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Protein

Ig gamma-2 chain C region

Gene

IGHG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156At or near the complement-binding site1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-33560-MONOMER.
ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2 chain C region
Gene namesi
Name:IGHG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5526. IGHG2.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • immunoglobulin complex, circulating Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3501.
OpenTargetsiENSG00000211893.
ENSG00000274497.
Orphaneti183675. Recurrent infections associated with rare immunoglobulin isotypes deficiency.

Polymorphism and mutation databases

DMDMi218512079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153579‹1 – 326Ig gamma-2 chain C regionAdd BLAST›326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation1 Publication
Disulfide bondi102Interchain (with a heavy chain)
Disulfide bondi103Interchain (with a heavy chain)
Disulfide bondi106Interchain (with a heavy chain)
Disulfide bondi109Interchain (with a heavy chain)
Disulfide bondi140 ↔ 200PROSITE-ProRule annotation1 Publication
Glycosylationi176N-linked (GlcNAc...) (complex)3 Publications1
Disulfide bondi246 ↔ 304PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP01859.
PeptideAtlasiP01859.
PRIDEiP01859.

2D gel databases

UCD-2DPAGEP01859.

PTM databases

iPTMnetiP01859.
PhosphoSitePlusiP01859.
UniCarbKBiP01859.

Expressioni

Gene expression databases

BgeeiENSG00000211893.
GenevisibleiP01859. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q281093EBI-1044662,EBI-8061363From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01859. 4 interactors.
MINTiMINT-1782619.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi118 – 122Combined sources5
Helixi126 – 130Combined sources5
Beta strandi137 – 145Combined sources9
Beta strandi147 – 149Combined sources3
Beta strandi152 – 158Combined sources7
Beta strandi161 – 163Combined sources3
Beta strandi179 – 186Combined sources8
Helixi189 – 193Combined sources5
Beta strandi198 – 204Combined sources7
Beta strandi207 – 209Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi226 – 230Combined sources5
Helixi234 – 238Combined sources5
Beta strandi239 – 254Combined sources16
Beta strandi257 – 262Combined sources6
Beta strandi265 – 267Combined sources3
Beta strandi270 – 272Combined sources3
Beta strandi283 – 292Combined sources10
Helixi293 – 297Combined sources5
Beta strandi302 – 307Combined sources6
Helixi312 – 314Combined sources3
Beta strandi316 – 320Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QSCX-ray2.80H1-99[»]
4HAFX-ray2.04A/B104-326[»]
4HAGX-ray3.40A104-326[»]
4L4JX-ray1.92A/B106-326[»]
ProteinModelPortaliP01859.
SMRiP01859.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01859.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 219CH2Add BLAST109
Regioni220 – 326CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01859.
OMAiVEWERNG.
PhylomeDBiP01859.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER
110 120 130 140 150
KCCVECPPCP APPVAGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP
160 170 180 190 200
EVQFNWYVDG VEVHNAKTKP REEQFNSTFR VVSVLTVVHQ DWLNGKEYKC
210 220 230 240 250
KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG
260 270 280 290 300
FYPSDISVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
310 320
VFSCSVMHEA LHNHYTQKSL SLSPGK
Length:326
Mass (Da):35,901
Last modified:December 16, 2008 - v2
Checksum:i95DC5D8C6860B7FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti109C → S (PubMed:6811139).Curated1
Sequence conflicti257S → A in AAB59393 (PubMed:6804948).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00388960S → A in myeloma proteins TIL and ZIE. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928742 Genomic DNA. No translation available.
J00230 Genomic DNA. Translation: AAB59393.1.
PIRiA93906. G2HU.
UniGeneiHs.510635.

Genome annotation databases

EnsembliENST00000390545; ENSP00000374987; ENSG00000211893.
ENST00000621803; ENSP00000480351; ENSG00000274497.
UCSCiuc059gct.1. human.

Cross-referencesi

Web resourcesi

IGHG2base

IGHG2 mutation db

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928742 Genomic DNA. No translation available.
J00230 Genomic DNA. Translation: AAB59393.1.
PIRiA93906. G2HU.
UniGeneiHs.510635.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QSCX-ray2.80H1-99[»]
4HAFX-ray2.04A/B104-326[»]
4HAGX-ray3.40A104-326[»]
4L4JX-ray1.92A/B106-326[»]
ProteinModelPortaliP01859.
SMRiP01859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01859. 4 interactors.
MINTiMINT-1782619.

Protein family/group databases

IMGTiSearch...
Search...

PTM databases

iPTMnetiP01859.
PhosphoSitePlusiP01859.
UniCarbKBiP01859.

Polymorphism and mutation databases

DMDMi218512079.

2D gel databases

UCD-2DPAGEP01859.

Proteomic databases

MaxQBiP01859.
PeptideAtlasiP01859.
PRIDEiP01859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390545; ENSP00000374987; ENSG00000211893.
ENST00000621803; ENSP00000480351; ENSG00000274497.
UCSCiuc059gct.1. human.

Organism-specific databases

DisGeNETi3501.
GeneCardsiIGHG2.
HGNCiHGNC:5526. IGHG2.
MIMi147110. gene.
neXtProtiNX_P01859.
OpenTargetsiENSG00000211893.
ENSG00000274497.
Orphaneti183675. Recurrent infections associated with rare immunoglobulin isotypes deficiency.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG005814.
InParanoidiP01859.
OMAiVEWERNG.
PhylomeDBiP01859.
TreeFamiTF334176.

Enzyme and pathway databases

BioCyciZFISH:G66-33560-MONOMER.
ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

EvolutionaryTraceiP01859.
PROiP01859.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211893.
GenevisibleiP01859. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 3 hits.
[Graphical view]
SMARTiSM00407. IGc1. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG2_HUMAN
AccessioniPrimary (citable) accession number: P01859
Secondary accession number(s): A6NE66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.