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P01850 (TRBC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell receptor beta-1 chain C region
Gene names
Name:TRBC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length177 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence caution

The sequence CAA25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRACP018481EBI-1034839,EBI-1034847

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 177›177T-cell receptor beta-1 chain C region
PRO_0000184526

Regions

Transmembrane151 – 17121Helical; Potential
Domain9 – 118110Ig-like

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Disulfide bond31 ↔ 96 Ref.7

Experimental info

Non-terminal residue11

Secondary structure

.............................. 177
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01850 [UniParc].

Last modified April 20, 2010. Version 3.
Checksum: 9242AFAA3E3DB4AE

FASTA17719,899
        10         20         30         40         50         60 
EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK EVHSGVSTDP 

        70         80         90        100        110        120 
QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF YGLSENDEWT QDRAKPVTQI 

       130        140        150        160        170 
VSAEAWGRAD CGFTSVSYQQ GVLSATILYE ILLGKATLYA VLVSALVLMA MVKRKDF 

« Hide

References

« Hide 'large scale' references
[1]"A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE YT35).
[2]"Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
Rowen L., Koop B.F., Hood L.
Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"A structural basis for immunodominant human T cell receptor recognition."
Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRAC.
[7]"The shaping of T cell receptor recognition by self-tolerance."
Gras S., Burrows S.R., Kjer-Nielsen L., Clements C.S., Liu Y.C., Sullivan L.C., Bell M.J., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J.
Immunity 30:193-203(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-B/B2M HETERODIMER AND TRAC, DISULFIDE BOND.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRRWHUCY. B25777.
UniGeneHs.382212.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
ProteinModelPortalP01850.
SMRP01850. Positions 1-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01850. 2 interactions.
MINTMINT-249879.
STRING9606.ENSP00000405398.

Polymorphism databases

DMDM294862488.

Proteomic databases

PaxDbP01850.
PRIDEP01850.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC07P9T0995.
HGNCHGNC:12156. TRBC1.
MIM186930. gene.
neXtProtNX_P01850.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46033.
HOVERGENHBG017899.
InParanoidP01850.
PhylomeDBP01850.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorP01850.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01850.
PROP01850.
SOURCESearch...

Entry information

Entry nameTRBC1_HUMAN
AccessionPrimary (citable) accession number: P01850
Secondary accession number(s): A0A5B8, A6NH51
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 20, 2010
Last modified: July 9, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM