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Protein

Immunoglobulin heavy constant gamma 2

Gene

IGHG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156At or near the complement-binding site1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-977606. Regulation of Complement cascade.

Protein family/group databases

IMGT/GENE-DBIGHG2.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 22 Publications
Alternative name(s):
Ig gamma-2 chain C regionCurated
Ig gamma-2 chain C region DOT1 Publication
Ig gamma-2 chain C region TIL1 Publication
Ig gamma-2 chain C region ZIE2 Publications
Gene namesi
Name:IGHG22 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5526. IGHG2.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • immunoglobulin complex, circulating Source: GO_Central

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3501.
MalaCardsiIGHG2.
OpenTargetsiENSG00000211893.
Orphaneti183675. Recurrent infections associated with rare immunoglobulin isotypes deficiency.

Chemistry databases

DrugBankiDB07329. 1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID.
DB08618. 3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER.
DB08323. 3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE.
DB08409. 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE.
DB08510. 5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE.
DB02854. Aetiocholanolone.
DB04688. ECGONINE METHYL ESTER.
DB08547. PROGESTERONE-11-ALPHA-OL-HEMISUCCINATE.

Polymorphism and mutation databases

DMDMi218512079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153579‹1 – 326Immunoglobulin heavy constant gamma 2Add BLAST›326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi102Interchain (with a heavy chain)
Disulfide bondi103Interchain (with a heavy chain)
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi140 ↔ 200PROSITE-ProRule annotation
Glycosylationi176N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi246 ↔ 304PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01859.
MaxQBiP01859.
PeptideAtlasiP01859.
PRIDEiP01859.

2D gel databases

UCD-2DPAGEiP01859.

PTM databases

iPTMnetiP01859.
PhosphoSitePlusiP01859.
UniCarbKBiP01859.

Expressioni

Gene expression databases

BgeeiENSG00000211893.
GenevisibleiP01859. HS.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Q281093EBI-1044662,EBI-8061363From Bos taurus.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01859. 4 interactors.
MINTiMINT-1782619.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi118 – 122Combined sources5
Helixi126 – 130Combined sources5
Beta strandi137 – 145Combined sources9
Beta strandi147 – 149Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi161 – 163Combined sources3
Beta strandi179 – 186Combined sources8
Helixi189 – 193Combined sources5
Beta strandi198 – 204Combined sources7
Beta strandi207 – 209Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi226 – 230Combined sources5
Helixi234 – 238Combined sources5
Beta strandi239 – 254Combined sources16
Beta strandi257 – 262Combined sources6
Beta strandi265 – 267Combined sources3
Beta strandi270 – 272Combined sources3
Beta strandi283 – 292Combined sources10
Helixi293 – 297Combined sources5
Beta strandi302 – 307Combined sources6
Helixi312 – 314Combined sources3
Beta strandi316 – 320Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QSCX-ray2.80H1-99[»]
4HAFX-ray2.04A/B104-326[»]
4HAGX-ray3.40A104-326[»]
4L4JX-ray1.92A/B106-326[»]
ProteinModelPortaliP01859.
SMRiP01859.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01859.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Domaini117 – 216Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini225 – 321Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 219CH2Add BLAST109
Regioni220 – 326CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01859.
OMAiYSATITF.
PhylomeDBiP01859.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.

Sequencei

Sequence statusi: Complete.

P01859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER
110 120 130 140 150
KCCVECPPCP APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP
160 170 180 190 200
EVQFNWYVDG VEVHNAKTKP REEQFNSTFR VVSVLTVVHQ DWLNGKEYKC
210 220 230 240 250
KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG
260 270 280 290 300
FYPSDISVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
310 320
VFSCSVMHEA LHNHYTQKSL SLSPGK
Length:326
Mass (Da):35,901
Last modified:December 16, 2008 - v2
Checksum:i95DC5D8C6860B7FC
GO

Sequence cautioni

The sequence AAB59393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG2*06.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00388960S → A2 Publications1
Natural variantiVAR_077892257S → A in IMGT allele IGHG2*01. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00230 Genomic DNA. Translation: AAB59393.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA93906. G2HU.
UniGeneiHs.510635.

Genome annotation databases

EnsembliENST00000390545; ENSP00000374987; ENSG00000211893.
ENST00000621803; ENSP00000480351; ENSG00000274497.
UCSCiuc059gct.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

IGHG2base

IGHG2 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00230 Genomic DNA. Translation: AAB59393.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA93906. G2HU.
UniGeneiHs.510635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QSCX-ray2.80H1-99[»]
4HAFX-ray2.04A/B104-326[»]
4HAGX-ray3.40A104-326[»]
4L4JX-ray1.92A/B106-326[»]
ProteinModelPortaliP01859.
SMRiP01859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01859. 4 interactors.
MINTiMINT-1782619.

Chemistry databases

DrugBankiDB07329. 1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID.
DB08618. 3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER.
DB08323. 3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE.
DB08409. 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE.
DB08510. 5-ALPHA-PREGNANE-3-BETA-OL-HEMISUCCINATE.
DB02854. Aetiocholanolone.
DB04688. ECGONINE METHYL ESTER.
DB08547. PROGESTERONE-11-ALPHA-OL-HEMISUCCINATE.

Protein family/group databases

IMGT/GENE-DBIGHG2.

PTM databases

iPTMnetiP01859.
PhosphoSitePlusiP01859.
UniCarbKBiP01859.

Polymorphism and mutation databases

DMDMi218512079.

2D gel databases

UCD-2DPAGEiP01859.

Proteomic databases

EPDiP01859.
MaxQBiP01859.
PeptideAtlasiP01859.
PRIDEiP01859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390545; ENSP00000374987; ENSG00000211893.
ENST00000621803; ENSP00000480351; ENSG00000274497.
UCSCiuc059gct.1. human.

Organism-specific databases

DisGeNETi3501.
GeneCardsiIGHG2.
HGNCiHGNC:5526. IGHG2.
MalaCardsiIGHG2.
MIMi147110. gene.
neXtProtiNX_P01859.
OpenTargetsiENSG00000211893.
Orphaneti183675. Recurrent infections associated with rare immunoglobulin isotypes deficiency.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01859.
OMAiYSATITF.
PhylomeDBiP01859.
TreeFamiTF334176.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-977606. Regulation of Complement cascade.

Miscellaneous databases

EvolutionaryTraceiP01859.
PROiPR:P01859.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211893.
GenevisibleiP01859. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 3 hits.
SMARTiView protein in SMART
SM00407. IGc1. 3 hits.
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG2_HUMAN
AccessioniPrimary (citable) accession number: P01859
Secondary accession number(s): A6NE66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.