P01850 (TRBC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell receptor beta-1 chain C region

Gene names

Name:

TRBC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.
Sequence caution	The sequence CAA25134.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRAC	P01848	1	EBI-1034839,EBI-1034847

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 177

›177

T-cell receptor beta-1 chain C region

PRO_0000184526

Regions

Transmembrane

151 – 171

21

Helical; Potential

Domain

9 – 118

110

Ig-like

Amino acid modifications

Glycosylation

70

1

N-linked (GlcNAc...) Potential

Disulfide bond

31 ↔ 96

Ref.7

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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177

Helix Strand Turn

Details...

Helix

3 – 5

3

Beta strand

10 – 14

5

Helix

18 – 24

7

Beta strand

25 – 39

15

Beta strand

41 – 47

7

Beta strand

50 – 52

3

Beta strand

54 – 58

5

Beta strand

63 – 65

3

Beta strand

69 – 71

3

Beta strand

74 – 83

10

Helix

84 – 87

4

Beta strand

88 – 91

4

Beta strand

93 – 100

8

Beta strand

105 – 107

3

Beta strand

111 – 113

3

Beta strand

117 – 126

10

Sequences

	Sequence		Length	Mass (Da)
	P01850 [UniParc]. Last modified April 20, 2010. Version 3. Checksum: 9242AFAA3E3DB4AE	FASTA	177	19,899
	10 20 30 40 50 60 EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK EVHSGVSTDP 70 80 90 100 110 120 QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF YGLSENDEWT QDRAKPVTQI 130 140 150 160 170 VSAEAWGRAD CGFTSVSYQQ GVLSATILYE ILLGKATLYA VLVSALVLMA MVKRKDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains." Yanagi Y., Yoshikai Y., Leggett K., Clark S.P., Aleksander I., Mak T.W. Nature 308:145-149(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CLONE YT35).
[2]	"Sequence and evolution of the human T-cell antigen receptor beta-chain genes." Tunnacliffe A., Kefford R., Milstein C., Forster A., Rabbitts T.H. Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The complete 685-kilobase DNA sequence of the human beta T cell receptor locus." Rowen L., Koop B.F., Hood L. Science 272:1755-1762(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"A structural basis for immunodominant human T cell receptor recognition." Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y. Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRAC.
[7]	"The shaping of T cell receptor recognition by self-tolerance." Gras S., Burrows S.R., Kjer-Nielsen L., Clements C.S., Liu Y.C., Sullivan L.C., Bell M.J., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J. Immunity 30:193-203(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1-130 IN COMPLEX WITH HLA-B/B2M HETERODIMER AND TRAC, DISULFIDE BOND.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.

IPI

IPI00879200.

PIR

RWHUCY. B25777.

UniGene

Hs.382212.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1FYT	X-ray	2.60	E	1-134	[»]
1J8H	X-ray	2.40	E	1-134	[»]
1KGC	X-ray	1.50	E	1-130	[»]
1KTK	X-ray	3.00	E/F	7-130	[»]
1MI5	X-ray	2.50	E	1-130	[»]
1OGA	X-ray	1.40	E	1-130	[»]
1YMM	X-ray	3.50	E	1-131	[»]
1ZGL	X-ray	2.80	P/R/T/V	1-131	[»]
2AK4	X-ray	2.50	E/J/P/U	1-130	[»]
2AXH	X-ray	2.70	A/B	1-130	[»]
2BNR	X-ray	1.90	E	1-130	[»]
2BNU	X-ray	1.40	B	1-130	[»]
2ESV	X-ray	2.60	E	1-130	[»]
2F53	X-ray	2.10	E	1-130	[»]
2F54	X-ray	2.70	E/L	1-130	[»]
2GJ6	X-ray	2.56	E	1-130	[»]
2IAL	X-ray	1.92	B/D	1-130	[»]
2IAM	X-ray	2.80	D	1-130	[»]
2IAN	X-ray	2.80	E/J/O/T	1-130	[»]
2NTS	X-ray	2.40	P	1-128	[»]
2NW2	X-ray	1.40	B	1-130	[»]
2NX5	X-ray	2.70	E/J/P/U	1-130	[»]
2P5E	X-ray	1.89	E	1-130	[»]
2P5W	X-ray	2.20	E	1-130	[»]
2PO6	X-ray	3.20	D/H	1-130	[»]
2PYE	X-ray	2.30	E	1-130	[»]
2PYF	X-ray	2.20	B	1-130	[»]
2VLJ	X-ray	2.40	E	1-130	[»]
2VLK	X-ray	2.50	E	1-130	[»]
2VLM	X-ray	1.98	E	1-130	[»]
2VLR	X-ray	2.30	E/J	1-130	[»]
2XN9	X-ray	2.30	B	1-130	[»]
2XNA	X-ray	2.10	B	1-130	[»]
3DX9	X-ray	2.75	B/D	1-130	[»]
3DXA	X-ray	3.50	E/J/O	1-130	[»]
3FFC	X-ray	2.80	E/J	1-130	[»]

ProteinModelPortal

P01850.

SMR

P01850. Positions 1-130.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01850. 2 interactions.

MINT

MINT-249879.

STRING

9606.ENSP00000405398.

Polymorphism databases

DMDM

294862488.

Proteomic databases

PaxDb

P01850.

PRIDE

P01850.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

GeneCards

GC07Pg41935.

HGNC

HGNC:12156. TRBC1.

neXtProt

NX_P01850.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG46033.

HOVERGEN

HBG017899.

InParanoid

P01850.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Genevestigator

P01850.

GermOnline

ENSG00000198446. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01850.

Entry information

Entry name

TRBC1_HUMAN

Accession

Primary (citable) accession number: P01850
Secondary accession number(s): A0A5B8, A6NH51

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	April 20, 2010
Last modified:	April 3, 2013
This is version 112 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.