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Protein

Immunoglobulin heavy constant gamma 3

Gene

IGHG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Caution

For an example of a full-length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-977606 Regulation of Complement cascade

Protein family/group databases

IMGT/GENE-DBIGHG3

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 32 Publications
Alternative name(s):
HDC
Heavy chain disease protein
Ig gamma-3 chain C regionCurated
Gene namesi
Name:IGHG32 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000211897.8
HGNCiHGNC:5527 IGHG3
MIMi147120 gene
neXtProtiNX_P01860

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3502

Polymorphism and mutation databases

DMDMi193806361

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001535801 – 377Immunoglobulin heavy constant gamma 3Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi111Interchain (with heavy chain dimer)
Disulfide bondi114Interchain (with heavy chain dimer)
Disulfide bondi120Interchain (with heavy chain dimer)
Disulfide bondi126Interchain (with heavy chain dimer)
Disulfide bondi129Interchain (with heavy chain dimer)
Disulfide bondi135Interchain (with heavy chain dimer)
Disulfide bondi141Interchain (with heavy chain dimer)
Disulfide bondi144Interchain (with heavy chain dimer)
Disulfide bondi150Interchain (with heavy chain dimer)
Disulfide bondi156Interchain (with heavy chain dimer)
Disulfide bondi159Interchain (with heavy chain dimer)
Disulfide bondi191 ↔ 251PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi297 ↔ 355PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01860
MaxQBiP01860
PeptideAtlasiP01860
PRIDEiP01860
ProteomicsDBi51496

2D gel databases

UCD-2DPAGEiP01860

PTM databases

iPTMnetiP01860
PhosphoSitePlusiP01860

Expressioni

Gene expression databases

BgeeiENSG00000211897

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01860, 4 interactors

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi169 – 173Combined sources5
Helixi177 – 181Combined sources5
Beta strandi188 – 196Combined sources9
Beta strandi204 – 209Combined sources6
Beta strandi212 – 214Combined sources3
Beta strandi230 – 237Combined sources8
Helixi240 – 244Combined sources5
Beta strandi249 – 254Combined sources6
Beta strandi258 – 260Combined sources3
Beta strandi262 – 266Combined sources5
Beta strandi277 – 281Combined sources5
Helixi285 – 289Combined sources5
Beta strandi290 – 305Combined sources16
Beta strandi308 – 313Combined sources6
Beta strandi316 – 318Combined sources3
Beta strandi319 – 323Combined sources5
Beta strandi334 – 343Combined sources10
Helixi344 – 348Combined sources5
Beta strandi353 – 358Combined sources6
Helixi363 – 365Combined sources3
Beta strandi366 – 371Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WWIX-ray2.31D/E/F168-377[»]
4ZNCX-ray2.28D/E/F168-377[»]
5M3VX-ray1.97A286-377[»]
5W38X-ray1.80A/B155-377[»]
ProteinModelPortaliP01860
SMRiP01860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Repeati116 – 130Add BLAST15
Repeati131 – 145Add BLAST15
Repeati146 – 160Add BLAST15
Domaini168 – 267Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini276 – 372Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 160HingeAdd BLAST62
Regioni161 – 270CH2Add BLAST110
Regioni271 – 376CH3Add BLAST106

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG005814
InParanoidiP01860
PhylomeDBiP01860

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 2 hits

Sequencei

Sequence statusi: Complete.

P01860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL
110 120 130 140 150
KTPLGDTTHT CPRCPEPKSC DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC
160 170 180 190 200
DTPPPCPRCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
210 220 230 240 250
PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH QDWLNGKEYK
260 270 280 290 300
CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK
310 320 330 340 350
GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG
360 370
NIFSCSVMHE ALHNRFTQKS LSLSPGK
Length:377
Mass (Da):41,287
Last modified:July 1, 2008 - v2
Checksum:iFEB7F537953F807F
GO

Sequence cautioni

The sequence AAA52805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG3*10.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0686951 – 76Missing in variant WIS. Add BLAST76
Natural variantiVAR_06869677 – 98GTQTY…VDKRV → QMQGVNCTVSS in variant WIS. Add BLAST22
Natural variantiVAR_068697213E → Q in variant WIS. 1
Natural variantiVAR_003891221P → L in variant OMM. 1
Natural variantiVAR_068698224E → Q in variant WIS. 1
Natural variantiVAR_003892226Y → F in variant ZUC and WIS. 1
Natural variantiVAR_068699242D → N in variant WIS. 1
Natural variantiVAR_068700245N → D in variant WIS. 1
Natural variantiVAR_003893269T → A in variant OMM. 1
Natural variantiVAR_003894314S → N in variant OMM. 1
Natural variantiVAR_003895314Missing in variant ZUC. 1
Natural variantiVAR_003896366F → Y in variant OMM. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03604 Genomic DNA Translation: CAA27268.1
AC244226 Genomic DNA No translation available.
AC246787 Genomic DNA No translation available.
AL122127 Genomic DNA No translation available.
J00231 mRNA Translation: AAA52805.1 Different initiation.
PIRiA23511
A90442 G3HUWI
UniGeneiHs.510635

Genome annotation databases

UCSCiuc059gdk.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGHG3_HUMAN
AccessioniPrimary (citable) accession number: P01860
Secondary accession number(s): A0A075B6N8, A2NU35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 2008
Last modified: June 20, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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