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P01860 (IGHG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-3 chain C region
Alternative name(s):
HDC
Heavy chain disease protein
Gene names
Name:IGHG3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Homodimer. Ref.3

Subcellular location

Secreted.

Polymorphism

The IGHG3 gene shows a structural polymorphism characterized by different hinge lengths. Variant WIS is lacking most of the V region and all of the CH1 region. It has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region. Variant ZUC lacks most of the V region, all of the CH1 region, and part of the hinge. Variant OMM may represent an allelic form or another gamma chain subclass.

Miscellaneous

The hinge region in gamma-3 chains is about 4 times as long as in other gamma chains and contains 3 identical 15-residue segments preceded by a similar 17-residue segment (12-28).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Ig gamma-3 chain C region
PRO_0000153580

Regions

Repeat116 – 13015
Repeat131 – 14515
Repeat146 – 16015
Region1 – 9898CH1
Region99 – 16062Hinge
Region161 – 270110CH2
Region271 – 376106CH3

Amino acid modifications

Glycosylation2271N-linked (GlcNAc...) Ref.8 Ref.9
Glycosylation3221N-linked (GlcNAc...) Ref.8
Disulfide bond27 ↔ 83
Disulfide bond111Interchain (with heavy chain dimer)
Disulfide bond114Interchain (with heavy chain dimer)
Disulfide bond120Interchain (with heavy chain dimer)
Disulfide bond126Interchain (with heavy chain dimer)
Disulfide bond129Interchain (with heavy chain dimer)
Disulfide bond135Interchain (with heavy chain dimer)
Disulfide bond141Interchain (with heavy chain dimer)
Disulfide bond144Interchain (with heavy chain dimer)
Disulfide bond150Interchain (with heavy chain dimer)
Disulfide bond156Interchain (with heavy chain dimer)
Disulfide bond159Interchain (with heavy chain dimer)

Natural variations

Natural variant1 – 7676Missing in variant WIS.
VAR_068695
Natural variant77 – 9822GTQTY…VDKRV → QMQGVNCTVSS in variant WIS.
VAR_068696
Natural variant2131E → Q in variant WIS.
VAR_068697
Natural variant2141V → B in variant ZUC.
VAR_003890
Natural variant2211P → L in variant OMM.
VAR_003891
Natural variant2241E → Q in variant WIS.
VAR_068698
Natural variant2261Y → F in variant ZUC and WIS.
VAR_003892
Natural variant2421D → N in variant WIS.
VAR_068699
Natural variant2451N → D in variant WIS.
VAR_068700
Natural variant2691T → A in variant OMM.
VAR_003893
Natural variant3141S → N in variant OMM.
VAR_003894
Natural variant3141Missing in variant ZUC.
VAR_003895
Natural variant3661F → Y in variant OMM.
VAR_003896

Sequences

Sequence LengthMass (Da)Tools
P01860 [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: FEB7F537953F807F

FASTA37741,287
        10         20         30         40         50         60 
ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 

        70         80         90        100        110        120 
GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL KTPLGDTTHT CPRCPEPKSC 

       130        140        150        160        170        180 
DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC DTPPPCPRCP APELLGGPSV FLFPPKPKDT 

       190        200        210        220        230        240 
LMISRTPEVT CVVVDVSHED PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH 

       250        260        270        280        290        300 
QDWLNGKEYK CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK 

       310        320        330        340        350        360 
GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG NIFSCSVMHE 

       370 
ALHNRFTQKS LSLSPGK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma genes."
Huck S., Fort P., Crawford D.H., Lefranc M.-P., Lefranc G.
Nucleic Acids Res. 14:1779-1789(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis."
Frangione B., Rosenwasser E., Prelli F., Franklin E.C.
Biochemistry 19:4304-4308(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (VARIANT WIS), SUBUNIT.
[4]"Primary structure of the 'hinge' region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit."
Michaelsen T.E., Frangione B., Franklin E.C.
J. Biol. Chem. 252:883-889(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 146-376 (VARIANT WIS/VARIANT ZUC).
[5]"The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3."
Wolfenstein-Todel C., Frangione B., Prelli F., Franklin E.C.
Biochem. Biophys. Res. Commun. 71:907-914(1976) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 59-289 (VARIANT WIS/VARIANT ZUC).
[6]"Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model."
Alexander A., Steinmetz M., Barritault D., Frangione B., Franklin E.C., Hood L., Buxbaum J.N.
Proc. Natl. Acad. Sci. U.S.A. 79:3260-3264(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 99-377 (VARIANT OMM).
[7]"Structure of human immunoglobulin gamma genes: implications for evolution of a gene family."
Takahashi N., Ueda S., Obata M., Nikaido T., Nakai S., Honjo T.
Cell 29:671-679(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-59.
[8]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227 AND ASN-322.
Tissue: Plasma.
[9]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X03604 Genomic DNA. Translation: CAA27268.1.
AL122127 Genomic DNA. No translation available.
J00231 mRNA. Translation: AAA52805.1. Sequence problems.
PIRA23511.
G3HUWI. A90442.
UniGeneHs.510635.

3D structure databases

ProteinModelPortalP01860.
SMRP01860. Positions 1-377.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-1135282.
STRING9606.ENSP00000374992.

Protein family/group databases

IMGTSearch...
Search...
Search...

Polymorphism databases

DMDM193806361.

2D gel databases

UCD-2DPAGEP01860.

Proteomic databases

PaxDbP01860.
PRIDEP01860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC14M106231.
HGNCHGNC:5527. IGHG3.
MIM147120. gene.
neXtProtNX_P01860.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313034.
HOVERGENHBG005814.
PhylomeDBP01860.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorP01860.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROP01860.
SOURCESearch...

Entry information

Entry nameIGHG3_HUMAN
AccessionPrimary (citable) accession number: P01860
Secondary accession number(s): A2NU35
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 2008
Last modified: April 16, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM