P01848 (TCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell receptor alpha chain C region

Gene names

Name:	TRAC
Synonyms:	TCRA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Miscellaneous	This clone was isolated from a human leukemic T-cell line, Jurkat. This alpha chain C region shows sequence homology to its beta chain counterpart. The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.
Sequence caution	The sequence CAA26435.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell costimulation Traceable author statement. Source: Reactome T cell receptor signaling pathway Traceable author statement. Source: Reactome cellular defense response Non-traceable author statement. Source: UniProtKB
Cellular_component	integral to plasma membrane Non-traceable author statement. Source: UniProtKB
Molecular_function	MHC protein binding Non-traceable author statement. Source: UniProtKB peptide antigen binding Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRBC1	P01850	1	EBI-1034847,EBI-1034839

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 142

›142

T-cell receptor alpha chain C region

PRO_0000184524

Regions

Transmembrane

118 – 137

20

Helical; Potential

Topological domain

138 – 142

5

Cytoplasmic Potential

Region

1 – 117

117

C region

Amino acid modifications

Glycosylation

34

1

N-linked (GlcNAc...) Ref.3

Glycosylation

61

1

N-linked (GlcNAc...) Ref.3

Glycosylation

68

1

N-linked (GlcNAc...) Ref.3

Glycosylation

115

1

N-linked (GlcNAc...) Potential

Disulfide bond

24 ↔ 74

Ref.5

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

142

Helix Strand Turn

Details...

Beta strand

9 – 20

12

Beta strand

22 – 28

7

Beta strand

39 – 42

4

Beta strand

43 – 45

3

Beta strand

49 – 53

5

Helix

54 – 56

3

Beta strand

58 – 68

11

Beta strand

69 – 71

3

Turn

74 – 80

7

Sequences

	Sequence		Length	Mass (Da)
	P01848 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: D46B44171D5784EE	FASTA	142	15,928
	10 20 30 40 50 60 PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV LDMRSMDFKS 70 80 90 100 110 120 NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL VEKSFETDTN LNFQNLSVIG 130 140 FRILLLKVAG FNLLMTLRLW SS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia." Rabbitts T.H., Lefranc M.P., Stinson M.A., Sims J.E., Schroder J., Steinmetz M., Spurr N.L., Solomon E., Goodfellow P.N. EMBO J. 4:1461-1465(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line." Yanagi Y., Chan A., Chin B., Minden M., Mak T.W. Proc. Natl. Acad. Sci. U.S.A. 82:3430-3434(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE (CLONE PY14).
[3]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-34; ASN-61 AND ASN-68, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[4]	"The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance." Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J. Structure 10:1521-1532(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-95.
[5]	"A structural basis for immunodominant human T cell receptor recognition." Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y. Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-93 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRBC1, DISULFIDE BOND.
[6]	"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule." Li Y., Huang Y., Lue J., Quandt J.A., Martin R., Mariuzza R.A. EMBO J. 24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 3-96 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER AND MBP PEPTIDE.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X02592 mRNA. Translation: CAA26435.1. Different initiation.

IPI

IPI00450949.

PIR

RWHUAC. S18893.

UniGene

Hs.74647.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J8H	X-ray	2.40	D	1-99	[»]
1KGC	X-ray	1.50	D	1-95	[»]
1MI5	X-ray	2.50	D	1-91	[»]
1OGA	X-ray	1.40	D	1-93	[»]
1QRN	X-ray	2.80	D	3-91	[»]
1YMM	X-ray	3.50	D	2-96	[»]
1ZGL	X-ray	2.80	M/Q/S/U	3-96	[»]
2AK4	X-ray	2.50	D/I/N/T	1-95	[»]
2BNQ	X-ray	1.70	D	3-91	[»]
2BNR	X-ray	1.90	D	3-91	[»]
2BNU	X-ray	1.40	A	3-91	[»]
2ESV	X-ray	2.60	D	3-91	[»]
2EYR	X-ray	2.40	A	1-95	[»]
2EYS	X-ray	2.21	A	1-95	[»]
2EYT	X-ray	2.60	A/C	1-95	[»]
2F53	X-ray	2.10	D	1-79	[»]
2F54	X-ray	2.70	D/K	1-93	[»]
2GJ6	X-ray	2.56	D	3-91	[»]
2IAL	X-ray	1.92	A/C	1-95	[»]
2IAM	X-ray	2.80	C	1-95	[»]
2IAN	X-ray	2.80	D/I/N/S	1-95	[»]
2NX5	X-ray	2.70	D/I/N/T	3-79	[»]
2P5E	X-ray	1.89	D	1-81	[»]
2P5W	X-ray	2.20	D	1-79	[»]
2PO6	X-ray	3.20	C/G	1-92	[»]
2PYE	X-ray	2.30	D	1-81	[»]
2PYF	X-ray	2.20	A	1-93	[»]
2VLJ	X-ray	2.40	D	1-91	[»]
2VLK	X-ray	2.50	D	1-91	[»]
2VLM	X-ray	1.98	D	1-91	[»]
2VLR	X-ray	2.30	D/I	1-91	[»]
2XN9	X-ray	2.30	A	1-95	[»]
2XNA	X-ray	2.10	A	1-95	[»]
3DX9	X-ray	2.75	A/C	3-92	[»]
3DXA	X-ray	3.50	D/I/N	3-93	[»]
3FFC	X-ray	2.80	D/I	1-91	[»]
3GSN	X-ray	2.80	A	1-91	[»]
3HG1	X-ray	3.00	D	1-87	[»]
3KPR	X-ray	2.60	D/I	1-91	[»]
3KPS	X-ray	2.70	D	1-91	[»]
3KXF	X-ray	3.10	D/G/M/N	1-91	[»]
3O6F	X-ray	2.80	C/G	1-96	[»]
3O8X	X-ray	2.74	C	8-95	[»]
3O9W	X-ray	2.80	C	8-95	[»]
3QDG	X-ray	2.69	D	1-91	[»]
3QDJ	X-ray	2.30	D	1-91	[»]
3QDM	X-ray	2.80	D	1-89	[»]
3QEQ	X-ray	2.59	D	1-88	[»]
3QEU	X-ray	2.09	A/D	1-93	[»]
3SCM	X-ray	2.50	C	3-95	[»]
3SDA	X-ray	2.80	C	3-95	[»]
3SDC	X-ray	3.10	C	3-95	[»]
3SDD	X-ray	3.00	C	3-95	[»]
3SDX	X-ray	3.12	E/G	3-92	[»]
3SKN	X-ray	2.90	A/C/E/G	1-95	[»]

DisProt

DP00093.

ProteinModelPortal

P01848.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01848. 2 interactions.

MINT

MINT-249869.

STRING

9606.ENSP00000411560.

Polymorphism databases

DMDM

135511.

Proteomic databases

PaxDb

P01848.

PRIDE

P01848.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

UCSC

uc001wdg.1. human.

Organism-specific databases

GeneCards

GC14P023463.

HGNC

HGNC:12029. TRAC.

neXtProt

NX_P01848.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45691.

HOVERGEN

HBG017898.

InParanoid

P01848.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Genevestigator

P01848.

GermOnline

ENSG00000129563. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR015370. DUF1968.
IPR013783. Ig-like_fold.
[Graphical view]

Pfam

PF09291. DUF1968. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P01848.

Entry information

Entry name

TCA_HUMAN

Accession

Primary (citable) accession number: P01848

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.