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Protein

Immunoglobulin heavy constant gamma 3

Gene

IGHG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Protein family/group databases

IMGT/GENE-DBIGHG3.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 32 Publications
Alternative name(s):
HDC
Heavy chain disease protein
Ig gamma-3 chain C regionCurated
Gene namesi
Name:IGHG32 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5527. IGHG3.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • immunoglobulin complex, circulating Source: GO_Central

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3502.

Polymorphism and mutation databases

DMDMi193806361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001535801 – 377Immunoglobulin heavy constant gamma 3Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi111Interchain (with heavy chain dimer)
Disulfide bondi114Interchain (with heavy chain dimer)
Disulfide bondi120Interchain (with heavy chain dimer)
Disulfide bondi126Interchain (with heavy chain dimer)
Disulfide bondi129Interchain (with heavy chain dimer)
Disulfide bondi135Interchain (with heavy chain dimer)
Disulfide bondi141Interchain (with heavy chain dimer)
Disulfide bondi144Interchain (with heavy chain dimer)
Disulfide bondi150Interchain (with heavy chain dimer)
Disulfide bondi156Interchain (with heavy chain dimer)
Disulfide bondi159Interchain (with heavy chain dimer)
Disulfide bondi191 ↔ 251PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi297 ↔ 355PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01860.
MaxQBiP01860.
PeptideAtlasiP01860.
PRIDEiP01860.

2D gel databases

UCD-2DPAGEiP01860.

PTM databases

iPTMnetiP01860.
PhosphoSitePlusiP01860.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01860. 4 interactors.
MINTiMINT-1135282.

Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi169 – 173Combined sources5
Helixi177 – 181Combined sources5
Beta strandi188 – 196Combined sources9
Beta strandi204 – 209Combined sources6
Beta strandi212 – 214Combined sources3
Beta strandi230 – 237Combined sources8
Helixi240 – 244Combined sources5
Beta strandi249 – 254Combined sources6
Beta strandi262 – 266Combined sources5
Beta strandi277 – 281Combined sources5
Helixi285 – 289Combined sources5
Beta strandi290 – 305Combined sources16
Beta strandi308 – 313Combined sources6
Beta strandi321 – 323Combined sources3
Beta strandi334 – 343Combined sources10
Helixi344 – 348Combined sources5
Beta strandi353 – 358Combined sources6
Helixi363 – 365Combined sources3
Beta strandi366 – 371Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WWIX-ray2.31D/E/F168-377[»]
4ZNCX-ray2.28D/E/F168-377[»]
ProteinModelPortaliP01860.
SMRiP01860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Repeati116 – 130Add BLAST15
Repeati131 – 145Add BLAST15
Repeati146 – 160Add BLAST15
Domaini168 – 267Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini276 – 372Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 160HingeAdd BLAST62
Regioni161 – 270CH2Add BLAST110
Regioni271 – 376CH3Add BLAST106

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01860.
PhylomeDBiP01860.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P01860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL
110 120 130 140 150
KTPLGDTTHT CPRCPEPKSC DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC
160 170 180 190 200
DTPPPCPRCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
210 220 230 240 250
PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH QDWLNGKEYK
260 270 280 290 300
CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK
310 320 330 340 350
GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG
360 370
NIFSCSVMHE ALHNRFTQKS LSLSPGK
Length:377
Mass (Da):41,287
Last modified:July 1, 2008 - v2
Checksum:iFEB7F537953F807F
GO

Sequence cautioni

The sequence AAA52805 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG3*10.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0686951 – 76Missing in variant WIS. Add BLAST76
Natural variantiVAR_06869677 – 98GTQTY…VDKRV → QMQGVNCTVSS in variant WIS. Add BLAST22
Natural variantiVAR_068697213E → Q in variant WIS. 1
Natural variantiVAR_003891221P → L in variant OMM. 1
Natural variantiVAR_068698224E → Q in variant WIS. 1
Natural variantiVAR_003892226Y → F in variant ZUC and WIS. 1
Natural variantiVAR_068699242D → N in variant WIS. 1
Natural variantiVAR_068700245N → D in variant WIS. 1
Natural variantiVAR_003893269T → A in variant OMM. 1
Natural variantiVAR_003894314S → N in variant OMM. 1
Natural variantiVAR_003895314Missing in variant ZUC. 1
Natural variantiVAR_003896366F → Y in variant OMM. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03604 Genomic DNA. Translation: CAA27268.1.
AC244226 Genomic DNA. No translation available.
AC246787 Genomic DNA. No translation available.
AL122127 Genomic DNA. No translation available.
J00231 mRNA. Translation: AAA52805.1. Different initiation.
PIRiA23511.
A90442. G3HUWI.
UniGeneiHs.510635.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03604 Genomic DNA. Translation: CAA27268.1.
AC244226 Genomic DNA. No translation available.
AC246787 Genomic DNA. No translation available.
AL122127 Genomic DNA. No translation available.
J00231 mRNA. Translation: AAA52805.1. Different initiation.
PIRiA23511.
A90442. G3HUWI.
UniGeneiHs.510635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WWIX-ray2.31D/E/F168-377[»]
4ZNCX-ray2.28D/E/F168-377[»]
ProteinModelPortaliP01860.
SMRiP01860.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01860. 4 interactors.
MINTiMINT-1135282.

Protein family/group databases

IMGT/GENE-DBIGHG3.

PTM databases

iPTMnetiP01860.
PhosphoSitePlusiP01860.

Polymorphism and mutation databases

DMDMi193806361.

2D gel databases

UCD-2DPAGEiP01860.

Proteomic databases

EPDiP01860.
MaxQBiP01860.
PeptideAtlasiP01860.
PRIDEiP01860.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi3502.
GeneCardsiIGHG3.
HGNCiHGNC:5527. IGHG3.
MIMi147120. gene.
neXtProtiNX_P01860.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG005814.
InParanoidiP01860.
PhylomeDBiP01860.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

PROiPR:P01860.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG3_HUMAN
AccessioniPrimary (citable) accession number: P01860
Secondary accession number(s): A0A075B6N8, A2NU35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 2008
Last modified: May 10, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.