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Protein

Ig gamma-4 chain C region

Gene

IGHG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31555-MONOMER.
ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-4 chain C region
Gene namesi
Name:IGHG4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5528. IGHG4.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • immunoglobulin complex, circulating Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000211892.
ENSG00000277016.

Polymorphism and mutation databases

DMDMi121047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153581‹1 – 327Ig gamma-4 chain C regionAdd BLAST›327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi27 ↔ 83
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi141 ↔ 201
Glycosylationi177N-linked (GlcNAc...) (complex)2 Publications1
Disulfide bondi247 ↔ 305

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01861.
PeptideAtlasiP01861.
PRIDEiP01861.

PTM databases

PhosphoSitePlusiP01861.
UniCarbKBiP01861.

Expressioni

Gene expression databases

BgeeiENSG00000211892.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-1179376.

Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi119 – 123Combined sources5
Helixi127 – 131Combined sources5
Beta strandi138 – 146Combined sources9
Beta strandi148 – 150Combined sources3
Beta strandi153 – 159Combined sources7
Beta strandi162 – 164Combined sources3
Turni165 – 167Combined sources3
Beta strandi173 – 175Combined sources3
Turni176 – 178Combined sources3
Beta strandi179 – 187Combined sources9
Helixi190 – 194Combined sources5
Beta strandi199 – 205Combined sources7
Beta strandi208 – 210Combined sources3
Beta strandi211 – 216Combined sources6
Beta strandi227 – 231Combined sources5
Helixi235 – 239Combined sources5
Beta strandi240 – 255Combined sources16
Beta strandi258 – 263Combined sources6
Beta strandi266 – 268Combined sources3
Beta strandi271 – 273Combined sources3
Beta strandi284 – 293Combined sources10
Helixi294 – 298Combined sources5
Beta strandi303 – 308Combined sources6
Helixi313 – 315Combined sources3
Beta strandi316 – 321Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ADQX-ray3.15A118-323[»]
1BBJX-ray3.10B/H1-98[»]
2FL5X-ray3.00B/D/F/H1-99[»]
4B53X-ray1.80A/B223-327[»]
4C54X-ray1.90A/B114-327[»]
4C55X-ray2.35A/B110-327[»]
4D2NX-ray2.70A/B/C/D102-327[»]
ProteinModelPortaliP01861.
SMRiP01861.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01861.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 220CH2Add BLAST110
Regioni221 – 327CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01861.
OMAiMENQESK.
PhylomeDBiP01861.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES
110 120 130 140 150
KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED
160 170 180 190 200
PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK
210 220 230 240 250
CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK
260 270 280 290 300
GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
310 320
NVFSCSVMHE ALHNHYTQKS LSLSLGK
Length:327
Mass (Da):35,941
Last modified:July 21, 1986 - v1
Checksum:i3EDBD811EF208E7A
GO

Sequence cautioni

The sequence AAB59394 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA90933. G4HU.
UniGeneiHs.510635.

Genome annotation databases

EnsembliENST00000390543; ENSP00000374985; ENSG00000211892.
ENST00000618981; ENSP00000483393; ENSG00000277016.
UCSCiuc059gcs.1. human.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA90933. G4HU.
UniGeneiHs.510635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ADQX-ray3.15A118-323[»]
1BBJX-ray3.10B/H1-98[»]
2FL5X-ray3.00B/D/F/H1-99[»]
4B53X-ray1.80A/B223-327[»]
4C54X-ray1.90A/B114-327[»]
4C55X-ray2.35A/B110-327[»]
4D2NX-ray2.70A/B/C/D102-327[»]
ProteinModelPortaliP01861.
SMRiP01861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1179376.

Protein family/group databases

IMGTiSearch...
Search...

PTM databases

PhosphoSitePlusiP01861.
UniCarbKBiP01861.

Polymorphism and mutation databases

DMDMi121047.

Proteomic databases

MaxQBiP01861.
PeptideAtlasiP01861.
PRIDEiP01861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390543; ENSP00000374985; ENSG00000211892.
ENST00000618981; ENSP00000483393; ENSG00000277016.
UCSCiuc059gcs.1. human.

Organism-specific databases

GeneCardsiIGHG4.
HGNCiHGNC:5528. IGHG4.
MIMi147130. gene.
neXtProtiNX_P01861.
OpenTargetsiENSG00000211892.
ENSG00000277016.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01861.
OMAiMENQESK.
PhylomeDBiP01861.
TreeFamiTF334176.

Enzyme and pathway databases

BioCyciZFISH:G66-31555-MONOMER.
ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

EvolutionaryTraceiP01861.
PROiP01861.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211892.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG4_HUMAN
AccessioniPrimary (citable) accession number: P01861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.