P01854 (IGHE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig epsilon chain C region

Gene names

Name:

IGHE

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Polymorphism	The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.
Sequence similarities	Contains 4 Ig-like (immunoglobulin-like) domains.
Sequence caution	The sequence AAB59424.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin C region Immunoglobulin domain Repeat
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.4. Source: UniProtKB
Molecular_function	antigen binding Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 428

›428

Ig epsilon chain C region

PRO_0000153574

Regions

Domain

6 – 103

98

Ig-like 1

Domain

112 – 210

99

Ig-like 2

Domain

214 – 318

105

Ig-like 3

Domain

324 – 423

100

Ig-like 4

Amino acid modifications

Glycosylation

21

1

N-linked (GlcNAc...) Ref.2

Glycosylation

49

1

N-linked (GlcNAc...) Ref.2

Glycosylation

99

1

N-linked (GlcNAc...) Ref.2

Glycosylation

146

1

N-linked (GlcNAc...)

Glycosylation

252

1

N-linked (GlcNAc...)

Glycosylation

275

1

N-linked (GlcNAc...) Ref.2

Disulfide bond

14

Interchain (with a light chain)

Disulfide bond

15 ↔ 105

Disulfide bond

29 ↔ 85

Disulfide bond

121

Interchain (with a heavy chain)

Disulfide bond

135 ↔ 193

Disulfide bond

209

Interchain (with a heavy chain)

Disulfide bond

239 ↔ 299

Disulfide bond

345 ↔ 405

Natural variations

Natural variant

43

1

W → C in allele IGHE*01.

VAR_044229

Natural variant

359

1

W → L Possible polymorphism. Ref.1

VAR_003885

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

428

Helix Strand Turn

Details...

Beta strand

115 – 119

5

Beta strand

125 – 127

3

Beta strand

129 – 140

12

Beta strand

145 – 151

7

Helix

158 – 160

3

Beta strand

161 – 168

8

Beta strand

171 – 181

11

Helix

182 – 186

5

Beta strand

191 – 197

7

Beta strand

200 – 206

7

Helix

214 – 216

3

Beta strand

218 – 221

4

Helix

226 – 230

5

Beta strand

236 – 244

9

Beta strand

252 – 257

6

Beta strand

269 – 272

4

Turn

274 – 276

3

Beta strand

278 – 285

8

Helix

288 – 292

5

Beta strand

297 – 302

6

Beta strand

306 – 308

3

Beta strand

310 – 314

5

Beta strand

325 – 330

6

Beta strand

335 – 338

4

Beta strand

340 – 353

14

Beta strand

356 – 361

6

Helix

368 – 370

3

Beta strand

371 – 373

3

Beta strand

380 – 393

14

Helix

394 – 399

6

Beta strand

403 – 408

6

Beta strand

410 – 412

3

Turn

413 – 415

3

Beta strand

416 – 422

7

Sequences

	Sequence		Length	Mass (Da)
	P01854 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 25C4CA072AA558A0	FASTA	428	47,019
	10 20 30 40 50 60 ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG TTMTLPATTL 70 80 90 100 110 120 TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK TFSVCSRDFT PPTVKILQSS 130 140 150 160 170 180 CDGGGHFPPT IQLLCLVSGY TPGTINITWL EDGQVMDVDL STASTTQEGE LASTQSELTL 190 200 210 220 230 240 SQKHWLSDRT YTCQVTYQGH TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL 250 260 270 280 290 300 VVDLAPSKGT VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR 310 320 330 340 350 360 VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF MPEDISVQWL 370 380 390 400 410 420 HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK DEFICRAVHE AASPSQTVQR AVSVNPGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Duplication and deletion in the human immunoglobulin epsilon genes." Max E.E., Battey J., Ney R., Kirsch I.R., Leder P. Cell 29:691-699(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01), VARIANT LEU-359.
[2]	"The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes." Flanagan J.G., Rabbitts T.H. EMBO J. 1:655-660(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
[3]	"Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns." Ueda S., Nakai S., Nishida Y., Hisajima H., Honjo T. EMBO J. 1:1539-1544(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01).
[4]	"Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA." Seno M., Kurokawa T., Ono Y., Onda H., Sasada R., Igarashi K., Kikuchi M., Sugino Y., Nishida Y., Honjo T. Nucleic Acids Res. 11:719-726(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Bennich H.H., Johansson S.G.O., von Bahr-Lindstroem H. (In) Bach M.K. (eds.); Immediate hypersensitivity: modern concepts and developments, pp.1-36, Marcel Dekker, New York (1978) Cited for: PRELIMINARY PROTEIN SEQUENCE (MYELOMA PROTEIN ND).
[7]	"Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line." Kenten J.H., Molgaard H.V., Houghton M., Derbyshire R.B., Viney J., Bell L.O., Gould H.J. Proc. Natl. Acad. Sci. U.S.A. 79:6661-6665(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40; 68-114 AND 427-428.
[8]	"A model of the Fc of immunoglobulin E." Padlan E.A., Davies D.R. Mol. Immunol. 23:1063-1075(1986) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1.
AL928742 Genomic DNA. No translation available.

IPI

IPI00399005.

PIR

EHHU. A22771.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1F6A	X-ray	3.50	B/D	211-428	[»]
1FP5	X-ray	2.30	A	211-428	[»]
1G84	NMR	-	A	106-208	[»]
1IGE	model	-	A/B	107-428	[»]
1O0V	X-ray	2.60	A/B	106-427	[»]
2WQR	X-ray	1.90	A/B	105-427	[»]
2Y7Q	X-ray	3.40	B/D	106-428	[»]
3H9Y	X-ray	2.23	A/B/E	209-428	[»]
3H9Z	X-ray	2.45	A/B/C/D	209-428	[»]
3HA0	X-ray	2.80	A/B/C/D/E/F	209-428	[»]
4EZM	X-ray	3.10	A/B/C/D/E/F	209-428	[»]
4GRG	X-ray	4.24	C/D	210-428	[»]
4GT7	X-ray	2.61	A/B/C/D	210-426	[»]

ProteinModelPortal

P01854.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-6167N.

STRING

9606.ENSP00000374983.

Protein family/group databases

IMGT

Search...
Search...
Search...

PTM databases

PhosphoSite

P01854.

Polymorphism databases

DMDM

119512.

Proteomic databases

PaxDb

P01854.

PRIDE

P01854.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000390541; ENSP00000374983; ENSG00000211891.

UCSC

uc001yrw.1. human.

Organism-specific databases

GeneCards

GC14M106066.

HGNC

HGNC:5522. IGHE.

MIM

147180. gene.

neXtProt

NX_P01854.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG119039.

HOVERGEN

HBG096066.

OMA

KSPKITC.

OrthoDB

EOG4RXZ0H.

PhylomeDB

P01854.

Enzyme and pathway databases

Pathway_Interaction_DB

fcer1pathway. Fc-epsilon receptor I signaling in mast cells.
il4_2pathway. IL4-mediated signaling events.

Gene expression databases

Bgee

P01854.

Genevestigator

P01854.

GermOnline

ENSG00000177154. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 4 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 4 hits.
[Graphical view]

SMART

SM00407. IGc1. 4 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view]

ProtoNet

Search...

Other

ChEMBL

CHEMBL1834.

EvolutionaryTrace

P01854.

SOURCE

Search...

Entry information

Entry name

IGHE_HUMAN

Accession

Primary (citable) accession number: P01854

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.