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Protein

Ig lambda-2 chain C region

Gene

Iglc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-2 chain C region
Gene namesi
Name:Iglc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:99547 Iglc2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153609‹1 – 104Ig lambda-2 chain C regionAdd BLAST›104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 85
Disulfide bondi103Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01844
PaxDbiP01844
PeptideAtlasiP01844
PRIDEiP01844

Expressioni

Gene expression databases

BgeeiENSMUSG00000076937
ExpressionAtlasiP01844 baseline and differential
GenevisibleiP01844 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100464

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Helixi15 – 19Combined sources5
Beta strandi22 – 35Combined sources14
Beta strandi38 – 43Combined sources6
Beta strandi46 – 48Combined sources3
Beta strandi52 – 54Combined sources3
Beta strandi58 – 60Combined sources3
Beta strandi63 – 73Combined sources11
Helixi74 – 79Combined sources6
Beta strandi83 – 89Combined sources7
Beta strandi92 – 98Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QHRX-ray2.00L1-102[»]
ProteinModelPortaliP01844
SMRiP01844
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01844

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-likeAdd BLAST94

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410KGIZ Eukaryota
ENOG4110S82 LUCA
GeneTreeiENSGT00730000110696
HOVERGENiHBG039526
InParanoidiP01844
OMAiTSTEWKS
PhylomeDBiP01844

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

P01844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSTPTLTV FPPSSEELKE NKATLVCLIS NFSPSGVTVA WKANGTPITQ
60 70 80 90 100
GVDTSNPTKE GNKFMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP

AECL
Length:104
Mass (Da):11,255
Last modified:July 21, 1986 - v1
Checksum:iCE4B67B8688862D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00595 Genomic DNA Translation: AAA39151.1
PIRiC93922 L2MS

Genome annotation databases

EnsembliENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937

Similar proteinsi

Entry informationi

Entry nameiLAC2_MOUSE
AccessioniPrimary (citable) accession number: P01844
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health