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Protein

Ig lambda-2 chain C region

Gene

Iglc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-2 chain C region
Gene namesi
Name:Iglc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:99547. Iglc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153609‹1 – 104Ig lambda-2 chain C regionAdd BLAST›104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 85
Disulfide bondi103Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01844.
PaxDbiP01844.
PeptideAtlasiP01844.
PRIDEiP01844.

Expressioni

Gene expression databases

BgeeiENSMUSG00000076937.
ExpressionAtlasiP01844. baseline and differential.
GenevisibleiP01844. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100464.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 19Combined sources5
Beta strandi22 – 35Combined sources14
Beta strandi38 – 43Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi63 – 73Combined sources11
Helixi74 – 79Combined sources6
Beta strandi83 – 89Combined sources7
Beta strandi92 – 98Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QHRX-ray2.00L1-102[»]
ProteinModelPortaliP01844.
SMRiP01844.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01844.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-likeAdd BLAST94

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410KGIZ. Eukaryota.
ENOG4110S82. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG039526.
InParanoidiP01844.
OMAiTHEGQAM.
PhylomeDBiP01844.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSTPTLTV FPPSSEELKE NKATLVCLIS NFSPSGVTVA WKANGTPITQ
60 70 80 90 100
GVDTSNPTKE GNKFMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP

AECL
Length:104
Mass (Da):11,255
Last modified:July 21, 1986 - v1
Checksum:iCE4B67B8688862D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00595 Genomic DNA. Translation: AAA39151.1.
PIRiC93922. L2MS.

Genome annotation databases

EnsembliENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00595 Genomic DNA. Translation: AAA39151.1.
PIRiC93922. L2MS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QHRX-ray2.00L1-102[»]
ProteinModelPortaliP01844.
SMRiP01844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100464.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01844.
PaxDbiP01844.
PeptideAtlasiP01844.
PRIDEiP01844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937.

Organism-specific databases

MGIiMGI:99547. Iglc2.

Phylogenomic databases

eggNOGiENOG410KGIZ. Eukaryota.
ENOG4110S82. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG039526.
InParanoidiP01844.
OMAiTHEGQAM.
PhylomeDBiP01844.

Enzyme and pathway databases

ReactomeiR-MMU-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

EvolutionaryTraceiP01844.
PROiP01844.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000076937.
ExpressionAtlasiP01844. baseline and differential.
GenevisibleiP01844. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC2_MOUSE
AccessioniPrimary (citable) accession number: P01844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.