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P01857 (IGHG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig gamma-1 chain C region
Gene names
Name:IGHG1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted.

Involvement in disease

Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Miscellaneous

Nie has the G1M(17) allotypic marker, 97-K, and the G1M1 markers, 239-D and 241-L. KOL and EU sequences have the G1M3 marker and the G1M (non-1) markers.

Sequence caution

The sequence AAC82527.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityChromosomal rearrangement
   DomainImmunoglobulin C region
Immunoglobulin domain
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processimmune response

Non-traceable author statement. Source: UniProtKB

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane fraction

Non-traceable author statement. Source: UniProtKB

   Molecular functionantigen binding

Traceable author statement Ref.1. Source: UniProtKB

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

FCGR2BP3199431EBI-356114,EBI-724784

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 330›330Ig gamma-1 chain C region
PRO_0000153578

Regions

Region1 – 9898CH1
Region99 – 11012Hinge
Region111 – 223113CH2
Region224 – 330107CH3

Amino acid modifications

Glycosylation1801N-linked (GlcNAc...) Ref.8
Disulfide bond27 ↔ 83 Ref.5 Ref.6 Ref.7
Disulfide bond103Interchain (with light chain) Ref.5 Ref.6 Ref.7
Disulfide bond109Interchain (with heavy chain) Ref.5 Ref.6 Ref.7
Disulfide bond112Interchain (with heavy chain) Ref.5 Ref.6 Ref.7
Disulfide bond144 ↔ 204 Ref.5 Ref.6 Ref.7
Disulfide bond250 ↔ 308 Ref.5 Ref.6 Ref.7

Natural variations

Natural variant971K → R in G1M(3) marker.
VAR_003886
Natural variant2391D → E in G1M(non-1) marker.
VAR_003887
Natural variant2411L → M in G1M(non-1) marker.
VAR_003888

Experimental info

Non-terminal residue11

Secondary structure

1 .................................................... 330
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01857 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 3770EE106C2FA33D

FASTA33036,106
        10         20         30         40         50         60 
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS 

        70         80         90        100        110        120 
GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG 

       130        140        150        160        170        180 
PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN 

       190        200        210        220        230        240 
STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE 

       250        260        270        280        290        300 
LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW 

       310        320        330 
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a human immunoglobulin C gamma1 gene."
Ellison J.W., Berson B.J., Hood L.E.
Nucleic Acids Res. 10:4071-4079(1982) [PubMed: 6287432] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4."
Cunningham B.A., Rutishauser U., Gall W.E., Gottlieb P.D., Waxdal M.J., Edelman G.M.
Biochemistry 9:3161-3170(1970) [PubMed: 5489771] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-135 (MYELOMA PROTEIN EU).
[3]"The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7."
Rutishauser U., Cunningham B.A., Bennett C., Konigsberg W.H., Edelman G.M.
Biochemistry 9:3171-3181(1970) [PubMed: 5530842] [Abstract]
Cited for: PROTEIN SEQUENCE OF 136-329 (EU).
[4]"The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure."
Ponstingl H., Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 357:1571-1604(1976) [PubMed: 826475] [Abstract]
Cited for: PROTEIN SEQUENCE (MYELOMA PROTEIN NIE).
[5]"Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I."
Schmidt W.E., Jung H.-D., Palm W., Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 364:713-747(1983) [PubMed: 6884994] [Abstract]
Cited for: PROTEIN SEQUENCE (MYELOMA PROTEIN KOL), DISULFIDE BONDS.
[6]"The covalent structure of a human gamma G-immunoglobulin. X. Intrachain disulfide bonds."
Gall W.E., Edelman G.M.
Biochemistry 9:3188-3196(1970) [PubMed: 4923144] [Abstract]
Cited for: DISULFIDE BONDS.
[7]"Rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie), I: purification and characterization of the protein, the L- and H-chains, the cyanogen bromide cleavage products, and the disulfide bridges."
Dreker L., Schwarz J., Reichel W., Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 357:1515-1540(1976) [PubMed: 1002129] [Abstract]
Cited for: DISULFIDE BONDS.
[8]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180, MASS SPECTROMETRY.
Tissue: Liver.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution."
Deisenhofer J.
Biochemistry 20:2361-2370(1981) [PubMed: 7236608] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS).
[11]"Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma."
Bergsagel P.L., Chesi M., Nardini E., Brents L.A., Kirby S.L., Kuehl W.M.
Proc. Natl. Acad. Sci. U.S.A. 93:13931-13936(1996) [PubMed: 8943038] [Abstract]
Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
[12]"Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis."
Harrison C.J., Mazzullo H., Ross F.M., Cheung K.L., Gerrard G., Harewood L., Mehta A., Lachmann H.J., Hawkins P.N., Orchard K.H.
Br. J. Haematol. 117:427-435(2002) [PubMed: 11972529] [Abstract]
Cited for: INVOLVEMENT IN MULTIPLE MYELOMA.
+Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J00228 Genomic DNA. Translation: AAC82527.1. Different initiation.
IPIIPI00423463.
PIRGHHU. A93433.
UniGeneHs.510635.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AJ7X-ray2.10H1-103[»]
1AQKX-ray1.84H1-103[»]
1BEYX-ray3.25H1-98[»]
1D5BX-ray2.80B/H1-101[»]
1D5IX-ray2.00H1-101[»]
1D6VX-ray2.00H1-101[»]
1DFBX-ray2.70H1-103[»]
1DN2X-ray2.70A/B120-326[»]
1E4KX-ray3.20A/B106-330[»]
1FC1X-ray2.90A/B106-329[»]
1FC2X-ray2.80D106-329[»]
1FCCX-ray3.20A/B121-326[»]
1GAFX-ray1.95H1-103[»]
1H3TX-ray2.40A/B108-330[»]
1H3UX-ray2.40A/B108-330[»]
1H3VX-ray3.10A/B108-330[»]
1H3WX-ray2.85M108-330[»]
1H3YX-ray4.10A/B108-330[»]
1HKLX-ray2.68H1-103[»]
1HZHX-ray2.70H/K1-330[»]
1I7ZX-ray2.30B/D1-103[»]
1L6XX-ray1.65A120-326[»]
1OP3X-ray1.75H/M1-102[»]
1OQOX-ray2.30A/B119-330[»]
1OQXX-ray2.60A/B119-330[»]
1T83X-ray3.00A/B107-330[»]
1T89X-ray3.50A/B107-330[»]
1VGEX-ray2.00H1-103[»]
2DTSX-ray2.20A/B108-330[»]
2GJ7X-ray5.00A/B106-330[»]
2I5YX-ray2.20H1-101[»]
2IWGX-ray2.35A/D120-326[»]
2J6EX-ray3.00A/B99-330[»]
2JB5X-ray2.80H1-102[»]
2JB6X-ray2.85B/H1-102[»]
2O5XX-ray2.05H1-108[»]
2O5YX-ray2.85H1-108[»]
2O5ZX-ray2.40H1-108[»]
2OSLX-ray2.60A/H1-103[»]
2QADX-ray3.30D/H1-101[»]
2QL1X-ray2.53A106-330[»]
2QQKX-ray2.75H1-107[»]
2QQLX-ray3.10H1-107[»]
2QQNX-ray2.20H1-107[»]
2QR0X-ray3.50B/F/H/L/N/R/T/X1-103[»]
2R56X-ray2.80H/I1-100[»]
2RCSX-ray2.10H1-103[»]
2VXQX-ray1.90H1-100[»]
3AGVX-ray2.15A/B120-330[»]
3AVEX-ray2.00A/B108-330[»]
3AY4X-ray2.20A/B108-330[»]
3B2UX-ray2.58C/F/H/J/N/Q/T/W1-102[»]
3B2VX-ray3.30H1-102[»]
3BDYX-ray2.60H1-107[»]
3BE1X-ray2.90H1-107[»]
3BKYX-ray2.61H1-104[»]
3BN9X-ray2.17D/F1-107[»]
3BQUX-ray3.00B2-103[»]
3C08X-ray2.15H1-102[»]
3C09X-ray3.20C/H1-102[»]
3C2SX-ray2.30A106-330[»]
3CFJX-ray2.60B/D/F/H1-104[»]
3CFKX-ray2.60B/D/F/H/I/K/N/P1-104[»]
3CSYX-ray3.40A/C/E/G1-101[»]
3D0LX-ray2.35B2-105[»]
3D0VX-ray2.05B2-105[»]
3D6GX-ray2.30A/B119-328[»]
3D85X-ray1.90B1-108[»]
3DJ9X-ray1.75A119-225[»]
3DNKX-ray2.84A/B119-330[»]
3DO3X-ray2.50A/B119-330[»]
3DROX-ray3.90B2-103[»]
3DRQX-ray2.00B2-103[»]
3DVGX-ray2.60B1-107[»]
3DVNX-ray2.70B/H1-107[»]
3EYFX-ray2.30B/D1-108[»]
3EYOX-ray2.50B/D1-108[»]
3EYQX-ray2.40D1-108[»]
3RY6X-ray3.80A/B114-327[»]
3SGJX-ray2.20A/B106-330[»]
3SGKX-ray2.40A/B106-330[»]
3TV3X-ray1.29H1-104[»]
3TWCX-ray1.65H1-104[»]
3TYGX-ray3.25H1-104[»]
3U7WX-ray2.60H1-104[»]
3U7YX-ray2.45H1-104[»]
ProteinModelPortalP01857.
SMRP01857. Positions 1-330.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-29187N.
IntActP01857. 75 interactions.
MINTMINT-120799.
STRINGP01857.

Protein family/group databases

IMGTSearch...

PTM databases

PhosphoSiteP01857.

Polymorphism databases

DMDM121039.

2D gel databases

Cornea-2DPAGEP01857.
DOSAC-COBS-2DPAGEP01857.
REPRODUCTION-2DPAGEP01857.
UCD-2DPAGEP01857.

Proteomic databases

PRIDEP01857.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390549; ENSP00000374991; ENSG00000211896.
UCSCuc001yse.2. human.

Organism-specific databases

GeneCardsGC14M106204.
H-InvDBHIX0175858.
HGNCHGNC:5525. IGHG1.
MIM147100. gene.
254500. phenotype.
neXtProtNX_P01857.
Orphanet67038. Chronic B-cell lymphocytic leukemia.
85443. Primary amyloidosis.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG10023.
HOVERGENHBG005814.
OrthoDBEOG4RR6HW.

Enzyme and pathway databases

Pathway_Interaction_DBil4_2pathway. IL4-mediated signaling events.
ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP01857.
CleanExHS_IGHG1.
GenevestigatorP01857.
GermOnlineENSG00000130076. Homo sapiens.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PfamPF07654. C1-set. 3 hits.
[Graphical view]
SMARTSM00407. IGc1. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS00290. IG_MHC. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

DrugBankDB00051. Adalimumab.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00065. Infliximab.
DB00043. Omalizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.
SOURCESearch...

Entry information

Entry nameIGHG1_HUMAN
AccessionPrimary (citable) accession number: P01857
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 25, 2012
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents