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P01854

- IGHE_HUMAN

UniProt

P01854 - IGHE_HUMAN

Protein

Ig epsilon chain C region

Gene

IGHE

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB

    GO - Biological processi

    1. Fc-epsilon receptor signaling pathway Source: Reactome
    2. immune response Source: UniProtKB
    3. innate immune response Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig epsilon chain C region
    Gene namesi
    Name:IGHE
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:5522. IGHE.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 428›428Ig epsilon chain C regionPRO_0000153574Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi14 – 14Interchain (with a light chain)
    Disulfide bondi15 ↔ 105
    Glycosylationi21 – 211N-linked (GlcNAc...)1 Publication
    Disulfide bondi29 ↔ 85
    Glycosylationi49 – 491N-linked (GlcNAc...)1 Publication
    Glycosylationi99 – 991N-linked (GlcNAc...)1 Publication
    Disulfide bondi121 – 121Interchain (with a heavy chain)
    Disulfide bondi135 ↔ 193
    Glycosylationi146 – 1461N-linked (GlcNAc...)
    Disulfide bondi209 – 209Interchain (with a heavy chain)
    Disulfide bondi239 ↔ 299
    Glycosylationi252 – 2521N-linked (GlcNAc...)
    Glycosylationi275 – 2751N-linked (GlcNAc...)1 Publication
    Disulfide bondi345 ↔ 405

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01854.
    PRIDEiP01854.

    PTM databases

    PhosphoSiteiP01854.

    Expressioni

    Gene expression databases

    BgeeiP01854.
    GenevestigatoriP01854.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-6167N.
    STRINGi9606.ENSP00000374983.

    Structurei

    Secondary structure

    1
    428
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi115 – 1195
    Beta strandi125 – 1273
    Beta strandi129 – 14012
    Beta strandi145 – 1517
    Helixi158 – 1603
    Beta strandi161 – 1688
    Beta strandi171 – 18111
    Helixi182 – 1865
    Beta strandi191 – 1977
    Beta strandi200 – 2067
    Helixi214 – 2163
    Beta strandi218 – 2214
    Helixi226 – 2305
    Beta strandi236 – 2449
    Beta strandi252 – 2576
    Beta strandi269 – 2724
    Turni274 – 2763
    Beta strandi278 – 2858
    Helixi288 – 2925
    Beta strandi297 – 3026
    Beta strandi306 – 3083
    Beta strandi310 – 3145
    Beta strandi325 – 3306
    Beta strandi335 – 3384
    Beta strandi340 – 35314
    Beta strandi356 – 3616
    Helixi368 – 3703
    Beta strandi371 – 3733
    Beta strandi380 – 39314
    Helixi394 – 3996
    Beta strandi403 – 4086
    Beta strandi410 – 4123
    Turni413 – 4153
    Beta strandi416 – 4227

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1F6AX-ray3.50B/D211-428[»]
    1FP5X-ray2.30A211-428[»]
    1G84NMR-A106-208[»]
    1IGEmodel-A/B107-428[»]
    1O0VX-ray2.60A/B104-427[»]
    2WQRX-ray1.90A/B105-427[»]
    2Y7QX-ray3.40B/D104-428[»]
    3H9YX-ray2.23A/B/E209-428[»]
    3H9ZX-ray2.45A/B/C/D209-428[»]
    3HA0X-ray2.80A/B/C/D/E/F209-428[»]
    4EZMX-ray3.10A/B/C/D/E/F209-428[»]
    4GKOX-ray3.30A/B/C/D/E/F209-428[»]
    4GRGX-ray4.24C/D210-428[»]
    4GT7X-ray2.61A/B/C/D210-426[»]
    4J4PX-ray2.91A/B105-427[»]
    4KI1X-ray3.20A/B/C/D209-428[»]
    ProteinModelPortaliP01854.
    SMRiP01854. Positions 1-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01854.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 10398Ig-like 1Add
    BLAST
    Domaini112 – 21099Ig-like 2Add
    BLAST
    Domaini214 – 318105Ig-like 3Add
    BLAST
    Domaini324 – 423100Ig-like 4Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain, Repeat

    Phylogenomic databases

    eggNOGiNOG119039.
    HOVERGENiHBG096066.
    OMAiFHSSCDP.
    PhylomeDBiP01854.
    TreeFamiTF334176.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 4 hits.
    [Graphical view]
    SMARTiSM00407. IGc1. 4 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    PS00290. IG_MHC. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01854-1 [UniParc]FASTAAdd to Basket

    « Hide

    ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG    50
    TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK 100
    TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL 150
    EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH 200
    TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT 250
    VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR 300
    VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF 350
    MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK 400
    DEFICRAVHE AASPSQTVQR AVSVNPGK 428
    Length:428
    Mass (Da):47,019
    Last modified:July 21, 1986 - v1
    Checksum:i25C4CA072AA558A0
    GO

    Sequence cautioni

    The sequence AAB59424.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Polymorphismi

    The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431W → C in allele IGHE*01.
    VAR_044229
    Natural varianti359 – 3591W → L Possible polymorphism. 1 Publication
    VAR_003885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
    J00222 Genomic DNA. Translation: AAB59395.1.
    AL928742 Genomic DNA. No translation available.
    PIRiA22771. EHHU.

    Genome annotation databases

    EnsembliENST00000390541; ENSP00000374983; ENSG00000211891.
    UCSCiuc001yrw.1. human.

    Polymorphism databases

    DMDMi119512.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00022 Genomic DNA. Translation: AAB59424.1 . Different initiation.
    J00222 Genomic DNA. Translation: AAB59395.1 .
    AL928742 Genomic DNA. No translation available.
    PIRi A22771. EHHU.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1F6A X-ray 3.50 B/D 211-428 [» ]
    1FP5 X-ray 2.30 A 211-428 [» ]
    1G84 NMR - A 106-208 [» ]
    1IGE model - A/B 107-428 [» ]
    1O0V X-ray 2.60 A/B 104-427 [» ]
    2WQR X-ray 1.90 A/B 105-427 [» ]
    2Y7Q X-ray 3.40 B/D 104-428 [» ]
    3H9Y X-ray 2.23 A/B/E 209-428 [» ]
    3H9Z X-ray 2.45 A/B/C/D 209-428 [» ]
    3HA0 X-ray 2.80 A/B/C/D/E/F 209-428 [» ]
    4EZM X-ray 3.10 A/B/C/D/E/F 209-428 [» ]
    4GKO X-ray 3.30 A/B/C/D/E/F 209-428 [» ]
    4GRG X-ray 4.24 C/D 210-428 [» ]
    4GT7 X-ray 2.61 A/B/C/D 210-426 [» ]
    4J4P X-ray 2.91 A/B 105-427 [» ]
    4KI1 X-ray 3.20 A/B/C/D 209-428 [» ]
    ProteinModelPortali P01854.
    SMRi P01854. Positions 1-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-6167N.
    STRINGi 9606.ENSP00000374983.

    Chemistry

    ChEMBLi CHEMBL1834.
    GuidetoPHARMACOLOGYi 2741.

    Protein family/group databases

    IMGTi Search...
    Search...
    Search...

    PTM databases

    PhosphoSitei P01854.

    Polymorphism databases

    DMDMi 119512.

    Proteomic databases

    PaxDbi P01854.
    PRIDEi P01854.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000390541 ; ENSP00000374983 ; ENSG00000211891 .
    UCSCi uc001yrw.1. human.

    Organism-specific databases

    GeneCardsi GC14M106066.
    HGNCi HGNC:5522. IGHE.
    MIMi 147180. gene.
    neXtProti NX_P01854.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119039.
    HOVERGENi HBG096066.
    OMAi FHSSCDP.
    PhylomeDBi P01854.
    TreeFami TF334176.

    Enzyme and pathway databases

    Reactomei REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.

    Miscellaneous databases

    EvolutionaryTracei P01854.
    PROi P01854.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01854.
    Genevestigatori P01854.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 4 hits.
    [Graphical view ]
    SMARTi SM00407. IGc1. 4 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    PS00290. IG_MHC. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Duplication and deletion in the human immunoglobulin epsilon genes."
      Max E.E., Battey J., Ney R., Kirsch I.R., Leder P.
      Cell 29:691-699(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01), VARIANT LEU-359.
    2. "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes."
      Flanagan J.G., Rabbitts T.H.
      EMBO J. 1:655-660(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
    3. "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns."
      Ueda S., Nakai S., Nishida Y., Hisajima H., Honjo T.
      EMBO J. 1:1539-1544(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01).
    4. "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA."
      Seno M., Kurokawa T., Ono Y., Onda H., Sasada R., Igarashi K., Kikuchi M., Sugino Y., Nishida Y., Honjo T.
      Nucleic Acids Res. 11:719-726(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Bennich H.H., Johansson S.G.O., von Bahr-Lindstroem H.
      (In) Bach M.K. (eds.); Immediate hypersensitivity: modern concepts and developments, pp.1-36, Marcel Dekker, New York (1978)
      Cited for: PRELIMINARY PROTEIN SEQUENCE (MYELOMA PROTEIN ND).
    7. "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line."
      Kenten J.H., Molgaard H.V., Houghton M., Derbyshire R.B., Viney J., Bell L.O., Gould H.J.
      Proc. Natl. Acad. Sci. U.S.A. 79:6661-6665(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40; 68-114 AND 427-428.
    8. Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiIGHE_HUMAN
    AccessioniPrimary (citable) accession number: P01854
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3