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P01848

- TCA_HUMAN

UniProt

P01848 - TCA_HUMAN

Protein

T-cell receptor alpha chain C region

Gene

TRAC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. regulation of immune response Source: Reactome
    2. T cell costimulation Source: Reactome
    3. T cell receptor signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-cell receptor alpha chain C region
    Gene namesi
    Name:TRAC
    Synonyms:TCRA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:12029. TRAC.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Immunodeficiency 7 (IMD7) [MIM:615387]: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi615387. phenotype.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 142›142T-cell receptor alpha chain C regionPRO_0000184524Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 741 Publication
    Glycosylationi34 – 341N-linked (GlcNAc...)1 Publication
    Glycosylationi61 – 611N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi68 – 681N-linked (GlcNAc...)1 Publication
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP01848.
    PRIDEiP01848.

    Expressioni

    Gene expression databases

    GenevestigatoriP01848.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRBC1P018501EBI-1034847,EBI-1034839

    Protein-protein interaction databases

    IntActiP01848. 2 interactions.
    MINTiMINT-249869.
    STRINGi9606.ENSP00000411560.

    Structurei

    Secondary structure

    1
    142
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi9 – 2012
    Beta strandi22 – 287
    Beta strandi40 – 423
    Beta strandi43 – 453
    Beta strandi49 – 535
    Helixi54 – 563
    Beta strandi58 – 6811
    Beta strandi69 – 713
    Turni74 – 807

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FYTX-ray2.60D1-99[»]
    1J8HX-ray2.40D1-99[»]
    1KGCX-ray1.50D1-95[»]
    1MI5X-ray2.50D1-91[»]
    1OGAX-ray1.40D1-97[»]
    1QRNX-ray2.80D1-91[»]
    1QSFX-ray2.80D1-91[»]
    1YMMX-ray3.50D2-96[»]
    1ZGLX-ray2.80M/Q/S/U1-96[»]
    2AK4X-ray2.50D/I/N/T1-95[»]
    2BNQX-ray1.70D1-91[»]
    2BNRX-ray1.90D1-91[»]
    2BNUX-ray1.40A1-91[»]
    2CDFX-ray2.25A1-80[»]
    2CDGX-ray2.60A1-80[»]
    2ESVX-ray2.60D1-91[»]
    2EYRX-ray2.40A3-95[»]
    2EYSX-ray2.21A3-95[»]
    2EYTX-ray2.60A/C3-95[»]
    2F53X-ray2.10D3-79[»]
    2F54X-ray2.70D/K3-93[»]
    2GJ6X-ray2.56D1-91[»]
    2IALX-ray1.92A/C1-95[»]
    2IAMX-ray2.80C1-95[»]
    2IANX-ray2.80D/I/N/S1-95[»]
    2NX5X-ray2.70D/I/N/T1-79[»]
    2P5EX-ray1.89D1-81[»]
    2P5WX-ray2.20D3-79[»]
    2PO6X-ray3.20C/G3-92[»]
    2PYEX-ray2.30D1-81[»]
    2PYFX-ray2.20A3-93[»]
    2VLJX-ray2.40D1-91[»]
    2VLKX-ray2.50D1-91[»]
    2VLMX-ray1.98D1-91[»]
    2VLRX-ray2.30D/I1-91[»]
    2XN9X-ray2.30A1-95[»]
    2XNAX-ray2.10A1-95[»]
    3ARBX-ray2.70C1-95[»]
    3ARDX-ray3.01C1-95[»]
    3AREX-ray2.80C1-95[»]
    3ARFX-ray2.90C1-95[»]
    3ARGX-ray3.00C1-95[»]
    3D39X-ray2.81D1-91[»]
    3DX9X-ray2.75A/C3-92[»]
    3DXAX-ray3.50D/I/N3-93[»]
    3FFCX-ray2.80D/I1-91[»]
    3GSNX-ray2.80A1-91[»]
    3HE7X-ray2.80C1-95[»]
    3HG1X-ray3.00D1-87[»]
    3KPRX-ray2.60D/I1-91[»]
    3KPSX-ray2.70D1-91[»]
    3KXFX-ray3.10D/G/M/N1-91[»]
    3O4LX-ray2.54D1-92[»]
    3O6FX-ray2.80C/G1-92[»]
    3O8XX-ray2.74C1-95[»]
    3O9WX-ray2.80C1-95[»]
    3PWPX-ray2.69D1-91[»]
    3QDGX-ray2.69D1-91[»]
    3QDJX-ray2.30D1-91[»]
    3QDMX-ray2.80D1-89[»]
    3QEQX-ray2.59D1-88[»]
    3QEUX-ray2.09A/D1-93[»]
    3QIBX-ray2.70C1-95[»]
    3QJFX-ray2.40A/C1-95[»]
    3QUXX-ray2.91C1-95[»]
    3SCMX-ray2.50C1-95[»]
    3SDAX-ray2.80C1-95[»]
    3SDCX-ray3.10C1-95[»]
    3SDDX-ray3.00C1-95[»]
    3SDXX-ray3.12E/G1-92[»]
    3SJVX-ray3.10D/I/N/S1-95[»]
    3SKNX-ray2.90A/C/E/G1-95[»]
    3T0EX-ray4.00C1-96[»]
    3TN0X-ray3.20C1-95[»]
    3TVMX-ray2.80C/G1-95[»]
    4APQX-ray3.00C1-95[»]
    4G8EX-ray2.20A2-92[»]
    4G8FX-ray2.10A2-95[»]
    4IRSX-ray2.80C1-95[»]
    4JFDX-ray2.46D1-88[»]
    4JFEX-ray2.70D1-89[»]
    4JFFX-ray2.43D1-89[»]
    4JFHX-ray2.40D1-92[»]
    4JRXX-ray2.30D1-91[»]
    4JRYX-ray2.80D1-91[»]
    4PRHX-ray2.50D1-95[»]
    4PRIX-ray2.40D1-91[»]
    4PRPX-ray2.50D1-91[»]
    ProteinModelPortaliP01848.
    SMRiP01848. Positions 1-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01848.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini138 – 1425CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13720HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 117117C regionAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45691.
    HOVERGENiHBG017898.
    InParanoidiP01848.
    PhylomeDBiP01848.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR015370. DUF1968.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF09291. DUF1968. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01848-1 [UniParc]FASTAAdd to Basket

    « Hide

    PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV    50
    LDMRSMDFKS NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL 100
    VEKSFETDTN LNFQNLSVIG FRILLLKVAG FNLLMTLRLW SS 142
    Length:142
    Mass (Da):15,928
    Last modified:July 21, 1986 - v1
    Checksum:iD46B44171D5784EE
    GO

    Sequence cautioni

    The sequence CAA26435.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02592 mRNA. Translation: CAA26435.1. Different initiation.
    PIRiS18893. RWHUAC.
    UniGeneiHs.74647.

    Genome annotation databases

    UCSCiuc001wdg.1. human.

    Polymorphism databases

    DMDMi135511.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02592 mRNA. Translation: CAA26435.1 . Different initiation.
    PIRi S18893. RWHUAC.
    UniGenei Hs.74647.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FYT X-ray 2.60 D 1-99 [» ]
    1J8H X-ray 2.40 D 1-99 [» ]
    1KGC X-ray 1.50 D 1-95 [» ]
    1MI5 X-ray 2.50 D 1-91 [» ]
    1OGA X-ray 1.40 D 1-97 [» ]
    1QRN X-ray 2.80 D 1-91 [» ]
    1QSF X-ray 2.80 D 1-91 [» ]
    1YMM X-ray 3.50 D 2-96 [» ]
    1ZGL X-ray 2.80 M/Q/S/U 1-96 [» ]
    2AK4 X-ray 2.50 D/I/N/T 1-95 [» ]
    2BNQ X-ray 1.70 D 1-91 [» ]
    2BNR X-ray 1.90 D 1-91 [» ]
    2BNU X-ray 1.40 A 1-91 [» ]
    2CDF X-ray 2.25 A 1-80 [» ]
    2CDG X-ray 2.60 A 1-80 [» ]
    2ESV X-ray 2.60 D 1-91 [» ]
    2EYR X-ray 2.40 A 3-95 [» ]
    2EYS X-ray 2.21 A 3-95 [» ]
    2EYT X-ray 2.60 A/C 3-95 [» ]
    2F53 X-ray 2.10 D 3-79 [» ]
    2F54 X-ray 2.70 D/K 3-93 [» ]
    2GJ6 X-ray 2.56 D 1-91 [» ]
    2IAL X-ray 1.92 A/C 1-95 [» ]
    2IAM X-ray 2.80 C 1-95 [» ]
    2IAN X-ray 2.80 D/I/N/S 1-95 [» ]
    2NX5 X-ray 2.70 D/I/N/T 1-79 [» ]
    2P5E X-ray 1.89 D 1-81 [» ]
    2P5W X-ray 2.20 D 3-79 [» ]
    2PO6 X-ray 3.20 C/G 3-92 [» ]
    2PYE X-ray 2.30 D 1-81 [» ]
    2PYF X-ray 2.20 A 3-93 [» ]
    2VLJ X-ray 2.40 D 1-91 [» ]
    2VLK X-ray 2.50 D 1-91 [» ]
    2VLM X-ray 1.98 D 1-91 [» ]
    2VLR X-ray 2.30 D/I 1-91 [» ]
    2XN9 X-ray 2.30 A 1-95 [» ]
    2XNA X-ray 2.10 A 1-95 [» ]
    3ARB X-ray 2.70 C 1-95 [» ]
    3ARD X-ray 3.01 C 1-95 [» ]
    3ARE X-ray 2.80 C 1-95 [» ]
    3ARF X-ray 2.90 C 1-95 [» ]
    3ARG X-ray 3.00 C 1-95 [» ]
    3D39 X-ray 2.81 D 1-91 [» ]
    3DX9 X-ray 2.75 A/C 3-92 [» ]
    3DXA X-ray 3.50 D/I/N 3-93 [» ]
    3FFC X-ray 2.80 D/I 1-91 [» ]
    3GSN X-ray 2.80 A 1-91 [» ]
    3HE7 X-ray 2.80 C 1-95 [» ]
    3HG1 X-ray 3.00 D 1-87 [» ]
    3KPR X-ray 2.60 D/I 1-91 [» ]
    3KPS X-ray 2.70 D 1-91 [» ]
    3KXF X-ray 3.10 D/G/M/N 1-91 [» ]
    3O4L X-ray 2.54 D 1-92 [» ]
    3O6F X-ray 2.80 C/G 1-92 [» ]
    3O8X X-ray 2.74 C 1-95 [» ]
    3O9W X-ray 2.80 C 1-95 [» ]
    3PWP X-ray 2.69 D 1-91 [» ]
    3QDG X-ray 2.69 D 1-91 [» ]
    3QDJ X-ray 2.30 D 1-91 [» ]
    3QDM X-ray 2.80 D 1-89 [» ]
    3QEQ X-ray 2.59 D 1-88 [» ]
    3QEU X-ray 2.09 A/D 1-93 [» ]
    3QIB X-ray 2.70 C 1-95 [» ]
    3QJF X-ray 2.40 A/C 1-95 [» ]
    3QUX X-ray 2.91 C 1-95 [» ]
    3SCM X-ray 2.50 C 1-95 [» ]
    3SDA X-ray 2.80 C 1-95 [» ]
    3SDC X-ray 3.10 C 1-95 [» ]
    3SDD X-ray 3.00 C 1-95 [» ]
    3SDX X-ray 3.12 E/G 1-92 [» ]
    3SJV X-ray 3.10 D/I/N/S 1-95 [» ]
    3SKN X-ray 2.90 A/C/E/G 1-95 [» ]
    3T0E X-ray 4.00 C 1-96 [» ]
    3TN0 X-ray 3.20 C 1-95 [» ]
    3TVM X-ray 2.80 C/G 1-95 [» ]
    4APQ X-ray 3.00 C 1-95 [» ]
    4G8E X-ray 2.20 A 2-92 [» ]
    4G8F X-ray 2.10 A 2-95 [» ]
    4IRS X-ray 2.80 C 1-95 [» ]
    4JFD X-ray 2.46 D 1-88 [» ]
    4JFE X-ray 2.70 D 1-89 [» ]
    4JFF X-ray 2.43 D 1-89 [» ]
    4JFH X-ray 2.40 D 1-92 [» ]
    4JRX X-ray 2.30 D 1-91 [» ]
    4JRY X-ray 2.80 D 1-91 [» ]
    4PRH X-ray 2.50 D 1-95 [» ]
    4PRI X-ray 2.40 D 1-91 [» ]
    4PRP X-ray 2.50 D 1-91 [» ]
    ProteinModelPortali P01848.
    SMRi P01848. Positions 1-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P01848. 2 interactions.
    MINTi MINT-249869.
    STRINGi 9606.ENSP00000411560.

    Polymorphism databases

    DMDMi 135511.

    Proteomic databases

    PaxDbi P01848.
    PRIDEi P01848.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc001wdg.1. human.

    Organism-specific databases

    GeneCardsi GC14P023636.
    HGNCi HGNC:12029. TRAC.
    MIMi 186880. gene.
    615387. phenotype.
    neXtProti NX_P01848.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45691.
    HOVERGENi HBG017898.
    InParanoidi P01848.
    PhylomeDBi P01848.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.

    Miscellaneous databases

    EvolutionaryTracei P01848.
    PROi P01848.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P01848.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR015370. DUF1968.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF09291. DUF1968. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia."
      Rabbitts T.H., Lefranc M.P., Stinson M.A., Sims J.E., Schroder J., Steinmetz M., Spurr N.L., Solomon E., Goodfellow P.N.
      EMBO J. 4:1461-1465(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line."
      Yanagi Y., Chan A., Chin B., Minden M., Mak T.W.
      Proc. Natl. Acad. Sci. U.S.A. 82:3430-3434(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (CLONE PY14).
    3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-34; ASN-61 AND ASN-68.
      Tissue: Leukemic T-cell.
    4. "Mutation in the TCRalpha subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRalphabeta+ T cells."
      Morgan N.V., Goddard S., Cardno T.S., McDonald D., Rahman F., Barge D., Ciupek A., Straatman-Iwanowska A., Pasha S., Guckian M., Anderson G., Huissoon A., Cant A., Tate W.P., Hambleton S., Maher E.R.
      J. Clin. Invest. 121:695-702(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN IMD7.
    5. "The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance."
      Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J.
      Structure 10:1521-1532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-95.
    6. "A structural basis for immunodominant human T cell receptor recognition."
      Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
      Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-93 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRBC1, DISULFIDE BOND.
    7. "Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule."
      Li Y., Huang Y., Lue J., Quandt J.A., Martin R., Mariuzza R.A.
      EMBO J. 24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 3-96 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER AND MBP PEPTIDE.

    Entry informationi

    Entry nameiTCA_HUMAN
    AccessioniPrimary (citable) accession number: P01848
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This clone was isolated from a human leukemic T-cell line, Jurkat.
    This alpha chain C region shows sequence homology to its beta chain counterpart.
    The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3