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P01854 (IGHE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 134. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig epsilon chain C region
Gene names
Name:IGHE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length428 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Polymorphism

The following alleles of IGHE are known: IGHE*01 and IGHE*02. The sequence shown is that of allele 02.

Sequence similarities

Contains 4 Ig-like (immunoglobulin-like) domains.

Sequence caution

The sequence AAB59424.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 428›428Ig epsilon chain C region
PRO_0000153574

Regions

Domain6 – 10398Ig-like 1
Domain112 – 21099Ig-like 2
Domain214 – 318105Ig-like 3
Domain324 – 423100Ig-like 4

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Ref.2
Glycosylation491N-linked (GlcNAc...) Ref.2
Glycosylation991N-linked (GlcNAc...) Ref.2
Glycosylation1461N-linked (GlcNAc...)
Glycosylation2521N-linked (GlcNAc...)
Glycosylation2751N-linked (GlcNAc...) Ref.2
Disulfide bond14Interchain (with a light chain)
Disulfide bond15 ↔ 105
Disulfide bond29 ↔ 85
Disulfide bond121Interchain (with a heavy chain)
Disulfide bond135 ↔ 193
Disulfide bond209Interchain (with a heavy chain)
Disulfide bond239 ↔ 299
Disulfide bond345 ↔ 405

Natural variations

Natural variant431W → C in allele IGHE*01.
VAR_044229
Natural variant3591W → L Possible polymorphism. Ref.1
VAR_003885

Experimental info

Non-terminal residue11

Secondary structure

............................................................... 428
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01854 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 25C4CA072AA558A0

FASTA42847,019
        10         20         30         40         50         60 
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG TTMTLPATTL 

        70         80         90        100        110        120 
TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK TFSVCSRDFT PPTVKILQSS 

       130        140        150        160        170        180 
CDGGGHFPPT IQLLCLVSGY TPGTINITWL EDGQVMDVDL STASTTQEGE LASTQSELTL 

       190        200        210        220        230        240 
SQKHWLSDRT YTCQVTYQGH TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL 

       250        260        270        280        290        300 
VVDLAPSKGT VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR 

       310        320        330        340        350        360 
VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF MPEDISVQWL 

       370        380        390        400        410        420 
HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK DEFICRAVHE AASPSQTVQR 


AVSVNPGK 

« Hide

References

« Hide 'large scale' references
[1]"Duplication and deletion in the human immunoglobulin epsilon genes."
Max E.E., Battey J., Ney R., Kirsch I.R., Leder P.
Cell 29:691-699(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01), VARIANT LEU-359.
[2]"The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes."
Flanagan J.G., Rabbitts T.H.
EMBO J. 1:655-660(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
[3]"Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns."
Ueda S., Nakai S., Nishida Y., Hisajima H., Honjo T.
EMBO J. 1:1539-1544(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*01).
[4]"Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA."
Seno M., Kurokawa T., Ono Y., Onda H., Sasada R., Igarashi K., Kikuchi M., Sugino Y., Nishida Y., Honjo T.
Nucleic Acids Res. 11:719-726(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE IGHE*02).
[5]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Bennich H.H., Johansson S.G.O., von Bahr-Lindstroem H.
(In) Bach M.K. (eds.); Immediate hypersensitivity: modern concepts and developments, pp.1-36, Marcel Dekker, New York (1978)
Cited for: PRELIMINARY PROTEIN SEQUENCE (MYELOMA PROTEIN ND).
[7]"Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line."
Kenten J.H., Molgaard H.V., Houghton M., Derbyshire R.B., Viney J., Bell L.O., Gould H.J.
Proc. Natl. Acad. Sci. U.S.A. 79:6661-6665(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-40; 68-114 AND 427-428.
[8]"A model of the Fc of immunoglobulin E."
Padlan E.A., Davies D.R.
Mol. Immunol. 23:1063-1075(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L00022 Genomic DNA. Translation: AAB59424.1. Different initiation.
J00222 Genomic DNA. Translation: AAB59395.1.
AL928742 Genomic DNA. No translation available.
PIREHHU. A22771.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
ProteinModelPortalP01854.
SMRP01854. Positions 1-427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-6167N.
STRING9606.ENSP00000374983.

Chemistry

ChEMBLCHEMBL1834.
GuidetoPHARMACOLOGY2741.

Protein family/group databases

IMGTSearch...
Search...
Search...

PTM databases

PhosphoSiteP01854.

Polymorphism databases

DMDM119512.

Proteomic databases

PaxDbP01854.
PRIDEP01854.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000390541; ENSP00000374983; ENSG00000211891.
ENST00000605414; ENSP00000474852; ENSG00000270340.
UCSCuc001yrw.1. human.

Organism-specific databases

GeneCardsGC14M106066.
HGNCHGNC:5522. IGHE.
MIM147180. gene.
neXtProtNX_P01854.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG119039.
HOVERGENHBG096066.
OMAFHSSCDP.
PhylomeDBP01854.
TreeFamTF334176.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP01854.
GenevestigatorP01854.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 4 hits.
[Graphical view]
SMARTSM00407. IGc1. 4 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 4 hits.
PS00290. IG_MHC. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01854.
PROP01854.
SOURCESearch...

Entry information

Entry nameIGHE_HUMAN
AccessionPrimary (citable) accession number: P01854
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 11, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM