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P01850

- TRBC1_HUMAN

UniProt

P01850 - TRBC1_HUMAN

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Protein
T-cell receptor beta-1 chain C region
Gene
TRBC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. T cell costimulation Source: Reactome
  2. T cell receptor signaling pathway Source: Reactome
  3. immune response Source: UniProtKB
  4. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-1 chain C region
Gene namesi
Name:TRBC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:12156. TRBC1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei151 – 17121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 177›177T-cell receptor beta-1 chain C region
PRO_0000184526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 961 Publication
Glycosylationi70 – 701N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01850.
PRIDEiP01850.

Expressioni

Gene expression databases

GenevestigatoriP01850.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRACP018481EBI-1034839,EBI-1034847

Protein-protein interaction databases

IntActiP01850. 2 interactions.
MINTiMINT-249879.
STRINGi9606.ENSP00000405398.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53
Beta strandi10 – 145
Helixi18 – 247
Beta strandi25 – 3915
Beta strandi41 – 477
Beta strandi50 – 523
Beta strandi54 – 585
Beta strandi63 – 653
Beta strandi69 – 713
Beta strandi74 – 8310
Helixi84 – 874
Beta strandi88 – 914
Beta strandi93 – 1008
Beta strandi105 – 1073
Beta strandi111 – 1133
Beta strandi117 – 12610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MJIX-ray2.99E/J1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4P46X-ray2.85B1-128[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
ProteinModelPortaliP01850.
SMRiP01850. Positions 1-130.

Miscellaneous databases

EvolutionaryTraceiP01850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 118110Ig-like
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46033.
HOVERGENiHBG017899.
InParanoidiP01850.
PhylomeDBiP01850.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01850-1 [UniParc]FASTAAdd to Basket

« Hide

EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK    50
EVHSGVSTDP QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF 100
YGLSENDEWT QDRAKPVTQI VSAEAWGRAD CGFTSVSYQQ GVLSATILYE 150
ILLGKATLYA VLVSALVLMA MVKRKDF 177
Length:177
Mass (Da):19,899
Last modified:April 20, 2010 - v3
Checksum:i9242AFAA3E3DB4AE
GO

Sequence cautioni

The sequence CAA25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRiB25777. RWHUCY.
UniGeneiHs.382212.

Polymorphism databases

DMDMi294862488.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00437 mRNA. Translation: CAA25134.1 . Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1 .
L36092 Genomic DNA. Translation: AAC80213.1 .
CH471198 Genomic DNA. Translation: EAW51914.1 .
PIRi B25777. RWHUCY.
UniGenei Hs.382212.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AO7 X-ray 2.60 E 1-130 [» ]
1FYT X-ray 2.60 E 1-134 [» ]
1J8H X-ray 2.40 E 1-134 [» ]
1KGC X-ray 1.50 E 1-130 [» ]
1KTK X-ray 3.00 E/F 5-130 [» ]
1MI5 X-ray 2.50 E 1-130 [» ]
1OGA X-ray 1.40 E 1-130 [» ]
1YMM X-ray 3.50 E 1-131 [» ]
1ZGL X-ray 2.80 P/R/T/V 1-131 [» ]
2AK4 X-ray 2.50 E/J/P/U 1-130 [» ]
2AXH X-ray 2.70 A/B 1-130 [» ]
2BNR X-ray 1.90 E 1-130 [» ]
2BNU X-ray 1.40 B 1-130 [» ]
2CDE X-ray 3.50 B/D/F 1-130 [» ]
2CDF X-ray 2.25 B 1-130 [» ]
2CDG X-ray 2.60 B 1-130 [» ]
2ESV X-ray 2.60 E 1-130 [» ]
2F53 X-ray 2.10 E 1-130 [» ]
2F54 X-ray 2.70 E/L 6-130 [» ]
2GJ6 X-ray 2.56 E 1-130 [» ]
2IAL X-ray 1.92 B/D 1-130 [» ]
2IAM X-ray 2.80 D 1-130 [» ]
2IAN X-ray 2.80 E/J/O/T 1-130 [» ]
2NTS X-ray 2.40 P 6-128 [» ]
2NW2 X-ray 1.40 B 1-130 [» ]
2NX5 X-ray 2.70 E/J/P/U 1-130 [» ]
2P5E X-ray 1.89 E 1-130 [» ]
2P5W X-ray 2.20 E 1-130 [» ]
2PO6 X-ray 3.20 D/H 1-130 [» ]
2PYE X-ray 2.30 E 1-130 [» ]
2PYF X-ray 2.20 B 1-130 [» ]
2VLJ X-ray 2.40 E 1-130 [» ]
2VLK X-ray 2.50 E 1-130 [» ]
2VLM X-ray 1.98 E 1-130 [» ]
2VLR X-ray 2.30 E/J 1-130 [» ]
2XN9 X-ray 2.30 B 1-130 [» ]
2XNA X-ray 2.10 B 1-130 [» ]
3ARB X-ray 2.70 D 1-130 [» ]
3ARD X-ray 3.01 D 1-130 [» ]
3ARE X-ray 2.80 D 1-130 [» ]
3ARF X-ray 2.90 D 1-130 [» ]
3ARG X-ray 3.00 D 1-130 [» ]
3D39 X-ray 2.81 E 1-130 [» ]
3D3V X-ray 2.80 E 1-130 [» ]
3DX9 X-ray 2.75 B/D 1-130 [» ]
3DXA X-ray 3.50 E/J/O 1-130 [» ]
3FFC X-ray 2.80 E/J 1-130 [» ]
3HE6 X-ray 2.90 D 1-130 [» ]
3HG1 X-ray 3.00 E 1-130 [» ]
3KPR X-ray 2.60 E/J 1-130 [» ]
3KPS X-ray 2.70 E 1-130 [» ]
3O4L X-ray 2.54 E 1-130 [» ]
3TN0 X-ray 3.20 D 1-130 [» ]
4G8E X-ray 2.20 B 1-130 [» ]
4G8F X-ray 2.10 B 1-130 [» ]
4GG6 X-ray 3.20 F/H 1-130 [» ]
4GG8 X-ray 3.20 B/F 1-130 [» ]
4IIQ X-ray 2.86 B 1-130 [» ]
4JFD X-ray 2.46 E 1-130 [» ]
4JFE X-ray 2.70 E 1-130 [» ]
4JFF X-ray 2.43 E 1-130 [» ]
4JFH X-ray 2.40 E 1-130 [» ]
4JRX X-ray 2.30 E 1-130 [» ]
4JRY X-ray 2.80 E 1-130 [» ]
4L4T X-ray 2.00 E/H 1-130 [» ]
4L4V X-ray 1.90 E/H 1-130 [» ]
4L9L X-ray 3.40 B 1-130 [» ]
4LCC X-ray 3.26 B 1-130 [» ]
4LCW X-ray 2.40 E/H 1-130 [» ]
4MJI X-ray 2.99 E/J 1-130 [» ]
4MNQ X-ray 2.74 E 2-130 [» ]
4NQC X-ray 2.50 E/H 1-130 [» ]
4NQD X-ray 2.20 E/H 1-130 [» ]
4NQE X-ray 2.10 E/H 1-130 [» ]
4OZF X-ray 2.70 H 1-130 [» ]
4OZG X-ray 3.00 F/H 1-130 [» ]
4OZH X-ray 2.80 F/H 1-130 [» ]
4OZI X-ray 3.20 F/H 1-130 [» ]
4P46 X-ray 2.85 B 1-128 [» ]
4PRH X-ray 2.50 E 1-130 [» ]
4PRI X-ray 2.40 E 1-130 [» ]
4PRP X-ray 2.50 E 1-130 [» ]
ProteinModelPortali P01850.
SMRi P01850. Positions 1-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P01850. 2 interactions.
MINTi MINT-249879.
STRINGi 9606.ENSP00000405398.

Polymorphism databases

DMDMi 294862488.

Proteomic databases

PaxDbi P01850.
PRIDEi P01850.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

GeneCardsi GC07P9T0995.
HGNCi HGNC:12156. TRBC1.
MIMi 186930. gene.
neXtProti NX_P01850.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46033.
HOVERGENi HBG017899.
InParanoidi P01850.
PhylomeDBi P01850.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_12555. Downstream TCR signaling.
REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
REACT_12596. Translocation of ZAP-70 to Immunological synapse.
REACT_12623. Generation of second messenger molecules.
REACT_19324. PD-1 signaling.

Miscellaneous databases

EvolutionaryTracei P01850.
PROi P01850.
SOURCEi Search...

Gene expression databases

Genevestigatori P01850.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains."
    Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W.
    Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE YT35).
  2. "Sequence and evolution of the human T-cell antigen receptor beta-chain genes."
    Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H.
    Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus."
    Rowen L., Koop B.F., Hood L.
    Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "A structural basis for immunodominant human T cell receptor recognition."
    Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
    Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRAC.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-B/B2M HETERODIMER AND TRAC, DISULFIDE BOND.

Entry informationi

Entry nameiTRBC1_HUMAN
AccessioniPrimary (citable) accession number: P01850
Secondary accession number(s): A0A5B8, A6NH51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 20, 2010
Last modified: September 3, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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