Reviewed, UniProtKB/Swiss-Prot P01848 (TCA_HUMAN)

Names and origin

Protein names

Recommended name:
    T-cell receptor alpha chain C region

Gene names

Name:

TRAC

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Miscellaneous	This clone was isolated from a human leukemic T-cell line, Jurkat. This alpha chain C region shows sequence homology to its beta chain counterpart. The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cellular defense response Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular function	MHC protein binding Non-traceable author statement. Source: UniProtKB peptide antigen binding Non-traceable author statement. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRBC1	P01850	1	EBI-1034847,EBI-1034839

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 142

›142

T-cell receptor alpha chain C region

PRO_0000184524

Regions

Transmembrane

118 – 137

20

Potential

Topological domain

138 – 142

5

Cytoplasmic Potential

Region

1 – 117

117

C region

Amino acid modifications

Glycosylation

34

1

N-linked (GlcNAc...) Ref.2

Glycosylation

61

1

N-linked (GlcNAc...) Ref.2

Glycosylation

68

1

N-linked (GlcNAc...) Ref.2

Glycosylation

115

1

N-linked (GlcNAc...) Potential

Disulfide bond

24 ↔ 74

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

142

Helix Strand Turn

Details...

Beta strand

9 – 20

12

Beta strand

22 – 28

7

Beta strand

43 – 45

3

Beta strand

49 – 53

5

Helix

54 – 56

3

Beta strand

58 – 68

11

Turn

74 – 80

7

Sequences

	Sequence		Length	Mass (Da)
	P01848-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: D46B44171D5784EE	FASTA	142	15,928
	10 20 30 40 50 60 PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV LDMRSMDFKS 70 80 90 100 110 120 NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL VEKSFETDTN LNFQNLSVIG 130 140 FRILLLKVAG FNLLMTLRLW SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line." Yanagi Y., Chan A., Chin B., Minden M., Mak T.W. Proc. Natl. Acad. Sci. U.S.A. 82:3430-3434(1985) [PubMed: 3873654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (CLONE PY14).
[2]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-34; ASN-61 AND ASN-68, MASS SPECTROMETRY.
[3]	"The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance." Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J. Structure 10:1521-1532(2002) [PubMed: 12429093] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-95.
[4]	"A structural basis for immunodominant human T cell receptor recognition." Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y. Nat. Immunol. 4:657-663(2003) [PubMed: 12796775] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-93.
+	Additional computationally mapped references.

Cross-references

Sequence databases

IPI

IPI00941012.

PIR

RWHUAC. S18893.

UniGene

Hs.74647

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KGC	X-ray	1.50	D	1-95	[»]
1MI5	X-ray	2.50	D	1-91	[»]
1OGA	X-ray	1.40	D	1-93	[»]
1QRN	X-ray	2.80	D	3-91	[»]
1YMM	X-ray	3.50	D	2-96	[»]
1ZGL	X-ray	2.80	M/Q/S/U	3-96	[»]
2AK4	X-ray	2.50	D/I/N/T	1-95	[»]
2BNQ	X-ray	1.70	D	3-91	[»]
2BNR	X-ray	1.90	D	3-91	[»]
2BNU	X-ray	1.40	A	3-91	[»]
2ESV	X-ray	2.60	D	3-91	[»]
2EYR	X-ray	2.40	A	1-95	[»]
2EYS	X-ray	2.21	A	1-95	[»]
2EYT	X-ray	2.60	A/C	1-95	[»]
2F53	X-ray	2.10	D	1-79	[»]
2F54	X-ray	2.70	D/K	1-93	[»]
2GJ6	X-ray	2.56	D	3-91	[»]
2IAL	X-ray	1.92	A/C	1-95	[»]
2IAM	X-ray	2.80	C	1-95	[»]
2IAN	X-ray	2.80	D/I/N/S	1-95	[»]
2P5E	X-ray	1.89	D	1-81	[»]
2P5W	X-ray	2.20	D	1-79	[»]
2PO6	X-ray	3.20	C/G	1-92	[»]
2PYE	X-ray	2.30	D	1-81	[»]
2PYF	X-ray	2.20	A	1-93	[»]
2VLJ	X-ray	2.40	D	1-91	[»]
2VLK	X-ray	2.50	D	1-91	[»]
2VLM	X-ray	1.98	D	1-91	[»]
2VLR	X-ray	2.30	D/I	1-91	[»]
3DX9	X-ray	2.75	A/C	3-92	[»]
3DXA	X-ray	3.50	D/I/N	3-93	[»]
3FFC	X-ray	2.80	D/I	1-91	[»]
3GSN	X-ray	2.80	A	1-91	[»]
3HG1	X-ray	3.00	D	1-87	[»]

DisProt

DP00093.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01848. 1 interaction.

STRING

P01848.

Proteomic databases

PRIDE

P01848.

Genome annotation databases

Ensembl

ENST00000417553; ENSP00000407568; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000431063; ENSP00000406179; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000441233; ENSP00000399297; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000442641; ENSP00000411560; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000446106; ENSP00000398164; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000446346; ENSP00000397832; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000451106; ENSP00000390114; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000452868; ENSP00000396640; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000454915; ENSP00000398994; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000456891; ENSP00000408870; ENSG00000229164; Homo sapiens. [Genome view]
ENST00000458619; ENSP00000405883; ENSG00000229164; Homo sapiens. [Genome view]

UCSC

uc001weg.2. human.

Organism-specific databases

GeneCards

GC14P022086.
GC14P022087.

H-InvDB

HIX0018085.

HGNC

HGNC:12027. TRA@.

PharmGKB

PA74.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P01848.

Enzyme and pathway databases

Reactome

REACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpress

P01848.

Bgee

P01848.

Genevestigator

P01848.

GermOnline

ENSG00000129563. Homo sapiens.

Family and domain databases

InterPro

IPR015370. DUF1968.
IPR013783. Ig-like_fold.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF09291. DUF1968. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TCA_HUMAN

Accession

Primary (citable) accession number: P01848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	November 3, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.