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P01854

- IGHE_HUMAN

UniProt

P01854 - IGHE_HUMAN

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Protein

Ig epsilon chain C region

Gene

IGHE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. Fc-epsilon receptor signaling pathway Source: Reactome
  2. immune response Source: UniProtKB
  3. innate immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig epsilon chain C region
Gene namesi
Name:IGHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:5522. IGHE.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 428›428Ig epsilon chain C regionPRO_0000153574Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi14 – 14Interchain (with a light chain)
Disulfide bondi15 ↔ 105
Glycosylationi21 – 211N-linked (GlcNAc...)1 Publication
Disulfide bondi29 ↔ 85
Glycosylationi49 – 491N-linked (GlcNAc...)1 Publication
Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
Disulfide bondi121 – 121Interchain (with a heavy chain)
Disulfide bondi135 ↔ 193
Glycosylationi146 – 1461N-linked (GlcNAc...)
Disulfide bondi209 – 209Interchain (with a heavy chain)
Disulfide bondi239 ↔ 299
Glycosylationi252 – 2521N-linked (GlcNAc...)
Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
Disulfide bondi345 ↔ 405

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01854.
PRIDEiP01854.

PTM databases

PhosphoSiteiP01854.

Expressioni

Gene expression databases

BgeeiP01854.
GenevestigatoriP01854.

Interactioni

Protein-protein interaction databases

DIPiDIP-6167N.
STRINGi9606.ENSP00000374983.

Structurei

Secondary structure

1
428
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi115 – 1195
Beta strandi125 – 1273
Beta strandi129 – 14012
Beta strandi145 – 1517
Helixi158 – 1603
Beta strandi161 – 1688
Beta strandi171 – 18111
Helixi182 – 1865
Beta strandi191 – 1977
Beta strandi200 – 2067
Helixi214 – 2163
Beta strandi218 – 2214
Helixi226 – 2305
Beta strandi236 – 2449
Beta strandi252 – 2576
Beta strandi269 – 2724
Turni274 – 2763
Beta strandi278 – 2858
Helixi288 – 2925
Beta strandi297 – 3026
Beta strandi306 – 3083
Beta strandi310 – 3145
Beta strandi325 – 3306
Beta strandi335 – 3384
Beta strandi340 – 35314
Beta strandi356 – 3616
Helixi368 – 3703
Beta strandi371 – 3733
Beta strandi380 – 39314
Helixi394 – 3996
Beta strandi403 – 4086
Beta strandi410 – 4123
Turni413 – 4153
Beta strandi416 – 4227

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
ProteinModelPortaliP01854.
SMRiP01854. Positions 1-427.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 10398Ig-like 1Add
BLAST
Domaini112 – 21099Ig-like 2Add
BLAST
Domaini214 – 318105Ig-like 3Add
BLAST
Domaini324 – 423100Ig-like 4Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiNOG119039.
GeneTreeiENSGT00530000063726.
HOVERGENiHBG096066.
InParanoidiP01854.
OMAiFHSSCDP.
PhylomeDBiP01854.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 4 hits.
[Graphical view]
SMARTiSM00407. IGc1. 4 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01854-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG
60 70 80 90 100
TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK
110 120 130 140 150
TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL
160 170 180 190 200
EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH
210 220 230 240 250
TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT
260 270 280 290 300
VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR
310 320 330 340 350
VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF
360 370 380 390 400
MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK
410 420
DEFICRAVHE AASPSQTVQR AVSVNPGK
Length:428
Mass (Da):47,019
Last modified:July 21, 1986 - v1
Checksum:i25C4CA072AA558A0
GO

Sequence cautioni

The sequence AAB59424.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Polymorphismi

The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431W → C in allele IGHE*01.
VAR_044229
Natural varianti359 – 3591W → L Possible polymorphism. 1 Publication
VAR_003885

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1.
AL928742 Genomic DNA. No translation available.
PIRiA22771. EHHU.

Genome annotation databases

EnsembliENST00000390541; ENSP00000374983; ENSG00000211891.
UCSCiuc001yrw.1. human.

Polymorphism databases

DMDMi119512.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00022 Genomic DNA. Translation: AAB59424.1 . Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1 .
AL928742 Genomic DNA. No translation available.
PIRi A22771. EHHU.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1F6A X-ray 3.50 B/D 211-428 [» ]
1FP5 X-ray 2.30 A 211-428 [» ]
1G84 NMR - A 106-208 [» ]
1IGE model - A/B 107-428 [» ]
1O0V X-ray 2.60 A/B 104-427 [» ]
2WQR X-ray 1.90 A/B 105-427 [» ]
2Y7Q X-ray 3.40 B/D 104-428 [» ]
3H9Y X-ray 2.23 A/B/E 209-428 [» ]
3H9Z X-ray 2.45 A/B/C/D 209-428 [» ]
3HA0 X-ray 2.80 A/B/C/D/E/F 209-428 [» ]
4EZM X-ray 3.10 A/B/C/D/E/F 209-428 [» ]
4GKO X-ray 3.30 A/B/C/D/E/F 209-428 [» ]
4GRG X-ray 4.24 C/D 210-428 [» ]
4GT7 X-ray 2.61 A/B/C/D 210-426 [» ]
4J4P X-ray 2.91 A/B 105-427 [» ]
4KI1 X-ray 3.20 A/B/C/D 209-428 [» ]
ProteinModelPortali P01854.
SMRi P01854. Positions 1-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-6167N.
STRINGi 9606.ENSP00000374983.

Chemistry

ChEMBLi CHEMBL1834.
GuidetoPHARMACOLOGYi 2741.

Protein family/group databases

IMGTi Search...
Search...
Search...

PTM databases

PhosphoSitei P01854.

Polymorphism databases

DMDMi 119512.

Proteomic databases

PaxDbi P01854.
PRIDEi P01854.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000390541 ; ENSP00000374983 ; ENSG00000211891 .
UCSCi uc001yrw.1. human.

Organism-specific databases

GeneCardsi GC14M106066.
HGNCi HGNC:5522. IGHE.
MIMi 147180. gene.
neXtProti NX_P01854.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG119039.
GeneTreei ENSGT00530000063726.
HOVERGENi HBG096066.
InParanoidi P01854.
OMAi FHSSCDP.
PhylomeDBi P01854.
TreeFami TF334176.

Enzyme and pathway databases

Reactomei REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.

Miscellaneous databases

EvolutionaryTracei P01854.
PROi P01854.
SOURCEi Search...

Gene expression databases

Bgeei P01854.
Genevestigatori P01854.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 4 hits.
[Graphical view ]
SMARTi SM00407. IGc1. 4 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Duplication and deletion in the human immunoglobulin epsilon genes."
    Max E.E., Battey J., Ney R., Kirsch I.R., Leder P.
    Cell 29:691-699(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01), VARIANT LEU-359.
  2. "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes."
    Flanagan J.G., Rabbitts T.H.
    EMBO J. 1:655-660(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
  3. "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns."
    Ueda S., Nakai S., Nishida Y., Hisajima H., Honjo T.
    EMBO J. 1:1539-1544(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01).
  4. "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA."
    Seno M., Kurokawa T., Ono Y., Onda H., Sasada R., Igarashi K., Kikuchi M., Sugino Y., Nishida Y., Honjo T.
    Nucleic Acids Res. 11:719-726(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Bennich H.H., Johansson S.G.O., von Bahr-Lindstroem H.
    (In) Bach M.K. (eds.); Immediate hypersensitivity: modern concepts and developments, pp.1-36, Marcel Dekker, New York (1978)
    Cited for: PRELIMINARY PROTEIN SEQUENCE (MYELOMA PROTEIN ND).
  7. "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line."
    Kenten J.H., Molgaard H.V., Houghton M., Derbyshire R.B., Viney J., Bell L.O., Gould H.J.
    Proc. Natl. Acad. Sci. U.S.A. 79:6661-6665(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40; 68-114 AND 427-428.
  8. Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiIGHE_HUMAN
AccessioniPrimary (citable) accession number: P01854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3