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Protein

Immunoglobulin heavy constant epsilon

Gene

IGHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-6785807. Interleukin-4 and 13 signaling.

Protein family/group databases

IMGT/GENE-DBIGHE.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant epsilon2 Publications
Alternative name(s):
Ig epsilon chain C regionCurated
Ig epsilon chain C region ND1 Publication
Gene namesi
Name:IGHE2 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000211891.5.
HGNCiHGNC:5522. IGHE.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3497.
OpenTargetsiENSG00000211891.

Chemistry databases

ChEMBLiCHEMBL1834.
GuidetoPHARMACOLOGYi2741.

Polymorphism and mutation databases

DMDMi119512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153574‹1 – 428Immunoglobulin heavy constant epsilonAdd BLAST›428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi14Interchain (with a light chain)
Disulfide bondi15 ↔ 105
Glycosylationi21N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi29 ↔ 85PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi121Interchain (with a heavy chain)
Disulfide bondi135 ↔ 193PROSITE-ProRule annotation
Glycosylationi146N-linked (GlcNAc...) asparagine1
Disulfide bondi209Interchain (with a heavy chain)
Disulfide bondi239 ↔ 299PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagine1
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi345 ↔ 405PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01854.
PRIDEiP01854.

PTM databases

iPTMnetiP01854.
PhosphoSitePlusiP01854.
UniCarbKBiP01854.

Expressioni

Gene expression databases

BgeeiENSG00000211891.
GenevisibleiP01854. HS.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-6167N.

Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi115 – 119Combined sources5
Beta strandi125 – 127Combined sources3
Beta strandi129 – 140Combined sources12
Beta strandi145 – 151Combined sources7
Helixi158 – 160Combined sources3
Beta strandi161 – 168Combined sources8
Beta strandi171 – 181Combined sources11
Helixi182 – 186Combined sources5
Beta strandi191 – 197Combined sources7
Beta strandi200 – 206Combined sources7
Helixi214 – 216Combined sources3
Beta strandi218 – 221Combined sources4
Helixi226 – 230Combined sources5
Beta strandi236 – 244Combined sources9
Beta strandi252 – 257Combined sources6
Beta strandi269 – 272Combined sources4
Turni274 – 276Combined sources3
Beta strandi278 – 285Combined sources8
Helixi288 – 292Combined sources5
Beta strandi297 – 302Combined sources6
Beta strandi306 – 308Combined sources3
Beta strandi310 – 314Combined sources5
Beta strandi325 – 330Combined sources6
Beta strandi335 – 338Combined sources4
Beta strandi340 – 353Combined sources14
Beta strandi356 – 361Combined sources6
Helixi368 – 370Combined sources3
Beta strandi371 – 373Combined sources3
Beta strandi380 – 393Combined sources14
Helixi394 – 399Combined sources6
Beta strandi403 – 408Combined sources6
Beta strandi410 – 412Combined sources3
Turni413 – 415Combined sources3
Beta strandi416 – 422Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
5ANMX-ray2.85E/F/G211-428[»]
5HYSX-ray2.50G/I/J/K209-428[»]
5LGJX-ray2.60A108-426[»]
B108-427[»]
5LGKX-ray3.50A/B/C/D114-421[»]
ProteinModelPortaliP01854.
SMRiP01854.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 103Ig-like 1PROSITE-ProRule annotationAdd BLAST98
Domaini112 – 210Ig-like 2PROSITE-ProRule annotationAdd BLAST99
Domaini214 – 318Ig-like 3PROSITE-ProRule annotationAdd BLAST105
Domaini324 – 423Ig-like 4PROSITE-ProRule annotationAdd BLAST100

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

GeneTreeiENSGT00530000063726.
HOVERGENiHBG096066.
InParanoidiP01854.
OMAiPKITCLV.
PhylomeDBiP01854.
TreeFamiTF334176.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 4 hits.
SMARTiView protein in SMART
SM00407. IGc1. 4 hits.
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.

Sequencei

Sequence statusi: Complete.

P01854-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG
60 70 80 90 100
TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK
110 120 130 140 150
TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL
160 170 180 190 200
EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH
210 220 230 240 250
TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT
260 270 280 290 300
VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR
310 320 330 340 350
VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF
360 370 380 390 400
MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK
410 420
DEFICRAVHE AASPSQTVQR AVSVNPGK
Length:428
Mass (Da):47,019
Last modified:July 21, 1986 - v1
Checksum:i25C4CA072AA558A0
GO

Sequence cautioni

The sequence AAB59395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB59424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 5ASTQS → GAWTL AA sequence (Ref. 1) Curated5
Non-terminal residuei11
Sequence conflicti53 – 54Missing AA sequence (Ref. 1) Curated2
Sequence conflicti93 – 94Missing AA sequence (Ref. 1) Curated2
Sequence conflicti124G → L AA sequence (Ref. 1) Curated1
Sequence conflicti166 – 168TQE → ESQ AA sequence (Ref. 1) Curated3
Sequence conflicti175Q → E AA sequence (Ref. 1) Curated1
Sequence conflicti177E → Q AA sequence (Ref. 1) Curated1
Sequence conflicti203E → Q AA sequence (Ref. 1) Curated1
Sequence conflicti398 – 399EQ → QE AA sequence (Ref. 1) Curated2

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHE*04.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04422943W → C in IMGT allele IGHE*01. 1 Publication1
Natural variantiVAR_003885359W → L Possible polymorphism. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1. Different initiation.
AL928742 Genomic DNA. No translation available.
PIRiA22771. EHHU.

Genome annotation databases

EnsembliENST00000390541; ENSP00000374983; ENSG00000211891.
ENST00000610670; ENSP00000481089; ENSG00000276192.
UCSCiuc059gcp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIGHE_HUMAN
AccessioniPrimary (citable) accession number: P01854
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full-length immunoglobulin epsilon heavy chain see AC P0DOX4.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references