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P01848 (TCA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
T-cell receptor alpha chain C region
Gene names
Name:TRAC
Synonyms:TCRA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length142 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Single-pass membrane protein Potential.

Involvement in disease

Immunodeficiency 7 (IMD7) [MIM:615387]: A primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4

Miscellaneous

This clone was isolated from a human leukemic T-cell line, Jurkat.

This alpha chain C region shows sequence homology to its beta chain counterpart.

The gene corresponding to this mRNA is rearranged specifically in T-cells; its organization is similar to an Ig gene, with V, D, J, and C regions.

Sequence caution

The sequence CAA26435.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TRBC1P018501EBI-1034847,EBI-1034839

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 142›142T-cell receptor alpha chain C region
PRO_0000184524

Regions

Transmembrane118 – 13720Helical; Potential
Topological domain138 – 1425Cytoplasmic Potential
Region1 – 117117C region

Amino acid modifications

Glycosylation341N-linked (GlcNAc...) Ref.3
Glycosylation611N-linked (GlcNAc...); atypical Ref.3
Glycosylation681N-linked (GlcNAc...) Ref.3
Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond24 ↔ 74 Ref.6

Experimental info

Non-terminal residue11

Secondary structure

................ 142
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01848 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: D46B44171D5784EE

FASTA14215,928
        10         20         30         40         50         60 
PNIQNPDPAV YQLRDSKSSD KSVCLFTDFD SQTNVSQSKD SDVYITDKTV LDMRSMDFKS 

        70         80         90        100        110        120 
NSAVAWSNKS DFACANAFNN SIIPEDTFFP SPESSCDVKL VEKSFETDTN LNFQNLSVIG 

       130        140 
FRILLLKVAG FNLLMTLRLW SS 

« Hide

References

« Hide 'large scale' references
[1]"The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia."
Rabbitts T.H., Lefranc M.P., Stinson M.A., Sims J.E., Schroder J., Steinmetz M., Spurr N.L., Solomon E., Goodfellow P.N.
EMBO J. 4:1461-1465(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line."
Yanagi Y., Chan A., Chin B., Minden M., Mak T.W.
Proc. Natl. Acad. Sci. U.S.A. 82:3430-3434(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (CLONE PY14).
[3]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-34; ASN-61 AND ASN-68.
Tissue: Leukemic T-cell.
[4]"Mutation in the TCRalpha subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRalphabeta+ T cells."
Morgan N.V., Goddard S., Cardno T.S., McDonald D., Rahman F., Barge D., Ciupek A., Straatman-Iwanowska A., Pasha S., Guckian M., Anderson G., Huissoon A., Cant A., Tate W.P., Hambleton S., Maher E.R.
J. Clin. Invest. 121:695-702(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN IMD7.
[5]"The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance."
Kjer-Nielsen L., Clements C.S., Brooks A.G., Purcell A.W., McCluskey J., Rossjohn J.
Structure 10:1521-1532(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 1-95.
[6]"A structural basis for immunodominant human T cell receptor recognition."
Stewart-Jones G.B.E., McMichael A.J., Bell J.I., Stuart D.I., Jones E.Y.
Nat. Immunol. 4:657-663(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-93 IN COMPLEX WITH HLA-A/B2M HETERODIMER AND TRBC1, DISULFIDE BOND.
[7]"Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule."
Li Y., Huang Y., Lue J., Quandt J.A., Martin R., Mariuzza R.A.
EMBO J. 24:2968-2979(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 3-96 IN COMPLEX WITH HLA-DRA/HLA-DRB5 HETERODIMER AND MBP PEPTIDE.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02592 mRNA. Translation: CAA26435.1. Different initiation.
PIRRWHUAC. S18893.
UniGeneHs.74647.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1FYTX-ray2.60D1-99[»]
1J8HX-ray2.40D1-99[»]
1KGCX-ray1.50D1-95[»]
1MI5X-ray2.50D1-91[»]
1OGAX-ray1.40D1-97[»]
1QRNX-ray2.80D1-91[»]
1QSFX-ray2.80D1-91[»]
1YMMX-ray3.50D2-96[»]
1ZGLX-ray2.80M/Q/S/U1-96[»]
2AK4X-ray2.50D/I/N/T1-95[»]
2BNQX-ray1.70D1-91[»]
2BNRX-ray1.90D1-91[»]
2BNUX-ray1.40A1-91[»]
2CDFX-ray2.25A1-80[»]
2CDGX-ray2.60A1-80[»]
2ESVX-ray2.60D1-91[»]
2EYRX-ray2.40A3-95[»]
2EYSX-ray2.21A3-95[»]
2EYTX-ray2.60A/C3-95[»]
2F53X-ray2.10D3-79[»]
2F54X-ray2.70D/K3-93[»]
2GJ6X-ray2.56D1-91[»]
2IALX-ray1.92A/C1-95[»]
2IAMX-ray2.80C1-95[»]
2IANX-ray2.80D/I/N/S1-95[»]
2NX5X-ray2.70D/I/N/T1-79[»]
2P5EX-ray1.89D1-81[»]
2P5WX-ray2.20D3-79[»]
2PO6X-ray3.20C/G3-92[»]
2PYEX-ray2.30D1-81[»]
2PYFX-ray2.20A3-93[»]
2VLJX-ray2.40D1-91[»]
2VLKX-ray2.50D1-91[»]
2VLMX-ray1.98D1-91[»]
2VLRX-ray2.30D/I1-91[»]
2XN9X-ray2.30A1-95[»]
2XNAX-ray2.10A1-95[»]
3ARBX-ray2.70C1-95[»]
3ARDX-ray3.01C1-95[»]
3AREX-ray2.80C1-95[»]
3ARFX-ray2.90C1-95[»]
3ARGX-ray3.00C1-95[»]
3D39X-ray2.81D1-91[»]
3DX9X-ray2.75A/C3-92[»]
3DXAX-ray3.50D/I/N3-93[»]
3FFCX-ray2.80D/I1-91[»]
3GSNX-ray2.80A1-91[»]
3HE7X-ray2.80C1-95[»]
3HG1X-ray3.00D1-87[»]
3KPRX-ray2.60D/I1-91[»]
3KPSX-ray2.70D1-91[»]
3KXFX-ray3.10D/G/M/N1-91[»]
3O4LX-ray2.54D1-92[»]
3O6FX-ray2.80C/G1-92[»]
3O8XX-ray2.74C1-95[»]
3O9WX-ray2.80C1-95[»]
3PWPX-ray2.69D1-91[»]
3QDGX-ray2.69D1-91[»]
3QDJX-ray2.30D1-91[»]
3QDMX-ray2.80D1-89[»]
3QEQX-ray2.59D1-88[»]
3QEUX-ray2.09A/D1-93[»]
3QIBX-ray2.70C1-95[»]
3QJFX-ray2.40A/C1-95[»]
3QUXX-ray2.91C1-95[»]
3SCMX-ray2.50C1-95[»]
3SDAX-ray2.80C1-95[»]
3SDCX-ray3.10C1-95[»]
3SDDX-ray3.00C1-95[»]
3SDXX-ray3.12E/G1-92[»]
3SJVX-ray3.10D/I/N/S1-95[»]
3SKNX-ray2.90A/C/E/G1-95[»]
3T0EX-ray4.00C1-96[»]
3TN0X-ray3.20C1-95[»]
3TVMX-ray2.80C/G1-95[»]
4APQX-ray3.00C1-95[»]
4G8EX-ray2.20A2-92[»]
4G8FX-ray2.10A2-95[»]
4IRSX-ray2.80C1-95[»]
4JFDX-ray2.46D1-88[»]
4JFEX-ray2.70D1-89[»]
4JFFX-ray2.43D1-89[»]
4JFHX-ray2.40D1-92[»]
4JRXX-ray2.30D1-91[»]
4JRYX-ray2.80D1-91[»]
4PRHX-ray2.50D1-95[»]
4PRIX-ray2.40D1-91[»]
4PRPX-ray2.50D1-91[»]
ProteinModelPortalP01848.
SMRP01848. Positions 1-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP01848. 2 interactions.
MINTMINT-249869.
STRING9606.ENSP00000411560.

Polymorphism databases

DMDM135511.

Proteomic databases

PaxDbP01848.
PRIDEP01848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc001wdg.1. human.

Organism-specific databases

GeneCardsGC14P023636.
HGNCHGNC:12029. TRAC.
MIM186880. gene.
615387. phenotype.
neXtProtNX_P01848.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45691.
HOVERGENHBG017898.
InParanoidP01848.
PhylomeDBP01848.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorP01848.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR015370. DUF1968.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF09291. DUF1968. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01848.
PROP01848.
SOURCESearch...

Entry information

Entry nameTCA_HUMAN
AccessionPrimary (citable) accession number: P01848
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM