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P01850

- TRBC1_HUMAN

UniProt

P01850 - TRBC1_HUMAN

Protein

T-cell receptor beta-1 chain C region

Gene

TRBC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. regulation of immune response Source: Reactome
    3. T cell costimulation Source: Reactome
    4. T cell receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell receptor beta-1 chain C region
    Gene namesi
    Name:TRBC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:12156. TRBC1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 177›177T-cell receptor beta-1 chain C regionPRO_0000184526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 961 PublicationPROSITE-ProRule annotation
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01850.
    PRIDEiP01850.

    Expressioni

    Gene expression databases

    GenevestigatoriP01850.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRACP018481EBI-1034839,EBI-1034847

    Protein-protein interaction databases

    IntActiP01850. 2 interactions.
    MINTiMINT-249879.
    STRINGi9606.ENSP00000405398.

    Structurei

    Secondary structure

    1
    177
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 53
    Beta strandi10 – 145
    Helixi18 – 247
    Beta strandi25 – 3915
    Beta strandi41 – 477
    Beta strandi50 – 523
    Beta strandi54 – 585
    Beta strandi63 – 653
    Beta strandi69 – 713
    Beta strandi74 – 8310
    Helixi84 – 874
    Beta strandi88 – 914
    Beta strandi93 – 1008
    Beta strandi105 – 1073
    Beta strandi111 – 1133
    Beta strandi117 – 12610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AO7X-ray2.60E1-130[»]
    1FYTX-ray2.60E1-134[»]
    1J8HX-ray2.40E1-134[»]
    1KGCX-ray1.50E1-130[»]
    1KTKX-ray3.00E/F5-130[»]
    1MI5X-ray2.50E1-130[»]
    1OGAX-ray1.40E1-130[»]
    1YMMX-ray3.50E1-131[»]
    1ZGLX-ray2.80P/R/T/V1-131[»]
    2AK4X-ray2.50E/J/P/U1-130[»]
    2AXHX-ray2.70A/B1-130[»]
    2BNRX-ray1.90E1-130[»]
    2BNUX-ray1.40B1-130[»]
    2CDEX-ray3.50B/D/F1-130[»]
    2CDFX-ray2.25B1-130[»]
    2CDGX-ray2.60B1-130[»]
    2ESVX-ray2.60E1-130[»]
    2F53X-ray2.10E1-130[»]
    2F54X-ray2.70E/L6-130[»]
    2GJ6X-ray2.56E1-130[»]
    2IALX-ray1.92B/D1-130[»]
    2IAMX-ray2.80D1-130[»]
    2IANX-ray2.80E/J/O/T1-130[»]
    2NTSX-ray2.40P6-128[»]
    2NW2X-ray1.40B1-130[»]
    2NX5X-ray2.70E/J/P/U1-130[»]
    2P5EX-ray1.89E1-130[»]
    2P5WX-ray2.20E1-130[»]
    2PO6X-ray3.20D/H1-130[»]
    2PYEX-ray2.30E1-130[»]
    2PYFX-ray2.20B1-130[»]
    2VLJX-ray2.40E1-130[»]
    2VLKX-ray2.50E1-130[»]
    2VLMX-ray1.98E1-130[»]
    2VLRX-ray2.30E/J1-130[»]
    2XN9X-ray2.30B1-130[»]
    2XNAX-ray2.10B1-130[»]
    3ARBX-ray2.70D1-130[»]
    3ARDX-ray3.01D1-130[»]
    3AREX-ray2.80D1-130[»]
    3ARFX-ray2.90D1-130[»]
    3ARGX-ray3.00D1-130[»]
    3D39X-ray2.81E1-130[»]
    3D3VX-ray2.80E1-130[»]
    3DX9X-ray2.75B/D1-130[»]
    3DXAX-ray3.50E/J/O1-130[»]
    3FFCX-ray2.80E/J1-130[»]
    3HE6X-ray2.90D1-130[»]
    3HG1X-ray3.00E1-130[»]
    3KPRX-ray2.60E/J1-130[»]
    3KPSX-ray2.70E1-130[»]
    3O4LX-ray2.54E1-130[»]
    3TN0X-ray3.20D1-130[»]
    4G8EX-ray2.20B1-130[»]
    4G8FX-ray2.10B1-130[»]
    4GG6X-ray3.20F/H1-130[»]
    4GG8X-ray3.20B/F1-130[»]
    4IIQX-ray2.86B1-130[»]
    4JFDX-ray2.46E1-130[»]
    4JFEX-ray2.70E1-130[»]
    4JFFX-ray2.43E1-130[»]
    4JFHX-ray2.40E1-130[»]
    4JRXX-ray2.30E1-130[»]
    4JRYX-ray2.80E1-130[»]
    4L4TX-ray2.00E/H1-130[»]
    4L4VX-ray1.90E/H1-130[»]
    4L9LX-ray3.40B1-130[»]
    4LCCX-ray3.26B1-130[»]
    4LCWX-ray2.40E/H1-130[»]
    4MJIX-ray2.99E/J1-130[»]
    4MNQX-ray2.74E2-130[»]
    4NQCX-ray2.50E/H1-130[»]
    4NQDX-ray2.20E/H1-130[»]
    4NQEX-ray2.10E/H1-130[»]
    4OZFX-ray2.70H1-130[»]
    4OZGX-ray3.00F/H1-130[»]
    4OZHX-ray2.80F/H1-130[»]
    4OZIX-ray3.20F/H1-130[»]
    4P46X-ray2.85B1-128[»]
    4PRHX-ray2.50E1-130[»]
    4PRIX-ray2.40E1-130[»]
    4PRPX-ray2.50E1-130[»]
    ProteinModelPortaliP01850.
    SMRiP01850. Positions 1-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01850.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 118110Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46033.
    HOVERGENiHBG017899.
    InParanoidiP01850.
    PhylomeDBiP01850.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01850-1 [UniParc]FASTAAdd to Basket

    « Hide

    EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK    50
    EVHSGVSTDP QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF 100
    YGLSENDEWT QDRAKPVTQI VSAEAWGRAD CGFTSVSYQQ GVLSATILYE 150
    ILLGKATLYA VLVSALVLMA MVKRKDF 177
    Length:177
    Mass (Da):19,899
    Last modified:April 20, 2010 - v3
    Checksum:i9242AFAA3E3DB4AE
    GO

    Sequence cautioni

    The sequence CAA25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00437 mRNA. Translation: CAA25134.1. Different initiation.
    M12887 Genomic DNA. Translation: AAA60661.1.
    L36092 Genomic DNA. Translation: AAC80213.1.
    CH471198 Genomic DNA. Translation: EAW51914.1.
    PIRiB25777. RWHUCY.
    UniGeneiHs.382212.

    Polymorphism databases

    DMDMi294862488.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00437 mRNA. Translation: CAA25134.1 . Different initiation.
    M12887 Genomic DNA. Translation: AAA60661.1 .
    L36092 Genomic DNA. Translation: AAC80213.1 .
    CH471198 Genomic DNA. Translation: EAW51914.1 .
    PIRi B25777. RWHUCY.
    UniGenei Hs.382212.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AO7 X-ray 2.60 E 1-130 [» ]
    1FYT X-ray 2.60 E 1-134 [» ]
    1J8H X-ray 2.40 E 1-134 [» ]
    1KGC X-ray 1.50 E 1-130 [» ]
    1KTK X-ray 3.00 E/F 5-130 [» ]
    1MI5 X-ray 2.50 E 1-130 [» ]
    1OGA X-ray 1.40 E 1-130 [» ]
    1YMM X-ray 3.50 E 1-131 [» ]
    1ZGL X-ray 2.80 P/R/T/V 1-131 [» ]
    2AK4 X-ray 2.50 E/J/P/U 1-130 [» ]
    2AXH X-ray 2.70 A/B 1-130 [» ]
    2BNR X-ray 1.90 E 1-130 [» ]
    2BNU X-ray 1.40 B 1-130 [» ]
    2CDE X-ray 3.50 B/D/F 1-130 [» ]
    2CDF X-ray 2.25 B 1-130 [» ]
    2CDG X-ray 2.60 B 1-130 [» ]
    2ESV X-ray 2.60 E 1-130 [» ]
    2F53 X-ray 2.10 E 1-130 [» ]
    2F54 X-ray 2.70 E/L 6-130 [» ]
    2GJ6 X-ray 2.56 E 1-130 [» ]
    2IAL X-ray 1.92 B/D 1-130 [» ]
    2IAM X-ray 2.80 D 1-130 [» ]
    2IAN X-ray 2.80 E/J/O/T 1-130 [» ]
    2NTS X-ray 2.40 P 6-128 [» ]
    2NW2 X-ray 1.40 B 1-130 [» ]
    2NX5 X-ray 2.70 E/J/P/U 1-130 [» ]
    2P5E X-ray 1.89 E 1-130 [» ]
    2P5W X-ray 2.20 E 1-130 [» ]
    2PO6 X-ray 3.20 D/H 1-130 [» ]
    2PYE X-ray 2.30 E 1-130 [» ]
    2PYF X-ray 2.20 B 1-130 [» ]
    2VLJ X-ray 2.40 E 1-130 [» ]
    2VLK X-ray 2.50 E 1-130 [» ]
    2VLM X-ray 1.98 E 1-130 [» ]
    2VLR X-ray 2.30 E/J 1-130 [» ]
    2XN9 X-ray 2.30 B 1-130 [» ]
    2XNA X-ray 2.10 B 1-130 [» ]
    3ARB X-ray 2.70 D 1-130 [» ]
    3ARD X-ray 3.01 D 1-130 [» ]
    3ARE X-ray 2.80 D 1-130 [» ]
    3ARF X-ray 2.90 D 1-130 [» ]
    3ARG X-ray 3.00 D 1-130 [» ]
    3D39 X-ray 2.81 E 1-130 [» ]
    3D3V X-ray 2.80 E 1-130 [» ]
    3DX9 X-ray 2.75 B/D 1-130 [» ]
    3DXA X-ray 3.50 E/J/O 1-130 [» ]
    3FFC X-ray 2.80 E/J 1-130 [» ]
    3HE6 X-ray 2.90 D 1-130 [» ]
    3HG1 X-ray 3.00 E 1-130 [» ]
    3KPR X-ray 2.60 E/J 1-130 [» ]
    3KPS X-ray 2.70 E 1-130 [» ]
    3O4L X-ray 2.54 E 1-130 [» ]
    3TN0 X-ray 3.20 D 1-130 [» ]
    4G8E X-ray 2.20 B 1-130 [» ]
    4G8F X-ray 2.10 B 1-130 [» ]
    4GG6 X-ray 3.20 F/H 1-130 [» ]
    4GG8 X-ray 3.20 B/F 1-130 [» ]
    4IIQ X-ray 2.86 B 1-130 [» ]
    4JFD X-ray 2.46 E 1-130 [» ]
    4JFE X-ray 2.70 E 1-130 [» ]
    4JFF X-ray 2.43 E 1-130 [» ]
    4JFH X-ray 2.40 E 1-130 [» ]
    4JRX X-ray 2.30 E 1-130 [» ]
    4JRY X-ray 2.80 E 1-130 [» ]
    4L4T X-ray 2.00 E/H 1-130 [» ]
    4L4V X-ray 1.90 E/H 1-130 [» ]
    4L9L X-ray 3.40 B 1-130 [» ]
    4LCC X-ray 3.26 B 1-130 [» ]
    4LCW X-ray 2.40 E/H 1-130 [» ]
    4MJI X-ray 2.99 E/J 1-130 [» ]
    4MNQ X-ray 2.74 E 2-130 [» ]
    4NQC X-ray 2.50 E/H 1-130 [» ]
    4NQD X-ray 2.20 E/H 1-130 [» ]
    4NQE X-ray 2.10 E/H 1-130 [» ]
    4OZF X-ray 2.70 H 1-130 [» ]
    4OZG X-ray 3.00 F/H 1-130 [» ]
    4OZH X-ray 2.80 F/H 1-130 [» ]
    4OZI X-ray 3.20 F/H 1-130 [» ]
    4P46 X-ray 2.85 B 1-128 [» ]
    4PRH X-ray 2.50 E 1-130 [» ]
    4PRI X-ray 2.40 E 1-130 [» ]
    4PRP X-ray 2.50 E 1-130 [» ]
    ProteinModelPortali P01850.
    SMRi P01850. Positions 1-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01850. 2 interactions.
    MINTi MINT-249879.
    STRINGi 9606.ENSP00000405398.

    Polymorphism databases

    DMDMi 294862488.

    Proteomic databases

    PaxDbi P01850.
    PRIDEi P01850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC07P9T0995.
    HGNCi HGNC:12156. TRBC1.
    MIMi 186930. gene.
    neXtProti NX_P01850.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46033.
    HOVERGENi HBG017899.
    InParanoidi P01850.
    PhylomeDBi P01850.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Miscellaneous databases

    EvolutionaryTracei P01850.
    PROi P01850.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P01850.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
      Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
      Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE YT35).
    2. "Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
      Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
      Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
      Rowen L., Koop B.F., Hood L.
      Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "A structural basis for immunodominant human T cell receptor recognition."
      Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
      Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRAC.
    7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-B/B2M HETERODIMER AND TRAC, DISULFIDE BOND.

    Entry informationi

    Entry nameiTRBC1_HUMAN
    AccessioniPrimary (citable) accession number: P01850
    Secondary accession number(s): A0A5B8, A6NH51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 124 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3