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Protein

Ig lambda-2 chain C region

Gene

Iglc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-2 chain C region
Gene namesi
Name:Iglc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:99547. Iglc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 104›104Ig lambda-2 chain C regionPRO_0000153609Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 85
Disulfide bondi103 – 103Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01844.
PaxDbiP01844.
PRIDEiP01844.

Expressioni

Gene expression databases

BgeeiP01844.
ExpressionAtlasiP01844. baseline and differential.
GenevisibleiP01844. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100464.

Structurei

Secondary structure

1
104
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 115Combined sources
Helixi15 – 195Combined sources
Beta strandi22 – 3514Combined sources
Beta strandi38 – 436Combined sources
Beta strandi46 – 483Combined sources
Beta strandi52 – 543Combined sources
Beta strandi58 – 603Combined sources
Beta strandi63 – 7311Combined sources
Helixi74 – 796Combined sources
Beta strandi83 – 897Combined sources
Beta strandi92 – 987Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QHRX-ray2.00L1-102[»]
ProteinModelPortaliP01844.
SMRiP01844. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01844.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 9994Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410KGIZ. Eukaryota.
ENOG4110S82. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG039526.
InParanoidiP01844.
OMAiTHEGQAM.
OrthoDBiEOG7HTHJS.
PhylomeDBiP01844.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QPKSTPTLTV FPPSSEELKE NKATLVCLIS NFSPSGVTVA WKANGTPITQ
60 70 80 90 100
GVDTSNPTKE GNKFMASSFL HLTSDQWRSH NSFTCQVTHE GDTVEKSLSP

AECL
Length:104
Mass (Da):11,255
Last modified:July 21, 1986 - v1
Checksum:iCE4B67B8688862D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00595 Genomic DNA. Translation: AAA39151.1.
PIRiC93922. L2MS.

Genome annotation databases

EnsembliENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00595 Genomic DNA. Translation: AAA39151.1.
PIRiC93922. L2MS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QHRX-ray2.00L1-102[»]
ProteinModelPortaliP01844.
SMRiP01844. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100464.

Protein family/group databases

IMGTiSearch...

Proteomic databases

MaxQBiP01844.
PaxDbiP01844.
PRIDEiP01844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103749; ENSMUSP00000100464; ENSMUSG00000076937.

Organism-specific databases

MGIiMGI:99547. Iglc2.

Phylogenomic databases

eggNOGiENOG410KGIZ. Eukaryota.
ENOG4110S82. LUCA.
GeneTreeiENSGT00730000110696.
HOVERGENiHBG039526.
InParanoidiP01844.
OMAiTHEGQAM.
OrthoDBiEOG7HTHJS.
PhylomeDBiP01844.

Miscellaneous databases

EvolutionaryTraceiP01844.
PROiP01844.
SOURCEiSearch...

Gene expression databases

BgeeiP01844.
ExpressionAtlasiP01844. baseline and differential.
GenevisibleiP01844. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of a chromosomal rearranged lambda 2 immunoglobulin gene of mouse."
    Wu G.E., Govindji N., Hozumi N., Murialdo H.
    Nucleic Acids Res. 10:3831-3843(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Somatic variants of murine immunoglobulin lambda light chains."
    Bothwell A.L.M., Paskind M., Reth M., Imanishi-Kari T., Rajewsky K., Baltimore D.
    Nature 298:380-382(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (MOPC 315).
  4. "Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315)."
    Dugan E.S., Bradshaw R.A., Simms E.S., Eisen H.N.
    Biochemistry 12:5400-5416(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (MOPC 315).
  5. "Identification of a third type of lambda light chain in mouse immunoglobulins."
    Azuma T., Steiner L.A., Eisen H.N.
    Proc. Natl. Acad. Sci. U.S.A. 78:569-573(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 66-104 (MOPC 315), SEQUENCE REVISION.

Entry informationi

Entry nameiLAC2_MOUSE
AccessioniPrimary (citable) accession number: P01844
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.