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Protein

T-cell receptor alpha chain C region

Gene

TRAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This clone was isolated from a human leukemic T-cell line, Jurkat.
This alpha chain C region shows sequence homology to its beta chain counterpart.
The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-389948 PD-1 signaling
SIGNORiP01848

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell receptor alpha chain C region
Gene namesi
Name:TRAC
Synonyms:TCRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:12029 TRAC
MIMi186880 gene
neXtProtiNX_P01848

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 142CytoplasmicSequence analysis5

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 7 (IMD7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta.
See also OMIM:615387

Organism-specific databases

DisGeNETi28755
MalaCardsiTRAC
MIMi615387 phenotype
Orphaneti397959 TCR-alpha-beta-positive T-cell deficiency

Chemistry databases

ChEMBLiCHEMBL3580506
DrugBankiDB02740 3-Indolebutyric Acid

Polymorphism and mutation databases

DMDMi135511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000184524‹1 – 142T-cell receptor alpha chain C regionAdd BLAST›142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 741 Publication
Glycosylationi34N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi61N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi68N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01848
PRIDEiP01848

PTM databases

iPTMnetiP01848

Interactioni

Protein-protein interaction databases

IntActiP01848, 3 interactors

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Beta strandi22 – 28Combined sources7
Beta strandi31 – 33Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi43 – 45Combined sources3
Beta strandi49 – 53Combined sources5
Helixi54 – 56Combined sources3
Beta strandi58 – 68Combined sources11
Beta strandi69 – 71Combined sources3
Helixi74 – 77Combined sources4
Turni78 – 80Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60D1-95[»]
1BD2X-ray2.50D1-95[»]
1FYTX-ray2.60D1-99[»]
1J8HX-ray2.40D1-99[»]
1KGCX-ray1.50D1-95[»]
1MI5X-ray2.50D1-91[»]
1OGAX-ray1.40D1-97[»]
1QRNX-ray2.80D1-91[»]
1QSFX-ray2.80D1-91[»]
1YMMX-ray3.50D2-96[»]
1ZGLX-ray2.80M/Q/S/U1-96[»]
2AK4X-ray2.50D/I/N/T1-95[»]
2BNQX-ray1.70D1-91[»]
2BNRX-ray1.90D1-91[»]
2BNUX-ray1.40A1-91[»]
2CDFX-ray2.25A1-80[»]
2CDGX-ray2.60A1-80[»]
2ESVX-ray2.60D1-91[»]
2EYRX-ray2.40A3-95[»]
2EYSX-ray2.21A3-95[»]
2EYTX-ray2.60A/C3-95[»]
2F53X-ray2.10D3-79[»]
2F54X-ray2.70D/K3-93[»]
2GJ6X-ray2.56D1-91[»]
2IALX-ray1.92A/C1-95[»]
2IAMX-ray2.80C1-95[»]
2IANX-ray2.80D/I/N/S1-95[»]
2NX5X-ray2.70D/I/N/T1-79[»]
2P5EX-ray1.89D1-81[»]
2P5WX-ray2.20D3-79[»]
2PO6X-ray3.20C/G3-92[»]
2PYEX-ray2.30D1-81[»]
2PYFX-ray2.20A3-93[»]
2VLJX-ray2.40D1-91[»]
2VLKX-ray2.50D1-91[»]
2VLMX-ray1.98D1-91[»]
2VLRX-ray2.30D/I1-91[»]
2XN9X-ray2.30A1-95[»]
2XNAX-ray2.10A1-95[»]
3ARBX-ray2.70C1-95[»]
3ARDX-ray3.01C1-95[»]
3AREX-ray2.80C1-95[»]
3ARFX-ray2.90C1-95[»]
3ARGX-ray3.00C1-95[»]
3D39X-ray2.81D1-91[»]
3DX9X-ray2.75A/C3-92[»]
3DXAX-ray3.50D/I/N3-93[»]
3FFCX-ray2.80D/I1-91[»]
3GSNX-ray2.80A1-91[»]
3HE7X-ray2.80C1-95[»]
3HG1X-ray3.00D1-87[»]
3KPRX-ray2.60D/I1-91[»]
3KPSX-ray2.70D1-91[»]
3KXFX-ray3.10D/G/M/N1-91[»]
3O4LX-ray2.54D1-92[»]
3O6FX-ray2.80C/G1-92[»]
3O8XX-ray2.74C1-95[»]
3O9WX-ray2.80C1-95[»]
3PWPX-ray2.69D1-91[»]
3QDGX-ray2.69D1-91[»]
3QDJX-ray2.30D1-91[»]
3QDMX-ray2.80D1-89[»]
3QEQX-ray2.59D1-88[»]
3QEUX-ray2.09A/D1-93[»]
3QIBX-ray2.70C1-95[»]
3QJFX-ray2.40A/C1-95[»]
3QUXX-ray2.91C1-95[»]
3SCMX-ray2.50C1-95[»]
3SDAX-ray2.80C1-95[»]
3SDCX-ray3.10C1-95[»]
3SDDX-ray3.00C1-95[»]
3SDXX-ray3.12E/G1-92[»]
3SJVX-ray3.10D/I/N/S1-95[»]
3SKNX-ray2.90A/C/E/G1-95[»]
3T0EX-ray4.00C1-96[»]
3TN0X-ray3.20C1-95[»]
3TVMX-ray2.80C/G1-95[»]
4APQX-ray3.00C1-95[»]
4C56X-ray2.90A/G2-95[»]
4G8EX-ray2.20A2-92[»]
4G8FX-ray2.10A2-95[»]
4IRSX-ray2.80C1-95[»]
4JFDX-ray2.46D1-88[»]
4JFEX-ray2.70D1-89[»]
4JFFX-ray2.43D1-89[»]
4JFHX-ray2.40D1-92[»]
4JRXX-ray2.30D1-91[»]
4JRYX-ray2.80D1-91[»]
4MVBX-ray3.09C1-95[»]
4MXQX-ray2.60C1-95[»]
4N0CX-ray2.90C/G1-95[»]
4N5EX-ray3.06C1-95[»]
4NHUX-ray2.90A/C1-95[»]
4ONHX-ray3.01A1-95[»]
4P4KX-ray2.80C/G1-95[»]
4PRHX-ray2.50D1-95[»]
4PRIX-ray2.40D1-91[»]
4PRPX-ray2.50D1-91[»]
4UDTX-ray1.35A1-95[»]
4UDUX-ray2.50A1-95[»]
4WW1X-ray1.38A1-95[»]
4WW2X-ray2.48A1-95[»]
4WWKX-ray3.10A1-95[»]
4X6BX-ray2.10A/C1-95[»]
4X6CX-ray2.80E/G1-95[»]
4X6DX-ray2.98E/G1-95[»]
4Y16X-ray2.60C1-95[»]
4Y2DX-ray3.05C/G1-95[»]
4Y4FX-ray3.19C/G1-95[»]
4Y4HX-ray3.10C/G1-95[»]
4Y4KX-ray2.90C1-95[»]
4ZDHX-ray2.10A3-93[»]
5BRZX-ray2.62D4-84[»]
5BS0X-ray2.40D3-84[»]
5C07X-ray2.11D/I1-90[»]
5C08X-ray2.33D/I1-82[»]
5C09X-ray2.48D/I1-92[»]
5C0AX-ray2.46D/I1-89[»]
5C0BX-ray2.03D/I1-91[»]
5C0CX-ray1.97D/I1-91[»]
5EU6X-ray2.02D1-89[»]
5FK9X-ray3.10A2-95[»]
5FKAX-ray2.40A2-95[»]
5HHMX-ray2.50D/I1-91[»]
5HHOX-ray2.95D1-91[»]
5HYJX-ray3.06D/I1-84[»]
5JZIX-ray2.50G/I1-95[»]
5KS9X-ray2.55E/G1-95[»]
5KSAX-ray2.00C1-95[»]
5KSBX-ray2.90E/G1-95[»]
ProteinModelPortaliP01848
SMRiP01848
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01848

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 117C regionAdd BLAST117

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017898
InParanoidiP01848
PhylomeDBiP01848

Family and domain databases

CDDicd07688 IgC_TCR_alpha, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR015370 TCR_alpha_C
PfamiView protein in Pfam
PF09291 DUF1968, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

P01848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV
60 70 80 90 100
LDMRSMDFKS NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL
110 120 130 140
VEKSFETDTN LNFQNLSVIG FRILLLKVAG FNLLMTLRLW SS
Length:142
Mass (Da):15,928
Last modified:July 21, 1986 - v1
Checksum:iD46B44171D5784EE
GO

Sequence cautioni

The sequence CAA26435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02592 mRNA Translation: CAA26435.1 Different initiation.
PIRiS18893 RWHUAC
UniGeneiHs.74647

Similar proteinsi

Entry informationi

Entry nameiTCA_HUMAN
AccessioniPrimary (citable) accession number: P01848
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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