Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01861 (IGHG4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-4 chain C region
Gene names
Name:IGHG4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Sequence caution

The sequence AAB59394.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 327›327Ig gamma-4 chain C region
PRO_0000153581

Regions

Region1 – 9898CH1
Region99 – 11012Hinge
Region111 – 220110CH2
Region221 – 327107CH3

Amino acid modifications

Glycosylation1771N-linked (GlcNAc...) (complex) Ref.4 Ref.5
Disulfide bond14Interchain (with a light chain)
Disulfide bond27 ↔ 83
Disulfide bond106Interchain (with a heavy chain)
Disulfide bond109Interchain (with a heavy chain)
Disulfide bond141 ↔ 201
Disulfide bond247 ↔ 305

Experimental info

Non-terminal residue11

Secondary structure

.......................................... 327
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01861 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 3EDBD811EF208E7A

FASTA32735,941
        10         20         30         40         50         60 
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 

        70         80         90        100        110        120 
GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV 

       130        140        150        160        170        180 
FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY 

       190        200        210        220        230        240 
RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK 

       250        260        270        280        290        300 
NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG 

       310        320 
NVFSCSVMHE ALHNHYTQKS LSLSLGK 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence of a human immunoglobulin C gamma 4 gene."
Ellison J.W., Buxbaum J.N., Hood L.E.
DNA 1:11-18(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain."
Pink J.R.L., Buttery S.H., de Vries G.M., Milstein C.
Biochem. J. 117:33-47(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-30 AND 81-326.
[4]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-177.
Tissue: Liver.
[5]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-177.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01316 Genomic DNA. Translation: AAB59394.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRG4HU. A90933.
UniGeneHs.510635.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ADQX-ray3.15A118-323[»]
1BBJX-ray3.10B/H1-98[»]
2FL5X-ray3.00B/D/F/H1-99[»]
4B53X-ray1.80A/B223-327[»]
4C54X-ray1.90A/B114-327[»]
4C55X-ray2.35A/B110-327[»]
ProteinModelPortalP01861.
SMRP01861. Positions 1-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1179376.
STRING9606.ENSP00000374985.

Protein family/group databases

IMGTSearch...
Search...

Polymorphism databases

DMDM121047.

Proteomic databases

PaxDbP01861.
PRIDEP01861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390543; ENSP00000374985; ENSG00000211892.
ENST00000605075; ENSP00000473843; ENSG00000270498.

Organism-specific databases

GeneCardsGC14M106090.
HGNCHGNC:5528. IGHG4.
MIM147130. gene.
neXtProtNX_P01861.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG115036.
HOVERGENHBG005814.
OMAFSWFVDD.
PhylomeDBP01861.
TreeFamTF334176.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP01861.
GenevestigatorP01861.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01861.
PROP01861.
SOURCESearch...

Entry information

Entry nameIGHG4_HUMAN
AccessionPrimary (citable) accession number: P01861
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM