T-cell receptor alpha chain C region

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Reviewed, UniProtKB/Swiss-Prot P01848 (TCA_HUMAN)

Last modified June 16, 2009. Version 75. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
T-cell receptor alpha chain C region

Gene names

Name:

TRAC

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Miscellaneous

This clone was isolated from a human leukemic T-cell line, Jurkat.

This alpha chain C region shows sequence homology to its beta chain counterpart.

The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

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Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure
Gene Ontology (GO)
Biological process	cellular defense response Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular function	MHC protein binding Non-traceable author statement. Source: UniProtKB peptide antigen binding Non-traceable author statement. Source: UniProtKB receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRBC1	P01850	1	EBI-1034847,EBI-1034839

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 142

›142

T-cell receptor alpha chain C region

PRO_0000184524

Regions

Transmembrane

118 – 137

Potential

Topological domain

138 – 142

Cytoplasmic Potential

Region

1 – 117

117

C region

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

115

N-linked (GlcNAc...) Potential

Disulfide bond

24 ↔ 74

Experimental info

Non-terminal residue

Secondary structure

142

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

P01848-1 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: D46B44171D5784EE
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FASTA

142

15,928

        10         20         30         40         50         60 
PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV LDMRSMDFKS 

        70         80         90        100        110        120 
NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL VEKSFETDTN LNFQNLSVIG 

       130        140 
FRILLLKVAG FNLLMTLRLW SS

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References

[1]	"Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line." Yanagi Y., Chan A., Chin B., Minden M., Mak T.W. Proc. Natl. Acad. Sci. U.S.A. 82:3430-3434(1985) [PubMed: 3873654] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (CLONE PY14).
[2]	"The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance." Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J. Structure 10:1521-1532(2002) [PubMed: 12429093] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-95.
[3]	"A structural basis for immunodominant human T cell receptor recognition." Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y. Nat. Immunol. 4:657-663(2003) [PubMed: 12796775] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-93.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

IPI

IPI00448929.

PIR

RWHUAC. S18893.

UniGene

Hs.74647

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1KGC	X-ray	1.50	D	1-95	[»]
1MI5	X-ray	2.50	D	1-91	[»]
1OGA	X-ray	1.40	D	1-93	[»]
1QRN	X-ray	2.80	D	3-91	[»]
1YMM	X-ray	3.50	D	2-96	[»]
1ZGL	X-ray	2.80	M/Q/S/U	3-96	[»]
2AK4	X-ray	2.50	D/I/N/T	1-95	[»]
2BNQ	X-ray	1.70	D	3-91	[»]
2BNR	X-ray	1.90	D	3-91	[»]
2BNU	X-ray	1.40	A	3-91	[»]
			B	45-47	[»]
2ESV	X-ray	2.60	D	3-91	[»]
2EYR	X-ray	2.40	A	1-95	[»]
2EYS	X-ray	2.21	A	1-95	[»]
2EYT	X-ray	2.60	A/C	1-95	[»]
2F53	X-ray	2.10	D	1-79	[»]
2F54	X-ray	2.70	D/K	1-93	[»]
2GJ6	X-ray	2.56	D	3-91	[»]
2IAL	X-ray	1.92	A/C	1-95	[»]
2IAM	X-ray	2.80	C	1-95	[»]
2IAN	X-ray	2.80	D/I/N/S	1-95	[»]
2P5E	X-ray	1.89	D	1-81	[»]
2P5W	X-ray	2.20	D	1-79	[»]
2PO6	X-ray	3.20	C/G	1-92	[»]
2PYE	X-ray	2.30	D	1-81	[»]
2PYF	X-ray	2.20	A	1-93	[»]
2VLJ	X-ray	2.40	D	1-91	[»]
2VLK	X-ray	2.50	D	1-91	[»]
2VLM	X-ray	1.98	D	1-91	[»]
2VLR	X-ray	2.30	D/I	1-91	[»]
3DX9	X-ray	2.75	A/C	3-92	[»]
3DXA	X-ray	3.50	D/I/N	3-93	[»]
3FFC	X-ray	2.80	D/I	1-91	[»]

DisProt

DP00093.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01848. 1 interaction.

Proteomic databases

PRIDE

P01848.

Genome annotation databases

Ensembl

ENSG00000211889. Homo sapiens. [Contig view]

Organism-specific databases

GeneCards

GC14P022086.
GC14P022087.

H-InvDB

HIX0018085.

HGNC

HGNC:12027. TRA@.

PharmGKB

PA74.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

P01848.

Enzyme and pathway databases

Reactome

REACT_6900. Signaling in Immune system.

Gene expression databases

ArrayExpress

P01848.

Bgee

P01848.

GermOnline

ENSG00000129563. Homo sapiens.

Family and domain databases

InterPro

IPR015370. DUF1968.
IPR013783. Ig-like_fold.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 1 hit.

Pfam

PF09291. DUF1968. 1 hit.
[Graphical view]

ProtoNet

Search...

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Entry information

Entry name

TCA_HUMAN

Accession

Primary (citable) accession number: P01848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	June 16, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents