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Protein

T-cell receptor beta-1 chain C region

Gene

TRBC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171082-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor beta-1 chain C region
Gene namesi
Name:TRBC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12156. TRBC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28639.

Polymorphism and mutation databases

DMDMi294862488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000184526‹1 – 177T-cell receptor beta-1 chain C regionAdd BLAST›177

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 96PROSITE-ProRule annotation1 Publication
Glycosylationi70N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01850.
PRIDEiP01850.

PTM databases

iPTMnetiP01850.
PhosphoSitePlusiP01850.

Interactioni

Protein-protein interaction databases

IntActiP01850. 2 interactors.
MINTiMINT-249879.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi10 – 14Combined sources5
Helixi18 – 24Combined sources7
Beta strandi25 – 39Combined sources15
Beta strandi41 – 47Combined sources7
Beta strandi50 – 52Combined sources3
Beta strandi54 – 58Combined sources5
Beta strandi63 – 65Combined sources3
Beta strandi69 – 71Combined sources3
Beta strandi74 – 83Combined sources10
Helixi84 – 87Combined sources4
Beta strandi88 – 91Combined sources4
Beta strandi93 – 100Combined sources8
Beta strandi105 – 107Combined sources3
Beta strandi111 – 113Combined sources3
Beta strandi117 – 126Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNQX-ray1.70E1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MJIX-ray2.99E/J1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4P46X-ray2.85B1-128[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
4X6BX-ray2.10B/D1-130[»]
4X6CX-ray2.80F/H1-130[»]
4X6DX-ray2.98F/H1-130[»]
4ZDHX-ray2.10B1-130[»]
ProteinModelPortaliP01850.
SMRiP01850.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01850.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 118Ig-likeAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017899.
InParanoidiP01850.
PhylomeDBiP01850.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EDLNKVFPPE VAVFEPSEAE ISHTQKATLV CLATGFFPDH VELSWWVNGK
60 70 80 90 100
EVHSGVSTDP QPLKEQPALN DSRYCLSSRL RVSATFWQNP RNHFRCQVQF
110 120 130 140 150
YGLSENDEWT QDRAKPVTQI VSAEAWGRAD CGFTSVSYQQ GVLSATILYE
160 170
ILLGKATLYA VLVSALVLMA MVKRKDF
Length:177
Mass (Da):19,899
Last modified:April 20, 2010 - v3
Checksum:i9242AFAA3E3DB4AE
GO

Sequence cautioni

The sequence CAA25134 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRiB25777. RWHUCY.
UniGeneiHs.382212.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA. Translation: CAA25134.1. Different initiation.
M12887 Genomic DNA. Translation: AAA60661.1.
L36092 Genomic DNA. Translation: AAC80213.1.
CH471198 Genomic DNA. Translation: EAW51914.1.
PIRiB25777. RWHUCY.
UniGeneiHs.382212.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-130[»]
1FYTX-ray2.60E1-134[»]
1J8HX-ray2.40E1-134[»]
1KGCX-ray1.50E1-130[»]
1KTKX-ray3.00E/F5-130[»]
1MI5X-ray2.50E1-130[»]
1OGAX-ray1.40E1-130[»]
1YMMX-ray3.50E1-131[»]
1ZGLX-ray2.80P/R/T/V1-131[»]
2AK4X-ray2.50E/J/P/U1-130[»]
2AXHX-ray2.70A/B1-130[»]
2BNQX-ray1.70E1-130[»]
2BNRX-ray1.90E1-130[»]
2BNUX-ray1.40B1-130[»]
2CDEX-ray3.50B/D/F1-130[»]
2CDFX-ray2.25B1-130[»]
2CDGX-ray2.60B1-130[»]
2ESVX-ray2.60E1-130[»]
2F53X-ray2.10E1-130[»]
2F54X-ray2.70E/L6-130[»]
2GJ6X-ray2.56E1-130[»]
2IALX-ray1.92B/D1-130[»]
2IAMX-ray2.80D1-130[»]
2IANX-ray2.80E/J/O/T1-130[»]
2NTSX-ray2.40P6-128[»]
2NW2X-ray1.40B1-130[»]
2NX5X-ray2.70E/J/P/U1-130[»]
2P5EX-ray1.89E1-130[»]
2P5WX-ray2.20E1-130[»]
2PO6X-ray3.20D/H1-130[»]
2PYEX-ray2.30E1-130[»]
2PYFX-ray2.20B1-130[»]
2VLJX-ray2.40E1-130[»]
2VLKX-ray2.50E1-130[»]
2VLMX-ray1.98E1-130[»]
2VLRX-ray2.30E/J1-130[»]
2XN9X-ray2.30B1-130[»]
2XNAX-ray2.10B1-130[»]
3ARBX-ray2.70D1-130[»]
3ARDX-ray3.01D1-130[»]
3AREX-ray2.80D1-130[»]
3ARFX-ray2.90D1-130[»]
3ARGX-ray3.00D1-130[»]
3D39X-ray2.81E1-130[»]
3D3VX-ray2.80E1-130[»]
3DX9X-ray2.75B/D1-130[»]
3DXAX-ray3.50E/J/O1-130[»]
3FFCX-ray2.80E/J1-130[»]
3HE6X-ray2.90D1-130[»]
3HG1X-ray3.00E1-130[»]
3KPRX-ray2.60E/J1-130[»]
3KPSX-ray2.70E1-130[»]
3O4LX-ray2.54E1-130[»]
3TN0X-ray3.20D1-130[»]
4G8EX-ray2.20B1-130[»]
4G8FX-ray2.10B1-130[»]
4GG6X-ray3.20F/H1-130[»]
4GG8X-ray3.20B/F1-130[»]
4IIQX-ray2.86B1-130[»]
4JFDX-ray2.46E1-130[»]
4JFEX-ray2.70E1-130[»]
4JFFX-ray2.43E1-130[»]
4JFHX-ray2.40E1-130[»]
4JRXX-ray2.30E1-130[»]
4JRYX-ray2.80E1-130[»]
4L4TX-ray2.00E/H1-130[»]
4L4VX-ray1.90E/H1-130[»]
4L9LX-ray3.40B1-130[»]
4LCCX-ray3.26B1-130[»]
4LCWX-ray2.40E/H1-130[»]
4MJIX-ray2.99E/J1-130[»]
4MNQX-ray2.74E2-130[»]
4NQCX-ray2.50E/H1-130[»]
4NQDX-ray2.20E/H1-130[»]
4NQEX-ray2.10E/H1-130[»]
4OZFX-ray2.70H1-130[»]
4OZGX-ray3.00F/H1-130[»]
4OZHX-ray2.80F/H1-130[»]
4OZIX-ray3.20F/H1-130[»]
4P46X-ray2.85B1-128[»]
4PRHX-ray2.50E1-130[»]
4PRIX-ray2.40E1-130[»]
4PRPX-ray2.50E1-130[»]
4X6BX-ray2.10B/D1-130[»]
4X6CX-ray2.80F/H1-130[»]
4X6DX-ray2.98F/H1-130[»]
4ZDHX-ray2.10B1-130[»]
ProteinModelPortaliP01850.
SMRiP01850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01850. 2 interactors.
MINTiMINT-249879.

PTM databases

iPTMnetiP01850.
PhosphoSitePlusiP01850.

Polymorphism and mutation databases

DMDMi294862488.

Proteomic databases

PeptideAtlasiP01850.
PRIDEiP01850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi28639.
GeneCardsiTRBC1.
TRBV25-1.
TRBV28.
HGNCiHGNC:12156. TRBC1.
MIMi186930. gene.
neXtProtiNX_P01850.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017899.
InParanoidiP01850.
PhylomeDBiP01850.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171082-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202424. Downstream TCR signaling.
R-HSA-202427. Phosphorylation of CD3 and TCR zeta chains.
R-HSA-202430. Translocation of ZAP-70 to Immunological synapse.
R-HSA-202433. Generation of second messenger molecules.
R-HSA-389948. PD-1 signaling.

Miscellaneous databases

EvolutionaryTraceiP01850.
PROiP01850.
SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRBC1_HUMAN
AccessioniPrimary (citable) accession number: P01850
Secondary accession number(s): A0A5B8, A6NH51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.