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Protein

Ig epsilon chain C region

Gene

IGHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • immunoglobulin receptor binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177154-MONOMER.
ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig epsilon chain C region
Gene namesi
Name:IGHE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:5522. IGHE.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3497.
OpenTargetsiENSG00000211891.
ENSG00000276192.

Chemistry databases

ChEMBLiCHEMBL1834.
GuidetoPHARMACOLOGYi2741.

Polymorphism and mutation databases

DMDMi119512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153574‹1 – 428Ig epsilon chain C regionAdd BLAST›428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi15 ↔ 105
Glycosylationi21N-linked (GlcNAc...)1 Publication1
Disulfide bondi29 ↔ 85
Glycosylationi49N-linked (GlcNAc...)1 Publication1
Glycosylationi99N-linked (GlcNAc...)1 Publication1
Disulfide bondi121Interchain (with a heavy chain)
Disulfide bondi135 ↔ 193
Glycosylationi146N-linked (GlcNAc...)1
Disulfide bondi209Interchain (with a heavy chain)
Disulfide bondi239 ↔ 299
Glycosylationi252N-linked (GlcNAc...)1
Glycosylationi275N-linked (GlcNAc...)1 Publication1
Disulfide bondi345 ↔ 405

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01854.
PRIDEiP01854.

PTM databases

iPTMnetiP01854.
PhosphoSitePlusiP01854.
UniCarbKBiP01854.

Expressioni

Gene expression databases

BgeeiENSG00000211891.
GenevisibleiP01854. HS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6167N.

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 119Combined sources5
Beta strandi125 – 127Combined sources3
Beta strandi129 – 140Combined sources12
Beta strandi145 – 151Combined sources7
Helixi158 – 160Combined sources3
Beta strandi161 – 168Combined sources8
Beta strandi171 – 181Combined sources11
Helixi182 – 186Combined sources5
Beta strandi191 – 197Combined sources7
Beta strandi200 – 206Combined sources7
Helixi214 – 216Combined sources3
Beta strandi218 – 221Combined sources4
Helixi226 – 230Combined sources5
Beta strandi236 – 244Combined sources9
Beta strandi252 – 257Combined sources6
Beta strandi269 – 272Combined sources4
Turni274 – 276Combined sources3
Beta strandi278 – 285Combined sources8
Helixi288 – 292Combined sources5
Beta strandi297 – 302Combined sources6
Beta strandi306 – 308Combined sources3
Beta strandi310 – 314Combined sources5
Beta strandi325 – 330Combined sources6
Beta strandi335 – 338Combined sources4
Beta strandi340 – 353Combined sources14
Beta strandi356 – 361Combined sources6
Helixi368 – 370Combined sources3
Beta strandi371 – 373Combined sources3
Beta strandi380 – 393Combined sources14
Helixi394 – 399Combined sources6
Beta strandi403 – 408Combined sources6
Beta strandi410 – 412Combined sources3
Turni413 – 415Combined sources3
Beta strandi416 – 422Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
5ANMX-ray2.85E/F/G211-428[»]
5HYSX-ray2.50G/I/J/K209-428[»]
ProteinModelPortaliP01854.
SMRiP01854.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 103Ig-like 1Add BLAST98
Domaini112 – 210Ig-like 2Add BLAST99
Domaini214 – 318Ig-like 3Add BLAST105
Domaini324 – 423Ig-like 4Add BLAST100

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG096066.
InParanoidiP01854.
OMAiGTRDWIE.
PhylomeDBiP01854.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 4 hits.
[Graphical view]
SMARTiSM00407. IGc1. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG
60 70 80 90 100
TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK
110 120 130 140 150
TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL
160 170 180 190 200
EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH
210 220 230 240 250
TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT
260 270 280 290 300
VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR
310 320 330 340 350
VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF
360 370 380 390 400
MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK
410 420
DEFICRAVHE AASPSQTVQR AVSVNPGK
Length:428
Mass (Da):47,019
Last modified:July 21, 1986 - v1
Checksum:i25C4CA072AA558A0
GO

Sequence cautioni

The sequence AAB59424 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04422943W → C in allele IGHE*01. 1
Natural variantiVAR_003885359W → L Possible polymorphism. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1.
AL928742 Genomic DNA. No translation available.
PIRiA22771. EHHU.

Genome annotation databases

EnsembliENST00000390541; ENSP00000374983; ENSG00000211891.
ENST00000610670; ENSP00000481089; ENSG00000276192.
UCSCiuc059gcp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1.
AL928742 Genomic DNA. No translation available.
PIRiA22771. EHHU.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
5ANMX-ray2.85E/F/G211-428[»]
5HYSX-ray2.50G/I/J/K209-428[»]
ProteinModelPortaliP01854.
SMRiP01854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6167N.

Chemistry databases

ChEMBLiCHEMBL1834.
GuidetoPHARMACOLOGYi2741.

Protein family/group databases

IMGTiSearch...
Search...
Search...

PTM databases

iPTMnetiP01854.
PhosphoSitePlusiP01854.
UniCarbKBiP01854.

Polymorphism and mutation databases

DMDMi119512.

Proteomic databases

PeptideAtlasiP01854.
PRIDEiP01854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390541; ENSP00000374983; ENSG00000211891.
ENST00000610670; ENSP00000481089; ENSG00000276192.
UCSCiuc059gcp.1. human.

Organism-specific databases

DisGeNETi3497.
GeneCardsiIGHE.
HGNCiHGNC:5522. IGHE.
MIMi147180. gene.
neXtProtiNX_P01854.
OpenTargetsiENSG00000211891.
ENSG00000276192.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG096066.
InParanoidiP01854.
OMAiGTRDWIE.
PhylomeDBiP01854.
TreeFamiTF334176.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177154-MONOMER.
ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.

Miscellaneous databases

EvolutionaryTraceiP01854.
PROiP01854.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211891.
GenevisibleiP01854. HS.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 4 hits.
[Graphical view]
SMARTiSM00407. IGc1. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIGHE_HUMAN
AccessioniPrimary (citable) accession number: P01854
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.