510635.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ADQ X-ray 3.15 A 118-323 [» ]
    1BBJ X-ray 3.10 B/H 1-98 [» ]
    2FL5 X-ray 3.00 B/D/F/H 1-99 [» ]
    4B53 X-ray 1.80 A/B 223-327 [» ]
    4C54 X-ray 1.90 A/B 114-327 [» ]
    4C55 X-ray 2.35 A/B 110-327 [» ]
    ProteinModelPortali P01861.
    SMRi P01861. Positions 1-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1179376.
    STRINGi 9606.ENSP00000374985.

    Protein family/group databases

    IMGTi Search...
    Search...

    Polymorphism databases

    DMDMi 121047.

    Proteomic databases

    PaxDbi P01861.
    PRIDEi P01861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390543 ; ENSP00000374985 ; ENSG00000211892 .

    Organism-specific databases

    GeneCardsi GC14M106090.
    HGNCi HGNC:5528. IGHG4.
    MIMi 147130. gene.
    neXtProti NX_P01861.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG115036.
    HOVERGENi HBG005814.
    OMAi FSWFVDD.
    PhylomeDBi P01861.
    TreeFami TF334176.

    Enzyme and pathway databases

    Reactomei REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160274. FCGR activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Miscellaneous databases

    EvolutionaryTracei P01861.
    PROi P01861.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01861.
    Genevestigatori P01861.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 3 hits.
    [Graphical view ]
    SMARTi SM00407. IGc1. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS00290. IG_MHC. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a human immunoglobulin C gamma 4 gene."
      Ellison J.W., Buxbaum J.N., Hood L.E.
      DNA 1:11-18(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain."
      Pink J.R.L., Buttery S.H., de Vries G.M., Milstein C.
      Biochem. J. 117:33-47(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-30 AND 81-326.
    4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-177.
      Tissue: Liver.
    5. Cited for: GLYCOSYLATION AT ASN-177.

    Entry informationi

    Entry nameiIGHG4_HUMAN
    AccessioniPrimary (citable) accession number: P01861
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3