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Protein

T-cell receptor beta-1 chain C region

Gene

TRBC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-1 chain C region
Gene namesi
Name:TRBC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12156. TRBC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi294862488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 177›177T-cell receptor beta-1 chain C regionPRO_0000184526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 96PROSITE-ProRule annotation1 Publication
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01850.
PRIDEiP01850.

Expressioni

Gene expression databases

GenevestigatoriP01850.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRACP018481EBI-1034839,EBI-1034847

Protein-protein interaction databases

IntActiP01850. 2 interactions.
MINTiMINT-249879.
STRINGi9606.ENSP00000405398.

Structurei

Secondary structure

1
177
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi10 – 145Combined sources
Helixi18 – 247Combined sources
Beta strandi25 – 3915Combined sources
Beta strandi41 – 477Combined sources
Beta strandi50 – 523Combined sources
Beta strandi54 – 585Combined sources
Beta strandi63 – 653Combined sources
Beta strandi69 – 713Combined sources
Beta strandi74 – 8310Combined sources
Helixi84 – 874Combined sources
Beta strandi88 – 914Combined sources
Beta strandi93 – 1008Combined sources
Beta strandi105 – 1073Combined sources
Beta strandi111 – 1133Combined sources
Beta strandi117 – 12610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MJIX-ray2.99E/J1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4P46X-ray2.85B1-128[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
ProteinModelPortaliP01850.
SMRiP01850. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 118110Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46033.
HOVERGENiHBG017899.
InParanoidiP01850.
PhylomeDBiP01850.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK
60 70 80 90 100
EVHSGVSTDP QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF
110 120 130 140 150
YGLSENDEWT QDRAKPVTQI VSAEAWGRAD CGFTSVSYQQ GVLSATILYE
160 170
ILLGKATLYA VLVSALVLMA MVKRKDF
Length:177
Mass (Da):19,899
Last modified:April 20, 2010 - v3
Checksum:i9242AFAA3E3DB4AE
GO

Sequence cautioni

The sequence CAA25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRiB25777. RWHUCY.
UniGeneiHs.382212.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRiB25777. RWHUCY.
UniGeneiHs.382212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MJIX-ray2.99E/J1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4P46X-ray2.85B1-128[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
ProteinModelPortaliP01850.
SMRiP01850. Positions 1-130.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01850. 2 interactions.
MINTiMINT-249879.
STRINGi9606.ENSP00000405398.

Polymorphism and mutation databases

DMDMi294862488.

Proteomic databases

PaxDbiP01850.
PRIDEiP01850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC07P9T0100.
HGNCiHGNC:12156. TRBC1.
MIMi186930. gene.
neXtProtiNX_P01850.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46033.
HOVERGENiHBG017899.
InParanoidiP01850.
PhylomeDBiP01850.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Miscellaneous databases

EvolutionaryTraceiP01850.
PROiP01850.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP01850.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
    Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
    Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE YT35).
  2. "Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
    Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
    Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
    Rowen L., Koop B.F., Hood L.
    Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "A structural basis for immunodominant human T cell receptor recognition."
    Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
    Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRAC.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-B/B2M HETERODIMER AND TRAC, DISULFIDE BOND.

Entry informationi

Entry nameiTRBC1_HUMAN
AccessioniPrimary (citable) accession number: P01850
Secondary accession number(s): A0A5B8, A6NH51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 20, 2010
Last modified: May 27, 2015
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.